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Topic · Molecular Biology

RNA modifications and cancer

RNA modifications and cancer is a research topic within Molecular Biology. Science Explorer counts 89k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the diverse landscape of RNA methylation, with a focus on m6A modification, its impact on gene expression, ribosome biogenesis, and its role in cancer progression. The research covers various aspects such as m6A-seq, tRNA fragments, YTHDF proteins, and the involvement of methyltransferases in mRNA modification.

  • m6A-seq
  • RNA methylation
  • mRNA modification
  • epitranscriptome
  • ribosome biogenesis
  • tRNA fragments
  • YTHDF proteins
  • cancer progression
  • methyltransferases
  • gene expression regulation
Research works
89k
fractional, since 1950
In the world top 10%
8.7k
per year above
Top-10% rate
9.8%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+15%
the tick is no change
Largest producer
China
55% of the 10 largest, 2022-now
RNA modifications and cancer

Which countries lead RNA modifications and cancer research?

By volume, China and the United States publish the most (9.5k and 4.1k works in 2022-now).

By volume, 2022-now

  1. 1 China 9.5k works
  2. 2 United States 4.1k works
  3. 3 Germany 638 works
  4. 4 Japan 599 works
  5. 5 India 588 works
  6. 6 United Kingdom 484 works
  7. 7 France 412 works
  8. 8 Italy 357 works
  9. 9 South Korea 323 works
  10. 10 Canada 323 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 54.7%United States: 23.8%Germany: 3.7%Japan: 3.5%6 others listed: 14.4%55%largest
China9,471 · 54.7%United States4,110 · 23.8%Germany638 · 3.7%Japan599 · 3.5%6 others listed2,486 · 14.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead RNA modifications and cancer research?

By volume in 2022-now, Sun Yat-sen University publishes the most RNA modifications and cancer research, followed by Shanghai Jiao Tong University and Nanjing Medical University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 321 works
  2. 2 Shanghai Jiao Tong UniversityChina 239 works
  3. 3 Nanjing Medical UniversityChina 236 works
  4. 4 Central South UniversityChina 223 works
  5. 5 Zhejiang UniversityChina 206 works
  6. 6 Chinese Academy of SciencesChina 205 works
  7. 7 Harvard UniversityUnited States 175 works
  8. 8 Wuhan UniversityChina 168 works
  9. 9 Fudan UniversityChina 158 works
  10. 10 Sichuan UniversityChina 157 works

Who are the leading researchers in RNA modifications and cancer?

The most-cited researchers publishing on RNA modifications and cancer include Eric S. Lander, Zhong Lin Wang and Rob Knight.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Zhong Lin Wang United States 491k citations
  3. 3 Rob Knight United States 468k citations
  4. 4 George Davey Smith United Kingdom 435k citations
  5. 5 Ali H. Mokdad United States 429k citations
  6. 6 Richard M. Durbin United Kingdom 410k citations
  7. 7 Mark J. Daly United States 403k citations
  8. 8 Stacey L. Gabriel United States 402k citations
  9. 9 Peer Bork Germany 396k citations
  10. 10 Robert John Tibshirani United States 396k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in RNA modifications and cancer?

The most cited paper in RNA modifications and cancer is "Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2" (Michael I. Love, Wolfgang K. Huber, Simon Anders, 2014), with 104,335 citations. Next come "Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles" (58,060) and "Cutadapt removes adapter sequences from high-throughput sequencing reads" (37,060).

Most cited papers
#PaperReleasedCitations
1 Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 Michael I. Love, Wolfgang K. Huber, Simon Anders · Genome biology Open access 5 Dec 2014 104,335
2 Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles Aravind N. Subramanian, Pablo Tamayo, Vamsi Krishna Mootha et al. · Proceedings of the National Academy of Sciences Open access 30 Sep 2005 58,060
3 Cutadapt removes adapter sequences from high-throughput sequencing reads Marcel Martin · EMBnet journal Open access 2 May 2011 37,060
4 The SILVA ribosomal RNA gene database project: improved data processing and web-based tools Christian Quast, Elmar Pruesse, Pelin Yilmaz et al. · Nucleic Acids Research Open access 27 Nov 2012 35,094
5 HISAT: a fast spliced aligner with low memory requirements Daehwan Kim, Ben Langmead, Steven L. Salzberg · Nature Methods Open access 9 Mar 2015 26,880
All 100 most cited papers, with filters and sorting

Where is RNA modifications and cancer research done?

The largest centres of RNA modifications and cancer research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China). Among places with at least 20 works in it, it is an unusually large share of all research in Chevy Chase and Nantong.

Largest cities, 2022-now

  1. 1 BeijingChina 866 works
  2. 2 ShanghaiChina 750 works
  3. 3 GuangzhouChina 718 works
  4. 4 WuhanChina 430 works
  5. 5 NanjingChina 427 works
  6. 6 HangzhouChina 378 works
  7. 7 ChangshaChina 362 works
  8. 8 JinanChina 257 works
  9. 9 ChengduChina 251 works
  10. 10 Xi'anChina 217 works

Where it is the local speciality

  1. Chevy ChaseUS · 38.4 works22×
  2. NantongCN · 90.9 works9.8×
← less than its size predicts1×more →

Location quotient: how much more of its research is in RNA modifications and cancer than the world average.

See RNA modifications and cancer on the map

Where is the best place to study RNA modifications and cancer?

Among universities, judged by research, Sun Yat-sen University, Rockefeller University and Harvard University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 15.6%fractional works in this field (log) →share of work in the world top 10% →Rockefeller UniversitySun Yat-sen UniversityHarvard UniversityShanghai Jiao Tong U…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sun Yat-sen UniversityChina 73.517.1%9.0×321 +32.5%
2Rockefeller UniversityUnited States 66.828.3%15.1×16 +25.5%
3Harvard UniversityUnited States 66.616.1%3.2×175 -5.2%
4Shanghai Jiao Tong UniversityChina 63.212.8%4.8×240 +30.2%
5Nanjing Medical UniversityChina 63.112.7%15.3×236 +14.0%
6Fudan UniversityChina 61.914.7%5.8×158 +32.9%
7Central South UniversityChina 61.611.9%6.7×223 +44.5%
8Zhejiang UniversityChina 61.311.3%4.5×206 +23.8%
9Massachusetts Institute of TechnologyUnited States 60.518.3%2.6×32 +17.3%
10Wuhan UniversityChina 59.912.8%6.8×168 +38.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in RNA modifications and cancer, country by country

Is RNA modifications and cancer research growing?

Output in 2022-2025 was 15% higher than in 2018-2021, peaking in 2022. The fastest-growing topics are RNA modifications and cancer.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is RNA modifications and cancer as a percentage of every work published that year, 0.088% in 2024.

still counting0.050%0.10%0.15%RNA modifications and cancer0.078% in 202519801990200020102020

Fractional works of RNA modifications and cancer over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%RNA modifications and cancer9.7% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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