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Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial
Jonathan M. Spergel, Marc E. Rothenberg, Margaret H. Collins et al. · Journal of Allergy and Clinical Immunology
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30 Dec 2011 |
556 |
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Wnt/β-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer
Lubomir Bodnar, Aleksandra M. Stanczak, Szczepan Cierniak et al. · Journal of Ovarian Research
Open access |
2014 |
81 |
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Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
Aleksandra M. Stanczak, Rafał Stec, Lubomir Bodnar et al. · Pathology & Oncology Research
Open access |
15 Jun 2011 |
78 |
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Epithelial–mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells
Paulina Grygielewicz, Barbara Dymek, Anna Bujak et al. · Gastric Cancer
Open access |
19 Nov 2014 |
72 |
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Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery
Lidia Gurba-Bryśkiewicz, Wioleta Maruszak, Damian A. Smuga et al. · Biomedicines
Open access |
11 Oct 2023 |
63 |
| 6 |
Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1–3)
Abdellah Yamani, Daria Zdżalik-Bielecka, Joanna Lipner et al. · European Journal of Medicinal Chemistry
Open access |
6 Nov 2020 |
46 |
| 7 |
Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists
Piotr Pankiewicz et al. · Pharmaceuticals
Open access |
21 Jul 2021 |
43 |
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MET-Pyk2 Axis Mediates Acquired Resistance to FGFR Inhibition in Cancer Cells
Kamila Kitowska, Monika Gorska‐Arcisz, Dima Antoun et al. · Frontiers in Oncology
Open access |
7 Apr 2021 |
43 |
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Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties
Jakub Staroń, Rafał Kurczab, Dawid Warszycki et al. · European Journal of Medicinal Chemistry
Open access |
7 Nov 2019 |
38 |
| 10 |
Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma
Daria Zdżalik-Bielecka, Barbara Dymek, Paulina Grygielewicz et al. · Journal of Cancer Research and Clinical Oncology
Open access |
7 Feb 2014 |
37 |
| 11 |
Silencing of Wnt-1 by siRNA induces apoptosis of MCF-7 human breast cancer cells
Maciej Wieczorek, Aleksandra Paczkowska, Piotr Guzenda et al. · Cancer Biology & Therapy
Open access |
4 Feb 2008 |
36 |
| 12 |
Characterization of the Heat-Stable Proteome during Seed Germination in Arabidopsis with Special Focus on LEA Proteins
Orarat Ginsawaeng, Michał Górka, Alexander Erban et al. · International Journal of Molecular Sciences
Open access |
29 Jul 2021 |
31 |
| 13 |
In vitro findings of alterations in intracellular calcium homeostasis in schizophrenia
Łukasz Bojarski, Katarzyna Debowska, Urszula Wojda · Progress in Neuro-Psychopharmacology and Biological Psychiatry
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Sep 2010 |
27 |
| 14 |
Synthesis and characterization of novel classes of PDE10A inhibitors - 1H-1,3-benzodiazoles and imidazo[1,2-a]pyrimidines
Rafał Moszczyński-Pętkowski, Jakub Majer, Małgorzata Borkowska et al. · European Journal of Medicinal Chemistry
Open access |
30 May 2018 |
26 |
| 15 |
Dual Piperidine-Based Histamine H 3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain
Katarzyna Szczepańska et al. · Journal of Medicinal Chemistry
Open access |
7 Jul 2023 |
22 |
| 16 |
2-Aminoimidazole-based antagonists of the 5-HT6 receptor – A new concept in aminergic GPCR ligand design
Adam S. Hogendorf et al. · European Journal of Medicinal Chemistry
Open access |
5 Jun 2019 |
21 |
| 17 |
Two-Front War on Cancer—Targeting TAM Receptors in Solid Tumour Therapy
Agata Mikołajczyk, Filip Mituła, Delfina Popiel et al. · Cancers
Open access |
18 May 2022 |
18 |
| 18 |
From NMR to AI: Designing a Novel Chemical Representation to Enhance Machine Learning Predictions of Physicochemical Properties
Arkadiusz Leniak, Wojciech Pietruś, Rafał Kurczab · Journal of Chemical Information and Modeling
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26 Mar 2024 |
17 |
| 19 |
HPLC method for simultaneous determination of salmeterol xinafoate and fluticasone propionate for the quality control of dry powder inhalation products
Edyta Carrion Paczkowska, D. Smukowska, Ewa Tratkiewicz et al. · Acta Chromatographica
Open access |
12 Apr 2014 |
17 |
| 20 |
microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling
Sarah A. Noureddine, Jia Nie, Augusto Schneider et al. · Proceedings of the National Academy of Sciences
Open access |
28 Mar 2023 |
16 |
| 21 |
Pyrroloquinoline scaffold-based 5-HT6R ligands: Synthesis, quantum chemical and molecular dynamic studies, and influence of nitrogen atom position in the scaffold on affinity
Katarzyna Grychowska, Rafał Kurczab, Paweł Śliwa et al. · Bioorganic & Medicinal Chemistry
Open access |
23 May 2018 |
16 |
| 22 |
How does the order of sample analysis influence the matrix effect during LC-MS bioanalysis?
