Most cited papers from Chiron (Norway)

Chiron (Norway)

What are the most cited papers from Chiron (Norway)?

The most cited paper from Chiron (Norway) is "Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification Reactions" (Russell Higuchi, Carita Fockler, Gavin D. Dollinger et al., 1993), with 2,177 citations. Next come "Simultaneous Amplification and Detection of Specific DNA Sequences" (1,135) and "Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt" (1,051).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 75 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification Reactions Russell Higuchi, Carita Fockler, Gavin D. Dollinger et al. · Nature Biotechnology	Sep 1993	2,177
2	Simultaneous Amplification and Detection of Specific DNA Sequences Russell Higuchi, Gavin D. Dollinger, P. Sean Walsh et al. · Nature Biotechnology	Apr 1992	1,135
3	Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt George Kulik, Anke Klippel, Michael J. Weber · Molecular and Cellular Biology Open access	Mar 1997	1,051
4	Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k Harold B.J. Jefferies, Stefano Fumagalli, Patrick B. Dennis et al. · The EMBO Journal Open access	15 Jun 1997	938
5	Maternal Viral Load, Zidovudine Treatment, and the Risk of Transmission of Human Immunodeficiency Virus Type 1 from Mother to Infant RHODA S. SPERLING, David E. Shapiro, Robert W. Coombs et al. · New England Journal of Medicine	28 Nov 1996	818
6	Advances in vaccine adjuvants Manmohan Singh, Derek T. O’Hagan · Nature Biotechnology	Nov 1999	511
7	A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain Anke Klippel, W. Michael Kavanaugh, David Pot et al. · Molecular and Cellular Biology Open access	1997	485
8	Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus Michael Simons, Robert O. Bonow, Nicolas A.F. Chronos et al. · Circulation	12 Sep 2000	461
9	Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways Anke Klippel, Christoph Reinhard, W. Michael Kavanaugh et al. · Molecular and Cellular Biology Open access	Aug 1996	445
10	Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro Yaning Wang, David Fei, Martin Vanderlaan et al. · Angiogenesis	Dec 2004	439
11	Controlled Trial of Interleukin-2 Infusions in Patients Infected with the Human Immunodeficiency Virus Joseph A. Kovacs, Susan E. Vogel, Jeffrey M. Albert et al. · New England Journal of Medicine Open access	31 Oct 1996	410
12	Lepirudin (Recombinant Hirudin) for Parenteral Anticoagulation in Patients With Heparin-Induced Thrombocytopenia Andreas Greinacher, Uwe Janssens, Günther Berg et al. · Circulation	10 Aug 1999	342
13	Counterselectable Markers: Untapped Tools for Bacterial Genetics and Pathogenesis Jean‐Marc Reyrat, Vladimir Pelicic, Brigitte Gicquel et al. · Infection and Immunity Open access	Sep 1998	285
14	Recent Advances in Vaccine Adjuvants Manmohan Singh, Derek T. O’Hagan · Pharmaceutical Research	Jun 2002	243
15	Structure-Function Analysis of Hepatitis C Virus Envelope-CD81 Binding Roberto Petracca, Fabiana Falugi, G. Galli et al. · Journal of Virology Open access	15 May 2000	224
16	Protein Disulfide Isomerase Overexpression Increases Secretion of Foreign Proteins in Saccharomyces cerevisiae Anne Skaja Robinson, Victoria Hines, Karl Dane Wittrup · Nature Biotechnology	Apr 1994	212
17	Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays Renata Grifantini, Erika Bartolini, Alessandro Muzzi et al. · Nature Biotechnology	12 Aug 2002	203
18	Genomic Approach for Analysis of Surface Proteins inChlamydia pneumoniae Silvia Montigiani, Fabiana Falugi, Maria Scarselli et al. · Infection and Immunity Open access	2002	200
19	Human Monoclonal Antibodies That Inhibit Binding of Hepatitis C Virus E2 Protein to CD81 and Recognize Conserved Conformational Epitopes Kenneth G. Hadlock, Robert E. Lanford, Susan Perkins et al. · Journal of Virology Open access	15 Nov 2000	193
20	Introduction to Pichia pastoris David R. Higgins, James M. Cregg · Methods in molecular biology Book chapter	1998	193
21	Immunotherapy of Recurrent Genital Herpes with Recombinant Herpes Simplex Virus Type 2 Glycoproteins D and B: Results of a Placebo‐Controlled Vaccine Trial Stephen E. Straus, Anna Wald, Rhonda G. Kost et al. · The Journal of Infectious Diseases Open access	Nov 1997	170
22	Recurrent Acyclovir-Resistant Genital Herpes in an Immunocompetent Patient Rhonda G. Kost, Edgar L. Hill, Michael A. Tigges et al. · New England Journal of Medicine	9 Dec 1993	162
23	Hepatitis C in Hiv–Infected Patients With and Without Aids: Prevalence and Relationship to Patient Survival Teresa Lyn Wright, Harry Hollander, Xiang Pu et al. · Hepatology	Nov 1994	162
24	Safety and Immunogenicity of a Canarypox‐Vectored Human Immunodeficiency Virus Type 1 Vaccine with or without gp120: A Phase 2 Study in Higher‐ and Lower‐Risk Volunteers Robert B. Belshe et al. · The Journal of Infectious Diseases Open access	May 2001	147
25	Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors Joseph Martín Alisky, Stephanie M. Hughes, Sybille L. Sauter et al. · Neuroreport	Aug 2000	143
26	A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo Armen B. Shanafelt et al. · Nature Biotechnology	Nov 2000	139
