Institution · Evotec (United Kingdom)
Most cited papers from Evotec (United Kingdom)
What are the most cited papers from Evotec (United Kingdom)?
The most cited paper from Evotec (United Kingdom) is "Natural products in drug discovery: advances and opportunities" (Atanas G. Atanasov et al., 2021), with 5,395 citations. Next come "Amide bond formation and peptide coupling" (1,773) and "Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia" (1,411).
Showing 50 of 61 papers. Every paper with more than 70 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Natural products in drug discovery: advances and opportunities Atanas G. Atanasov et al. · Nature Reviews Drug Discovery | 28 Jan 2021 | 5,395 |
| 2 | Amide bond formation and peptide coupling Christian Montalbetti, Virginie M. Falque · Tetrahedron | 20 Sep 2005 | 1,773 |
| 3 | Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia Eliza Yankova et al. · Nature | 26 Apr 2021 | 1,411 |
| 4 | Alternatives to antibiotics—a pipeline portfolio review Lloyd G. Czaplewski et al. · The Lancet Infectious Diseases | 13 Jan 2016 | 864 |
| 5 | Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1 Andrew D. Napper, Jeffrey Hixon, Thomas McDonagh et al. · Journal of Medicinal Chemistry | 9 Nov 2005 | 532 |
| 6 | Accurate calculation of the absolute free energy of binding for drug molecules Matteo Aldeghi, Alexander Heifetz, Michael J. Bodkin et al. · Chemical Science | 25 Sep 2015 | 402 |
| 7 | GDC-0449—A potent inhibitor of the hedgehog pathway Kirk D. Robarge et al. · Bioorganic & Medicinal Chemistry Letters | 16 Aug 2009 | 388 |
| 8 | SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration Matthew D. Figley et al. · Neuron | 2 Mar 2021 | 354 |
| 9 | Sensitivity of a new commercial enzyme-linked immunospot assay (T SPOT-TB) for diagnosis of tuberculosis in clinical practice Thomas Meier, H.-P. Eulenbruch, Peter Wrighton-Smith et al. · European Journal of Clinical Microbiology & Infectious Diseases | Aug 2005 | 208 |
| 10 | Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations Matteo Aldeghi, Alexander Heifetz, Michael J. Bodkin et al. · Journal of the American Chemical Society | 23 Dec 2016 | 203 |
| 11 | Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors Melissa L. Boby et al. · Science | 9 Nov 2023 | 188 |
| 12 | The histamine H3 receptor as a therapeutic drug target for CNS disorders Mark J. Gemkow, Adam J. Davenport, Silke Harich et al. · Drug Discovery Today | 7 Mar 2009 | 182 |
| 13 | Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex Eric Jnoff et al. · ChemMedChem | 6 Feb 2014 | 180 |
| 14 | Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy Todd Bosanac, Robert O Hughes, Thomas M. Engber et al. · Brain | 6 May 2021 | 158 |
| 15 | Application of statistical ‘design of experiments’ methods in drug discovery Heather Tye · Drug Discovery Today | 25 May 2004 | 154 |
| 16 | Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules Yun Yu Shi et al. · Molecular Cell | 24 Mar 2022 | 152 |
| 17 | Statistical Analysis on the Performance of Molecular Mechanics Poisson–Boltzmann Surface Area versus Absolute Binding Free Energy Calculations: Bromodomains as a Case Study Matteo Aldeghi, Michael J. Bodkin, Stefan Knapp et al. · Journal of Chemical Information and Modeling | 8 Aug 2017 | 150 |
| 18 | Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741 David F. Corbett, Andrew K. Wise, Tara Langley et al. · Antimicrobial Agents and Chemotherapy | 23 May 2017 | 150 |
| 19 | Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery Adam J. Lucas, Joanne L. Sproston, Patrick Barton et al. · Expert Opinion on Drug Discovery | 20 Sep 2019 | 142 |
| 20 | Mechanistic analysis by NMR spectroscopy: A users guide Yael Ben‐Tal, Patrick J. Boaler, Harvey J. A. Dale et al. · Progress in Nuclear Magnetic Resonance Spectroscopy | 19 Jan 2022 | 133 |
| 21 | Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives Ravindra B. Pathak, P.T. Chovatia, Harendra S. Parekh · Bioorganic & Medicinal Chemistry Letters | 24 May 2012 | 133 |
| 22 | A comparison of the pharmacophore identification programs: Catalyst, DISCO and GASP Yogendra Patel, Valerie J. Gillet, Gianpaolo Bravi et al. · Journal of Computer-Aided Molecular Design | Aug 2002 | 132 |
| 23 | Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity Andrew A. Guirguis et al. · Cancer Discovery | 7 Aug 2023 | 129 |
| 24 | Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies Luke F. Peterson, Hanshi Sun, Yi‐Hong Liu et al. · Blood | 27 Mar 2015 | 129 |
| 25 | Captured and Cross-Linked Palladium Nanoparticles Jin Ku Cho, Romain Najman, Tony W. Dean et al. · Journal of the American Chemical Society | 27 Apr 2006 | 128 |
