Science Explorer Back to mapMap
Discussion
Company · Carlsbad · United States

Ionis Pharmaceuticals (United States)

In research, Ionis Pharmaceuticals (United States) stands highest in Life Sciences (#2,040 of 6,403 worldwide) and Biochemistry, Genetics and Molecular Biology (#1,253 of 2,964 worldwide), 2022-now. Relative to its size it is most specialised in Molecular Biology (Molecular Biology is 9.9× its share of world research).

ionispharma.comROR OpenAlex
World rank, 2022-now
#12,695
of 22,385 · #3,647 all time
Rank in United States
#1,787
of 3,332
Research works
1.7k
▼ 30% vs 2018-21
Citations
99k
59.8 per fractional work
Top-10% rate
16.3%
all institutions 10.0%
vs its own fields
1.05×
1.00× is exactly expected
Open access
35%
world 40%
International
16%
world 18%
Ionis Pharmaceuticals (United States)

What is Ionis Pharmaceuticals (United States) known for in research?

The fields where it stands highest, 2022-now, ranked among every institution above the floor in each field.

FieldWorld rankWhere that sitsTop-10% rateWorksAll time
Life SciencesDomain #2,040 of 6,403 15.7%79 #1194
Biochemistry, Genetics and Molecular BiologyField #1,253 of 2,964 16.9%61 #910

Each strip is that field's whole ranked pool, with the notch where Ionis Pharmaceuticals (United States) sits in it, in the colour of the band that rank falls in. The track under the rate is the rate itself: it carries no average mark, because the average differs by field (from about 6% in Dentistry to 21% in Economics).

Which fields of science does Ionis Pharmaceuticals (United States) work in?

In 2022-now, 54% of research at Ionis Pharmaceuticals (United States) is in Life Sciences, 40% in Health Sciences. Its largest fields are Biochemistry, Genetics and Molecular Biology (41%), Medicine (39%), Immunology and Microbiology (7%). It does 3.7× the world's share of Life Sciences.

