| 1 |
Regional Nodal Irradiation in Early-Stage Breast Cancer
Timothy Joseph Whelan et al. · New England Journal of Medicine
Open access |
22 Jul 2015 |
1,324 |
| 2 |
Radiomics strategies for risk assessment of tumour failure in head-and-neck cancer
Martin Vallières, Emily Kay‐Rivest, Léo Jean Perrin et al. · Scientific Reports
Open access |
25 Aug 2017 |
562 |
| 3 |
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
Linda M. Liau et al. · Journal of Translational Medicine
Open access |
25 May 2018 |
547 |
| 4 |
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex
Volney L. Sheen, Vijay S Ganesh, Meral Topçu et al. · Nature Genetics
Open access |
30 Nov 2003 |
398 |
| 5 |
Point-of-Care Hemostatic Testing in Cardiac Surgery
Keyvan Karkouti, Jeannie Callum, Duminda Nalaka Wijeysundera et al. · Circulation
|
21 Sep 2016 |
318 |
| 6 |
Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis
William Manzanares, Margot Lemieux, Pascal L. Langlois et al. · Critical Care
ReviewOpen access |
18 Aug 2016 |
300 |
| 7 |
Inflamm-aging does not simply reflect increases in pro-inflammatory markers
Vincent Morrisette-Thomas, Alan A. Cohen, Tamàs Fülöp et al. · Mechanisms of Ageing and Development
Open access |
Jul 2014 |
284 |
| 8 |
A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
Alan A. Cohen, Emmanuel Milot, Jian Yong et al. · Mechanisms of Ageing and Development
Open access |
31 Jan 2013 |
226 |
| 9 |
Respiratory gating for 3-dimensional PET of the thorax: feasibility and initial results.
Luc Boucher, Serge Rodrigue, Roger Lecomte et al. · PubMed
|
Feb 2004 |
226 |
| 10 |
Physiological regulatory networks: ecological roles and evolutionary constraints
Alan A. Cohen, Lynn B. Martin, John C. Wingfield et al. · Trends in Ecology & Evolution
ReviewOpen access |
21 May 2012 |
224 |
| 11 |
Narrative Review: Fabry Disease
Joe T.R. Clarke · Annals of Internal Medicine
Review |
20 Mar 2007 |
204 |
| 12 |
Continued vs. interrupted direct oral anticoagulants at the time of device surgery, in patients with moderate to high risk of arterial thrombo-embolic events (BRUISE CONTROL-2)
David H. Birnie, Jeff S. Healey, George A. Wells et al. · European Heart Journal
|
29 Jun 2018 |
194 |
| 13 |
Cell wall extension results in the coordinate separation of parallel microfibrils: evidence from scanning electron microscopy and atomic force microscopy
Francoise S. Marga, Michel Grandbois, Daniel J. Cosgrove et al. · The Plant Journal
Open access |
17 Jun 2005 |
174 |
| 14 |
Complications associated with defibrillation threshold testing: The Canadian experience
DAVID H. BIRNIE, Stanley Tung, Christopher S. Simpson et al. · Heart Rhythm
|
30 Nov 2007 |
171 |
| 15 |
G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigmThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell.
Fernand Gobeil, Audrey Fortier, Tang Zhu et al. · Canadian Journal of Physiology and Pharmacology
|
Mar 2006 |
166 |
| 16 |
An international trial of antioxidants in the prevention of preeclampsia (INTAPP)
Hairong Xu et al. · American Journal of Obstetrics and Gynecology
|
Mar 2010 |
162 |
| 17 |
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
Philip L. De Jager et al. · Genes and Immunity
Open access |
31 May 2007 |
149 |
| 18 |
Cytokines and Brain Injury: Invited Review
Hazim J. Kadhim, Jean Duchateau, Guillaume Sébire · Journal of Intensive Care Medicine
|
25 May 2008 |
144 |
| 19 |
Complex systems dynamics in aging: new evidence, continuing questions
Alan A. Cohen · Biogerontology
Open access |
19 May 2015 |
143 |
| 20 |
Sample study protocol for adapting and translating the 5C scale to assess the psychological antecedents of vaccination
Cornelia Betsch, Katrine Bach Habersaat, Sergei Deshevoi et al. · BMJ Open
Open access |
Mar 2020 |
133 |
| 21 |
Lentivirus-mediated gene therapy for Fabry disease
Aneal Khan et al. · Nature Communications
Open access |
25 Feb 2021 |
121 |
| 22 |
Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases
Wouter van Rheenen et al. · Neurology
Open access413 authors |
27 Jul 2012 |
119 |
| 23 |
Buprenorphine transdermal system in adults with chronic low back pain: A randomized, double-blind, placebo-controlled crossover study, followed by an open-label extension phase
ALLAN S. GORDON, Denis J.G. Callaghan, Donald R. Spink et al. · Clinical Therapeutics
|
May 2010 |
118 |
| 24 |
A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins
Jean‐Philippe Gagné, Joanna M. Hunter, Benoît Labrecque et al. · Biochemical Journal
Open access |
9 Apr 2003 |
115 |
| 25 |
Acute Transverse Myelitis in Children: Clinical Course and Prognostic Factors
Pierre Defresne, Henri Hollenberg, B. Husson et al. · Journal of Child Neurology
|
Jun 2003 |
111 |
| 26 |
Comparison of Toxicity Associated With Early Morning Versus Late Afternoon Radiotherapy in Patients With Head-and-Neck Cancer: A Prospective Randomized Trial of the National Cancer Institute of Canada Clinical Trials Group (HN3)
Georg Arnold Bjarnason, Robert G. MacKenzie, Abdenour Nabid et al. · International Journal of Radiation Oncology*Biology*Physics
|
20 Sep 2008 |
109 |
| 27 |
Pre-emptive lumbar epidural anaesthesia reduces postoperative pain and patient-controlled morphine consumption after lower abdominal surgery
Joel D Katz, Michel Clairoux, Brian P. Kavanagh et al. · Pain
Open access |
Dec 1994 |
107 |
| 28 |
Secretory Breast Carcinoma
Marie Del Castillo, Frédéric Chibon, Laurent Arnould et al. · The American Journal of Surgical Pathology
|
20 Aug 2015 |
101 |
| 29 |
Susac syndrome: report of four cases and review of the literature.
