| 1 |
Fiji: an open-source platform for biological-image analysis
Johannes Schindelin, Ignacio Arganda‐Carreras, Erwin Frise et al. · Nature Methods
Open access |
28 Jun 2012 |
73,171 |
| 2 |
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Clotilde Théry et al. · Journal of Extracellular Vesicles
Open access382 authors |
23 Nov 2018 |
11,535 |
| 3 |
In silico prediction of protein-protein interactions in human macrophages
Oussema Souiai, Fatma Zahra Guerfali, Slimane Ben Miled et al. · BMC Research Notes
Open access |
2014 |
10,946 |
| 4 |
The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
Colin Hill, Francisco Guarner, Gregor Reid et al. · Nature Reviews Gastroenterology & Hepatology
ReviewOpen access |
10 Jun 2014 |
9,518 |
| 5 |
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Alexandra C. Walls, Young‐Jun Park, M. Alejandra Tortorici et al. · Cell
Open access |
9 Mar 2020 |
9,155 |
| 6 |
On the nature of allosteric transitions: A plausible model
Jacques Monod, Jeffries Wyman, Jean‐Pierre Changeux · Journal of Molecular Biology
|
May 1965 |
8,938 |
| 7 |
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Stewart Thomas Cole et al. · Nature
Open access |
Jun 1998 |
7,928 |
| 8 |
Generic Assignments, Strain Histories and Properties of Pure Cultures of Cyanobacteria
Rosmarie Rippka, Roger Y. Stanier, Josette Deruelles et al. · Microbiology
|
Mar 1979 |
7,814 |
| 9 |
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
Leandra Abarca-Gómez et al. · The Lancet
Open access1,040 authors |
13 Oct 2017 |
7,739 |
| 10 |
Report of the Ad Hoc Committee on Reconciliation of Approaches to Bacterial Systematics
L G Wayne, William E. Moore, Erko Stackebrandt et al. · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
|
Oct 1987 |
7,348 |
| 11 |
Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)
Françoise Barré‐Sinoussi, Jean‐Claude Chermann, FA Rey et al. · Science
|
20 May 1983 |
6,979 |
| 12 |
Genetic regulatory mechanisms in the synthesis of proteins
François Jacob, Jacques Monod · Journal of Molecular Biology
|
Jun 1961 |
6,659 |
| 13 |
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al. · Autophagy
Open access2,467 authors |
2 Jan 2016 |
6,023 |
| 14 |
Natural products in drug discovery: advances and opportunities
Atanas G. Atanasov et al. · Nature Reviews Drug Discovery
ReviewOpen access |
28 Jan 2021 |
5,395 |
| 15 |
Genetic studies of body mass index yield new insights for obesity biology
The LifeLines Cohort Study et al. · Nature
Open access487 authors |
10 Feb 2015 |
4,954 |
| 16 |
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi et al. · Nature Medicine
|
Aug 2001 |
4,950 |
| 17 |
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
David Ezra Gordon et al. · Nature
Open access125 authors |
30 Apr 2020 |
4,901 |
| 18 |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
European Alzheimer's Disease Initiative (EADI) et al. · Nature Genetics
ReviewOpen access184 authors |
27 Oct 2013 |
4,711 |
| 19 |
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol, Bénédicte Pigneur, Laurie Watterlot et al. · Proceedings of the National Academy of Sciences
Open access |
20 Oct 2008 |
4,444 |
| 20 |
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Rosa Chiara Paolicelli, Giulia Bolasco, Francesca Pagani et al. · Science
|
21 Jul 2011 |
4,383 |
| 21 |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Joshua A Welsh et al. · Journal of Extracellular Vesicles
Open access |
Feb 2024 |
4,377 |
| 22 |
Life with 6000 Genes
A. Goffeau, B. G. Barrell, Howard Bussey et al. · Science
|
25 Oct 1996 |
4,332 |
| 23 |
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Toshimasa Yamauchi, Junji Kamon, Yasuhiko Minokoshi et al. · Nature Medicine
|
7 Oct 2002 |
4,251 |
| 24 |
Molecular characterization of mitochondrial apoptosis-inducing factor
Santos A. Susín, Hans Kristian Lorenzo, Naoufal Zamzami et al. · Nature
