| 1 |
Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia
Hagop M. Kantarjian, Neil P. Shah, Andreas Hochhaus et al. · New England Journal of Medicine
|
5 Jun 2010 |
1,601 |
| 2 |
Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women
Raphael J. Landovitz et al. · New England Journal of Medicine
Open access |
11 Aug 2021 |
913 |
| 3 |
Mapping and predicting mortality from systemic sclerosis
Muriel Elhaï et al. · Annals of the Rheumatic Diseases
Open access |
23 Aug 2017 |
707 |
| 4 |
Whole-genome sequencing of patients with rare diseases in a national health system
Ernest Turro et al. · Nature
Open access512 authors |
24 Jun 2020 |
589 |
| 5 |
Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses
Caroline Ovadia et al. · The Lancet
Open access |
14 Feb 2019 |
587 |
| 6 |
Clinical efficacy of amiodarone as an antiarrhythmic agent
Mauricio Bernardo Rosenbaum, Pablo Ambrosio Chiale, M.Susana Halpern et al. · The American Journal of Cardiology
|
Dec 1976 |
574 |
| 7 |
Adjunctive perampanel for refractory partial-onset seizures
Jacqueline A. French et al. · Neurology
Open access |
27 Jul 2012 |
480 |
| 8 |
The Effects of Tibolone in Older Postmenopausal Women
Steven Ron Cummings, Bruce B. Ettinger, Pierre Dominique Delmas et al. · New England Journal of Medicine
Open access |
13 Aug 2008 |
456 |
| 9 |
Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up
Richard A. Larson, Andreas Hochhaus, Timothy P. Hughes et al. · Leukemia
|
18 May 2012 |
442 |
| 10 |
Electrotonic modulation of the T wave and cardiac memory
Mauricio Bernardo Rosenbaum, Horacio H. Blanco, Marcelo Victor Elizari et al. · The American Journal of Cardiology
|
Aug 1982 |
430 |
| 11 |
Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM
Oliver A. Cornely et al. · The Lancet Infectious Diseases
Open access105 authors |
13 Feb 2025 |
392 |
| 12 |
Influence of Hepatitis C Virus Infection on HIV‐1 Disease Progression and Response to Highly Active Antiretroviral Therapy
Jürgen Kurt Rockstroh, Amanda Mocroft, Vincent Soriano et al. · The Journal of Infectious Diseases
Open access |
19 Aug 2005 |
384 |
| 13 |
Parkinson's disease severity levels and MDS-Unified Parkinson's Disease Rating Scale
Pablo Martínez‐Martín, Carmen Rodríguez‐Blázquez, Mario Álvarez et al. · Parkinsonism & Related Disorders
Open access |
5 Nov 2014 |
369 |
| 14 |
Expectation and Attention in Hierarchical Auditory Prediction
Srivas Chennu, Valdas Noreika, David Gueorguiev et al. · Journal of Neuroscience
Open access |
3 Jul 2013 |
331 |
| 15 |
Helminth infections associated with multiple sclerosis induce regulatory B cells
Jorge Daniel Correale, Mauricio Farez, Gabriela Razzitte · Annals of Neurology
|
24 Jul 2008 |
314 |
| 16 |
Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
Jonggeol Jeffrey Kim et al. · Nature Genetics
ReviewOpen access300 authors |
28 Dec 2023 |
286 |
| 17 |
Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons
Colleen Frances Kelley et al. · New England Journal of Medicine
|
27 Nov 2024 |
285 |
| 18 |
Expanded and independent validation of the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS)
Pablo Martínez‐Martín, Carmen Rodríguez‐Blázquez, Mario Álvarez et al. · Journal of Neurology
|
4 Aug 2012 |
266 |
| 19 |
Cardiac morbidity and mortality due to Chagas' disease: prospective electrocardiographic study of a Brazilian community.
James H. Maguire, Rodney Hoff, Italo A. Sherlock et al. · Circulation
Open access |
Jun 1987 |
262 |
| 20 |
Control of tachyarrhythmias associated with Wolff-Parkinson-White syndrome by amiodarone hydrochloride
Mauricio Bernardo Rosenbaum, Pablo Ambrosio Chiale, David M. Ryba et al. · The American Journal of Cardiology
|
Aug 1974 |
258 |
| 21 |
Normalisation of CD4 counts in patients with HIV-1 infection and maximum virological suppression who are taking combination antiretroviral therapy: an observational cohort study
Amanda Mocroft, AN Phillips, JM Gatell et al. · The Lancet
Open access |
20 Jul 2007 |
256 |
| 22 |
Functional changes in motoneurones of hemiparetic patients
Alan J. McComas, Roberto E.P. Sica, Adrian R. M. Upton et al. · Journal of Neurology Neurosurgery & Psychiatry
Open access |
Apr 1973 |
248 |
| 23 |
Neuroinflammation: An Integrating Overview of Reactive‐Neuroimmune Cell Interactions in Health and Disease
Rodolfo Alberto Kölliker-Frers, Lucas Udovin, Matilde E. Otero Losada et al. · Mediators of Inflammation
Open access |
2021 |
246 |
| 24 |
Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test
Jorge Sepulcre, Sandra Vanotti, Roberto Lagos-Hernández et al. · Multiple Sclerosis Journal
|
Apr 2006 |
236 |
| 25 |
Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial
Jesús S. Mora et al. · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Open access |
7 Jul 2019 |
222 |
