| 1 |
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menéndez, Ruth Lupu · Nature reviews. Cancer
Review |
20 Sep 2007 |
3,020 |
| 2 |
Screening for Undernutrition in Geriatric Practice: Developing the Short-Form Mini-Nutritional Assessment (MNA-SF)
Laurence Z. Rubenstein, Judith O. Harker, Antoni Salvà et al. · The Journals of Gerontology Series A
Open access |
Jun 2001 |
2,794 |
| 3 |
Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer
Rafael Rosell et al. · New England Journal of Medicine
Open access |
19 Aug 2009 |
2,388 |
| 4 |
Analysis of shared heritability in common disorders of the brain
Verneri Anttila et al. · Science
Open access577 authors |
21 Jun 2018 |
2,056 |
| 5 |
ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma
Nicole Concin et al. · International Journal of Gynecological Cancer
Open access |
23 Dec 2020 |
2,012 |
| 6 |
Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial
Surya S. A. Y. Biere, Mark I. van Berge Henegouwen, Kirsten W. Maas et al. · The Lancet
|
May 2012 |
1,736 |
| 7 |
Sleep Apnea
Shahrokh Javaheri, Shahrokh Javaheri, F Barbe et al. · Journal of the American College of Cardiology
Open access |
Feb 2017 |
1,418 |
| 8 |
COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study
Florian Götzinger et al. · The Lancet Child & Adolescent Health
Open access115 authors |
25 Jun 2020 |
1,307 |
| 9 |
Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC
Augusto Tommaso Caraceni et al. · The Lancet Oncology
|
31 Jan 2012 |
1,256 |
| 10 |
NF-kB in development and progression of human cancer
Xavier Dolcet, David Llobet‐Navàs, Judit Pallarés et al. · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
|
27 Apr 2005 |
1,196 |
| 11 |
Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study
Federico Soriguer et al. · Diabetologia
Open access |
10 Oct 2011 |
1,160 |
| 12 |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Sekar Kathiresan et al. · Nature Genetics
Open access123 authors |
8 Feb 2009 |
1,106 |
| 13 |
Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain
Joan D. Fernandez-Ballart, Josep Lluís Piñol, Itzíar Zazpe et al. · British Journal Of Nutrition
Open access |
27 Jan 2010 |
939 |
| 14 |
Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet
Jordi Salas‐Salvadó, Mònica Bulló, Nancy Babió et al. · Diabetes Care
Open access |
7 Oct 2010 |
909 |
| 15 |
Expression of p95HER2, a Truncated Form of the HER2 Receptor, and Response to Anti-HER2 Therapies in Breast Cancer
Maurizio Scaltriti, Federico Rojo, Alberto Ocaña et al. · JNCI Journal of the National Cancer Institute
Open access |
17 Apr 2007 |
894 |
| 16 |
COVID-19 and the 5G Conspiracy Theory: Social Network Analysis of Twitter Data
Wasim Ahmed, Josep Vidal‐Alaball, Joseph Downing et al. · Journal of Medical Internet Research
Open access |
25 Apr 2020 |
842 |
| 17 |
Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design
Karim S. Fizazi et al. · The Lancet
Open access |
Apr 2022 |
823 |
| 18 |
Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea
Ferrán Barbé, Joaquín Durán‐Cantolla, Manuel Sánchez‐de‐la‐Torre et al. · JAMA
Open access |
22 May 2012 |
807 |
| 19 |
Perfusion-CT Assessment of Infarct Core and Penumbra
Max Wintermark et al. · Stroke
|
2 Mar 2006 |
773 |
| 20 |
Soliciting the patient's agenda: have we improved?
