Most cited papers from Discovery Centre

Discovery Centre

What are the most cited papers from Discovery Centre?

The most cited paper from Discovery Centre is "Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development" (Charles E. Murry, Gordon M. Keller, 2008), with 1,750 citations. Next come "The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass" (1,098) and "3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 2: Surgical Management and Special Situations" (780).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 61 papers. Every paper with more than 141 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development Charles E. Murry, Gordon M. Keller · Cell Open access	Feb 2008	1,750
2	The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass Noriyuki Nishioka, Ken‐ichi Inoue, Kenjiro Adachi et al. · Developmental Cell Open access	Mar 2009	1,098
3	3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 2: Surgical Management and Special Situations Paolo Gionchetti, Axel U Dignass, Silvio Danese et al. · Journal of Crohn s and Colitis Open access	22 Sep 2016	780
4	Copy-number variations associated with neuropsychiatric conditions Edwin H. Cook, Stephen W. Scherer · Nature	Oct 2008	680
5	Role of innate and adaptive immune mechanisms in cardiac injury and repair Slava Epelman, Peter P. Liu, Douglas L. Mann · Nature reviews. Immunology ReviewOpen access	23 Jan 2015	646
6	Distribution patterns of tau pathology in progressive supranuclear palsy Gábor Géza Kovács et al. · Acta Neuropathologica Open access	7 May 2020	502
7	Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2 Amy Ralston, Brian Cox, Noriyuki Nishioka et al. · Development Open access	16 Jan 2010	486
8	Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin Andrew D. Medhurst, Carol A. Jennings, Melanie J. Robbins et al. · Journal of Neurochemistry Open access	18 Feb 2003	446
9	TAp73 knockout shows genomic instability with infertility and tumor suppressor functions Richard Tomasini, Katsuya Tsuchihara, Margareta Wilhelm et al. · Genes & Development Open access	19 Sep 2008	434
10	Mouse models of allergic asthma: acute and chronic allergen challenge Anthony T. Nials, Sorif Uddin · Disease Models & Mechanisms Open access	21 Nov 2008	431
11	Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza Jesús F. Bermejo-Martín et al. · Critical Care Open access	11 Dec 2009	383
12	Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo Amy Ralston, Janet Rossant · Developmental Biology Open access	14 Nov 2007	347
13	Side population cells in human cancers Colleen Wu, Benjamin Aaron Alman · Cancer Letters	20 May 2008	341
14	Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development Ryan E. Morgan, Michael A Trauner, Carlo J. van Staden et al. · Toxicological Sciences Open access	9 Sep 2010	335
15	Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β Margaret M. Racke, Laura I. Boone, Deena L. Hepburn et al. · Journal of Neuroscience Open access	19 Jan 2005	332
16	Clopidogrel and Ticlopidine: P2Y12Adenosine Diphosphate-Receptor Antagonists for the Prevention of Atherothrombosis Pierre Savi, Jean‐Marc Herbert · Seminars in Thrombosis and Hemostasis	Apr 2005	325
17	A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development Martina L. Sanderson‐Smith, David M. P. De Oliveira, Julien Guglielmini et al. · The Journal of Infectious Diseases Open access	5 May 2014	323
18	Fundamentals of protein interaction network mapping Jamie D. Snider, Max Kotlyar, Punit Saraon et al. · Molecular Systems Biology Open access	Dec 2015	314
19	Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning Korsuk Sirinukunwattana et al. · Gut Open access	20 Jul 2020	281
20	Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies Sameer Agnihotri, Kelly E. Burrell, Amparo Wolf et al. · Archivum Immunologiae et Therapiae Experimentalis	6 Dec 2012	269
21	Studies on durability of sustainable biobased composites: a review Boon Peng Chang, Amar Kumar Mohanty, Manjusri Misra · RSC Advances Open access	2020	268
22	Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis Thomas J. Struble et al. · Journal of Medicinal Chemistry Open access	3 Apr 2020	263
23	Mechanical Stiffness Controls Dendritic Cell Metabolism and Function Mainak Chakraborty et al. · Cell Reports Open access	2021	259
24	Machine Learning for Antimicrobial Resistance Prediction: Current Practice, Limitations, and Clinical Perspective Jee In Kim, Finlay Maguire, Kara K. Tsang et al. · Clinical Microbiology Reviews Open access	25 May 2022	253
25	Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set J. Khadake et al. · Nature Communications Open access	27 Dec 2018	250
