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Most cited papers from Cochrane

Cochrane

What are the most cited papers from Cochrane?

The most cited paper from Cochrane is "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews" (Matthew James Page et al., 2021), with 105,915 citations. Next come "The Cochrane Collaboration's tool for assessing risk of bias in randomised trials" (34,881) and "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration" (28,074).

Showing 43 of 43 papers. Every paper with more than 405 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The PRISMA 2020 statement: an updated guideline for reporting systematic reviews Matthew James Page et al. · BMJ ReviewOpen access 29 Mar 2021 105,915
2 The Cochrane Collaboration's tool for assessing risk of bias in randomised trials Julian P. T. Higgins, Doug G. Altman, Peter Christian Gøtzsche et al. · BMJ Open access 18 Oct 2011 34,881
3 The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration Alessandro Liberati, Douglas G. Altman, Jennifer Tetzlaff et al. · PLoS Medicine ReviewOpen access 20 Jul 2009 28,074
4 The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies Erik B von Elm, Douglas G. Altman, Matthias Egger et al. · PLoS Medicine Open access 10 Oct 2007 22,347
5 Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies Erik B von Elm, Douglas G. Altman, Matthias Egger et al. · BMJ Open access 18 Oct 2007 10,774
6 CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials David Moher, Sally Hopewell, Kenneth F. Schulz et al. · BMJ Open access 23 Mar 2010 9,147
7 Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration Jan Paul Vandenbroucke, Erik B von Elm, Douglas G. Altman et al. · PLoS Medicine Open access 10 Oct 2007 8,626
8 SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials A.-W. Chan, Jennifer Tetzlaff, Peter Christian Gøtzsche et al. · BMJ Open access 9 Jan 2013 7,135
9 The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration Douglas G. Altman, Kenneth F. Schulz, David Moher et al. · Annals of Internal Medicine 17 Apr 2001 3,860
10 Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Jan Paul Vandenbroucke, Erik B von Elm, Douglas G. Altman et al. · Epidemiology Open access Nov 2007 2,777
11 Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention Goran Bjelaković, Dimitrinka Nikolova, Lise Lotte Gluud et al. · JAMA 27 Feb 2007 2,276
12 Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed Jan Kottner, Laurent Audigé, Stig Brorson et al. · Journal of Clinical Epidemiology 18 Jun 2010 2,186
13 The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement Erik B von Elm, Douglas G. Altman, Matthias Egger et al. · Epidemiology Nov 2007 2,000
14 Screening for breast cancer with mammography Peter Christian Gøtzsche, Karsten Juhl Jørgensen · Cochrane Database of Systematic Reviews Open access 4 Jun 2013 1,882
15 Is the Placebo Powerless? Asbjørn Hróbjartsson, Peter Christian Gøtzsche · New England Journal of Medicine Open access 24 May 2001 1,517
16 Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses Jesper Sune Brok, Kristian Thorlund, Christian Nyfeldt Gluud et al. · Journal of Clinical Epidemiology 15 Apr 2008 1,182
17 CONSORT 2025 statement: updated guideline for reporting randomised trials Sally Hopewell et al. · BMJ Open access 14 Apr 2025 988
18 A tool to assess risk of bias in non-randomized follow-up studies of exposure effects (ROBINS-E) Julian P. T. Higgins et al. · Environment International Open access 24 Mar 2024 941
19 Increasing value and reducing waste: addressing inaccessible research An‐Wen Chan, Fujian Song, Andrew Julian Vickers et al. · The Lancet Open access 2014 928
20 Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases Goran Bjelaković, Dimitrinka Nikolova, Lise Lotte Gluud et al. · Cochrane Database of Systematic Reviews Open access 9 Mar 2012 915
21 Is screening for breast cancer with mammography justifiable? Peter Christian Gøtzsche, Ole Olsen · The Lancet 2000 861
22 Placebo interventions for all clinical conditions Asbjørn Hróbjartsson, Peter Christian Gøtzsche · Cochrane Database of Systematic Reviews Open access 18 Jan 2010 770