Tai Hung, Christiane Fisch, François Evoy · PubMed
Open access |
Mar 2004 |
95 |
| 30 |
COVID-19: How the quarantine could lead to the depreobesity
Mohamed Mediouni, Riadh Madiouni, Karolina Elżbieta Kaczor‐Urbanowicz · Obesity Medicine
Open access |
15 May 2020 |
91 |
| 31 |
The effect of load on the coordination of the trunk for subjects with and without chronic low back pain during flexion–extension and lateral bending tasks
Christian Larivière, Denis J. Gagnon, Patrick Loisel · Clinical Biomechanics
Open access |
Jul 2000 |
89 |
| 32 |
A Three‐Component Reaction for Diversity‐Oriented Synthesis of Polysubstituted Piperidines: Solution and Solid‐Phase Optimization of the First Tandem Aza[4+2]/Allylboration
B. Barry Touré, Hamid R. Hoveyda, Jyoti Tailor et al. · Chemistry - A European Journal
|
16 Jan 2003 |
89 |
| 33 |
At least 60 ADP‐ribosylated variant histones are present in nuclei from dimethylsulfate‐treated and untreated cells.
Teni Boulikas · The EMBO Journal
Open access |
1988 |
87 |
| 34 |
What is Really Social Capital? A Critical Review
Thomas G. Poder · The American Sociologist
|
30 Mar 2011 |
85 |
| 35 |
Mechanisms of absorption of caseinophosphopeptide bound iron
Jean-Michel Pérès, Saı̈d Bouhallab, François Bureau et al. · The Journal of Nutritional Biochemistry
Open access |
Apr 1999 |
82 |
| 36 |
A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer
Antonio Jimeno, Julie E. Bauman, Charles Weissman et al. · Oral Oncology
Open access |
13 Jan 2015 |
79 |
| 37 |
Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations
Emmanuel Milot, Vincent Morissette-Thomas, Qing Li et al. · Mechanisms of Ageing and Development
Open access |
20 Oct 2014 |
79 |
| 38 |
Implantable Doppler in monitoring free flaps: A cost-effectiveness analysis based on a systematic review of the literature
Thomas-Andreas Põder, Pierre‐Hugues Fortier · European Annals of Otorhinolaryngology Head and Neck Diseases
ReviewOpen access |
23 Nov 2012 |
75 |
| 39 |
Effect of Maternal Docosahexaenoic Acid Supplementation on Bronchopulmonary Dysplasia–Free Survival in Breastfed Preterm Infants
Isabelle Marc et al. · JAMA
Open access |
14 Jul 2020 |
74 |
| 40 |
UPLC-MS/MS detection of disaccharides derived from glycosaminoglycans as biomarkers of mucopolysaccharidoses
Christiane Auray‐Blais, Paméla Lavoie, Shunji Tomatsu et al. · Analytica Chimica Acta
|
3 Jul 2016 |
71 |
| 41 |
Mental health effects from urban bed bug infestation ( Cimex lectularius L.): a cross-sectional study
Stephanie Rebecca Susser, Stéphane Perron, Michel Fournier et al. · BMJ Open
Open access |
2012 |
71 |
| 42 |
Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy
Martin Beauchamp, Florian Sennlaub, Giovanna Speranza et al. · Free Radical Biology and Medicine
|
28 Sep 2004 |
70 |
| 43 |
Retropharyngeal abscesses: a clinical and radiologic correlation.
Christilla Boucher, Dominique Dorion, Caroline Fisch · PubMed
|
Jun 1999 |
69 |
| 44 |
Chromosome organization and chromatin modification: influence on genome function and evolution
G.P. Holmquist, Terry Ashley · Cytogenetic and Genome Research
|
2006 |
67 |
| 45 |
Rocuronium is the best non-depolarizing relaxant to prevent succinylcholine fasciculations and myalgia
René Martin, J L Carrier, Martine Pirlet et al. · Canadian Journal of Anesthesia/Journal canadien d anesthésie
Open access |
Jun 1998 |
67 |
| 46 |
Extra-virgin olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1 anti-inflammatory activities
Soumaya Loued, Hicham Berrougui, Pamela Componova et al. · British Journal Of Nutrition
Open access |
19 Mar 2013 |
65 |
| 47 |
A comparative study of the antipyretic effects of indomethacin and dipyrone in rats
G. E. P. de Souza, R. A. Cardoso, M. C. C. Melo et al. · Inflammation Research
Open access |
2002 |
65 |
| 48 |
Pomalidomide, bortezomib, and dexamethasone for multiple myeloma previously treated with lenalidomide (OPTIMISMM): outcomes by prior treatment at first relapse
Meletios Athanasios Dimopoulos, Katja Christina Weisel, Philippe Moreau et al. · Leukemia
Open access |
7 Sep 2020 |
64 |
| 49 |
Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
Alan A. Cohen, Emmanuel Milot, Qing Li et al. · Experimental Gerontology
Open access |
5 May 2014 |
64 |
| 50 |
Outcome of individuals with low-moderate methylmalonic aciduria detected through a neonatal screening program
Lisa C. Sniderman, Marie Lambert, Robert Giguère et al. · The Journal of Pediatrics
|
Jun 1999 |
63 |