Institution · Ionis Pharmaceuticals (United States)

Most cited papers from Ionis Pharmaceuticals (United States)

Ionis Pharmaceuticals (United States)

What are the most cited papers from Ionis Pharmaceuticals (United States)?

The most cited paper from Ionis Pharmaceuticals (United States) is "Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy" (Richard S. Finkel et al., 2017), with 2,357 citations. Next come "The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation" (2,272) and "PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules" (2,092).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 551 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy Richard S. Finkel et al. · New England Journal of Medicine Open access	Nov 2017	2,357
2	The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation Vidisha Tripathi, Jonathan D. Ellis, Zhen Shen et al. · Molecular Cell Open access	27 Aug 2010	2,272
3	PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules Michael Egholm, Ole Buchardt, Leif Christensen et al. · Nature	Oct 1993	2,092
4	miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Christine Esau, Scott P. Davis, Susan Murray et al. · Cell Metabolism Open access	Feb 2006	2,088
5	PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients Yoichi Nagata, Keng‐Hsueh Lan, Xiaoyan Zhou et al. · Cancer Cell Open access	Aug 2004	1,878
6	ElliPro: a new structure-based tool for the prediction of antibody epitopes Julia V. Ponomarenko, Huynh‐Hoa Bui, Wei Li et al. · BMC Bioinformatics Open access	Dec 2008	1,787
7	Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP) Eric L. Van Nostrand, Gabriel A. Pratt, Alexander A. Shishkin et al. · Nature Methods Open access	28 Mar 2016	1,619
8	The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells Tony Gutschner, Monika Hämmerle, Moritz F. Eissmann et al. · Cancer Research Open access	15 Dec 2012	1,597
9	Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy Eugenio Maria Mercuri et al. · New England Journal of Medicine Open access	14 Feb 2018	1,466
10	Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43 Magdalini Polymenidou, Clotilde Lagier‐Tourenne, Kasey R. Hutt et al. · Nature Neuroscience Open access	27 Feb 2011	1,398
11	RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform C. Frank Bennett, Eric E. Swayze · The Annual Review of Pharmacology and Toxicology Review	8 Jan 2010	1,384
12	Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi et al. · Nature Open access	21 May 2014	1,311
13	Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis Guilian Niu, Kenneth L. Wright, Mei Huang et al. · Oncogene	21 Mar 2002	1,218
14	Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation Brian J. Bennett, Thomas Q. de Aguiar Vallim, Zeneng Wang et al. · Cell Metabolism Open access	2013	1,084
15	Lipoprotein(a) Reduction in Persons with Cardiovascular Disease Sotirios Tsimikas, Ewa Karwatowska‐Prokopczuk, Ioanna Gouni‐Berthold et al. · New England Journal of Medicine Open access	2020	1,075
16	Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study Richard S. Finkel, Claudia A. Chiriboga, Jiri Vajsar et al. · The Lancet	Dec 2016	1,043
17	MicroRNA-143 Regulates Adipocyte Differentiation Christine Esau, Xiaolin Kang, Eigen R. Peralta et al. · Journal of Biological Chemistry Open access	26 Oct 2004	1,029
18	Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis Kanji Yamaguchi, Liu Yang, Shannon Jones McCall et al. · Hepatology Open access	3 May 2007	1,022
19	CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation Frederick J. Sheedy, Alena Grebe, Katey J. Rayner et al. · Nature Immunology Open access	30 Jun 2013	935
20	Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial Frederick Johan Raal, Raul Dias Santos, Dirk Jacobus Blom et al. · The Lancet	Mar 2010	921
21	RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention Christopher J. Donnelly, Ping‐Wu Zhang, Jacqueline T. Pham et al. · Neuron Open access	Oct 2013	895
22	Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides Richard S. Geary, Daniel A. Norris, Rosie Z. Yu et al. · Advanced Drug Delivery Reviews ReviewOpen access	7 Feb 2015	863
23	RNA-Targeted Therapeutics Stanley T. Crooke, Joseph Lee Witztum, C. Frank Bennett et al. · Cell Metabolism Open access	Apr 2018	834
24	Management of Acute Myocarditis and Chronic Inflammatory Cardiomyopathy Enrico Ammirati, Maria Frigerio, ERIC D. ADLER et al. · Circulation Heart Failure Open access	Nov 2020	809
