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Finding the missing heritability of complex diseases
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Oct 2009 |
8,637 |
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Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke et al. · Nature
Open access297 authors |
Jul 2014 |
8,181 |
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Genetic studies of body mass index yield new insights for obesity biology
The LifeLines Cohort Study et al. · Nature
Open access487 authors |
10 Feb 2015 |
4,954 |
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Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich et al. · Nature
Open access209 authors |
Aug 2010 |
3,706 |
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
eQTLGen et al. · Nature Genetics
Open access218 authors |
26 Apr 2018 |
3,347 |
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Discovery and refinement of loci associated with lipid levels
Cristen J. Willer et al. · Nature Genetics
Open access259 authors |
6 Oct 2013 |
3,319 |
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC et al. · Nature Genetics
Open access376 authors |
10 Oct 2010 |
2,999 |
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Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Vassily Vladimirovich Trubetskoy et al. · Nature
Open access613 authors |
8 Apr 2022 |
2,894 |
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Identification of common genetic risk variants for autism spectrum disorder
Jakob Grove et al. · Nature Genetics
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25 Feb 2019 |
2,721 |
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Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Thorlákur Jónsson et al. · New England Journal of Medicine
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14 Nov 2012 |
2,654 |
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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
Iris E. Jansen et al. · Nature Genetics
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2 Jan 2019 |
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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Ditte Demontis et al. · Nature Genetics
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23 Nov 2018 |
2,356 |
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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Struan F.A. Grant et al. · Nature Genetics
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15 Jan 2006 |
2,303 |
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Rate of de novo mutations and the importance of father’s age to disease risk
Augustine Kong et al. · Nature
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Aug 2012 |
2,298 |
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis et al. · Nature Genetics
Open access263 authors |
17 Jan 2010 |
2,239 |
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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Mengzhen Liu et al. · Nature Genetics
Open access124 authors |
7 Jan 2019 |
2,179 |
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Defining the role of common variation in the genomic and biological architecture of adult human height
Andrew R. Wood et al. · Nature Genetics
446 authors |
5 Oct 2014 |
2,114 |
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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
the Alzheimer's Disease Neuroimaging Initiative et al. · Nature Genetics
Open access173 authors |
3 Apr 2011 |
2,100 |
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Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen et al. · Nature
Open access293 authors |
29 Sep 2010 |
2,063 |
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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew Paul Morris et al. · Nature Genetics
Open access204 authors |
12 Aug 2012 |
2,021 |
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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Mike A. Nalls et al. · Nature Genetics
ReviewOpen access |
27 Jul 2014 |
1,998 |
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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Anubha Mahajan et al. · Nature Genetics
Open access115 authors |
Oct 2018 |
1,968 |
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Genome-wide association study identifies five new schizophrenia loci
Stephan Ripke et al. · Nature Genetics
Open access196 authors |
18 Sep 2011 |
1,966 |
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics et al. · Nature Genetics
Open access167 authors |
6 Mar 2011 |
1,959 |
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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini et al. · Nature Genetics
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30 Mar 2008 |
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Strelka2: fast and accurate calling of germline and somatic variants
Sangtae Kim, Konrad Scheffler, Aaron L. Halpern et al. · Nature Methods
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11 Jul 2018 |
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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
The MAGIC investigators et al. · Nature Genetics
Open access159 authors |
27 Jun 2010 |
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A high-resolution recombination map of the human genome
Augustine Kong, Daniel Fannar Gudbjartsson, Jesús Sainz et al. · Nature Genetics
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10 Jun 2002 |
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Large-scale integration of the plasma proteome with genetics and disease
Egil Ferkingstad et al. · Nature Genetics
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Dec 2021 |
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Large recurrent microdeletions associated with schizophrenia
GROUP et al. · Nature
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30 Jul 2008 |
1,787 |
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Missing heritability and strategies for finding the underlying causes of complex disease
Evan E. Eichler, Jonathan Flint, Greg C. Gibson et al. · Nature Reviews Genetics
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18 May 2010 |
1,767 |
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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Thorlákur Jónsson et al. · Nature
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10 Jul 2012 |
1,763 |
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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik et al. · Nature Genetics
Open access428 authors |
12 Mar 2018 |
1,753 |
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Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Antonio F. Pardiñas et al. · Nature Genetics
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25 Feb 2018 |
1,748 |
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Association between Microdeletion and Microduplication at 16p11.2 and Autism
Lauren A. Weiss et al. · New England Journal of Medicine
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9 Jan 2008 |
1,727 |
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New genetic loci link adipose and insulin biology to body fat distribution
Dmitry Shungin et al. · Nature
Open access410 authors |
10 Feb 2015 |
1,726 |
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Common variants conferring risk of schizophrenia
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Jul 2009 |
1,723 |
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Neuregulin 1 and Susceptibility to Schizophrenia
Hreinn Stefánsson et al. · The American Journal of Human Genetics
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Oct 2002 |
1,697 |
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Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas et al. · Nature Genetics
Open access183 authors |
2 Dec 2012 |
1,681 |
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Genome-wide association study identifies 30 loci associated with bipolar disorder
Eli A. Stahl et al. · Nature Genetics
Open access277 authors |
May 2019 |
1,654 |
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Niamh Mullins et al. · Nature Genetics
Open access318 authors |
17 May 2021 |
1,635 |
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A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction
Anna Helgadóttir et al. · Science
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Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Stephan Ripke et al. · Nature Genetics
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25 Aug 2013 |
1,574 |
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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeir Elís Thorgeirsson et al. · Nature
Open access |
Apr 2008 |
1,536 |
| 45 |
Genome-wide association study identifies 74 loci associated with educational attainment
Aysu Okbay et al. · Nature
Open access256 authors |
10 May 2016 |
1,500 |
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Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
Pamela Sklar et al. · Nature Genetics
Open access172 authors |
18 Sep 2011 |
1,418 |
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Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Guðmar Þorleifsson et al. · Nature Genetics
Open access |
14 Dec 2008 |
1,416 |
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Replicating genotype–phenotype associations
Stephen Jacob Chanock et al. · Nature
Open access |
6 Jun 2007 |
1,358 |
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Genetics of gene expression and its effect on disease
Valur Emilsson et al. · Nature
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Mar 2008 |
1,351 |
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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Karol Estrada et al. · Nature Genetics
Open access180 authors |
15 Apr 2012 |
1,223 |