Topic · Chemical Synthesis and Analysis
Most cited papers in Chemical Synthesis and Analysis
What are the most cited papers in Chemical Synthesis and Analysis?
The most cited paper in Chemical Synthesis and Analysis is "Click Chemistry: Diverse Chemical Function from a Few Good Reactions" (Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless, 2001), with 13,223 citations. Next come "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes" (11,614) and "A procedure for the isolation of deoxyribonucleic acid from micro-organisms" (11,599).
Showing 50 of 98 papers. Every paper with more than 1,773 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless · Angewandte Chemie International Edition | Jun 2001 | 13,223 |
| 2 | A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition | 15 Jul 2002 | 11,614 |
| 3 | A procedure for the isolation of deoxyribonucleic acid from micro-organisms Julius Marmur · Journal of Molecular Biology | Apr 1961 | 11,599 |
| 4 | A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases Stanley Reitman, Sam Frankel · American Journal of Clinical Pathology | Jul 1957 | 10,038 |
| 5 | Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides Christian Wenzel Tornøe, Caspar Elo Christensen, Morten Meldal · The Journal of Organic Chemistry | 2 Apr 2002 | 8,627 |
| 6 | In situ click chemistry generation of cyclooxygenase-2 inhibitors Atul Bhardwaj, Jatinder Paul Kaur, Melinda Wuest et al. · Nature Communications | 9 Feb 2017 | 7,563 |
| 7 | Principles that Govern the Folding of Protein Chains Christian B. Anfinsen · Science | 20 Jul 1973 | 7,215 |
| 8 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019 David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 12 Mar 2020 | 7,078 |
| 9 | Fluorine in Pharmaceuticals: Looking Beyond Intuition Klaus Müller, Christoph Faeh, François Diederich · Science | 27 Sep 2007 | 6,622 |
| 10 | Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments G. Madhavi Sastry, Matvey Adzhigirey, Tyler Day et al. · Journal of Computer-Aided Molecular Design | Mar 2013 | 6,230 |
| 11 | Natural Products as Sources of New Drugs over the Last 25 Years David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 20 Feb 2007 | 5,531 |
| 12 | Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011) Jiang Wang, María Sánchez‐Roselló, José Luis Aceña et al. · Chemical Reviews | 3 Dec 2013 | 4,838 |
| 13 | The Atom Economy—A Search for Synthetic Efficiency BM Trost · Science | 6 Dec 1991 | 4,807 |
| 14 | Structure validation by Cα geometry: ϕ,ψ and Cβ deviation Simon C. Lovell, Ian Davis, W.B. Arendall et al. · Proteins Structure Function and Bioinformatics | 8 Jan 2003 | 4,652 |
| 15 | Cu-Catalyzed Azide−Alkyne Cycloaddition Morten Meldal, Christian Wenzel Tornøe · Chemical Reviews | Aug 2008 | 4,612 |
| 16 | Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success Frank Lovering, Jack Andrew Bikker, Christine C. Humblet · Journal of Medicinal Chemistry | 14 Oct 2009 | 4,568 |
| 17 | A simple and very efficient method for generating cDNA libraries Ueli Gubler, Beth J. Hoffman · Gene | Nov 1983 | 4,567 |
| 18 | A highly sensitive adenylate cyclase assay Yoram Salomon, Constantine Londos, Martin Rodbell · Analytical Biochemistry | Apr 1974 | 4,192 |
| 19 | Thiol–Ene Click Chemistry Charles E. Hoyle, Christopher N. Bowman · Angewandte Chemie International Edition | 17 Feb 2010 | 4,186 |
| 20 | Synthesis of Proteins by Native Chemical Ligation Philip E. Dawson, Tom W. Muir, Ian Clark‐Lewis et al. · Science | 4 Nov 1994 | 4,169 |
| 21 | ZINC − A Free Database of Commercially Available Compounds for Virtual Screening John J. Irwin, Brian K. Shoichet · Journal of Chemical Information and Modeling | 14 Dec 2004 | 4,130 |
| 22 | NCIPLOT: A Program for Plotting Noncovalent Interaction Regions Julia Contreras‐García, Erin R. Johnson, Shahar Keinan et al. · Journal of Chemical Theory and Computation | 25 Jan 2011 | 4,124 |
| 23 | LTP and LTD Robert C. Malenka, Mark F. Bear · Neuron | Sep 2004 | 4,025 |
| 24 | Molecular Self-Assembly and Nanochemistry: a Chemical Strategy for the Synthesis of Nanostructures George M. Whitesides, John P. Mathias, Christopher T. Seto · Science | 29 Nov 1991 | 3,641 |