| 26 | Identification of Diverse Database Subsets using Property‐Based and Fragment‐Based Molecular Descriptions Mark R. Ashton, John M. Barnard, Florence Casset et al. · Quantitative Structure-Activity Relationships | Dec 2002 | 117 |
| 27 | The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR–Ligand Interactions Alexander Heifetz, Ewa I. Chudyk, Laura Gleave et al. · Journal of Chemical Information and Modeling | 7 Dec 2015 | 116 |
| 28 | Microwave-assisted multi-component synthesis of fused 3-aminoimidazoles Sarah M. Ireland, Heather Tye, Mark A. Whittaker · Tetrahedron Letters | 13 May 2003 | 113 |
| 29 | Prediction of cyclin-dependent kinase 2 inhibitor potency using the fragment molecular orbital method Michael P. Mazanetz, Osamu Ichihara, Richard J Law et al. · Journal of Cheminformatics | 10 Jan 2011 | 113 |
| 30 | Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes María Velasco‐Estevez, Myrthe Mampay, Hervé Boutin et al. · Frontiers in Aging Neuroscience | 22 Oct 2018 | 106 |
| 31 | The structural basis of fatty acid elongation by the ELOVL elongases Laiyin Nie, Tomas C. Pascoa, Ashley C. W. Pike et al. · Nature Structural & Molecular Biology | Jun 2021 | 103 |
| 32 | Drug Discovery Applications for KNIME: An Open Source Data Mining Platform Michael P. Mazanetz, Robert J. Marmon, Catherine B. T. Reisser et al. · Current Topics in Medicinal Chemistry | Sep 2012 | 103 |
| 33 | Compound Design by Fragment‐Linking Osamu Ichihara, John J. Barker, Richard J Law et al. · Molecular Informatics | 6 Apr 2011 | 102 |
| 34 | Comparisons betweenin vitrowhole cell imaging andin vivozebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development Adrian J. Hill, Natalie Mesens, Margino Steemans et al. · Drug Metabolism Reviews | 14 Jan 2012 | 102 |
| 35 | Photocatalytic Carboxylate to Sulfinamide Switching Delivers a Divergent Synthesis of Sulfonamides and Sulfonimidamides Jonathan A. Andrews, Jagadeesh Kalepu, Christopher F. Palmer et al. · Journal of the American Chemical Society | 22 Sep 2023 | 101 |
| 36 | Development of a Selective Inhibitor of Protein Arginine Deiminase 2 Aaron Muth, Venkataraman Subramanian, Edward Beaumont et al. · Journal of Medicinal Chemistry | 24 Mar 2017 | 101 |
| 37 | Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae Martin J. Everett, Nicolas Sprynski, Alicia Coelho et al. · Antimicrobial Agents and Chemotherapy | 13 Mar 2018 | 99 |
| 38 | The lipoprotein Pal stabilises the bacterial outer membrane during constriction by a mobilisation-and-capture mechanism Joanna Szczepaniak, Peter C. Holmes, Karthik V. Rajasekar et al. · Nature Communications | 11 Mar 2020 | 97 |
| 39 | Syntheses and antiproliferative evaluation of oxyphenisatin derivatives Muhammed K. Uddin, Serge G. Reignier, Tom Coulter et al. · Bioorganic & Medicinal Chemistry Letters | 26 Feb 2007 | 96 |
| 40 | 2023 FDA TIDES (Peptides and Oligonucleotides) Harvest Danah Al Shaer, Othman Al Musaimi, Fernando Alberício et al. · Pharmaceuticals | 13 Feb 2024 | 92 |
| 41 | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation Cyril Dian, Inmaculada Pérez‐Dorado, Frédéric Rivière et al. · Nature Communications | 28 Feb 2020 | 92 |
| 42 | Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ Lloyd G. Czaplewski, Ian F. Collins, Edward A. Boyd et al. · Bioorganic & Medicinal Chemistry Letters | 14 Nov 2008 | 92 |
| 43 | Antibacterial drug discovery and structure-based design John J. Barker · Drug Discovery Today | 23 Apr 2006 | 88 |
| 44 | Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase Michael E. Prime, Stephen M. Courtney, Frederick A. Brookfield et al. · Journal of Medicinal Chemistry | 3 Dec 2010 | 86 |
| 45 | Introduction to small molecule drug discovery and preclinical development Michelle W. Y. Southey, Michael Brunavs · Frontiers in Drug Discovery | 30 Nov 2023 | 85 |
| 46 | Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors Alexander Heifetz, Giancarlo Trani, Matteo Aldeghi et al. · Journal of Medicinal Chemistry | 7 Mar 2016 | 85 |
| 47 | Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor David F. C. Moffat, Sanjay R. Patel, Francesca A. Day et al. · Journal of Medicinal Chemistry | 16 Nov 2010 | 83 |
| 48 | Effect of increasing concentration of ammonium acetate as an additive in supercritical fluid chromatography using CO2–methanol mobile phase Amaury Cazenave‐Gassiot, Robert J. Boughtflower, Jeffrey Caldwell et al. · Journal of Chromatography A | 18 Jul 2009 | 83 |
| 49 | Liposomal Packaging Generates Wnt Protein with In Vivo Biological Activity Nathan T. Morrell, Philipp Leucht, Ludan Zhao et al. · PLoS ONE | 12 Aug 2008 | 82 |
| 50 | The Structure of Mammalian Serine Racemase Myron A. Smith, Volker Mack, Andreas Ebneth et al. · Journal of Biological Chemistry | 28 Jan 2010 | 80 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.