Topic · DNA and Nucleic Acid Chemistry
Most cited papers in DNA and Nucleic Acid Chemistry
What are the most cited papers in DNA and Nucleic Acid Chemistry?
The most cited paper in DNA and Nucleic Acid Chemistry is "Detection of specific sequences among DNA fragments separated by gel electrophoresis" (E.M. Southern, 1975), with 32,849 citations. Next come "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity" (25,160) and "Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease" (22,217).
Showing 50 of 100 papers. Every paper with more than 1,869 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Detection of specific sequences among DNA fragments separated by gel electrophoresis E.M. Southern · Journal of Molecular Biology | Nov 1975 | 32,849 |
| 2 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity Andrew P. Feinberg, Bert Vogelstein · Analytical Biochemistry | Jul 1983 | 25,160 |
| 3 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease John M. Chirgwin, Alan Przybyla, Raymond J. MacDonald et al. · Biochemistry | Nov 1979 | 22,217 |
| 4 | Development and testing of a general amber force field Junmei Wang, Romain M. Wolf, James W. Caldwell et al. · Journal of Computational Chemistry | 13 Apr 2004 | 20,214 |
| 5 | Mfold web server for nucleic acid folding and hybridization prediction Michael Zuker · Nucleic Acids Research | 24 Jun 2003 | 13,707 |
| 6 | A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules Wendy D. Cornell, Piotr Cieplak, Christopher I. Bayly et al. · Journal of the American Chemical Society | May 1995 | 13,239 |
| 7 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I Peter W. J. Rigby, Marianne Dieckmann, Carl Rhodes et al. · Journal of Molecular Biology | Jun 1977 | 11,663 |
| 8 | A procedure for the isolation of deoxyribonucleic acid from micro-organisms Julius Marmur · Journal of Molecular Biology | Apr 1961 | 11,599 |
| 9 | Studies on transformation of Escherichia coli with plasmids Douglas Hanahan · Journal of Molecular Biology | Jun 1983 | 11,339 |
| 10 | Evolution of Protein Molecules Thomas H. Jukes, Charles R. Cantor · Elsevier eBooks | 1969 | 11,260 |
| 11 | CHARMM: The biomolecular simulation program Bernard R. Brooks et al. · Journal of Computational Chemistry | 14 May 2009 | 9,331 |
| 12 | Genomic sequencing. George M. Church, W Gilbert · Proceedings of the National Academy of Sciences | Apr 1984 | 8,225 |
| 13 | Folding DNA to create nanoscale shapes and patterns Paul W. K. Rothemund · Nature | 15 Mar 2006 | 7,535 |
| 14 | Comparison of multiple Amber force fields and development of improved protein backbone parameters Viktor Horn̆ák, Robert Abel, Asim Okur et al. · Proteins Structure Function and Bioinformatics | 15 Sep 2006 | 7,174 |
| 15 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers Jeffrey Vieira, Joachim W. Messing · Gene | Oct 1982 | 6,134 |
| 16 | ViennaRNA Package 2.0 Ronny Lorenz, Stephan H Bernhart, Christian Höner zu Siederdissen et al. · Algorithms for Molecular Biology | 24 Nov 2011 | 5,580 |
| 17 | DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139 Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr et al. · Journal of Biological Chemistry | Mar 1998 | 5,501 |
| 18 | Calculating Structures and Free Energies of Complex Molecules: Combining Molecular Mechanics and Continuum Models Peter A. Kollman, Irina Massova, Carolina Reyes et al. · Accounts of Chemical Research | 4 Oct 2000 | 5,049 |
| 19 | A simple, rapid, and sensitive DNA assay procedure Cesar G. Labarca, Kenneth Paigen · Analytical Biochemistry | Mar 1980 | 4,971 |
| 20 | g_mmpbsa —A GROMACS Tool for High-Throughput MM-PBSA Calculations Rashmi Kumari, Rajendra Kumar, Open Source Drug Discovery Consortium et al. · Journal of Chemical Information and Modeling | 21 May 2014 | 4,935 |
| 21 | Precise Measurement of the G+C Content of Deoxyribonucleic Acid by High-Performance Liquid Chromatography M. K. M. Mesbah, USHA PREMACHANDRAN, William B. Whitman · International Journal of Systematic Bacteriology | Apr 1989 | 4,557 |
| 22 | A point‐charge force field for molecular mechanics simulations of proteins based on condensed‐phase quantum mechanical calculations Yong Duan, Chun Fu Wu, Shibasish Chowdhury et al. · Journal of Computational Chemistry | 25 Sep 2003 | 4,520 |