| 25 | Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers Jeffrey D. Hartgerink, Elia Beniash, Samuel Isaac Stupp · Science | 23 Nov 2001 | 3,610 |
| 26 | A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate Alfred G. Gilman · Proceedings of the National Academy of Sciences | Sep 1970 | 3,270 |
| 27 | Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter Donald A. Tomalia, Adel M. Naylor, William A. Goddard · Angewandte Chemie International Edition in English | Feb 1990 | 3,213 |
| 28 | Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality Ellen M. Sletten, Carolyn Ruth Bertozzi · Angewandte Chemie International Edition | 27 Aug 2009 | 3,183 |
| 29 | The growing impact of click chemistry on drug discovery Hartmuth Christian Kolb, Karl Barry Sharpless · Drug Discovery Today | Dec 2003 | 3,149 |
| 30 | A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases Arup K. Ghose, Vellarkad N. Viswanadhan, John J. Wendoloski · Journal of Combinatorial Chemistry | 18 Dec 1998 | 3,107 |
| 31 | Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties Peter F. Ertl, Bernhard Rohde, Paul M. Selzer · Journal of Medicinal Chemistry | 19 Sep 2000 | 3,103 |
| 32 | Peptide therapeutics: current status and future directions Keld Fosgerau, Torsten Hoffmann · Drug Discovery Today | 16 Oct 2014 | 3,077 |
| 33 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. Günter Blobel, B Dobberstein · The Journal of Cell Biology | Dec 1975 | 3,023 |
| 34 | The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures Douglas A. Horton, Gregory T. Bourne, Mark L. Smythe · Chemical Reviews | 22 Feb 2003 | 3,010 |
| 35 | Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation Thien-Khai H. Vu, David T. Hung, Virginia I. Wheaton et al. · Cell | Mar 1991 | 3,007 |
| 36 | The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain Linus Carl Pauling, Robert B. Corey, H. R. Branson · Proceedings of the National Academy of Sciences | Apr 1951 | 2,932 |
| 37 | 1,3‐Dipolar Cycloadditions. Past and Future Rolf Huisgen · Angewandte Chemie International Edition in English | Oct 1963 | 2,898 |
| 38 | Asymmetric Transition-Metal-Catalyzed Allylic Alkylations: Applications in Total Synthesis Barry M. Trost, Matthew L. Crawley · Chemical Reviews | 21 Jun 2003 | 2,854 |
| 39 | Asymmetric Enamine Catalysis Santanu Mukherjee, Jung Woon Yang, S.D. Hoffmann et al. · Chemical Reviews | Dec 2007 | 2,854 |
| 40 | The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates Stephen D. Roughley, Allan Michael Jordan · Journal of Medicinal Chemistry | 19 Apr 2011 | 2,771 |
| 41 | FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE BENGT FALCK, N.‐Å. Hillarp, Georg Thieme et al. · Journal of Histochemistry & Cytochemistry | May 1962 | 2,708 |
| 42 | Light-Directed, Spatially Addressable Parallel Chemical Synthesis Stephen P. A. Fodor, Jill Read, Michael C. Pirrung et al. · Science | 15 Feb 1991 | 2,705 |
| 43 | SH2 domains recognize specific phosphopeptide sequences S Zhou · Cell | 12 Mar 1993 | 2,683 |
| 44 | Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp Dennis A. Dougherty · Science | 12 Jan 1996 | 2,669 |
| 45 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design Nicholas A. Meanwell · Journal of Medicinal Chemistry | 5 Feb 2018 | 2,663 |
| 46 | Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range Sidney Udenfriend, Stanley J. Stein, Peter Böhlen et al. · Science | 24 Nov 1972 | 2,660 |
| 47 | Small-Molecule H-Bond Donors in Asymmetric Catalysis Abigail G. Doyle, Eric N. Jacobsen · Chemical Reviews | Dec 2007 | 2,607 |
| 48 | The evolving role of natural products in drug discovery Frank E. Koehn, Guy T. Carter · Nature Reviews Drug Discovery | 24 Feb 2005 | 2,586 |
| 49 | The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid Bruce N. Ames, Donald T. Dubin · Journal of Biological Chemistry | Mar 1960 | 2,583 |
| 50 | Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery Stuart L. Schreiber · Science | 17 Mar 2000 | 2,579 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.