26	The non-coding RNA interactome in joint health and disease Shabana Amanda Ali, Mandy Jayne Peffers, Michelle J. Ormseth et al. · Nature Reviews Rheumatology Review	29 Sep 2021	235
27	Overcoming the Fundamental Challenges in Improving the Impact Strength and Crystallinity of PLA Biocomposites: Influence of Nucleating Agent and Mold Temperature Vidhya Nagarajan, Kunyu Zhang, Manjusri Misra et al. · ACS Applied Materials & Interfaces Open access	19 May 2015	234
28	Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells Sheela A. Abraham, Lisa E. M. Hopcroft, Emma Carrick et al. · Nature Open access	Jun 2016	233
29	Information fusion as an integrative cross-cutting enabler to achieve robust, explainable, and trustworthy medical artificial intelligence Andreas Holzinger, Matthias Dehmer, Frank Emmert‐Streib et al. · Information Fusion Open access	12 Nov 2021	222
30	Knowledge Discovery and interactive Data Mining in Bioinformatics - State-of-the-Art, future challenges and research directions Andreas Holzinger, Matthias Dehmer, Igor Jurišica · BMC Bioinformatics Open access	May 2014	222
31	Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota Paige V. Bauer, Sophie C. Hamr, Frank Anthony Duca · Cellular and Molecular Life Sciences Open access	5 Nov 2015	214
32	Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study Sandra Sharpe Cohen et al. · The Lancet Haematology	5 Nov 2019	210
33	Gut-associated IgA+ immune cells regulate obesity-related insulin resistance Helen Luck et al. · Nature Communications Open access	13 Aug 2019	207
34	Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by Recombinant Strains ofLactococcus lactisCoexpressing Antigen and Cytokine Lothar Steidler, Karen Robinson, Lisa M. Chamberlain et al. · Infection and Immunity Open access	Jul 1998	207
35	The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins Prashant R. Bharadwaj, Nadeeja Wijesekara, Milindu Liyanapathirana et al. · Journal of Alzheimer s Disease	6 Mar 2017	203
36	Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production in vivo Ishrut Hussain, Julie A. Hawkins, David C. Harrison et al. · Journal of Neurochemistry Open access	9 Oct 2006	200
37	Porous organic molecular solids by dynamic covalent scrambling Shan Hao Jiang, James T. A. Jones, Tom Hasell et al. · Nature Communications Open access	22 Feb 2011	196
38	Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis Tilman Ziegler et al. · Journal of Clinical Investigation Open access	30 Jun 2013	194
39	Carrier Cell-based Delivery of an Oncolytic Virus Circumvents Antiviral Immunity Anthony Power, Jiahu Wang, Theresa J. Falls et al. · Molecular Therapy Open access	13 Dec 2006	193
40	Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 Anup Aggarwal et al. · Cell Open access	29 Jun 2017	188
41	A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy Maneka Chitiprolu, Chantal Jagow, Véronique Tremblay et al. · Nature Communications Open access	12 Jul 2018	185
42	Redox Flow Battery Membranes: Improving Battery Performance by Leveraging Structure–Property Relationships Craig A. Machado, Gerald O. Brown, Ruidong Yang et al. · ACS Energy Letters	14 Dec 2020	179
43	Effects of microgravity on osteoclast bone resorption and osteoblast cytoskeletal organization and adhesion Noushin Nabavi, Arian Khandani, Anne Camirand et al. · Bone	4 Aug 2011	178
44	Inflammatory Cytokine Expression Is Associated with Chikungunya Virus Resolution and Symptom Severity Alyson A. Kelvin, David W. Banner, Giuliano Silvi et al. · PLoS neglected tropical diseases Open access	16 Aug 2011	175
45	Critical role of the gut microbiota in immune responses and cancer immunotherapy Zehua Li, Weixi Xiong, Liang Wei Zhu et al. · Journal of Hematology & Oncology Open access	14 May 2024	172
46	Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer Christine M. Misquitta-Ali, Edith Cheng, Dave O’Hanlon et al. · Molecular and Cellular Biology Open access	2 Nov 2010	167
47	PTMProphet: Fast and Accurate Mass Modification Localization for the Trans-Proteomic Pipeline David D. Shteynberg, Eric W. Deutsch, David S Campbell et al. · Journal of Proteome Research Open access	10 Jul 2019	166
48	Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons Uma S. Anand, William R Otto, Daniel Sánchez et al. · Pain	10 Aug 2008	165
49	High surface area amorphous microporous poly(aryleneethynylene) networks using tetrahedral carbon- and silicon-centred monomers Ev Stöckel, Xiaofeng Wu, Abbie Trewin et al. · Chemical Communications	14 Nov 2008	160
50	Frailty and cognitive decline Daiene de Morais Fabrício, Marcos Hortes Nisihara Chagas, Breno Satler Diniz · Translational research	23 Jan 2020	157

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.