25	Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB Vidisha Tripathi, Zhen Shen, Arindam Chakraborty et al. · PLoS Genetics Open access	21 Mar 2013	789
26	Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis Holly B. Kordasiewicz, Lisa M. Stanek, Edward V. Wancewicz et al. · Neuron Open access	Jun 2012	787
27	Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression Brett P. Monia, Elena A. Lesnik, C. Gonzalez et al. · Journal of Biological Chemistry Open access	Jul 1993	780
28	Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs Clotilde Lagier‐Tourenne et al. · Nature Neuroscience Open access	30 Sep 2012	764
29	Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model Yimin Hua, Kentaro Sahashi, Frank Rigo et al. · Nature Open access	Oct 2011	760
30	Antisense technology: an overview and prospectus Stanley T. Crooke, Brenda F. Baker, Rosanne M. Crooke et al. · Nature Reviews Drug Discovery Review	24 Mar 2021	759
31	Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials Nicholas J. Viney, Julian C. van Capelleveen, Richard S. Geary et al. · The Lancet	21 Sep 2016	759
32	3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA Jeremy E. Wilusz, Susan M. Freier, David L. Spector · Cell Open access	Nov 2008	737
33	Regulating Gene Expression through RNA Nuclear Retention Kannanganattu V. Prasanth, Supriya G. Prasanth, Zhenyu Xuan et al. · Cell Open access	Oct 2005	717
34	Patterns of Variant Polyadenylation Signal Usage in Human Genes Emmanuel Beaudoing, Susan M. Freier, Jacqueline R. Wyatt et al. · Genome Research Open access	Jul 2000	705
35	Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion Dhruv Sareen, Jacqueline G. O’Rourke, Pratap Meera et al. · Science Translational Medicine Open access	23 Oct 2013	697
36	The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes Sandra Freier · Nucleic Acids Research Open access	15 Nov 1997	692
37	Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration Ze’ev Melamed, Jone López‐Erauskin, Michael W. Baughn et al. · Nature Neuroscience Open access	8 Jan 2019	689
38	Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome Joseph Lee Witztum, Daniel Gaudet, Steven D. Freedman et al. · New England Journal of Medicine Open access	7 Aug 2019	687
39	Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model Yimin Hua, Kentaro Sahashi, Gene Hung et al. · Genes & Development Open access	12 Jul 2010	677
40	Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression Pearlie K. Epling‐Burnette, Jin Hong Liu, Robyn Catlett-Falcone et al. · Journal of Clinical Investigation Open access	Feb 2001	647
41	Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis Harry Roger Buller, Claudette Bethune, Sanjay Bhanot et al. · New England Journal of Medicine Open access	7 Dec 2014	632
42	Results from a phase 1 study of nusinersen (ISIS-SMN Rx ) in children with spinal muscular atrophy Claudia A. Chiriboga, Kathryn J. Swoboda, Basil T. Darras et al. · Neurology Open access	11 Feb 2016	618
43	An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study Timothy M. Miller, Alan Pestronk, William David et al. · The Lancet Neurology Open access	28 Mar 2013	618
44	Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice Thazha P. Prakash, Mark J. Graham, Jinghua Yu et al. · Nucleic Acids Research Open access	3 Jul 2014	618
45	Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. C. Frank Bennett, M Y Chiang, Huai En Huang Chan et al. · Molecular Pharmacology	Jun 1992	618
46	The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult Bin Zhang, Gayatri Arun, Yuntao S. Mao et al. · Cell Reports Open access	28 Jun 2012	615
47	Pleiotropic cell-division defects and apoptosis induced by interference with survivin function Fengzhi Li, Elizabeth J. Ackermann, C. Frank Bennett et al. · Nature Cell Biology	27 Oct 1999	605
48	Therapeutic Antisense Oligonucleotides Are Coming of Age C. Frank Bennett · Annual Review of Medicine ReviewOpen access	27 Jan 2019	603
49	Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice Lindsay A. Becker, Brenda Huang, Gregor Bieri et al. · Nature Open access	11 Apr 2017	598
50	Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides Mark J. Graham, Richard G. Lee, Teresa A. Brandt et al. · New England Journal of Medicine Open access	24 May 2017	587

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.