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Most cited papers from Duke Medical Center

What are the most cited papers from Duke Medical Center?

The most cited paper from Duke Medical Center is "PHENIX : a comprehensive Python-based system for macromolecular structure solution" (Paul D. Adams, Pavel V. Afonine, G. Bunkóczi et al., 2010), with 24,924 citations. Next come "An integrated encyclopedia of DNA elements in the human genome" (19,751) and "Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels" (12,959).

Showing 50 of 59 papers. Every paper with more than 3,069 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 PHENIX : a comprehensive Python-based system for macromolecular structure solution Paul D. Adams, Pavel V. Afonine, G. Bunkóczi et al. · Acta Crystallographica Section D Biological Crystallography Open access 21 Jan 2010 24,924
2 An integrated encyclopedia of DNA elements in the human genome Ian Dunham et al. · Nature Open access442 authors Sep 2012 19,751
3 Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels Charles Beauchamp, Irwin Fridovich · Analytical Biochemistry Nov 1971 12,959
4 Superoxide Dismutase Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry Open access Nov 1969 12,906
5 Development of a new resilience scale: The Connor-Davidson Resilience Scale (CD-RISC) Kathryn M. Connor, Jonathan R. T. Davidson · Depression and Anxiety Sep 2003 11,835
6 Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Clotilde Théry et al. · Journal of Extracellular Vesicles Open access382 authors 23 Nov 2018 11,535
7 MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS Frank E. Harrell, Kerry L. Lee, Daniel B. Mark · Statistics in Medicine 29 Feb 1996 10,006
8 Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science 13 Aug 1993 9,582
9 Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer H. Borghaei et al. · New England Journal of Medicine Open access 27 Sep 2015 9,557
10 Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation Manesh R. Patel, Kenneth W. Mahaffey, Jyotsna Garg et al. · New England Journal of Medicine Open access 10 Aug 2011 9,484
11 Apixaban versus Warfarin in Patients with Atrial Fibrillation Christopher B. Granger et al. · New England Journal of Medicine Open access 28 Aug 2011 9,001
12 Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer Julie Renee Brahmer et al. · New England Journal of Medicine Open access 31 May 2015 8,632
13 Integrated genomic analyses of ovarian carcinoma Debra Bell et al. · Nature Open access255 authors 28 Jun 2011 8,268
14 Comprehensive genomic characterization defines human glioblastoma genes and core pathways Roger E. McLendon et al. · Nature Open access231 authors 4 Sep 2008 7,893
15 Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Charles E. Murry, Robert B. Jennings, K A Reimer · Circulation Open access Nov 1986 7,857
16 Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery Martin B. Leon et al. · New England Journal of Medicine Open access 20 Oct 2010 7,239
17 Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Daniel R. Rosen et al. · Nature Mar 1993 7,116
18 Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Shideng Bao, Qiulian Wu, Roger E. McLendon et al. · Nature 18 Oct 2006 6,478
19 Neuroinflammation in Alzheimer's disease Michael Thomas Heneka et al. · The Lancet Neurology Open access 16 Mar 2015 6,318
20 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Daniel J. Klionsky et al. · Autophagy Open access2,467 authors 2 Jan 2016 6,023
21 A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure Lawrence J. Appel, Thomas J. Moore, Eva Obarzanek et al. · New England Journal of Medicine Open access 17 Apr 1997 6,008
22 Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia Jeffrey Alan Lieberman, T. Scott Stroup, Joseph P. McEvoy et al. · New England Journal of Medicine Open access 19 Sep 2005 5,930
23 Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia Shannon L. Maude et al. · New England Journal of Medicine Open access 31 Jan 2018 5,818
24 The Warburg Effect: How Does it Benefit Cancer Cells? Maria V. Liberti, Jason W. Locasale · Trends in Biochemical Sciences ReviewOpen access 5 Jan 2016 5,355
25 Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management Steven Y. C. Tong, Joshua Saul Davis, Emily M. Eichenberger et al. · Clinical Microbiology Reviews Open access 27 May 2015 5,276
26 The Somatic Genomic Landscape of Glioblastoma Cameron Brennan et al. · Cell Open access300 authors Oct 2013 5,261
27 Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee A. MICHAEL PARFITT, Marc K. Drezner, Francis H. Glorieux et al. · Journal of Bone and Mineral Research Dec 1987 5,049
28 PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer Jing Li, Clifford Yen, Danny Liaw et al. · Science 28 Mar 1997 4,843
29 Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease Alison Goate et al. · Nature 21 Feb 1991 4,701
30 Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy Howard I. Scher, Karim S. Fizazi, Fred Saad et al. · New England Journal of Medicine Open access 15 Aug 2012 4,645
31 Clinical Rating Systems for the Ankle-Hindfoot, Midfoot, Hallux, and Lesser Toes Harold B. Kitaoka, Ian James Alexander, Robert S. Adelaar et al. · Foot & Ankle International Jul 1994 4,519
32 Lipopolysaccharide Endotoxins Christian R.H. Raetz, Chris Whitfield · Annual Review of Biochemistry ReviewOpen access Jun 2002 4,420
33 The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction Richard C. Bump, Anders Mattiasson, Kari Bø et al. · American Journal of Obstetrics and Gynecology Jul 1996 4,305
34 Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease Robin P. Sherrington et al. · Nature Jun 1995 4,080
35 Features and uses of high-fidelity medical simulations that lead to effective learning: a BEME systematic review Saul Barry Issenberg, William C. McGaghie, EMIL R. PETRUSA et al. · Medical Teacher Review 2005 3,976
36 Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study Lisa A. Carey, Charles M. Perou, Chad Livasy et al. · JAMA 6 Jun 2006 3,866
37 Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice Vanessa K. Ridaura et al. · Science Open access 5 Sep 2013 3,861
38 Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer Sunil Verma, David W. Miles, Luca Gianni et al. · New England Journal of Medicine Open access Oct 2012 3,859
39 The repertoire of mutational signatures in human cancer Ludmil B. Alexandrov et al. · Nature Open access1,384 authors 5 Feb 2020 3,854
40 Wnt signalling in stem cells and cancer Tannishtha Reya, Hans C. Clevers · Nature 13 Apr 2005 3,705
41 Identification of the breast cancer susceptibility gene BRCA2 Richard Wooster et al. · Nature Dec 1995 3,687
42 Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome Gregory G. Schwartz et al. · New England Journal of Medicine Open access 7 Nov 2018 3,654
43 Dopamine Receptors: From Structure to Function Cristina Missale, Stuart Nash, Susan W. Robinson et al. · Physiological Reviews Review 1998 3,654
44 Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation William A. Zoghbi, David H Adams, Robert O. Bonow et al. · Journal of the American Society of Echocardiography 14 Mar 2017 3,570
45 The APACHE III Prognostic System William A. Knaus, Douglas P. Wagner, Elizabeth A. Draper et al. · CHEST Journal Dec 1991 3,502
46 Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations Robert H. Dworkin et al. · Journal of Pain Open access 13 Dec 2007 3,496
47 High Frequency of Mutations of the PIK3CA Gene in Human Cancers Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science 15 Mar 2004 3,473
48 SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES Irwin Fridovich · Annual Review of Biochemistry Jun 1995 3,456
49 Pan-cancer analysis of whole genomes Lauri A. Aaltonen et al. · Nature Open access1,324 authors 5 Feb 2020 3,360
50 The Biology of Oxygen Radicals Irwin Fridovich · Science 8 Sep 1978 3,349

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.