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Genetic studies of body mass index yield new insights for obesity biology
The LifeLines Cohort Study et al. · Nature
Open access487 authors |
10 Feb 2015 |
4,954 |
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
European Alzheimer's Disease Initiative (EADI) et al. · Nature Genetics
ReviewOpen access184 authors |
27 Oct 2013 |
4,711 |
| 3 |
Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich et al. · Nature
Open access209 authors |
Aug 2010 |
3,706 |
| 4 |
Discovery and refinement of loci associated with lipid levels
Cristen J. Willer et al. · Nature Genetics
Open access259 authors |
6 Oct 2013 |
3,319 |
| 5 |
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle et al. · Nature Genetics
ReviewOpen access469 authors |
28 Feb 2019 |
3,277 |
| 6 |
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC et al. · Nature Genetics
Open access376 authors |
10 Oct 2010 |
2,999 |
| 7 |
C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease
John Danesh, Jeremy G. Wheeler, Gideon Morris Hirschfield et al. · New England Journal of Medicine
Open access |
31 Mar 2004 |
2,970 |
| 8 |
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay et al. · Nature Genetics
ReviewOpen access151 authors |
7 Sep 2015 |
2,733 |
| 9 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez et al. · Nature Genetics
Open access1,266 authors |
Apr 2022 |
2,608 |
| 10 |
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Struan F.A. Grant et al. · Nature Genetics
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15 Jan 2006 |
2,303 |
| 11 |
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis et al. · Nature Genetics
Open access263 authors |
17 Jan 2010 |
2,239 |
| 12 |
Defining the role of common variation in the genomic and biological architecture of adult human height
Andrew R. Wood et al. · Nature Genetics
446 authors |
5 Oct 2014 |
2,114 |
| 13 |
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Georg Ehret et al. · Nature
Open access346 authors |
9 Sep 2011 |
2,085 |
| 14 |
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen et al. · Nature
Open access293 authors |
29 Sep 2010 |
2,063 |
| 15 |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew Paul Morris et al. · Nature Genetics
Open access204 authors |
12 Aug 2012 |
2,021 |
| 16 |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics et al. · Nature Genetics
Open access167 authors |
6 Mar 2011 |
1,959 |
| 17 |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
The MAGIC investigators et al. · Nature Genetics
Open access159 authors |
27 Jun 2010 |
1,801 |
| 18 |
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang et al. · Cell
Open access |
Apr 2013 |
1,792 |
| 19 |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik et al. · Nature Genetics
Open access428 authors |
12 Mar 2018 |
1,753 |
| 20 |
New genetic loci link adipose and insulin biology to body fat distribution
Dmitry Shungin et al. · Nature
Open access410 authors |
10 Feb 2015 |
1,726 |
| 21 |
Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas et al. · Nature Genetics
Open access183 authors |
2 Dec 2012 |
1,681 |
| 22 |
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
the Million Veteran Program et al. · Nature Genetics
Open access281 authors |
17 Sep 2018 |
1,523 |
| 23 |
Genome-wide association study identifies 74 loci associated with educational attainment
Aysu Okbay et al. · Nature
Open access256 authors |
10 May 2016 |
1,500 |
| 24 |
Triglycerides and the Risk of Coronary Heart Disease
Nadeem Sarwar, John Danesh, Guðný Eiríksdóttir et al. · Circulation
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27 Dec 2006 |
1,428 |
| 25 |
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Valentina Escott‐Price et al. · PLoS ONE
Open access188 authors |
12 Jun 2014 |
1,408 |
| 26 |
Vitamin D deficiency in Europe: pandemic?
Kevin D. Cashman et al. · American Journal of Clinical Nutrition
Open access |
11 Feb 2016 |
1,401 |
| 27 |
Genome-wide association study of blood pressure and hypertension
Daniel Levy et al. · Nature Genetics
Open access |
10 May 2009 |
1,397 |
| 28 |
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
Jennifer E. Huffman et al. · PLoS ONE
Open access120 authors |
26 Mar 2015 |
1,233 |
| 29 |
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Karol Estrada et al. · Nature Genetics
Open access180 authors |
15 Apr 2012 |
1,223 |
| 30 |
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Mary Furlan Feitosa et al. · PLoS ONE
Open access273 authors |
18 Jun 2018 |
1,174 |
| 31 |
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
LifeLines Cohort Study et al. · Nature Genetics
Open access188 authors |
18 Apr 2016 |
1,144 |
| 32 |
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca C. Sims et al. · Nature Genetics
Open access450 authors |
17 Jul 2017 |
1,122 |
| 33 |
The power of genetic diversity in genome-wide association studies of lipids
Sarah E. Graham et al. · Nature
Open access527 authors |
9 Dec 2021 |
1,099 |
| 34 |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Valgerður Steinthórsdóttir et al. · Nature Genetics
Open access |
26 Apr 2007 |
1,090 |
| 35 |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Anubha Mahajan et al. · Nature Genetics
Open access332 authors |
9 Feb 2014 |
1,085 |
| 36 |
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
Elizabeth K. Speliotes et al. · PLoS Genetics
Open access |
10 Mar 2011 |
1,021 |
| 37 |
Genetic Associations with Valvular Calcification and Aortic Stenosis
George Thanassoulis et al. · New England Journal of Medicine
Open access |
6 Feb 2013 |
1,009 |
| 38 |
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
MAGIC et al. · Nature Genetics
301 authors |
10 Oct 2010 |
965 |
| 39 |
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Lifelines Cohort Study et al. · Nature Genetics
Open access329 authors |
31 May 2019 |
946 |
| 40 |
A saturated map of common genetic variants associated with human height
Loïc Yengo et al. · Nature
Open access632 authors |
12 Oct 2022 |
934 |
| 41 |
Common genetic variants influence human subcortical brain structures
The Alzheimer’s Disease Neuroimaging Initiative et al. · Nature
Open access291 authors |
20 Jan 2015 |
934 |
| 42 |
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
Anna Helgadóttir et al. · Nature Genetics
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8 Feb 2004 |
930 |
| 43 |
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Cornelius A. Rietveld et al. · Science
Open access204 authors |
31 May 2013 |
919 |
| 44 |
The trans-ancestral genomic architecture of glycemic traits
Jihua Chen et al. · Nature Genetics
Open access417 authors |
31 May 2021 |
918 |
| 45 |
Common variants associated with plasma triglycerides and risk for coronary artery disease
Ron Do et al. · Nature Genetics
Open access263 authors |
6 Oct 2013 |
912 |
| 46 |
The genetic architecture of the human cerebral cortex
Katrina L. Grasby et al. · Science
Open access362 authors |
19 Mar 2020 |
910 |
| 47 |
Simple Risk Model Predicts Incidence of Atrial Fibrillation in a Racially and Geographically Diverse Population: the CHARGE‐AF Consortium
Álvaro Alonso et al. · Journal of the American Heart Association
Open access |
12 Mar 2013 |
902 |
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Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility – Reykjavik Study
Gary F. Mitchell, Mark A. van Buchem, Sigurdur Oli Sigurdsson et al. · Brain
Open access |
Nov 2011 |
901 |
| 49 |
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Alisa K Manning et al. · Nature Genetics
Open access216 authors |
13 May 2012 |
894 |
| 50 |
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
LifeLines Cohort Study et al. · Nature Genetics
Open access226 authors |
21 Dec 2012 |
893 |