Institution · Horizon Discovery (United Kingdom)

Most cited papers from Horizon Discovery (United Kingdom)

Horizon Discovery (United Kingdom)

What are the most cited papers from Horizon Discovery (United Kingdom)?

The most cited paper from Horizon Discovery (United Kingdom) is "Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)" (Ursula A. Germann et al., 2017), with 239 citations. Next come "A generic strategy for CRISPR-Cas9-mediated gene tagging" (212) and "A Quantitative Comparison of Antibodies to Programmed Cell Death 1 Ligand 1" (202).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 16 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) Ursula A. Germann et al. · Molecular Cancer Therapeutics	22 Sep 2017	239
2	A generic strategy for CRISPR-Cas9-mediated gene tagging Daniel H. Lackner, Alexia Carré, Paloma M. Guzzardo et al. · Nature Communications Open access	17 Dec 2015	212
3	A Quantitative Comparison of Antibodies to Programmed Cell Death 1 Ligand 1 Patricia Gaule, James William Smithy, Maria I Toki et al. · JAMA Oncology Open access	19 Aug 2016	202
4	Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA Davina Gillian Gale et al. · PLoS ONE Open access	16 Mar 2018	174
5	Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT) Alexandra R. Grassian, Fallon Lin, Rosemary Barrett et al. · Journal of Biological Chemistry Open access	4 Oct 2012	142
6	JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations Srinivas Niranj Chandrasekaran et al. · bioRxiv (Cold Spring Harbor Laboratory) PreprintOpen access	24 Mar 2023	110
7	New Business Models for Biodiversity Conservation Joshua Bishop, Sachin Kapila, Frank Hicks et al. · Journal of Sustainable Forestry	13 May 2009	109
8	Pin1 inhibitors: Pitfalls, progress and cellular pharmacology Jonathan D. Moore, Andrew J. Potter · Bioorganic & Medicinal Chemistry Letters Open access	6 Jun 2013	107
9	Overview of Target Enrichment Strategies Iwanka Kozarewa, Javier Armisen, Andrew F. Gardner et al. · Current Protocols in Molecular Biology	Oct 2015	107
10	Synthetic Lethal Targeting of ARID1A -Mutant Ovarian Clear Cell Tumors with Dasatinib Rowan E. Miller et al. · Molecular Cancer Therapeutics Open access	30 Jun 2016	87
11	Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations Dean E. Hammond, Craig J. Mageean, Emma V. Rusilowicz et al. · Journal of Proteome Research Open access	19 Jan 2015	86
12	CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours Sara Costa-Cabral, Rachel Brough, Asha Konde et al. · PLoS ONE Open access	16 Feb 2016	78
13	The impact of CRISPR–Cas9 on target identification and validation Jonathan D. Moore · Drug Discovery Today	5 Jan 2015	70
14	Targeting EGFR and PI3K pathways in ovarian cancer Sharon Glaysher, Louise M Bolton, Peter Johnson et al. · British Journal of Cancer Open access	10 Sep 2013	70
15	Quantitative assessment of PD-L1 as an analyte in immunohistochemistry diagnostic assays using a standardized cell line tissue microarray Sandra Martínez-Morilla et al. · Laboratory Investigation Open access	13 Aug 2019	67
16	[(η-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(η-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0–2), and CO2CH2CH2OH: a new group of CO-releasing molecules David Scapens, Harry Adams, Tony R Johnson et al. · Dalton Transactions	2007	66
17	Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance Carlos le Sage, Steffen Lawo, Prince Panicker et al. · Scientific Reports Open access	12 Dec 2017	65
18	Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2 Evanthia Nikolopoulou, Caroline S. Hirst, Gabriel L. Galea et al. · Nature Communications Open access	6 Jun 2019	64
19	Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer Matthew P. Humphries, Seán O. Hynes, Victoria Bingham et al. · Journal of Oncology Open access	17 Dec 2018	64
20	VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells Jonathan D. Moore, Anna D. Staniszewska, Terence Shaw et al. · Oncotarget Open access	2 Nov 2014	64
21	Remote impact Florian Mueller, Stefan Agamanolis, Martin Gibbs et al. Conference paper	5 Apr 2008	63
22	TP53-independent Function of miR-34a via HDAC1 and p21CIP1/WAF1 Jane Y. Zhao, Paul Lammers, Chris J Torrance et al. · Molecular Therapy Open access	9 Jul 2013	59
23	The Antibody Society’s antibody validation webinar series Jan L. A. Voskuil, Anita E. Bandrowski, C. Glenn Begley et al. · mAbs Open access	2020	56
24	Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets Harri Lempiäinen et al. · Scientific Reports Open access	15 Feb 2018	49
