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Most cited papers from Instituto Alexander Fleming

What are the most cited papers from Instituto Alexander Fleming?

The most cited paper from Instituto Alexander Fleming is "Erlotinib in Previously Treated Non–Small-Cell Lung Cancer" (Frances Alice Shepherd, José Rodrigues Pereira, Tudor–Eliade Ciuleanu et al., 2005), with 5,471 citations. Next come "First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial" (1,396) and "Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up" (671).

Showing 50 of 60 papers. Every paper with more than 58 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Erlotinib in Previously Treated Non–Small-Cell Lung Cancer Frances Alice Shepherd, José Rodrigues Pereira, Tudor–Eliade Ciuleanu et al. · New England Journal of Medicine Open access 13 Jul 2005 5,471
2 First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial Luis G Paz-Ares et al. · The Lancet Oncology 18 Jan 2021 1,396
3 Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up Ana Oaknin, Tjalling Bosse, Carien L. Creutzberg et al. · Annals of Oncology Open access 8 Jun 2022 671
4 ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological, Nuclear Medicine and Hybrid Imaging Anders Sundin, Rudolf Arnold, Éric Baudin et al. · Neuroendocrinology Open access 2017 506
5 ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum Bruno Niederle, Ulrich Frank Pape, Frederico Perego Costa et al. · Neuroendocrinology Open access 2016 478
6 Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019 Silke Gillessen et al. · European Urology Open access 27 Jan 2020 400
7 ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas) Ulrich‐Frank Pape, Bruno Niederle, Frederico Perego Costa et al. · Neuroendocrinology Open access 2016 299
8 Gastrinoma (Duodenal and Pancreatic) Robert T. Jensen, Bruno Niederle, Emmanuel Mitry et al. · Neuroendocrinology Open access 2006 287
9 ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers Dermot O’Toole, Ashley Grossman, David Gross et al. · Neuroendocrinology Open access 2009 267
10 Triple-negative breast cancer Reinaldo Daniel Chacon, María Victoria Costanzo · Breast Cancer Research Open access Oct 2010 241
11 Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer Patrick M. Forde et al. · New England Journal of Medicine 2 Jun 2025 232
12 Lung cancer in never smokers: The role of different risk factors other than tobacco smoking Luis Corrales, Rafael Rosell, Andrés Felipe Cardona et al. · Critical Reviews in Oncology/Hematology 31 Jan 2020 225
13 Systemic Therapy for Melanoma: ASCO Guideline Update Rahul Seth et al. · Journal of Clinical Oncology Open access 14 Aug 2023 224
14 Natural Killer Cells in Human Cancer: From Biological Functions to Clinical Applications Estrella Mariel Levy, María Paula Roberti, José Mordoh · BioMed Research International Open access 2011 216
15 Atezolizumab plus cabozantinib versus cabozantinib monotherapy for patients with renal cell carcinoma after progression with previous immune checkpoint inhibitor treatment (CONTACT-03): a multicentre, randomised, open-label, phase 3 trial Sumanta Kumar Pal et al. · The Lancet Open access 5 Jun 2023 211
16 Updated Frequency of EGFR and KRAS Mutations in NonSmall-Cell Lung Cancer in Latin America: The Latin-American Consortium for the Investigation of Lung Cancer (CLICaP) Oscar G. Arrieta, Andrés Felipe Cardona, Claudio Marcelo Martin et al. · Journal of Thoracic Oncology Open access 28 Jan 2015 197
17 First-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone (four cycles) in advanced non-small-cell lung cancer: CheckMate 9LA 2-year update Martin Reck et al. · ESMO Open Open access Oct 2021 192
18 Interactions Within Stroke Systems of Care Randall T. Higashida, Mark J. Alberts, David N. Alexander et al. · Stroke Open access 30 Aug 2013 189
19 The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022 Michel Pierre Ducreux et al. · ESMO Open Open access 31 May 2023 169
20 Management of patients with advanced prostate cancer—metastatic and/or castration-resistant prostate cancer: Report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022 Silke Gillessen et al. · European Journal of Cancer Open access118 authors 2 Mar 2023 166
21 ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Systemic Therapy - Biotherapy and Novel Targeted Agents Marianne Ellen Pavel, Juan W. Valle, Barbro K. Eriksson et al. · Neuroendocrinology Open access 2017 160
22 Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network George D. Demetri et al. · Annals of Oncology Open access 3 Sep 2020 148
23 Pembrolizumab Plus Olaparib for Patients With Previously Treated and Biomarker-Unselected Metastatic Castration-Resistant Prostate Cancer: The Randomized, Open-Label, Phase III KEYLYNK-010 Trial Emmanuel S. Antonarakis et al. · Journal of Clinical Oncology Open access 8 Jun 2023 145
24 Management of relapsed ovarian cancer: a review Gonzalo H. Giornelli · SpringerPlus Open access 27 Jul 2016 144
25 Altered phenotype in peripheral blood and tumor-associated NK cells from colorectal cancer patients Yamila Rocca, María P. Roberti, Juan Martín Arriaga et al. · Innate Immunity Open access 10 Jul 2012 137
