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Hyperforin as a possible antidepressant component of hypericum extracts
Shyam S Chatterjee, S.K. Bhattacharya, Meinolf Wonnemann et al. · Life Sciences
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Jul 1998 |
446 |
| 2 |
Incidence and prognostic significance of fever following intracerebral hemorrhage
Štefan Schwarz, Kurt Häfner, Alfred A. Aschoff et al. · Neurology
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25 Jan 2000 |
379 |
| 3 |
Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12
Michael Heinrich, Banaz Jalil, Mona Abdel‐Tawab et al. · Frontiers in Pharmacology
Open access |
13 Sep 2022 |
371 |
| 4 |
Proof of Efficacy of the Ginkgo Biloba Special Extract EGb 761 in Outpatients Suffering from Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Multi-infarct Dementia
S. Kanowski, Wolfgang R. Herrmann, K. Stephan et al. · Pharmacopsychiatry
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Mar 1996 |
370 |
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St. John's Wort in Mild to Moderate Depression: The Relevance of Hyperforin for the Clinical Efficacy
G. Laakmann, Cornelius Schüle, Thomas C. Baghai et al. · Pharmacopsychiatry
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Jun 1998 |
341 |
| 6 |
Combining different phases in the development of medical treatments within a single trial
Péter Bauer, Meinhard Kieser · Statistics in Medicine
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30 Jul 1999 |
284 |
| 7 |
A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder
Helmut Woelk, Sandra Schläfke · Phytomedicine
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7 Dec 2009 |
238 |
| 8 |
On the Use of the Upper Confidence Limit for the Variance from a Pilot Sample for Sample Size Determination
Meinhard Kieser, Gernot Wassmer · Biometrical Journal
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1996 |
222 |
| 9 |
Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine
Armin Szegedi, Ralf Kohnen, Angelika Dienel et al. · BMJ
Open access |
11 Feb 2005 |
221 |
| 10 |
Lavender oil preparation Silexan is effective in generalized anxiety disorder – a randomized, double-blind comparison to placebo and paroxetine
Siegfried F. Kasper, Markus Gastpar, Walter E Müller et al. · The International Journal of Neuropsychopharmacology
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23 Jan 2014 |
220 |
| 11 |
Oral Bioavailability of Hyperforin from Hypericum Extracts in Rats and Human Volunteers
A. Biber, Hartmut Fischer, Axel Römer et al. · Pharmacopsychiatry
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Jun 1998 |
214 |
| 12 |
Antidepressant Activity of Hypericum Perforatum and Hyperforin: the Neglected Possibility
Shyam S Chatterjee, Michael Nöldner, Egon Koch et al. · Pharmacopsychiatry
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Jun 1998 |
207 |
| 13 |
Sample Size Recalculation in Internal Pilot Study Designs: A Review
Tim Friede, Meinhard Kieser · Biometrical Journal
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25 Jul 2006 |
205 |
| 14 |
Kava-kava Extract WS 1490 versus Placebo in Anxiety Disorders - A Randomized Placebo-controlled 25-week Outpatient Trial
Hans‐Peter Volz, Meinhard Kieser · Pharmacopsychiatry
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1997 |
200 |
| 15 |
Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia
Bernd May, Stephan Köhler, B Schneider · Alimentary Pharmacology & Therapeutics
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27 Dec 2000 |
199 |
| 16 |
A Randomized, Double-Blind, Placebo-Controlled Trial of Two Doses of Ginkgo Biloba Extract in Dementia of the Alzheimers Type
Lon S. Schneider, Steven T. DeKosky, Martin Rhys Farlow et al. · Current Alzheimer Research
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25 Nov 2005 |
184 |
| 17 |
Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg
Horst Friedrich Herrschaft, Anatol Nacu, С А Лихачев et al. · Journal of Psychiatric Research
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27 Mar 2012 |
