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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
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8 Sep 2014 |
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The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways
Günaj Rakipovski, Bidda Rolin, Jane Nøhr et al. · JACC Basic to Translational Science
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21 Nov 2018 |
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Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals
Malte Palm Suppli, Kristoffer T. G. Rigbolt, Sanne Skovgård Veidal et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology
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17 Jan 2019 |
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Mouse models of nonalcoholic steatohepatitis in preclinical drug development
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4 Jul 2017 |
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Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis
Michelle L. Boland, Rhianna Che Laker, KARLY M. MATHER et al. · Nature Metabolism
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21 May 2020 |
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An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)
Michèle Vacca et al. · Nature Metabolism
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12 Jun 2024 |
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Robust anti‐obesity and metabolic effects of a dual GLP ‐1/glucagon receptor peptide agonist in rodents and non‐human primates
Susan J Henderson et al. · Diabetes Obesity and Metabolism
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Nuclear morphology is a deep learning biomarker of cellular senescence
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15 Aug 2022 |
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An ex vivo imaging pipeline for producing high‐quality and high‐resolution diffusion‐weighted imaging datasets
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The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach
Suryaprakash Raichur, Bodo Brunner, Maximilian Bielohuby et al. · Molecular Metabolism
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2 Jan 2019 |
200 |
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Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain
Kristy M. Heppner, Melissa Ann Kirigiti, Anna Secher et al. · Endocrinology
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7 Nov 2014 |
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A genetic map of the mouse dorsal vagal complex and its role in obesity
Mette Q. Ludwig, Wenwen Cheng, Desiree Gordian et al. · Nature Metabolism
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25 Mar 2021 |
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Half‐Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation
Søren B. van Witteloostuijn, Søren Ljungberg Pedersen, Knud J. Jensen · ChemMedChem
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24 Oct 2016 |
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The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer’s Disease
Henrik H. Hansen, Katrine Fabricius, Pernille Barkholt et al. · Journal of Alzheimer s Disease
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26 Jun 2015 |
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Liraglutide: short‐lived effect on gastric emptying—long lasting effects on body weight
Jacob Jelsing, Niels Vrang, Gitte Hansen et al. · Diabetes Obesity and Metabolism
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6 Jan 2012 |
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Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects
Tea Lund Laursen, Christoffer Andersen Hagemann, Chunshan Wei et al. · World Journal of Hepatology
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26 Feb 2019 |
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Enteroendocrine K and L cells in healthy and type 2 diabetic individuals
Tina Jorsal, Nicolai Alexander Rhee, Jens Pedersen et al. · Diabetologia
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27 Sep 2017 |
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Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
Henrik H. Hansen, Helene M. Ægidius, Denise Oró et al. · BMC Gastroenterology
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6 Jul 2020 |
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CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice
Chih‐Hao Wang, Morten Lundh, Accalia Fu et al. · Science Translational Medicine
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26 Aug 2020 |
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Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome
Andreas Nygaard Madsen, Gitte Hansen, Sarah Juel Paulsen et al. · Journal of Endocrinology
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27 May 2010 |
154 |
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Activation of thyroid hormone receptor‐β improved disease activity and metabolism independent of body weight in a mouse model of non‐alcoholic steatohepatitis and fibrosis
Aimo Kannt, Paulus Wohlfart, Andreas Nygaard Madsen et al. · British Journal of Pharmacology
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3 Mar 2021 |
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Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis
K.S. Tølbøl, Maria Nicoline Baandrup Kristiansen, Henrik H. Hansen et al. · World Journal of Gastroenterology
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14 Jan 2018 |
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Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides
Niels Vrang, Philip Just Larsen · Progress in Neurobiology
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17 Jul 2010 |
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Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source
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4 Sep 2019 |
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Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer T.G. Rigbolt et al. · World Journal of Hepatology
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2016 |
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Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes
Nicolai Alexander Rhee, Camilla D. Wahlgren, Jens Pedersen et al. · Diabetologia
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17 Jul 2015 |
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Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice
Mette Simone Aae Madsen, Jacob Bak Holm, Albert Pallejá et al. · Scientific Reports
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30 Oct 2019 |
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Hypertrophy Dependent Doubling of L-Cells in Roux-en-Y Gastric Bypass Operated Rats
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11 Jun 2013 |
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Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells
Kadla Røskva Rosholm, Natascha Leijnse, Anna Mantsiou et al. · Nature Chemical Biology
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Blood pressure and glucose independent renoprotective effects of dipeptidyl peptidase-4 inhibition in a mouse model of type-2 diabetic nephropathy
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12 Sep 2014 |
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The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy
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31 Dec 2015 |
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Glucagon Resistance at the Level of Amino Acid Turnover in Obese Subjects With Hepatic Steatosis
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23 Jan 2020 |
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The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis
Niels Vrang, Jacob Jelsing, Lotte Simonsen et al. · American Journal of Physiology-Endocrinology and Metabolism
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The novel GLP ‐1‐gastrin dual agonist, ZP3022 , increases β‐cell mass and prevents diabetes in db/db mice
Keld Fosgerau, Lene Jessen, Jakob L. Tolborg et al. · Diabetes Obesity and Metabolism
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3 Aug 2012 |
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Characterisation of Age-Dependent Beta Cell Dynamics in the Male db/db Mice
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6 Dec 2013 |
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An Optimized Mouse Brain Atlas for Automated Mapping and Quantification of Neuronal Activity Using iDISCO+ and Light Sheet Fluorescence Microscopy
Johanna Perens, Casper Gravesen Salinas, Jacob Lercke Skytte et al. · Neuroinformatics
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15 Oct 2020 |
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Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH
Mathias Bonde Møllerhøj, Sanne Skovgård Veidal, Kirstine Tølbøl Thrane et al. · Clinical and Translational Science
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10 Feb 2022 |
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Non‐alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion
Peter Lykke Eriksen, Hendrik Vilstrup, Kristoffer T. G. Rigbolt et al. · Liver International
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LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men
Christoffer Andersen Hagemann, Malene S. Jensen, Stephanie Kjærulff Holm et al. · Cell Reports Medicine
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30 Mar 2022 |
80 |
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Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Chloé Berland et al. · Cell Metabolism
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9 Mar 2020 |
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Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery
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INT-767 improves histopathological features in a diet-inducedob/obmouse model of biopsy-confirmed non-alcoholic steatohepatitis
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14 Jan 2018 |
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Faecal Microbiota transplantation affects liver DNA methylation in Non-alcoholic fatty liver disease: a multi-omics approach
Daniela Stols‐Gonçalves, Anne Linde Mak, Mette Simone Aae Madsen et al. · Gut Microbes
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14 Jun 2023 |
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Whole-brain activation signatures of weight-lowering drugs
Henrik H. Hansen, Johanna Perens, Urmas Roostalu et al. · Molecular Metabolism
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30 Jan 2021 |
72 |
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Whole-brain spatial transcriptional analysis at cellular resolution
Shigeaki Kanatani et al. · Science
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Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model
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11 Apr 2017 |
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Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats
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Expression of the Fatty Acid Receptor GPR120 in the Gut of Diet-Induced-Obese Rats and Its Role in GLP-1 Secretion
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10 Feb 2014 |
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The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU‐120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat
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27 Apr 2012 |
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Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease
Henrik H. Hansen, Katrine Fabricius, Pernille Barkholt et al. · PLoS ONE
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15 Jul 2016 |
61 |