27	Transcutaneous Immunization with Bacterial ADP-Ribosylating Exotoxins, Subunits, and Unrelated Adjuvants Tanya Scharton‐Kersten, Jianmei Yu, Russell A. Vassell et al. · Infection and Immunity Open access	Sep 2000	130
28	A Modified Enzyme-Linked Immunosorbent Assay for Measurement of Antibody Responses to Meningococcal C Polysaccharide That Correlate with Bactericidal Responses Dan M. Granoff, Susan E. Maslanka, George M. Carlone et al. · Clinical and Diagnostic Laboratory Immunology Open access	Jul 1998	127
29	HEPATITIS C—ITS PREVALENCE IN END-STAGE RENAL FAILURE PATIENTS AND CLINICAL COURSE AFTER KIDNEY TRANSPLANTATION Carlos Stempel, John R. Lake, George C. Kuo et al. · Transplantation	Feb 1993	122
30	Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I‐bound determinant Janice M. Kelly, Sandra J. Sterry, Stephen Cose et al. · European Journal of Immunology	Dec 1993	118
31	Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease Timothy D. Murphy, Ran D. Anbar, Lucille A. Lester et al. · Pediatric Pulmonology	26 Jul 2004	118
32	Importance of Complement Source in Measuring Meningococcal Bactericidal Titers George França dos Santos, R. Randall Deck, John Donnelly et al. · Clinical and Diagnostic Laboratory Immunology Open access	May 2001	115
33	Cationic Microparticles Are an Effective Delivery System for Immune Stimulatory CpG DNA Manmohan Singh, Gary S. Ott, Jina Kazzaz et al. · Pharmaceutical Research	Oct 2001	115
34	Prevalence and Incidence of Herpes Simplex Virus Type 2 Infection among Male Zimbabwean Factory Workers William C. McFarland, Lovemore Gwanzura, Mary Travis Bassett et al. · The Journal of Infectious Diseases	Nov 1999	113
35	Pooled Analysis of 3 Randomized, Controlled Trials of Interleukin‐2 Therapy in Adult Human Immunodeficiency Virus Type 1 Disease Sean Emery, William B. Capra, David A. Cooper et al. · The Journal of Infectious Diseases	Aug 2000	107
36	Freeze‐Drying of Mannitol–Trehalose–Sodium Chloride‐Based Formulations: The Impact of Annealing on Dry Layer Resistance to Mass Transfer and Cake Structure Xiaofeng Lu, Michael Jon Pikal · Pharmaceutical Development and Technology	2004	107
37	Nucleotide sequence of the bovine viral diarrhoea virus Osloss strain: comparison with related viruses and identification of specific DNA probes in the 5' untranslated region Laurence De Moerlooze, C. Lecomte, S. Brown-Shimmer et al. · Journal of General Virology	Jul 1993	104
38	Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer Michael A. Trakselis, Stephen C. Alley, Ernesto Abel‐Santos et al. · Proceedings of the National Academy of Sciences Open access	17 Jul 2001	103
39	Hepatitis C Virus and eliminating post-transfusion hepatitis Harvey J. Alter, Michael Houghton · Nature Medicine	Oct 2000	102
40	Therapeutic Vaccination against Helicobacter pylori in the Beagle Dog Experimental Model: Safety, Immunogenicity, and Efficacy Giacomo Rossi, Paolo Ruggiero, Samuele Peppoloni et al. · Infection and Immunity Open access	20 May 2004	100
41	Standardized procedure for measurement of nasal potential difference: An outcome measure in multicenter cystic fibrosis clinical trials Thomas A. Standaert, Louis J Boitano, Julia Emerson et al. · Pediatric Pulmonology	13 Apr 2004	99
42	Mutants ofEscherichia coliHeat-Labile Toxin Act as Effective Mucosal Adjuvants for Nasal Delivery of an Acellular Pertussis Vaccine: Differential Effects of the Nontoxic AB Complex and Enzyme Activity on Th1 and Th2 Cells Elizabeth J. Ryan, Edel A. McNeela, Geraldine A. Murphy et al. · Infection and Immunity Open access	Dec 1999	98
43	Affinity Selection and Mass Spectrometry-Based Strategies to Identify Lead Compounds in Combinatorial Libraries Surinder Kaur, Lisa C. McGuire, Dazhi Tang et al. · Journal of Protein Chemistry	Jul 1997	96
44	Amino Terminal Acetylation of Authentic Human Cu,Zn Superoxide Dismutase Produced in Yeast Robert A. Hallewell, Robert H. Mills, Patricia Tekamp-Olson et al. · Nature Biotechnology	Apr 1987	95
45	c-Jun Triggers Apoptosis in Human Vascular Endothelial Cells Nanping Wang, Lynne K. Verna, Stephen F. Hardy et al. · Circulation Research Open access	3 Sep 1999	94
46	Rapid Clearance of Simian Immunodeficiency Virus Particles from Plasma of Rhesus Macaques Linqi Zhang, Peter J. Dailey, He Tian et al. · Journal of Virology Open access	1999	93
47	Gut microbiome catabolites as novel modulators of muscle cell glucose metabolism Michael James Houghton, Asimina Kerimi, Vincent Mouly et al. · The FASEB Journal	5 Sep 2018	91
48	Primary structure of the Streptomyces R61 extracellular DD‐peptidase Colette Duez, Claudine Piron-Fraipont, Bernard Joris et al. · European Journal of Biochemistry Open access	Feb 1987	91
49	The Region Comprising Amino Acids 100 to 255 ofNeisseria meningitidisLipoprotein GNA 1870 Elicits Bactericidal Antibodies Marzia Monica Giuliani, Laura Santini, Brunella Brunelli et al. · Infection and Immunity Open access	21 Jan 2005	89
50	The specificity of recognition of a cytotoxic T lymphocyte epitope Scott R. Burrows, Stuart J. Rodda, Andreas Suhrbier et al. · European Journal of Immunology	1992	86

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.