| 26 |
A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in adults with previously untreated epilepsy
Pierre Alfred Bill, Ulf Vigonius, Harald Pohlmann et al. · Epilepsy Research
|
Jun 1997 |
217 |
| 27 |
Ponatinib dose-ranging study in chronic-phase chronic myeloid leukemia: a randomized, open-label phase 2 clinical trial
Jörge E. Cortes et al. · Blood
Open access |
18 Aug 2021 |
203 |
| 28 |
Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial
Michael Aboud, Richard Kaplan, Johannes Jurgens Lombaard et al. · The Lancet Infectious Diseases
|
4 Feb 2019 |
201 |
| 29 |
Cellular Elements of the Blood-Brain Barrier
Jorge Daniel Correale, Andres Maria Villa · Neurochemical Research
|
24 Oct 2009 |
196 |
| 30 |
Stroke in South America
Gustavo Saposnik, Óscar H. Del Brutto · Stroke
Open access |
12 Aug 2003 |
192 |
| 31 |
A reappraisal of Gaucher disease—diagnosis and disease management algorithms
Pramod Kumar Mistry, Maria Domenica Cappellini, Elena Lukina et al. · American Journal of Hematology
Open access |
23 Sep 2010 |
192 |
| 32 |
Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study
Jean‐Paul Viard, Jean‐Claude Souberbielle, Ole Kirk et al. · AIDS
Open access |
26 Apr 2011 |
192 |
| 33 |
Sequence Analysis of In Vivo Defective Interfering-Like RNA of Influenza A H1N1 Pandemic Virus
Kazima Saira, Xudong Lin, Jay V. DePasse et al. · Journal of Virology
Open access |
15 May 2013 |
187 |
| 34 |
Biomarker‐driven phenotyping in Parkinson's disease: A translational missing link in disease‐modifying clinical trials
Alberto J. Espay, Michael A. Schwarzschild, Caroline M. Tanner et al. · Movement Disorders
Open access |
24 Feb 2017 |
186 |
| 35 |
Subtypes of ischemic stroke in children and young adults
Linda S. Williams, Bhuwan P. Garg, M M Cohen et al. · Neurology
|
Dec 1997 |
173 |
| 36 |
Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial
Srđan Verstovšek et al. · Haematologica
Open access |
21 Apr 2016 |
163 |
| 37 |
Motor-language coupling: Direct evidence from early Parkinson’s disease and intracranial cortical recordings
Agustín M. Ibáñez, Juan F. Cardona, Yamil Vidal et al. · Cortex
Open access |
8 Mar 2012 |
163 |
| 38 |
The Spectrum of Pathogenic Mutations in SPINK5 in 19 Families with Netherton Syndrome: Implications for Mutation Detection and First Case of Prenatal Diagnosis
Eli Sprecher, Shivan H. Amin, Karl Nielsen et al. · Journal of Investigative Dermatology
Open access |
Aug 2001 |
162 |
| 39 |
Improvement in hematological, visceral, and skeletal manifestations of Gaucher disease type 1 with oral eliglustat tartrate (Genz-112638) treatment: 2-year results of a phase 2 study
Elena Lukina, Nora Patricia Watman, Elsa Ávila Arreguin et al. · Blood
Open access |
17 Aug 2010 |
159 |
| 40 |
Chagasic myocardiopathy
Mauricio Bernardo Rosenbaum · Progress in Cardiovascular Diseases
|
Nov 1964 |
158 |
| 41 |
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
Caroline Ovadia et al. · The Lancet. Gastroenterology & hepatology
ReviewOpen access |
27 Apr 2021 |
156 |
| 42 |
A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1
Elena Lukina, Nora Patricia Watman, Elsa Ávila Arreguin et al. · Blood
Open access |
4 May 2010 |
156 |
| 43 |
Antifungal Susceptibility and Phylogeny of Opportunistic Members of the Order Mucorales
Roxana G. Vitale, Sybren de Hoog, Patrick Schwarz et al. · Journal of Clinical Microbiology
Open access |
10 Nov 2011 |
155 |
| 44 |
Recommendations of the Latin American Thyroid Society on diagnosis and management of differentiated thyroid cancer
Fabián Pitoia, Laura Sterian Ward, Nelson Wohllk et al. · Arquivos Brasileiros de Endocrinologia & Metabologia
Open access |
Oct 2009 |
154 |
| 45 |
Chronic Amiodarone Reduces Transmural Dispersion of Repolarization in the Canine Heart
Serge Sicouri, SANDRA MORO, Silvio Hector Litovsky et al. · Journal of Cardiovascular Electrophysiology
|
Nov 1997 |
151 |
| 46 |
Effect of chlorambucil on spermatogenesis in the human with malignant lymphoma
Pablo Richter, Juan C. Calamera, Marcos Carlos Morgenfeld et al. · Cancer
|
May 1970 |
150 |
| 47 |
Hemiblocks Revisited
Marcelo Victor Elizari, Rafael Salvador Acunzo, Marcela Ferreiro · Circulation
|
5 Mar 2007 |
148 |
| 48 |
Long-term efficacy and safety of ruxolitinib versus best available therapy in polycythaemia vera (RESPONSE): 5-year follow up of a phase 3 study
Jean‐Jacques Kiladjian et al. · The Lancet Haematology
Open access |
23 Jan 2020 |
147 |
| 49 |
Differences in MDS ‐ UPDRS Scores Based on Hoehn and Yahr Stage and Disease Duration
Matěj Škorvánek et al. · Movement Disorders Clinical Practice
Open access |
24 Jan 2017 |
147 |
| 50 |
The neuroprotective role of inflammation in nervous system Injuries
Jorge Daniel Correale, Andr�s Villa · Journal of Neurology
|
Nov 2004 |
147 |