25	Cancer cell senescence: a new frontier in drug development Claire J. Cairney, Alan E Bilsland, Thomas R. Jeffry Evans et al. · Drug Discovery Today	31 Jan 2012	49
26	Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition Mahito Sadaie, Christian Dillon, Masashi Narita et al. · Molecular Biology of the Cell Open access	2 Jul 2015	49
27	Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes Jeffrey J. Wallin, Jane Guan, Kyle A. Edgar et al. · PLoS ONE Open access	3 May 2012	49
28	Type IX Collagen Interacts with Fibronectin Providing an Important Molecular Bridge in Articular Cartilage Philippa Parsons, Sophie J. Gilbert, Anne Vaughan‐Thomas et al. · Journal of Biological Chemistry Open access	16 Jul 2011	48
29	Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors Anita C. Bellail, Hong Ri Jin, Ho‐Yin Lo et al. · Science Translational Medicine Open access	13 Oct 2021	46
30	Identification of novel,in vivoactive Chk1 inhibitors utilizing structure guided drug design Andrew J. Massey, S.P. Stokes, Helen L. Browne et al. · Oncotarget Open access	30 Sep 2015	46
31	Increasing the performance of pooled CRISPR–Cas9 drop-out screening Benedict C. S. Cross, Steffen Lawo, Caroline R. Archer et al. · Scientific Reports Open access	22 Aug 2016	45
32	Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets Charles Swanton et al. · Genome Medicine Open access	11 Aug 2010	45
33	Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines Dorna Varshavi, Dorsa Varshavi, Nicola Jane McCarthy et al. · Metabolomics Open access	Apr 2020	44
34	Attitudes and Behaviours to Antimicrobial Prescribing following Introduction of a Smartphone App Preet Panesar, Alisdair Jones, Alicia Aldous et al. · PLoS ONE Open access	25 Apr 2016	42
35	ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress Diana Guallar et al. · Cell stem cell Open access	11 May 2020	39
36	The general stress response of Staphylococcus aureus promotes tolerance of antibiotics and survival in whole human blood Nisha Ranganathan, Rebecca Johnson, Andrew M. Edwards · Microbiology Open access	23 Oct 2020	35
37	Evidence of Neurobiological Changes in the Presymptomatic PINK1 Knockout Rat Craig F. Ferris, Thomas R. Morrison, Sade C. Iriah et al. · Journal of Parkinson s Disease Open access	25 Apr 2018	35
38	Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin Julien Brustel, Zuza Kozik, Natalia Gromak et al. · Scientific Reports Open access	23 Feb 2018	31
39	HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State Laura H. Rosenberg, Anne-Laure Cattin, Xavier Fontana et al. · Cell Reports Open access	Dec 2018	30
40	Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis Andrew Brown et al. · Cell Genomics Open access	24 Apr 2023	29
41	Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling Chia-Wen Hsu, Ruili Huang, Thai Khuc et al. · Oncotarget Open access	23 Jan 2016	27
42	RNA ‐editing enzymes ADAR 1 and ADAR 2 coordinately regulate the editing and expression of Ctn RNA Aparna Anantharaman, Omid Gholamalamdari, Abid Ali Khan et al. · FEBS Letters Open access	18 Aug 2017	26
43	A small cassette enables conditional gene inactivation by CRISPR/Cas9 Paloma M. Guzzardo, Christina Rashkova, Rodrigo L. dos Santos et al. · Scientific Reports Open access	27 Nov 2017	25
44	Efficient generation and reversion of chromosomal translocations using CRISPR/Cas technology Sergey Lekomtsev, Sofia Aligianni, Ana Lapão et al. · BMC Genomics Open access	17 Sep 2016	25
45	Circulating pEGFR Is a Candidate Response Biomarker of Cetuximab Therapy in Colorectal Cancer Theodora Katsila, Mercè Juliachs, Josep Gregori et al. · Clinical Cancer Research Open access	17 Oct 2014	25
46	Children and Young People's Improving Access to Psychological Therapies: inspiring innovation or more of the same? Sami B. Timimi · BJPsych Bulletin Open access	Apr 2015	25
47	Mechanistic insights into non-coding Y RNA processing Martina Billmeier, Darrell Green, Adam E. Hall et al. · RNA Biology Open access	30 Mar 2022	24
48	Protein kinase A controls yeast growth in visible light Mikael Molin, Katarina Logg, Kristofer Bodvard et al. · BMC Biology Open access	16 Nov 2020	24
49	The Coronary Artery Disease-associated Coding Variant in Zinc Finger C3HC-type Containing 1 (ZC3HC1) Affects Cell Cycle Regulation Peter D. Jones, Michael Kaiser, Maryam Ghaderi Najafabadi et al. · Journal of Biological Chemistry Open access	20 May 2016	23
50	CRISPR: A Screener’s Guide Carlos le Sage, Steffen Lawo, Benedict C. S. Cross · SLAS DISCOVERY Open access	29 Oct 2019	20

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.