| 23 | A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining Janet D. Rowley · Nature | Jun 1973 | 4,335 |
| 24 | Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells Edgar H. Schreiber, Patrick Matthias, Michael M. Müller et al. · Nucleic Acids Research | 1989 | 4,246 |
| 25 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature Julius Marmur, Paul M. Doty · Journal of Molecular Biology | Jul 1962 | 4,109 |
| 26 | A complementation analysis of the restriction and modification of DNA in Escherichia coli Herbert W. Boyer, Daisy Roulland-Dussoix · Journal of Molecular Biology | May 1969 | 3,863 |
| 27 | Cellular processing of platinum anticancer drugs Dong Wang, Stephen J. Lippard · Nature Reviews Drug Discovery | 24 Mar 2005 | 3,802 |
| 28 | Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences | Apr 1989 | 3,646 |
| 29 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information Michael Zuker, Patrick Stiegler · Nucleic Acids Research | 1981 | 3,640 |
| 30 | Fast, efficient generation of high‐quality atomic charges. AM1‐BCC model: II. Parameterization and validation Araz Jakalian, D. B. Jack, Christopher I. Bayly · Journal of Computational Chemistry | 18 Oct 2002 | 3,577 |
| 31 | CpG motifs in bacterial DNA trigger direct B-cell activation Arthur M. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature | Apr 1995 | 3,560 |
| 32 | An approach to computing electrostatic charges for molecules U. Chandra Singh, Peter A. Kollman · Journal of Computational Chemistry | Apr 1984 | 3,486 |
| 33 | Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction Masato Orita, Youichi Suzuki, Takao Sekiya et al. · Genomics | Nov 1989 | 3,481 |
| 34 | CpG Islands in vertebrate genomes Margaret Gardiner‐Garden, Marianne Frommer · Journal of Molecular Biology | Jul 1987 | 3,466 |
| 35 | An all atom force field for simulations of proteins and nucleic acids Scott J. Weiner, Peter A. Kollman, Dzung T. Nguyen et al. · Journal of Computational Chemistry | Apr 1986 | 3,450 |
| 36 | Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide Peter Eigil Nielsen, Michael Egholm, Rolf H. Berg et al. · Science | 6 Dec 1991 | 3,345 |
| 37 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs Marilyn Kozak · Nucleic Acids Research | 1984 | 3,343 |
| 38 | New Giemsa method for the differential staining of sister chromatids Paul Perry, Sheldon M. Wolff · Nature | Sep 1974 | 3,202 |
| 39 | Complexation Thermodynamics of Cyclodextrins M.V. Rekharsky, Yoshihisa Inoue · Chemical Reviews | 14 Jul 1998 | 3,197 |
| 40 | Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line Susan P.C. Cole, Gabu Bhardwaj, James H. Gerlach et al. · Science | 4 Dec 1992 | 3,071 |
| 41 | Theoretical aspects of DNA-protein interactions: Co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice James D. McGhee, Peter H. von Hippel · Journal of Molecular Biology | Jun 1974 | 2,973 |
| 42 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides Gerald S. Manning · Quarterly Reviews of Biophysics | May 1978 | 2,962 |
| 43 | Structure, Recognition, and Processing of Cisplatin−DNA Adducts Elizabeth R. Jamieson, Stephen J. Lippard · Chemical Reviews | 14 Aug 1999 | 2,952 |
| 44 | Strong Inference John Rader Platt · Science | 16 Oct 1964 | 2,887 |
| 45 | Design and self-assembly of two-dimensional DNA crystals Erik Winfree, Furong Liu, Lisa A. Wenzler et al. · Nature | Aug 1998 | 2,876 |
| 46 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics John SantaLucia · Proceedings of the National Academy of Sciences | 17 Feb 1998 | 2,867 |
| 47 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis Michael Gregory Fried, Donald M. Crothers · Nucleic Acids Research | 1981 | 2,859 |
| 48 | Repeated Sequences in DNA Roy J. Britten, David E. Kohne · Science | 9 Aug 1968 | 2,824 |
| 49 | A general method for isolation of high molecular weight DNA from eukaryotes Nikolaus Blin, Darrel W. Stafford · Nucleic Acids Research | Sep 1976 | 2,814 |
| 50 | DNA in a material world Nadrian C. Seeman · Nature | 22 Jan 2003 | 2,797 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.