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A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Stephen S Lim et al. · The Lancet
Open access209 authors |
Dec 2012 |
12,027 |
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Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Christopher J L Murray et al. · The Lancet
Open access362 authors |
Dec 2012 |
9,055 |
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Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Theo Vos et al. · The Lancet
Open access358 authors |
Dec 2012 |
8,461 |
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Nivolumab in Previously Untreated Melanoma without BRAF Mutation
Caroline Robert et al. · New England Journal of Medicine
Open access |
16 Nov 2014 |
5,431 |
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K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer
Christos Stelios Karapetis, Shirin Khambata‐Ford, Derek J. Jonker et al. · New England Journal of Medicine
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22 Oct 2008 |
3,629 |
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The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
Marita Cross, Emma U.R. Smith, Damian Hoy et al. · Annals of the Rheumatic Diseases
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20 Feb 2014 |
3,624 |
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Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012
Paul Robert McCrory et al. · British Journal of Sports Medicine
Open access |
11 Mar 2013 |
2,596 |
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Non-specific low back pain
Christopher Gerard Maher, Martin R Underwood, Rachelle Buchbinder · The Lancet
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15 Oct 2016 |
2,586 |
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Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton et al. · Nature
Open access239 authors |
27 May 2007 |
2,342 |
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Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
Sandra Navarra, Renato Guzmán, A Gallacher et al. · The Lancet
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Feb 2011 |
2,098 |
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Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study
Michael S. Hofman et al. · The Lancet
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22 Mar 2020 |
2,053 |
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Open-Label Phase III Trial of Panitumumab Plus Best Supportive Care Compared With Best Supportive Care Alone in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer
Eric Van Cutsem, Marc Peeters, Salvatore Siena et al. · Journal of Clinical Oncology
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30 Apr 2007 |
2,002 |
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Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma
Toni K. Choueiri et al. · New England Journal of Medicine
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3 Mar 2021 |
1,801 |
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Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017
Aimin Wu, LYN M. MARCH, Xuan-Qi Zheng et al. · Annals of Translational Medicine
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Mar 2020 |
1,620 |
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The standardization of terminology of lower urinary tract function in children and adolescents: Update report from the standardization committee of the International Children's Continence Society
Paul F. Austin, Stuart B. Bauer, Wendy Bower et al. · Neurourology and Urodynamics
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14 Mar 2015 |
1,548 |
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A Randomized Trial of Vertebroplasty for Painful Osteoporotic Vertebral Fractures
Rachelle Buchbinder, Richard H. Osborne, Peter Robert Ebeling et al. · New England Journal of Medicine
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5 Aug 2009 |
1,434 |
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Developing theory-informed behaviour change interventions to implement evidence into practice: a systematic approach using the Theoretical Domains Framework
Simon David French, Sally Green, Denise A O’Connor et al. · Implementation Science
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24 Apr 2012 |
1,434 |
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The grounded psychometric development and initial validation of the Health Literacy Questionnaire (HLQ)
Richard H. Osborne, Roy W. Batterham, Gerald R. Elsworth et al. · BMC Public Health
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15 Jul 2013 |
1,407 |
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Low back pain: a call for action
Rachelle Buchbinder et al. · The Lancet
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21 Mar 2018 |
1,288 |
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Consensus statement on concussion in sport: the 6th International Conference on Concussion in Sport–Amsterdam, October 2022
Jon Patricios et al. · British Journal of Sports Medicine
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Jun 2023 |
1,185 |
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The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study
Marita Cross, Emma U.R. Smith, Damian Hoy et al. · Annals of the Rheumatic Diseases
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19 Feb 2014 |
1,168 |
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Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial
Stephen M. Davis et al. · The Lancet Neurology
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2 Mar 2008 |
1,050 |
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Consensus on Exercise Reporting Template (CERT): Explanation and Elaboration Statement
Susan Carolyn Slade, Clermont E. Dionne, Martin R Underwood et al. · British Journal of Sports Medicine
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5 Oct 2016 |
1,004 |
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Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo
Ralf Kießlich, Juergen Burg, Michael Vieth et al. · Gastroenterology
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Sep 2004 |
847 |
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Adverse effects of biologics: a network meta-analysis and Cochrane overview