|
Feb 1999 |
4,082 |
| 25 |
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
Bin Zhou et al. · The Lancet
Open access1,145 authors |
24 Aug 2021 |
3,934 |
| 26 |
TrackMate: An open and extensible platform for single-particle tracking
Jean-Yves Tinévez, Nick Perry, Johannes Schindelin et al. · Methods
Open access |
7 Oct 2016 |
3,890 |
| 27 |
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines
Michael J. Hallek, Bruce D. Cheson, Daniel Catovsky et al. · Blood
Open access |
23 Jan 2008 |
3,806 |
| 28 |
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo, Piyush B. Gupta, Dennis C. Sgroi et al. · Cell
Open access |
May 2005 |
3,791 |
| 29 |
The complete genome sequence of the Gram-positive bacterium Bacillus subtilis
Frank Kunst et al. · Nature
Open access151 authors |
Nov 1997 |
3,720 |
| 30 |
LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1
S. Hacein-Bey-Abina et al. · Science
|
16 Oct 2003 |
3,582 |
| 31 |
Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
John C. LaRosa, Scott M. Grundy, David D. Waters et al. · New England Journal of Medicine
Open access |
9 Mar 2005 |
3,517 |
| 32 |
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp et al. · New England Journal of Medicine
Open access |
29 Jul 2009 |
3,505 |
| 33 |
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Marie Vétizou et al. · Science
Open access |
5 Nov 2015 |
3,498 |
| 34 |
Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis
Raoul Herbrecht et al. · New England Journal of Medicine
Open access |
8 Aug 2002 |
3,326 |
| 35 |
Cellular Senescence: Defining a Path Forward
Vassilis G. Gorgoulis et al. · Cell
Open access |
Oct 2019 |
3,322 |
| 36 |
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle et al. · Nature Genetics
ReviewOpen access469 authors |
28 Feb 2019 |
3,277 |
| 37 |
Zika Virus Outbreak on Yap Island, Federated States of Micronesia
Mark R. Duffy, Tai-Ho Chen, W. Thane Hancock et al. · New England Journal of Medicine
Open access |
10 Jun 2009 |
3,232 |
| 38 |
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Jérôme Hadjadj et al. · Science
Open access |
13 Jul 2020 |
3,200 |
| 39 |
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi et al. · Nature
|
11 Jun 2003 |
3,196 |
| 40 |
Long non-coding RNAs: new players in cell differentiation and development
Alessandro Fatica, Irene Bozzoni · Nature Reviews Genetics
Review |
3 Dec 2013 |
3,183 |
| 41 |
The effect of human mobility and control measures on the COVID-19 epidemic in China
Moritz U. G. Kraemer, Chia-Hung Yang, Bernardo Gutiérrez et al. · Science
Open access |
25 Mar 2020 |
3,137 |
| 42 |
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek et al. · Nature
|
Feb 2007 |
3,022 |
| 43 |
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC et al. · Nature Genetics
Open access376 authors |
10 Oct 2010 |
2,999 |
| 44 |
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Colin N A Palmer et al. · Nature Genetics
|
19 Mar 2006 |
2,989 |
| 45 |
Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium
J. Peter Donnelly et al. · Clinical Infectious Diseases
Open access |
8 Oct 2019 |
2,973 |
| 46 |
Animals in a bacterial world, a new imperative for the life sciences
Margaret McFall‐Ngai et al. · Proceedings of the National Academy of Sciences
Open access |
7 Feb 2013 |
2,965 |
| 47 |
Bacillus thuringiensis and Its Pesticidal Crystal Proteins
E. Schnepf, Neil Crickmore, Jeroen Van Rie et al. · Microbiology and Molecular Biology Reviews
ReviewOpen access |
Sep 1998 |
2,947 |
| 48 |
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Paul Bastard et al. · Science
Open access752 authors |
24 Sep 2020 |
2,885 |
| 49 |
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Daniel J. Klionsky et al. · Autophagy
Open access2,930 authors |
2 Jan 2021 |
2,743 |
| 50 |
Evolution and Tinkering
François Jacob · Science
|
10 Jun 1977 |
2,741 |