Elżbieta Gniazdowska, Joanna Giebułtowicz, Piotr J. Rudzki · Journal of Chromatography B
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24 Jun 2023 |
15 |
| 23 |
Implementation of QbD Approach to the Development of Chromatographic Methods for the Determination of Complete Impurity Profile of Substance on the Preclinical and Clinical Step of Drug Discovery Studies
Lidia Gurba-Bryśkiewicz, Urszula Dawid, Damian A. Smuga et al. · International Journal of Molecular Sciences
Open access |
14 Sep 2022 |
15 |
| 24 |
Esketamine inhaled as dry powder: Pharmacokinetic, pharmacodynamic and safety assessment in a preclinical study
Mikołaj Matłoka, Sylwia Janowska, Anna Gajos‐Draus et al. · Pulmonary Pharmacology & Therapeutics
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14 Apr 2022 |
14 |
| 25 |
Discovery and development of CPL207280 as new GPR40/FFA1 agonist
Mateusz Mach, Katarzyna Bazydło‐Guzenda, Paweł Buda et al. · European Journal of Medicinal Chemistry
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Sep 2021 |
14 |
| 26 |
A novel JAK/ROCK inhibitor, CPL409116, demonstrates potent efficacy in the mouse model of systemic lupus erythematosus
Maria Gabriela Dulak-Lis, Anna Bujak, Kamila Gala et al. · Journal of Pharmacological Sciences
Open access |
9 Feb 2021 |
14 |
| 27 |
Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats
Piotr Popik, Shaun Yon‐Seng Khoo, Agata Kuziak et al. · Pharmacology Biochemistry and Behavior
Open access |
3 Aug 2020 |
14 |
| 28 |
Antiparkinsonian-like effects of CPL500036, a novel selective inhibitor of phosphodiesterase 10A, in the unilateral rat model of Parkinson's disease
Tomasz Lenda, Krystyna Ossowska, Klemencja Berghauzen-Maciejewska et al. · European Journal of Pharmacology
Open access |
29 Aug 2021 |
12 |
| 29 |
From NMR to AI: Do We Need 1 H NMR Experimental Spectra to Obtain High-Quality logD Prediction Models?