Jasvinder A. Singh et al. · Cochrane Database of Systematic Reviews
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4 Feb 2011 |
829 |
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Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial
Paul E. Emery, Ferdinand C. Breedveld, Stephen Hall et al. · The Lancet
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17 Jul 2008 |
825 |
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Tofacitinib versus Methotrexate in Rheumatoid Arthritis
Eun Bong Lee, Roy Fleischmann, Stephen Hall et al. · New England Journal of Medicine
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18 Jun 2014 |
790 |
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The global burden of neck pain: estimates from the Global Burden of Disease 2010 study
Damian Hoy, LYN M. MARCH, Anthony D. Woolf et al. · Annals of the Rheumatic Diseases
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30 Jan 2014 |
766 |
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Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Simon I Hay et al. · The Lancet
Open access2,780 authors |
Oct 2025 |
762 |
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Realist synthesis: illustrating the method for implementation research
Jo Rycroft‐Malone, Brendan George McCormack, Alison Margaret Hutchinson et al. · Implementation Science
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19 Apr 2012 |
759 |
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Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration
Wassim M. Abida et al. · Journal of Clinical Oncology
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14 Aug 2020 |
695 |
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Global, regional, and national burden of neck pain in the general population, 1990-2017: systematic analysis of the Global Burden of Disease Study 2017
Saeid Safiri, Ali‐Asghar Kolahi, Damian Hoy et al. · BMJ
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26 Mar 2020 |
675 |
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Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries
Vincenzo Russotto et al. · JAMA
Open access404 authors |
23 Mar 2021 |
668 |
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Health literacy: applying current concepts to improve health services and reduce health inequalities
Roy W. Batterham, Mélanie Hawkins, Patricia Collins et al. · Public Health
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9 Feb 2016 |
629 |
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Crohn's disease management after intestinal resection: a randomised trial
Peter P. De Cruz et al. · The Lancet
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23 Dec 2014 |
619 |
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Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials
Allan Lipton, Karim S. Fizazi, Alison Stopeck et al. · European Journal of Cancer
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592 |
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Physiotherapy interventions for shoulder pain
Sally Green, Rachelle Buchbinder, Sarah Elisabeth Hetrick · Cochrane Database of Systematic Reviews
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22 Apr 2003 |
577 |
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Corticosteroid injections for shoulder pain
Rachelle Buchbinder, Sally Green, Joanne M Youd · Cochrane Database of Systematic Reviews
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20 Jan 2003 |
577 |
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Tofacitinib or Adalimumab versus Placebo for Psoriatic Arthritis
Philip J. Mease, Stephen Hall, Oliver FitzGerald et al. · New England Journal of Medicine
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18 Oct 2017 |
574 |
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Burden of disability due to musculoskeletal (MSK) disorders
LYN M. MARCH, Emma U.R. Smith, Damian G Hoy et al. · Best Practice & Research Clinical Rheumatology
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Jun 2014 |
569 |
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Golimumab, a human antibody to tumour necrosis factor α given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study
Edward Clark Keystone, Mark C. Genovese, Lars Klareskog et al. · Annals of the Rheumatic Diseases
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9 Dec 2008 |
545 |
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Plantar Fasciitis
Rachelle Buchbinder · New England Journal of Medicine
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509 |
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Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial
Roy Fleischmann et al. · The Lancet
216 authors |
16 Jun 2017 |
506 |
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Consensus on Exercise Reporting Template (CERT): Modified Delphi Study
Susan Carolyn Slade et al. · Physical Therapy
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6 May 2016 |
504 |
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Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Mohsen Naghavi et al. · The Lancet
Open access2,463 authors |
Oct 2025 |
500 |
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Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial
Fabrice André et al. · The Lancet Oncology
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14 Apr 2014 |
496 |
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Core outcome measurement instruments for clinical trials in nonspecific low back pain
Alessandro Chiarotto, Maarten Boers, Richard A. Deyo et al. · Pain
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24 Nov 2017 |
486 |
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The American Congress of Rehabilitation Medicine Diagnostic Criteria for Mild Traumatic Brain Injury
Noah D. Silverberg et al. · Archives of Physical Medicine and Rehabilitation
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19 May 2023 |
462 |
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Longitudinal Study Comparing Sonographic and MRI Assessments of Acute and Healing Hamstring Injuries
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457 |
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Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis
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452 |