Life Sciences: 91 fractional works · 53.8% of its workBiochemistry, Genetics and Molecular Biology: 70 fractional works · 41.1% of its workMolecular Biology: 51 fractional works · 29.8% of its workGenetics: 6 fractional works · 3.8% of its workCancer Research: 5 fractional works · 2.9% of its workCell Biology: 4 fractional works · 2.3% of its workClinical Biochemistry: 2 fractional works · 0.9% of its workBiochemistry: 1 fractional works · 0.7% of its workBiophysics: 0 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.3% of its workImmunology and Microbiology: 12 fractional works · 6.9% of its workImmunology: 11 fractional works · 6.5% of its workMicrobiology: 1 fractional works · 0.3% of its workNeuroscience: 8 fractional works · 4.8% of its workCellular and Molecular Neuroscience: 6 fractional works · 3.3% of its workNeurology: 1 fractional works · 0.4% of its workBiological Psychiatry: 1 fractional works · 0.4% of its workDevelopmental Neuroscience: 0 fractional works · 0.3% of its workSmaller subfields together: 1 fractional works · 0.5% of its workAgricultural and Biological Sciences: 2 fractional works · 0.9% of its workPlant Science: 1 fractional works · 0.6% of its workSmaller subfields together: 1 fractional works · 0.4% of its workPharmacology, Toxicology and Pharmaceutics: 0 fractional works · 0.1% of its workHealth Sciences: 68 fractional works · 40.2% of its workMedicine: 66 fractional works · 39.1% of its workCardiology and Cardiovascular Medicine: 10 fractional works · 5.7% of its workGenetics: 10 fractional works · 5.6% of its workHematology: 7 fractional works · 3.9% of its workPhysiology: 6 fractional works · 3.5% of its workEpidemiology: 5 fractional works · 3.0% of its workSurgery: 4 fractional works · 2.3% of its workNeurology: 3 fractional works · 1.8% of its workEndocrinology, Diabetes and Metabolism: 3 fractional works · 1.7% of its workOncology: 3 fractional works · 1.6% of its workPulmonary and Respiratory Medicine: 3 fractional works · 1.5% of its workPsychiatry and Mental health: 2 fractional works · 1.1% of its workPathology and Forensic Medicine: 2 fractional works · 1.0% of its workNephrology: 1 fractional works · 0.8% of its workHepatology: 1 fractional works · 0.8% of its workPublic Health, Environmental and Occupational Health: 1 fractional works · 0.8% of its workRadiology, Nuclear Medicine and Imaging: 1 fractional works · 0.7% of its workPharmacology: 1 fractional works · 0.7% of its workInfectious Diseases: 1 fractional works · 0.6% of its workRheumatology: 1 fractional works · 0.4% of its workPediatrics, Perinatology and Child Health: 1 fractional works · 0.4% of its workGeriatrics and Gerontology: 0 fractional works · 0.3% of its workImmunology and Allergy: 0 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.7% of its workNursing: 1 fractional works · 0.5% of its workNutrition and Dietetics: 1 fractional works · 0.5% of its workVeterinary: 1 fractional works · 0.4% of its workSmall Animals: 1 fractional works · 0.4% of its workHealth Professions: 0 fractional works · 0.2% of its workPhysical Sciences: 9 fractional works · 5.2% of its workChemistry: 4 fractional works · 2.4% of its workSpectroscopy: 3 fractional works · 1.7% of its workOrganic Chemistry: 1 fractional works · 0.6% of its workSmaller subfields together: 0 fractional works · 0.0% of its workEngineering: 2 fractional works · 1.2% of its workBiomedical Engineering: 2 fractional works · 0.9% of its workSmaller subfields together: 1 fractional works · 0.3% of its workMaterials Science: 1 fractional works · 0.5% of its workBiomaterials: 1 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.2% of its workEnvironmental Science: 1 fractional works · 0.5% of its workEcology: 1 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.2% of its workComputer Science: 1 fractional works · 0.4% of its workComputational Theory and Mathematics: 1 fractional works · 0.4% of its workMathematics: 0 fractional works · 0.1% of its workPhysics and Astronomy: 0 fractional works · 0.1% of its workSocial Sciences: 1 fractional works · 0.8% of its workEconomics, Econometrics and Finance: 1 fractional works · 0.5% of its workEconomics and Econometrics: 1 fractional works · 0.5% of its workPsychology: 0 fractional works · 0.2% of its workSocial Sciences: 0 fractional works · 0.0% of its workDecision Sciences: 0 fractional works · 0.0% of its workALL ITS WORKIonisPharmaceuticals…170fractional works, 2022-now
Life Sciences54%Physical Sciences5%Health Sciences40%Social Sciences1%

Each ring splits the one inside it: the four domains of science, their fields, their subfields. Size is fractional works in 2022-now. Every slice is a page; the interactive view zooms down to single topics and colours each by how much more of it this institution does than the world.

Its 4 domains and 21 fields, with their numbers
    1. Biochemistry, Genetics and Molecular Biology7041.1%
    2. Immunology and Microbiology126.9%
    3. Neuroscience84.8%
    4. Agricultural and Biological Sciences20.9%
    5. Pharmacology, Toxicology and Pharmaceutics00.1%
    1. Medicine6639.1%
    2. Nursing10.5%
    3. Veterinary10.4%
    4. Health Professions00.2%
    1. Chemistry42.4%
    2. Engineering21.2%
    3. Materials Science10.5%
    4. Environmental Science10.5%
    5. Computer Science10.4%
    6. Mathematics00.1%
    7. Physics and Astronomy00.1%
    1. Economics, Econometrics and Finance10.5%
    2. Psychology00.2%
    3. Social Sciences00.0%
    4. Decision Sciences00.0%
    5. Business, Management and Accounting00.0%
All of science, and how each field's share has moved since 1950: the Science domain explorer

What does Ionis Pharmaceuticals (United States) specialise in?

Where its research is concentrated relative to its size: Molecular Biology takes 9.9× the share of its output that it takes of world research.