M. Kim Marvel, Ronald M. Epstein, Kristine Flowers et al. · PubMed
|
20 Jan 1999 |
739 |
| 21 |
Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
Mercè Fernández-Balsells, Mohammad Hassan Murad, Melanie A. Lane et al. · The Journal of Clinical Endocrinology & Metabolism
ReviewOpen access |
Jun 2010 |
721 |
| 22 |
Cross-Talk Between Iron Metabolism and Diabetes
José Manuel Fernández‐Real, Abel López‐Bermejo, Wifredo Ricart · Diabetes
|
Aug 2002 |
707 |
| 23 |
β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial
Càndid Villanueva, Agustı́n Albillos, Joan Genescà et al. · The Lancet
|
22 Mar 2019 |
703 |
| 24 |
Physiology and role of irisin in glucose homeostasis
Nikolaos Perakakis, Georgios A. Triantafyllou, José Manuel Fernández‐Real et al. · Nature Reviews Endocrinology
ReviewOpen access |
17 Feb 2017 |
645 |
| 25 |
Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association
Albert Saiz, Yolanda Blanco, Lídia Sabater et al. · Brain
|
7 Aug 2008 |
624 |
| 26 |
Mobile Phone Apps to Promote Weight Loss and Increase Physical Activity: A Systematic Review and Meta-Analysis
Gemma Flores‐Mateo, Esther Granado‐Font, Carme Ferré‐Grau et al. · Journal of Medical Internet Research
ReviewOpen access |
10 Nov 2015 |
620 |
| 27 |
Relationship of Therapeutic Improvements and 28-Day Case Fatality in Patients Hospitalized With Acute Myocardial Infarction Between 1978 and 1993 in the REGICOR Study, Gerona, Spain
M. Gil, Jaume Marrugat, Joan Sala et al. · Circulation
|
6 Apr 1999 |
605 |
| 28 |
In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis
Jordi Pijuan, Carla Barceló, David F. Moreno et al. · Frontiers in Cell and Developmental Biology
Open access |
14 Jun 2019 |
580 |
| 29 |
Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study
Werner Hacke, Anthony J. Furlan, Yasir Al‐Rawi et al. · The Lancet Neurology
Open access |
26 Dec 2008 |
574 |
| 30 |
Minimally Invasive Versus Open Esophageal Resection
Jennifer Straatman, Nicole van der Wielen, Miguel Angel Cuesta et al. · Annals of Surgery
Open access |
10 Feb 2017 |
571 |
| 31 |
Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial
Manuel Sánchez‐de‐la‐Torre et al. · The Lancet Respiratory Medicine
Open access |
12 Dec 2019 |
541 |
| 32 |
Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial
Estefanía Toledo et al. · JAMA Internal Medicine
Open access |
14 Sep 2015 |
525 |
| 33 |
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis
Sebastián Morán et al. · The Lancet Oncology
|
2 Sep 2016 |
521 |
| 34 |
Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008
José López‐Miranda et al. · Nutrition Metabolism and Cardiovascular Diseases
|
23 Mar 2010 |
520 |
| 35 |
Vitamin D receptor polymorphisms and diseases
José Manuel Valdivielso, Elvira Fernández · Clinica Chimica Acta
|
8 Mar 2006 |
519 |
| 36 |
Blood Pressure Decrease During the Acute Phase of Ischemic Stroke Is Associated With Brain Injury and Poor Stroke Outcome
José Castillo, Rogelio Leira, Maria García-Gil et al. · Stroke
|
20 Jan 2004 |
508 |
| 37 |
Dyslipidemia and inflammation: an evolutionary conserved mechanism
Eduardo Esteve, Wifredo Ricart, José Manuel Fernández‐Real · Clinical Nutrition
|
29 Jan 2005 |
508 |
| 38 |
ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer
Rowan E. Miller, Alexandra F. Leary, Clare L. Scott et al. · Annals of Oncology
Open access |
28 Sep 2020 |
503 |
| 39 |
Effect of Malnutrition After Acute Stroke on Clinical Outcome
Antoni Dávalos, Wifred Ricart, Ferrán Gónzalez‐Huix et al. · Stroke
|
Jun 1996 |
500 |
| 40 |
Obstructive sleep apnoea and cardiovascular disease
Manuel Sánchez‐de‐la‐Torre, Francisco Campos‐Rodríguez, Ferrán Barbé · The Lancet Respiratory Medicine
|
6 Nov 2012 |
490 |
| 41 |
Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study
Laura Rosiñol et al. · Blood
Open access |
14 Jul 2012 |
488 |
| 42 |
The changing epidemiology of hepatitis C virus infection in Europe
Juan Ignacio Esteban, Sílvia Sauleda, Josep Quer · Journal of Hepatology
|
27 Nov 2007 |
484 |
| 43 |
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
Neibla Priego et al. · Nature Medicine
Open access |
8 Jun 2018 |
470 |
| 44 |
Chronic hepatitis B reactivation following infliximab therapy in Crohn’s disease patients: need for primary prophylaxis
María Esteve, C Saro, F González-Huix et al. · Gut
Open access |
11 Aug 2004 |
467 |
| 45 |
Bortezomib, melphalan, and prednisone versus bortezomib, thalidomide, and prednisone as induction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple myeloma: a randomised trial
María‐Victoria Mateos et al. · The Lancet Oncology
Open access |
24 Aug 2010 |
463 |
| 46 |
Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain
Jordi Rello et al. · Critical Care
Open access |
11 Sep 2009 |
451 |
| 47 |
Estimación del riesgo coronario en España mediante la ecuación de Framingham calibrada
Jaume Marrugat, Pascual Solanas, Ralph B. D’Agostino et al. · Revista Española de Cardiología
|
2003 |
448 |
| 48 |
Validity of composite end points in clinical trials
Víctor M. Montori, Gaietà Permanyer-Miralda, Ignacio Ferreira‐González et al. · BMJ
Open access |
10 Mar 2005 |
442 |
| 49 |
Present Status of Brugada Syndrome
Josép Brugada, Óscar Campuzano, Elena Arbelo et al. · Journal of the American College of Cardiology
Open access |
Aug 2018 |
441 |
| 50 |
Sublingual immunotherapy for hazelnut food allergy: A randomized, double-blind, placebo-controlled study with a standardized hazelnut extract
Ernesto Enrique, Fernando Pineda, Tamim Malek et al. · Journal of Allergy and Clinical Immunology
Open access |
4 Oct 2005 |
433 |