181 |
| 18 |
Serum procalcitonin levels in bacterial and abacterial meningitis
Stefan Theodor Schwarz, Markus Bertram, Stefan Schwab et al. · Critical Care Medicine
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Jun 2000 |
180 |
| 19 |
Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial
Siegfried F. Kasper, Markus Gastpar, Walter E. Müller et al. · International Clinical Psychopharmacology
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28 May 2010 |
174 |
| 20 |
Efficacy and tolerability of Ginkgo biloba extract EGb 761® in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials
Serge G. Gauthier, Sandra Schlaefke · Clinical Interventions in Aging
ReviewOpen access |
Nov 2014 |
174 |
| 21 |
Lipid microparticles as a parenteral controlled release device for peptides
Helmut Reithmeier, Joachım Herrmann, Achim M. Göpferich · Journal of Controlled Release
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Jun 2001 |
172 |
| 22 |
A 26-Week Analysis of a Double-Blind, Placebo-Controlled Trial of the Ginkgo biloba Extract EGb 761® in Dementia
Pierre L. Le Bars, Meinhard Kieser, Kurt Z. Itil · Dementia and Geriatric Cognitive Disorders
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2000 |
165 |
| 23 |
Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease
Xu Liu, Wenlin Hao, Yiren Qin et al. · Brain Behavior and Immunity
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27 Jan 2015 |
150 |
| 24 |
Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts
Egon Koch · Phytomedicine
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16 Dec 2004 |
150 |
| 25 |
Rutin is Essential for the Antidepressant Activity of Hypericum perforatum Extracts in the Forced Swimming Test
Michael Nöldner, Karl Schötz · Planta Medica
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Jul 2002 |
150 |
| 26 |
Efficacy and safety of a once‐daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial
Ralf Ihl, Natalia Yu. Bachinskaya, Amos D. Korczyn et al. · International Journal of Geriatric Psychiatry
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7 Dec 2010 |
141 |
| 27 |
Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels
Anita M. Schuwald, Michael Nöldner, Thomas Wilmes et al. · PLoS ONE
Open access |
29 Apr 2013 |
138 |
| 28 |
Silexan in anxiety disorders: Clinical data and pharmacological background
Siegfried F. Kasper, Walter E. Müller, Hans‐Peter Volz et al. · The World Journal of Biological Psychiatry
Open access |
17 May 2017 |
137 |
| 29 |
Re-calculating the sample size in internal pilot study designs with control of the type I error rate
Meinhard Kieser, Tim Friede · Statistics in Medicine
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15 Apr 2000 |
133 |
| 30 |
Influence of the Severity of Cognitive Impairment on the Effect of the Ginkgo biloba Extract EGb 761® in Alzheimer’s Disease
Pierre L. Le Bars, F.M. Velasco, James M. Ferguson et al. · Neuropsychobiology
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2002 |
132 |
| 31 |
Development and characterization of lipid microparticles as a drug carrier for somatostatin
Helmut Reithmeier, Joachım Herrmann, Achim M. Göpferich · International Journal of Pharmaceutics
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May 2001 |
131 |
| 32 |
A randomized placebo‐controlled trial on the effects of Menthacarin, a proprietary peppermint‐ and caraway‐oil‐preparation, on symptoms and quality of life in patients with functional dyspepsia
G. Rich, Ayesha Shah, Natasha A. Koloski et al. · Neurogastroenterology & Motility
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10 Jul 2017 |
128 |
| 33 |
Simple procedures for blinded sample size adjustment that do not affect the type I error rate
Meinhard Kieser, Tim Friede · Statistics in Medicine
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14 Nov 2003 |
128 |
| 34 |
Ginkgo biloba extract EGb 761®, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: A randomised, double-blind, exploratory trial