Arkadiusz Leniak, Wojciech Pietruś, Aleksandra Świderska et al. · Journal of Chemical Information and Modeling
Open access |
5 Mar 2025 |
11 |
| 30 |
FGFR1–4 RNA-Based Gene Alteration and Expression Analysis in Squamous Non-Small Cell Lung Cancer
Joanna Moes-Sosnowska, Monika Skupińska, Urszula Lechowicz et al. · International Journal of Molecular Sciences
Open access |
10 Sep 2022 |
10 |
| 31 |
Design, Synthesis, and Development of Pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part II—Benzimidazole Derivatives
Mariola Stypik et al. · Pharmaceuticals
Open access |
27 Jul 2022 |
10 |
| 32 |
Results from Genetic Studies in Patients Affected with Craniosynostosis: Clinical and Molecular Aspects
Ewelina Bukowska‐Olech, Anna Sowińska‐Seidler, Dawid Larysz et al. · Frontiers in Molecular Biosciences
Open access |
28 Apr 2022 |
10 |
| 33 |
p38 Mediates Resistance to FGFR Inhibition in Non-Small Cell Lung Cancer
Izabela Zarczynska, Monika Gorska‐Arcisz, Alexander Jorge Cortez et al. · Cells
Open access |
30 Nov 2021 |
10 |
| 34 |
Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets
Ewelina Juszczyk, Piotr Kulinowski, Ewelina Baran et al. · Materials
Open access |
30 Jan 2021 |
10 |
| 35 |
Identification and characterization of aptameric inhibitors of human neutrophil elastase
Stanisłąw Malicki, Mirosław Książęk, Alicja Sochaj Gregorczyk et al. · Journal of Biological Chemistry
Open access |
5 Jun 2023 |
9 |
| 36 |
A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects
Mikołaj Matłoka, Sylwia Janowska, Piotr Pankiewicz et al. · Frontiers in Pharmacology
Open access |
9 Nov 2022 |
9 |
| 37 |
Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation
Ewelina Juszczyk, Piotr Kulinowski, Ewelina Baran et al. · Materials
Open access |
29 Oct 2021 |
9 |
| 38 |
Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil
Joanna Sikora, Maria Podsiedlik, Tadeusz Pietras et al. · Journal of Enzyme Inhibition and Medicinal Chemistry
Open access |
2020 |
9 |
| 39 |
Simultaneous 5-HT1BR agonist/5-HT6R antagonist action as a potential treatment of Parkinson’s disease and its comorbidities
Paweł Zajdel et al. · Journal of Pharmacology and Experimental Therapeutics
Open access |
10 Dec 2024 |
8 |
| 40 |
The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415)
Stanisław Michałek, Lidia Gurba-Bryśkiewicz, Wioleta Maruszak et al. · RSC Advances
Open access |
2022 |
8 |
| 41 |
Early synaptic deficits in GSK-3β overexpressing mice
Ewa Banach, Tomasz Jaworski, Joanna Urban‐Ciećko · Neuroscience Letters
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16 Jun 2022 |
8 |
| 42 |
Replicates Number for Drug Stability Testing during Bioanalytical Method Validation—An Experimental and Retrospective Approach
Elżbieta Gniazdowska, Wojciech Goch, Joanna Giebułtowicz et al. · Molecules
Open access |
11 Jan 2022 |
7 |
| 43 |
Preclinical characterization of CPL302-253, a selective inhibitor of PI3Kδ, as the candidate for the inhalatory treatment and prevention of Asthma
Paweł Gunerka, Kamila Gala, Martyna Banach et al. · PLoS ONE
Open access |
23 Jul 2020 |
7 |
| 44 |
Safety and pharmacokinetics study of inhaled esketamine after a single dose in healthy volunteers
Sylwia Janowska, Ewa Tratkiewicz, Mikołaj Matłoka et al. · European Neuropsychopharmacology
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2019 |
7 |
| 45 |
Cell-based assay for low- and high-scale screening of the Wnt/β-catenin signaling modulators
Maria Mazur, Anna Bujak, Mikołaj Matłoka et al. · Analytical Biochemistry
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7 Feb 2015 |
7 |
| 46 |
Hydroxysteroid 17-β dehydrogenase 14 (HSD17B14) is an L-fucose dehydrogenase, the initial enzyme of the L-fucose degradation pathway
Apolonia Witecka, Varvara Kazak, S. Kwiatkowski et al. · Journal of Biological Chemistry
Open access |
27 Jun 2024 |
6 |
| 47 |
Preclinical characterization of CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 for gastric, bladder, and squamous cell lung cancer
Delfina Popiel et al. · Frontiers in Oncology
Open access |
12 Jan 2024 |
6 |
| 48 |
Evaluation of the hepatotoxicity of the novel GPR40 (FFAR1) agonist CPL207280 in the rat and monkey
Katarzyna Bazydło‐Guzenda, Paweł Buda, Mateusz Mach et al. · PLoS ONE
Open access |
23 Sep 2021 |
6 |
| 49 |
Development and Bio-Predictive Evaluation of Biopharmaceutical Properties of Sustained-Release Tablets with a Novel GPR40 Agonist for a First-in-Human Clinical Trial
Ewelina Juszczyk, Kamil Kisło, Paweł Żero et al. · Pharmaceutics
Open access |
28 May 2021 |
6 |
| 50 |
Discovery of TRAF-2 and NCK-interacting kinase (TNIK) inhibitors by ligand-based virtual screening methods
Anna Bujak, Filip Stefaniak, Daria Zdżalik-Bielecka et al. · MedChemComm
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2015 |
6 |