  1. Molecular BiologySubfield · 50.6 works9.9×
← less than its size predicts1×more →

Location quotient, a volume reading rather than an impact one. It surfaces small, lopsided specialities.

Field profile

Location quotient across every field it publishes in: outside the ring is more than an institution of this size would be expected to publish, inside it is less.

Agricultural and Biological Sciences: 0.19× its world share, 2 worksAgricultural and Bio…Biochemistry, Genetics and Molecular Biology: 7.70× its world share, 70 worksBiochemistry, Geneti…Immunology and Microbiology: 6.83× its world share, 12 worksImmunology and Micro…Neuroscience: 2.98× its world share, 8 worksNeurosciencePharmacology, Toxicology and Pharmaceutics: 0.40× its world share, 0 worksPharmacology, Toxico…Chemistry: 1.53× its world share, 4 worksChemistryComputer Science: 0.05× its world share, 1 worksComputer ScienceEngineering: 0.08× its world share, 2 worksEngineeringEnvironmental Science: 0.10× its world share, 1 worksEnvironmental ScienceMaterials Science: 0.15× its world share, 1 worksMaterials ScienceMathematics: 0.08× its world share, 0 worksMathematicsPhysics and Astronomy: 0.03× its world share, 0 worksPhysics and AstronomyHealth Professions: 0.07× its world share, 0 worksHealth ProfessionsMedicine: 2.03× its world share, 66 worksMedicineNursing: 1.01× its world share, 1 worksNursingVeterinary: 2.79× its world share, 1 worksVeterinaryDecision Sciences: 0.03× its world share, 0 worksDecision SciencesEconomics, Econometrics and Finance: 0.25× its world share, 1 worksEconomics, Econometr…Psychology: 0.05× its world share, 0 worksPsychology1×world share
more than its size predictsabout as predictedless

Rings at 0.5×, 1× and 2×. Widest outward: Biochemistry, Genetics and Molecular Biology, 7.7×. Every wedge is a field page.

All 19 fields, with their numbers
  1. Biochemistry, Genetics and Molecular Biology7.70×70 works
  2. Immunology and Microbiology6.83×12 works
  3. Neuroscience2.98×8 works
  4. Veterinary2.79×1 works
  5. Medicine2.03×66 works
  6. Chemistry1.53×4 works
  7. Nursing1.01×1 works
  8. Pharmacology, Toxicology and Pharmaceutics0.40×0 works
  9. Economics, Econometrics and Finance0.25×1 works
  10. Agricultural and Biological Sciences0.19×2 works
  11. Materials Science0.15×1 works
  12. Environmental Science0.10×1 works
  13. Engineering0.08×2 works
  14. Mathematics0.08×0 works
  15. Health Professions0.07×0 works
  16. Computer Science0.05×1 works
  17. Psychology0.05×0 works
  18. Physics and Astronomy0.03×0 works
  19. Decision Sciences0.03×0 works

Who are the top researchers at Ionis Pharmaceuticals (United States)?

Ranked on the quality score, C. Frank Bennett, Frank Rigo and Holly B. Kordasiewicz lead among researchers whose main affiliation is Ionis Pharmaceuticals (United States).

  1. 1 C. Frank Bennett United States · #8,887 worldwide 48k citations · 326 works
  2. 2 Frank Rigo United States · #20,263 worldwide 21k citations · 249 works
  3. 3 Holly B. Kordasiewicz United States · #37,322 worldwide 8.7k citations · 112 works
  4. 4 Sanjay Bhanot United States · #39,753 worldwide 15k citations · 151 works
  5. 5 Richard G. Lee United States · #44,899 worldwide 9.6k citations · 128 works
  6. 6 Susan M. Freier United States · #46,762 worldwide 21k citations · 149 works
  7. 7 Rosanne M. Crooke United States · #51,998 worldwide 14k citations · 129 works
  8. 8 Mark J. Graham United States · #53,015 worldwide 19k citations · 210 works
  9. 9 A. Robert MacLeod United States · #69,077 worldwide 10k citations · 180 works
  10. 10 Veronica J. Alexander United States · #75,116 worldwide 4.9k citations · 84 works
All ranked researchers at Ionis Pharmaceuticals (United States)

What are the most cited papers from Ionis Pharmaceuticals (United States)?

