Science Explorer Back to mapMap

Most cited papers from Center for Clinical & Basic Research

What are the most cited papers from Center for Clinical & Basic Research?

The most cited paper from Center for Clinical & Basic Research is "The diagnosis of osteoporosis" (John A. Professor Kanis, L. Joseph Melton, Claus Christiansen et al., 1994), with 3,904 citations. Next come "Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis" (3,503) and "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes" (2,303).

Showing 50 of 60 papers. Every paper with more than 254 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The diagnosis of osteoporosis John A. Professor Kanis, L. Joseph Melton, Claus Christiansen et al. · Journal of Bone and Mineral Research Aug 1994 3,904
2 Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis Steven Ron Cummings, Javier San Martín, Michael R. McClung et al. · New England Journal of Medicine Open access 11 Aug 2009 3,503
3 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Struan F.A. Grant et al. · Nature Genetics 15 Jan 2006 2,303
4 Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection Robert E. Lanford, Elisabeth S. Hildebrandt-Eriksen, Andreas Petri et al. · Science Open access 3 Dec 2009 1,664
5 Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women Pierre Dominique Delmas, Nina H. Bjarnason, Bruce Mitlak et al. · New England Journal of Medicine Open access 4 Dec 1997 1,651
6 Effects of Oral Ibandronate Administered Daily or Intermittently on Fracture Risk in Postmenopausal Osteoporosis Charles H. Chesnut, Arne Skag, Claus Christiansen et al. · Journal of Bone and Mineral Research Open access Aug 2004 1,232
7 The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women John A. Kanis et al. · Osteoporosis International 23 Feb 2007 1,228
8 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture Karol Estrada et al. · Nature Genetics Open access180 authors 15 Apr 2012 1,223
9 A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Valgerður Steinthórsdóttir et al. · Nature Genetics Open access 26 Apr 2007 1,090
10 Toward a new definition of mental health Silvana Galderisi, Andreas Heinz, Marianne Carisius Kastrup et al. · World Psychiatry Open access Jun 2015 959
11 Shear Strength of Stud Connectors in Lightweight and Normal-Weight Concrete Jorgen G. Ollgaard, R. G. Slutter, John W. Fisher · Engineering Journal Open access 30 Jun 1971 874
12 Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis Paul D. Miller, Gary Hattersley, Bente Juel Riis et al. · JAMA Open access 16 Aug 2016 869
13 Vertebral Fractures After Discontinuation of Denosumab: A Post Hoc Analysis of the Randomized Placebo-Controlled FREEDOM Trial and Its Extension Steven Ron Cummings, Serge Ferrari, Richard Eastell et al. · Journal of Bone and Mineral Research Open access 4 Nov 2017 732
14 A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia Dirk Jacobus Blom, Tomas Hala, Michael A. Bolognese et al. · New England Journal of Medicine Open access 29 Mar 2014 730
15 Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes Jūlı́us Guðmundsson et al. · Nature Genetics Jul 2007 728
16 The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases Patrick Garnero, Olivier Borel, I. Byrjalsen et al. · Journal of Biological Chemistry Open access Nov 1998 644
17 Multiple Genetic Loci for Bone Mineral Density and Fractures Unnur Styrkársdóttir, Bjarni V. Halldórsson, Sólveig Grétarsdóttir et al. · New England Journal of Medicine Open access 29 Apr 2008 634
18 Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones Michael T. Engsig, Qingjun Chen, Thiennu H. Vu et al. · The Journal of Cell Biology Open access 13 Nov 2000 599
19 Incorporation and distribution of strontium in bone Svein G. Dahl, Philippe Allain, Pierre J. Marie et al. · Bone Apr 2001 588
20 Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm Shunichi Homma et al. · New England Journal of Medicine Open access 2 May 2012 587
21 Relationship Between Osteoporosis and Cardiovascular Disease in Postmenopausal Women László B. Tankó, Claus Christiansen, David Alan Cox et al. · Journal of Bone and Mineral Research Nov 2005 548
22 Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution Agnar Helgason et al. · Nature Genetics 7 Jan 2007 530
23 Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia Jennifer G. Robinson, Bettina S. Nedergaard, William John Rogers et al. · JAMA 13 May 2014 507
24 Efficacy of Bazedoxifene in Reducing New Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis: Results From a 3-Year, Randomized, Placebo-, and Active-Controlled Clinical Trial Stuart L. Silverman, Claus Christiansen, Harry K. Genant et al. · Journal of Bone and Mineral Research 29 Jul 2008 507