23 PRISMA for Abstracts: Reporting Systematic Reviews in Journal and Conference Abstracts Elaine Beller, Paul Glasziou, Douglas G. Altman et al. · PLoS Medicine ReviewOpen access 9 Apr 2013 741
24 Cochrane review on screening for breast cancer with mammography Ole Olsen, Peter Christian Gøtzsche · The Lancet Oct 2001 715
25 Barriers and facilitators to utilizing digital health technologies by healthcare professionals Israel Júnior Borges do Nascimento, Hebatullah Mohamed Abdulazeem, Lenny Vasanthan et al. · npj Digital Medicine Open access 18 Sep 2023 689
26 Vitamin D supplementation for prevention of mortality in adults Goran Bjelaković, Lise Lotte Gluud, Dimitrinka Nikolova et al. · Cochrane Database of Systematic Reviews Open access 10 Jan 2014 680
27 Bias in Clinical Intervention Research Lise Lotte Gluud · American Journal of Epidemiology 27 Jan 2006 670
28 Interventions for preoperative smoking cessation Thordis Thomsen, Nete Villebro, Ann Merete Møller · Cochrane Database of Systematic Reviews Open access 27 Mar 2014 669
29 Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis Goran Bjelaković, Dimitrinka Nikolova, Rosa Giovanna Simonetti et al. · The Lancet Review Oct 2004 612
30 Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis Simon Wandel, Peter Jüni, Britta Tendal et al. · BMJ Open access 16 Sep 2010 584
31 Observer bias in randomized clinical trials with measurement scale outcomes: a systematic review of trials with both blinded and nonblinded assessors Asbjørn Hróbjartsson, Ann Sofia Skou Thomsen, Frida Emanuelsson et al. · Canadian Medical Association Journal ReviewOpen access 28 Jan 2013 574
32 Observer bias in randomised clinical trials with binary outcomes: systematic review of trials with both blinded and non-blinded outcome assessors Asbjørn Hróbjartsson, Ann Sofia Skou Thomsen, Frida Emanuelsson et al. · BMJ ReviewOpen access 27 Feb 2012 534
33 Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain Mette Frahm Olsen, Eik Dybboe Bjerre, Maria Damkjær Hansen et al. · BMC Medicine ReviewOpen access 8 Feb 2017 514
34 Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends Karsten Juhl Jørgensen, Peter Christian Gøtzsche · BMJ ReviewOpen access 9 Jul 2009 502
35 Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials Julie Pildal, Asbjørn Hróbjartsson, Karsten Juhl Jørgensen et al. · International Journal of Epidemiology Open access 21 May 2007 492
36 Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing patients to blind and nonblind sub-studies Asbjørn Hróbjartsson, Frida Emanuelsson, Ann Sofia Skou Thomsen et al. · International Journal of Epidemiology ReviewOpen access 30 May 2014 491
37 Cochrane reviews compared with industry supported meta-analyses and other meta-analyses of the same drugs: systematic review Anders W Jørgensen, Jørgen Hilden, Peter Christian Gøtzsche · BMJ ReviewOpen access 6 Oct 2006 448
38 Spontaneous improvement in randomised clinical trials: meta-analysis of three-armed trials comparing no treatment, placebo and active intervention Lasse Theis Krogsbøll, Asbjørn Hróbjartsson, Peter Christian Gøtzsche · BMC Medical Research Methodology ReviewOpen access 5 Jan 2009 444
39 Association between competing interests and authors' conclusions: epidemiological study of randomised clinical trials published in the BMJ Lise Lotte Kjaergard, Bodil Als-Nielsen · BMJ Open access 3 Aug 2002 439
40 Declaración de la Iniciativa STROBE (Strengthening the Reporting of Observational studies in Epidemiology): directrices para la comunicación de estudios observacionales Erik B von Elm, Douglas G. Altman, Matthias Egger et al. · Gaceta Sanitaria Open access Mar 2008 431
41 Antimicrobial prophylaxis for colorectal surgery Richard L. Nelson, Ed Gladman, Marija Barbateskovic · Cochrane Database of Systematic Reviews Open access 9 May 2014 416
42 Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review Gloria Córdoba, Lisa Schwartz, Steven Woloshin et al. · BMJ ReviewOpen access 18 Aug 2010 411
43 Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis Chuanfang Lee, Yan Gong, Jesper Sune Brok et al. · BMJ ReviewOpen access 27 Jan 2006 405

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.