Most cited papers from Cancer Research UK

Cancer Research UK

What are the most cited papers from Cancer Research UK?

The most cited paper from Cancer Research UK is "Measuring inconsistency in meta-analyses" (Julian P. T. Higgins, Simon G. Thompson, Jonathan J Deeks et al., 2003), with 64,184 citations. Next come "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines" (11,535) and "Cancer-related inflammation" (11,477).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 59 papers. Every paper with more than 2,501 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Measuring inconsistency in meta-analyses Julian P. T. Higgins, Simon G. Thompson, Jonathan J Deeks et al. · BMJ Open access	4 Sep 2003	64,184
2	Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Clotilde Théry et al. · Journal of Extracellular Vesicles Open access382 authors	23 Nov 2018	11,535
3	Cancer-related inflammation Alberto Mantovani, Paola Allavena, Antonio Sica et al. · Nature Open access	Jul 2008	11,477
4	Mutations of the BRAF gene in human cancer Helen Ruth Davies et al. · Nature	Jun 2002	10,791
5	Signatures of mutational processes in human cancer Australian Pancreatic Cancer Genome Initiative et al. · Nature Open access	14 Aug 2013	10,284
6	Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Paul R. Burton et al. · Nature Open access276 authors	6 Jun 2007	9,692
7	The MR-Base platform supports systematic causal inference across the human phenome Gibran Hemani, Jie Zheng, Benjamin L. Elsworth et al. · eLife Open access	30 May 2018	8,708
8	Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration Jan Paul Vandenbroucke, Erik B von Elm, Douglas G. Altman et al. · PLoS Medicine Open access	10 Oct 2007	8,626
9	Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing Marco Gerlinger et al. · New England Journal of Medicine Open access	7 Mar 2012	7,931
10	Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Hannah Farmer, Nuala McCabe, Christopher J. Lord et al. · Nature	Apr 2005	6,785
11	Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 Lorenzo Galluzzi et al. · Cell Death and Differentiation Open access169 authors	23 Jan 2018	6,760
12	The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups METABRIC Group et al. · Nature Open access	17 Apr 2012	6,505
13	Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Daniel J. Klionsky et al. · Autophagy Open access2,467 authors	2 Jan 2016	6,023
14	Docetaxel plus Prednisone or Mitoxantrone plus Prednisone for Advanced Prostate Cancer Ian F. Tannock, Ronald de Wit, William R. Berry et al. · New England Journal of Medicine	6 Oct 2004	5,779
15	Osimertinib in Untreated EGFR -Mutated Advanced Non–Small-Cell Lung Cancer Jean‐Charles Soria et al. · New England Journal of Medicine Open access	18 Nov 2017	5,475
16	Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Andrew G. Renehan, Margaret Tyson, Matthias Egger et al. · The Lancet Review	Feb 2008	5,283
17	Rho GTPases in cell biology Sandrine Etienne‐Manneville, Alan K. Hall · Nature	Dec 2002	4,844
18	Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma Robert John Motzer et al. · New England Journal of Medicine Open access	21 Mar 2018	4,756
19	Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents Philip L. Ross, Yulin Huang, Jason Marchese et al. · Molecular & Cellular Proteomics Open access	22 Sep 2004	4,464
20	Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia Catherine D. Nobes, Alan K. Hall · Cell Open access	Apr 1995	4,456
21	N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO Guifang Jia, Ye Fu, Xu Zhao et al. · Nature Chemical Biology Open access	16 Oct 2011	4,230
22	Succinate is an inflammatory signal that induces IL-1β through HIF-1α Gillian M. Tannahill et al. · Nature Open access	22 Mar 2013	4,197
23	Guidelines for the use and interpretation of assays for monitoring autophagy Daniel J. Klionsky et al. · Autophagy Open access1,270 authors	Apr 2012	4,068