26 Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC) Silke Gillessen et al. · European Urology Open access121 authors 11 Oct 2024 133
27 Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021 Silke Gillessen et al. · European Urology Open access 18 Apr 2022 131
28 Avelumab, an IgG1 anti-PD-L1 Immune Checkpoint Inhibitor, Triggers NK Cell-Mediated Cytotoxicity and Cytokine Production Against Triple Negative Breast Cancer Cells Estefanía Paula Juliá, Analía Amante, María Betina Pampena et al. · Frontiers in Immunology Open access 20 Sep 2018 129
29 ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Systemic Therapy - Chemotherapy Rocio García‐Carbonero, Anja Rinke, Juan W. Valle et al. · Neuroendocrinology Open access 2017 125
30 Management of Patients with Advanced Prostate Cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022 Silke Gillessen et al. · European Urology Open access118 authors 6 Dec 2022 123
31 Human leukocyte antigen-E protein is overexpressed in primary human colorectal cancer Estrella Mariel Levy, Michele Bianchini, Erika von Euw et al. · International Journal of Oncology Open access Mar 2008 118
32 A Diagnostic Biopsy-Adapted Immunoscore Predicts Response to Neoadjuvant Treatment and Selects Patients with Rectal Cancer Eligible for a Watch-and-Wait Strategy Carine El Sissy et al. · Clinical Cancer Research 15 Jul 2020 115
33 Intensive care in patients with lung cancer: a multinational study Márcio Soares et al. · Annals of Oncology Open access 21 Jun 2014 115
34 Tecemotide in unresectable stage III non-small-cell lung cancer in the phase III START study: updated overall survival and biomarker analyses Paul Mitchell, N. M. Thatcher, Mark A. Socinski et al. · Annals of Oncology Open access 27 Feb 2015 109
35 Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease: a secondary analysis from MARIPOSA Enriqueta Felip et al. · Annals of Oncology Open access 26 Jun 2024 101
36 Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15 Yamila Rocca, María Paula Roberti, Estefanía Paula Juliá et al. · Frontiers in Immunology Open access 10 Oct 2016 98
37 Bintrafusp Alfa Versus Pembrolizumab in Patients With Treatment-Naive, Programmed Death-Ligand 1–High Advanced NSCLC: A Randomized, Open-Label, Phase 3 Trial Byoung Chul Cho et al. · Journal of Thoracic Oncology Open access 18 Aug 2023 93
38 Third- or Later-line Therapy for Metastatic Colorectal Cancer: Reviewing Best Practice Tanios Bekaii‐Saab, Richard D. Kim, Tae Won Kim et al. · Clinical Colorectal Cancer Open access 15 Nov 2018 89
39 Clinical Performance Measures for Adults Hospitalized With Acute Ischemic Stroke Eric Edward Smith, Jeffrey L. Saver, David N. Alexander et al. · Stroke 26 Sep 2014 88
40 Chagas disease in bone marrow transplantation: an approach to preemptive therapy Javier Altclas, Angel J. Sinagra, Miguel Dictar et al. · Bone Marrow Transplantation 23 May 2005 88
41 Clinical Performance Measures for Adults Hospitalized With Intracerebral Hemorrhage: Performance Measures for Healthcare Professionals From the American Heart Association/American Stroke Association J. Claude Hemphill, Opeolu M. Adeoye, David N. Alexander et al. · Stroke Open access 21 May 2018 84
42 SELNET clinical practice guidelines for soft tissue sarcoma and GIST Jean‐Yves Blay et al. · Cancer Treatment Reviews Open access 14 Nov 2021 81
43 Safety and effectiveness of regorafenib in patients with metastatic colorectal cancer in routine clinical practice in the prospective, observational CORRELATE study Michel Pierre Ducreux, Lone Nørgård Pétersen, Leopold Öhler et al. · European Journal of Cancer Open access 4 Nov 2019 78
44 NEPTUNE: Phase 3 Study of First-Line Durvalumab Plus Tremelimumab in Patients With Metastatic NSCLC Gilberto de Castro et al. · Journal of Thoracic Oncology Open access 12 Oct 2022 77
45 Targeting ADCC: A different approach to HER2 breast cancer in the immunotherapy era Pablo Mandó, Sergio Gabriel Rivero, Manglio Rizzo et al. · The Breast Open access 19 Aug 2021 77
46 Galectin-3 Expression Correlates with Apoptosis of Tumor-Associated Lymphocytes in Human Melanoma Biopsies Mariana Rodríguez Zubieta, David Furman, Marcela Barrio et al. · American Journal Of Pathology Open access May 2006 76
47 Immunohistochemical expression of somatostatin receptors in digestive endocrine tumours Víctor Zamora, Ana Maria Cabanne, Rubén Salanova et al. · Digestive and Liver Disease 13 Oct 2009 73
48 Radiochemotherapy with short daily infusion of low-dose oxaliplatin, leucovorin, and 5-FU in T3–T4 unresectable rectal cancer: a phase II IATTGI study Silvia Carraro, Enrique Luis Roca, Cristina Cartelli et al. · International Journal of Radiation Oncology*Biology*Physics Oct 2002 71
49 Poorly-Differentiated Endocrine Carcinomas of Midgut and Hindgut Origin Håkan Ahlman, Ola Nilsson, Anne M. McNicol et al. · Neuroendocrinology Open access 16 Oct 2007 71
50 In vivo localizations of membrane stress controllers PspA and PspG in Escherichia coli Christoph Engl, Goran Jovanović, Louise J. Lloyd et al. · Molecular Microbiology Open access 23 Jun 2009 70

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.