The most cited paper from Ionis Pharmaceuticals (United States) is "Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy" (Richard S. Finkel et al., 2017), with 2,357 citations. Next come "The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation" (2,272) and "PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules" (2,092).

Most cited papers
#PaperReleasedCitations
1 Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy Richard S. Finkel et al. · New England Journal of Medicine Open access Nov 2017 2,357
2 The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation Vidisha Tripathi, Jonathan D. Ellis, Zhen Shen et al. · Molecular Cell Open access 27 Aug 2010 2,272
3 PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules Michael Egholm, Ole Buchardt, Leif Christensen et al. · Nature Oct 1993 2,092
4 miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Christine Esau, Scott P. Davis, Susan Murray et al. · Cell Metabolism Open access Feb 2006 2,088
5 PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients Yoichi Nagata, Keng‐Hsueh Lan, Xiaoyan Zhou et al. · Cancer Cell Open access Aug 2004 1,878
All 60 most cited papers, with filters and sorting

Which keywords describe research at Ionis Pharmaceuticals (United States)?

By fractional works in 2022-now, weighted toward what it does more of than the world: Inflammation, Metabolic Syndrome, Antisense Oligonucleotides, Genomic Stability, Therapeutic Targets, Oxidative Stress, Atherosclerosis and DNA Structure.

▲ more of its work than of the world's◆ about the world's share▼ less than the world's

Size is fractional works in 2022-now in the topics tagged with each word; colour is the word's share of this institution's work against its share of the world's. The 40 words are chosen for being large and distinctive. Each links to the topic it comes from most.

All 40 words, with their numbers
  1. Inflammation17▲ 4.7×42 topics
  2. Oxidative Stress12▲ 4.3×26 topics
  3. Metabolic Syndrome12▲ 8.6×10 topics
  4. Antisense Oligonucleotides11▲ 155×2 topics
  5. Cancer11▲ 4.7×35 topics
  6. Genomic Stability9▲ 146×2 topics
  7. Therapeutic Targets9▲ 36×2 topics
  8. Atherosclerosis9▲ 18×7 topics
  9. DNA Structure9▲ 253×1 topic
  10. G-Quadruplexes9▲ 253×1 topic
  11. Gene Therapy8▲ 26×4 topics
  12. Thrombosis7▲ 16×5 topics
  13. Cardiovascular Disease7▲ 3.5×15 topics
  14. Insulin Resistance7▲ 8.7×6 topics
  15. Mitochondrial Dysfunction7▲ 13×8 topics
  16. Innate Immunity6▲ 12×9 topics
  17. Neurodegeneration6▲ 12×10 topics
  18. Obesity6▲ 4.8×10 topics
  19. Gene Silencing6▲ 36×2 topics
  20. Nanoparticles6▲ 2.7×7 topics
  21. RNA Interference6▲ 40×1 topic
  22. siRNA Delivery6▲ 58×1 topic
  23. Adipose Tissue5▲ 58×2 topics
  24. Hereditary Angioedema5▲ 166×1 topic
  25. Kinin Receptor Family5▲ 166×1 topic
  26. Biosensors5▲ 6.1×2 topics
  27. Genetics5▲ 4.2×8 topics
  28. DNA nanotechnology5▲ 25×1 topic
  29. Self-Assembly5▲ 9.0×1 topic
  30. ANGPTL35▲ 209×1 topic
  31. Lipoprotein Lipase5▲ 209×1 topic
  32. Regulation5▲ 5.1×8 topics
  33. Metabolism4▲ 4.8×15 topics
  34. Genetic Mutations4▲ 5.3×13 topics
  35. Alternative Splicing4▲ 46×1 topic
  36. RNA-Binding Proteins4▲ 46×1 topic
  37. Apoptosis4▲ 6.8×12 topics
  38. Chaperones4▲ 35×2 topics
  39. Hepatic Steatosis3▲ 14×2 topics
  40. Protein Aggregation3▲ 37×3 topics

Which research topics does Ionis Pharmaceuticals (United States) publish most on?