S. Yancheva, Ralf Ihl, Gabriela Dobromirova Nikolova et al. · Aging & Mental Health
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Mar 2009 |
127 |
| 35 |
Ginkgo biloba Extract EGb 761® in Dementia: Intent-to-treat Analyses of a 24-week, Multi-center, Double-blind, Placebo-controlled, Randomized Trial
S. Kanowski, Robert A. Hoerr · Pharmacopsychiatry
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Nov 2003 |
127 |
| 36 |
Efficacy and Tolerability of a Once Daily Formulation of Ginkgo biloba Extract EGb 761® in Alzheimer's Disease and Vascular Dementia: Results from a Randomised Controlled Trial
Ralf Ihl, Michael Tribanek, Natalia Yu. Bachinskaya et al. · Pharmacopsychiatry
Open access |
15 Nov 2011 |
122 |
| 37 |
Ginkgo biloba special extract EGb 761® in generalized anxiety disorder and adjustment disorder with anxious mood: A randomized, double-blind, placebo-controlled trial
Helmut Woelk, K. Arnoldt, Meinhard Kieser et al. · Journal of Psychiatric Research
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4 Jul 2006 |
120 |
| 38 |
Inference on Multiple Endpoints in Clinical Trials with Adaptive Interim Analyses
Meinhard Kieser, Péter Bauer, Walter Lehmacher · Biometrical Journal
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Jun 1999 |
118 |
| 39 |
Pharmacological profile of extracts of Pelargonium sidoides and their constituents
Herbert Kolodziej, Oliver Kayser, Oliver A. Radtke et al. · Phytomedicine
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2003 |
116 |
| 40 |
Efficacy and safety of Ginkgo biloba extract EGb 761 ® in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo‐controlled, double‐blind, multi‐center trial
Gavrilova Si, Ulrich W. Preuss, J. W. M. Wong et al. · International Journal of Geriatric Psychiatry
Open access |
16 Mar 2014 |
114 |
| 41 |
Tannins from Hamamelis virginiana Bark Extract: Characterization and Improvement of the Antiviral Efficacy against Influenza A Virus and Human Papillomavirus
Linda L. Theisen, Clemens A. J. Erdelmeier, Gilles A. Spoden et al. · PLoS ONE
Open access |
31 Jan 2014 |
112 |
| 42 |
Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus
Oksana Weichel, Michael Hilgert, Shyam S Chatterjee et al. · Naunyn-Schmiedeberg s Archives of Pharmacology
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Dec 1999 |
111 |
| 43 |
Plasma Levels and Distribution of Flavonoids in Rat Brain after Single and Repeated Doses of StandardizedGinkgo bilobaExtract EGb 761®
Laura Rangel-Ordóñez, Michael Nöldner, Manfred Schubert‐Zsilavecz et al. · Planta Medica
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19 May 2010 |
108 |
| 44 |
Superior efficacy of St John's wort extract WS®5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]
Siegfried F. Kasper, Ion‐George Anghelescu, Armin Szegedi et al. · BMC Medicine
Open access |
23 Jun 2006 |
107 |
| 45 |
Towards the concept of disease-modifier in post-stroke or vascular cognitive impairment: a consensus report
Régis Bordet, Ralf Ihl, Amos D. Korczyn et al. · BMC Medicine
Open access |
24 May 2017 |
106 |
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Hyperforin, Possibly the Major Non-Nitrogenous Secondary Metabolite of Hypericum perforatum L.
C. A. J. ERDELMEIER · Pharmacopsychiatry
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Jun 1998 |
104 |
| 47 |
Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials
Egemen Savaskan, Heiko Mueller, Robert A. Hoerr et al. · International Psychogeriatrics
ReviewOpen access |
21 Sep 2017 |
103 |
| 48 |
Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761)
S. Høyer, Heinrich Lannert, Michael Nöldner et al. · Journal of Neural Transmission
Book chapter |
15 Feb 1999 |
103 |
| 49 |
A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children
Sylke-Monina Müller, Stephan Klement · Phytomedicine
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20 Feb 2006 |
103 |
| 50 |
In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L.
Helke Hecker, Reiner Johannissón, Egon Koch et al. · Toxicology
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Aug 2002 |
103 |