25 Prevention of Bone Loss with Alendronate in Postmenopausal Women under 60 Years of Age David J. Hosking, Clair E.D. Chilvers, Claus Christiansen et al. · New England Journal of Medicine Open access 19 Feb 1998 489
26 A Meta-Analysis of the Association of Fracture Risk and Body Mass Index in Women Helena Johansson et al. · Journal of Bone and Mineral Research Review 17 Jun 2013 482
27 Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review Sergio Davinelli, Michael Engelbrecht Nielsen, Giovanni Scapagnini · Nutrients Open access 22 Apr 2018 471
28 Low Body Mass Index Is an Important Risk Factor for Low Bone Mass and Increased Bone Loss in Early Postmenopausal Women Pernille Ravn, Giovanni Cizza, N. H. Bjarnason et al. · Journal of Bone and Mineral Research Sep 1999 457
29 The Effects of Tibolone in Older Postmenopausal Women Steven Ron Cummings, Bruce B. Ettinger, Pierre Dominique Delmas et al. · New England Journal of Medicine Open access 13 Aug 2008 456
30 Anti-PCSK9 Monotherapy for Hypercholesterolemia Michael J. Koren, Pernille Lundqvist, Michael A. Bolognese et al. · Journal of the American College of Cardiology Open access 29 Mar 2014 415
31 The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation Vincent E. Everts, Jean‐Marie Delaissé, Wolf Korper et al. · Journal of Bone and Mineral Research 2002 409
32 The association between low bone mass at the menopause and cardiovascular mortality Peter von der Recke, M.A. Hansen, Christian Hassager · The American Journal of Medicine Mar 1999 404
33 The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells Marina Simian, Yohei Hirai, Marc Navre et al. · Development Open access 15 Aug 2001 395
34 Changes in Bone Mineral Density with Age in Men and Women: A Longitudinal Study Lise Warming, Christian Hassager, Claus Christiansen · Osteoporosis International Feb 2002 388
35 Generation and degradation of human endostatin proteins by various proteinases Mercedes Ferreras, Ute Felbor, Thomas Lenhard et al. · FEBS Letters 12 Dec 2000 372
36 New sequence variants associated with bone mineral density Unnur Styrkársdóttir, Bjarni V. Halldórsson, Sólveig Grétarsdóttir et al. · Nature Genetics 14 Dec 2008 365
37 Association between the Five Factor personality traits and perceived stress: is the effect mediated by general self-efficacy? Jeanette Frost Ebstrup, Lene Falgaard Eplov, Charlotta Holm Pisinger et al. · Anxiety Stress & Coping 20 Nov 2010 363
38 Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting Per Qvist, Stephan Christgau, B.J. Pedersen et al. · Bone Jul 2002 356
39 Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities Jean‐Marie Delaissé, Thomas Levin Andersen, Michael T. Engsig et al. · Microscopy Research and Technique 18 Jul 2003 341
40 Immunoassay for quantifying type I collagen degradation products in urine evaluated Martin Bonde, Per Qvist, Christian Fledelius et al. · Clinical Chemistry Nov 1994 333
41 Role of Gastrointestinal Hormones in Postprandial Reduction of Bone Resorption Dennis Bang Henriksen, Peter Alexandersen, Nina H. Bjarnason et al. · Journal of Bone and Mineral Research Open access Dec 2003 333
42 Efficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis: 2 year results from the MOBILE study Reginster Jy, S. Adámi, Peter Laszlo Lakatos et al. · Annals of the Rheumatic Diseases Open access 9 Dec 2005 328
43 Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density Guðmar Þorleifsson et al. · Nature Genetics Open access 28 Jun 2009 324
44 Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen Christian Rosenquist, Christian Fledelius, Stephan Christgau et al. · Clinical Chemistry Nov 1998 320
45 Age- and menopause-associated variations in body composition and fat distribution in healthy women as measured by dual-energy x-ray absorptiometry Ole Lander Svendsen, Christian Hassager, Claus Christiansen · Metabolism Mar 1995 306
46 Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial Jean‐Yves Reginster, Janusz E. Badurski, Nicholas Bellamy et al. · Annals of the Rheumatic Diseases Open access Nov 2012 295
47 Collagen type II C-telopeptide fragments as an index of cartilage degradation Stephan Christgau, Patrick Garnero, Christian Fledelius et al. · Bone Sep 2001 289
48 Low bone mass and fast rate of bone loss at menopause: Equal risk factors for future fracture: A 15-year follow-up Study B. Juel Riis, M.A. Hansen, Alexandria M. Jensen et al. · Bone Jul 1996 282
49 Daily and intermittent oral ibandronate normalize bone turnover and provide significant reduction in vertebral fracture risk: results from the BONE study For the Oral Ibandronate Osteoporosis Vertebral Fracture Trial in North America , Pierre Dominique Delmas, Robert R. Recker et al. · Osteoporosis International 7 Apr 2004 280
50 Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits Unnur Styrkársdóttir et al. · Nature Open access 3 May 2013 278

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.