24	A framework for advancing our understanding of cancer-associated fibroblasts Erik A. Sahai et al. · Nature reviews. Cancer ReviewOpen access	24 Jan 2020	3,962
25	Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Hiroki Kato, Osamu Takeuchi, Shintaro Sato et al. · Nature	9 Apr 2006	3,913
26	The repertoire of mutational signatures in human cancer Ludmil B. Alexandrov et al. · Nature Open access1,384 authors	5 Feb 2020	3,854
27	Genomic analyses identify molecular subtypes of pancreatic cancer Peter J. Bailey et al. · Nature 103 authors	23 Feb 2016	3,805
28	Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies Antonis C. Antoniou et al. · The American Journal of Human Genetics Open access	23 Apr 2003	3,727
29	Regulation of Wound Healing by Growth Factors and Cytokines Sabine Werner, Richard Philip Grose · Physiological Reviews Review	Jul 2003	3,647
30	Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA Sandra S. Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi et al. · Science	23 Feb 2004	3,453
31	Pan-cancer analysis of whole genomes Lauri A. Aaltonen et al. · Nature Open access1,324 authors	5 Feb 2020	3,360
32	Cellular Senescence: Defining a Path Forward Vassilis G. Gorgoulis et al. · Cell Open access	Oct 2019	3,322
33	Targeting RAS signalling pathways in cancer therapy Julian Downward · Nature reviews. Cancer Review	2003	3,287
34	Blinded by the Light: The Growing Complexity of p53 Karen H. Vousden, Carol L. Prives · Cell Open access	May 2009	3,205
35	Interaction revisited: the difference between two estimates Douglas G. Altman, J Martin Bland · BMJ Open access	23 Jan 2003	3,202
36	Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer Kenneth P. Olive et al. · Science Open access	21 May 2009	3,195
37	Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade Nicholas McGranahan et al. · Science Open access	3 Mar 2016	3,177
38	Patterns of somatic mutation in human cancer genomes Christopher D. Greenman et al. · Nature Open access	Mar 2007	3,167
39	The extracellular matrix: A dynamic niche in cancer progression Pengfei Lu, Valerie Marie Weaver, Zena Werb · The Journal of Cell Biology Open access	20 Feb 2012	3,079
40	RHO GTPASES: Biochemistry and Biology Aron B. Jaffe, Alan K. Hall · Annual Review of Cell and Developmental Biology Review	28 Jun 2005	3,071
41	MAP kinase signalling pathways in cancer Amardeep S. Dhillon, Suzanne Hagan, Oliver Rath et al. · Oncogene	14 May 2007	3,062
42	Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families Deborah Ford et al. · The American Journal of Human Genetics Open access	Mar 1998	3,057
43	Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future Nicholas McGranahan, Charles Swanton · Cell Open access	Feb 2017	3,002
44	EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent Nicolas Mottet et al. · European Urology Open access	7 Nov 2020	2,876
45	Liquid biopsies come of age: towards implementation of circulating tumour DNA Jonathan C. M. Wan, Charles E. Massie, Javier García-Corbacho et al. · Nature reviews. Cancer ReviewOpen access	24 Feb 2017	2,855
46	Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF Paul Wan, Mathew J. Garnett, Stephen Mark Roe et al. · Cell Open access	Mar 2004	2,841
47	Basic and Therapeutic Aspects of Angiogenesis Michael Potente, Holger Gerhardt, Peter Carmeliet · Cell Open access	Sep 2011	2,838
48	Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors Laleh Haghverdi, Aaron T. L. Lun, Michael David Morgan et al. · Nature Biotechnology Open access	2 Apr 2018	2,808
49	Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Jan Paul Vandenbroucke, Erik B von Elm, Douglas G. Altman et al. · Epidemiology Open access	Nov 2007	2,777
50	The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates Stephen D. Roughley, Allan Michael Jordan · Journal of Medicinal Chemistry	19 Apr 2011	2,771

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.