By volume in 2022-now: DNA and Nucleic Acid Chemistry, RNA Interference and Gene Delivery, Coagulation, Bradykinin, Polyphosphates, and Angioedema and Advanced biosensing and bioanalysis techniques.

DNA and Nucleic Acid Chemistry: 9 fractional worksRNA Interference and Gene Delivery: 6 fractional worksCoagulation, Bradykinin,…5Coagulation, Bradykinin, Polyphosphates, and Angioedema: 5 fractional worksAdvanced biosensing and …5Advanced biosensing and bioanalysis techniques: 5 fractional worksLipid metabolism and disorders: 5 fractional worksRNA Research and Splicing: 4 fractional worksLiver Disease Diagnosis …3Liver Disease Diagnosis and Treatment: 3 fractional worksGenetic Neurodegenerative Diseases: 3 fractional worksRNA and protein synthesis mechanisms: 3 fractional worksNeurogenetic and Muscular Disorders Research: 2 fractional works
Molecular BiologyGeneticsCardiology and Cardiovascular MedicineEpidemiology1 others

Area is fractional works; colour is the subfield each topic belongs to.

  1. 1 DNA and Nucleic Acid Chemistry Molecular Biology 9 works
  2. 2 RNA Interference and Gene Delivery Molecular Biology 6 works
  3. 3 Coagulation, Bradykinin, Polyphosphates, and Angioedema Genetics 5 works
  4. 4 Advanced biosensing and bioanalysis techniques Molecular Biology 5 works
  5. 5 Lipid metabolism and disorders Cardiology and Cardiovascular Medicine 5 works
  6. 6 RNA Research and Splicing Molecular Biology 4 works
  7. 7 Liver Disease Diagnosis and Treatment Epidemiology 3 works
  8. 8 Genetic Neurodegenerative Diseases Cellular and Molecular Neuroscience 3 works
  9. 9 RNA and protein synthesis mechanisms Molecular Biology 3 works
  10. 10 Neurogenetic and Muscular Disorders Research Genetics 2 works

How open and international is its research?

Against the world's own shares: the tick on each track. Both are shares of its output, so they sit on one scale and can be read against each other as well as against the world.

openly available34.7%not open65.3%

World: 40% of research is openly available.

with international co-authors16.3%domestic only83.7%

World: 18% is written across borders.

How has Ionis Pharmaceuticals (United States)'s research output changed?

Output in 2022-2025 was 30% lower than in 2018-2021.

still counting1990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Ionis Pharmaceuticals (United States) as a percentage of every work published that year, 0.00053% in 2024.

still counting0.0050%0.010%Ionis Pharmaceuticals (United States)0.00065% in 20251990200020102020

Fractional works of Ionis Pharmaceuticals (United States) over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year, against all institutions in the same year.

still counting20%40%Ionis Pharmaceuticals (United States)16.1% in 2025all institutions10.0% in 2025200020102020

Of each year's output, the share that reached the world's 10% most cited for its field and year. Peak 31.2% in 1993.

Other research institutions in Carlsbad

All research institutions in Carlsbad

Share Ionis Pharmaceuticals (United States)'s ranking

Ionis Pharmaceuticals (United States) on Science Explorer

A card with Ionis Pharmaceuticals (United States)'s standing and the fields it leads in, for a post or a slide. A link to this page previews as the same card.

Download the card

1200 × 630 PNG, sized for social posts, drawn from the latest snapshot.

Badges for a website1Each links back here and updates with every snapshot

Research measures only: rankings here say nothing about teaching, admissions or student experience. Comparable institutions and collaboration partners have tabs of their own, above.

Discussion

Ask a question or share a note about Ionis Pharmaceuticals (United States). Keep it to the research: no personal attacks, advertising or links. Any reader can report a post, which collapses it for everyone until it is opened.