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Topic · Molecular Biology

RNA regulation and disease

RNA regulation and disease is a research topic within Molecular Biology. Science Explorer counts 28k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the functions and regulation of RNA editing by ADAR deaminases, including its impact on gene regulation, innate immunity, microRNA processing, and the genomic landscape. It covers a wide range of topics such as neurological disorders, cancer, and transcriptome diversity.

  • RNA Editing
  • ADAR Deaminases
  • Gene Regulation
  • Innate Immunity
  • MicroRNA Processing
  • Genomic Landscape
  • Neurological Disorders
  • Cancer
  • Transcriptome Diversity
  • Nucleic Acid Sensing
Research works
28k
fractional, since 1950
In the world top 10%
2.8k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+14%
the tick is no change
Largest producer
China
33% of the 10 largest, 2022-now
RNA regulation and disease

Which countries lead RNA regulation and disease research?

By volume, China and the United States publish the most (1.4k and 1.4k works in 2022-now).

By volume, 2022-now

  1. 1 China 1.4k works
  2. 2 United States 1.4k works
  3. 3 India 300 works
  4. 4 Japan 253 works
  5. 5 Germany 210 works
  6. 6 United Kingdom 189 works
  7. 7 Italy 178 works
  8. 8 France 170 works
  9. 9 Canada 126 works
  10. 10 South Korea 125 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 32.7%United States: 31.6%India: 6.9%Japan: 5.8%6 others listed: 23.0%33%largest
China1,419 · 32.7%United States1,374 · 31.6%India300 · 6.9%Japan253 · 5.8%6 others listed998 · 23.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead RNA regulation and disease research?

By volume in 2022-now, Harvard University publishes the most RNA regulation and disease research, followed by Chinese Academy of Sciences and National Institutes of Health.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 63 works
  2. 2 Chinese Academy of SciencesChina 53 works
  3. 3 National Institutes of HealthUnited States 49 works
  4. 4 Centre National de la Recherche ScientifiqueFrance 43 works
  5. 5 Sun Yat-sen UniversityChina 42 works
  6. 6 InsermFrance 33 works
  7. 7 Shanghai Jiao Tong UniversityChina 31 works
  8. 8 Zhejiang UniversityChina 31 works
  9. 9 Fudan UniversityChina 28 works
  10. 10 Russian Academy of SciencesRussia 28 works

Who are the leading researchers in RNA regulation and disease?

The most-cited researchers publishing on RNA regulation and disease include Eric S. Lander, Richard M. Durbin and Mark J. Daly.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Richard M. Durbin United Kingdom 410k citations
  3. 3 Mark J. Daly United States 403k citations
  4. 4 Stacey L. Gabriel United States 402k citations
  5. 5 Peer Bork Germany 396k citations
  6. 6 Guido Kroemer France 386k citations
  7. 7 Shizuo Akira Japan 342k citations
  8. 8 Jun Wang China 340k citations
  9. 9 John P. A. Ioannidis United States 317k citations
  10. 10 Gregory Y.H. Lip United Kingdom 311k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in RNA regulation and disease?

The most cited paper in RNA regulation and disease is "TopHat: discovering splice junctions with RNA-Seq" (Cole Trapnell, Lior S. Pachter, Steven L. Salzberg, 2009), with 12,264 citations. Next come "In vitro selection of RNA molecules that bind specific ligands" (9,885) and "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage" (5,677).

Most cited papers
#PaperReleasedCitations
1 TopHat: discovering splice junctions with RNA-Seq Cole Trapnell, Lior S. Pachter, Steven L. Salzberg · Bioinformatics Open access 16 Mar 2009 12,264
2 In vitro selection of RNA molecules that bind specific ligands Andrew D. Ellington, Jack W. Szostak · Nature Aug 1990 9,885
3 Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage Alexis C. Komor, Y. Bill Kim, Michael S. Packer et al. · Nature Open access 19 Apr 2016 5,677
4 Novel Proteinaceous Infectious Particles Cause Scrapie Stanley Ben Prusiner · Science 9 Apr 1982 5,188
5 Search-and-replace genome editing without double-strand breaks or donor DNA Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature Open access 21 Oct 2019 4,928
All 100 most cited papers, with filters and sorting

Where is RNA regulation and disease research done?

The largest centres of RNA regulation and disease research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Paris (France). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda.

Largest cities, 2022-now

  1. 1 BeijingChina 204 works
  2. 2 ShanghaiChina 122 works
  3. 3 GuangzhouChina 105 works
  4. 4 ParisFrance 83 works
  5. 5 LondonUnited Kingdom 72 works
  6. 6 TokyoJapan 69 works
  7. 7 New YorkUnited States 66 works
  8. 8 WuhanChina 64 works
  9. 9 SeoulSouth Korea 60 works
  10. 10 HangzhouChina 55 works

Where it is the local speciality

  1. BethesdaUS · 44.0 works6.7×
← less than its size predicts1×more →

Location quotient: how much more of its research is in RNA regulation and disease than the world average.

See RNA regulation and disease on the map

Where is the best place to study RNA regulation and disease?

Among universities, judged by research, Harvard University, Massachusetts Institute of Technology and University of California San Diego score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.36%fractional works in this field (log) →share of work in the world top 10% →Massachusetts Instit…University of Califo…Harvard UniversitySun Yat-sen University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 78.516.8%4.1×63 +5.4%
2Massachusetts Institute of TechnologyUnited States 62.924.7%2.8×10 +78.3%
3University of California San DiegoUnited States 62.718.4%5.4×25 +23.6%
4Sun Yat-sen UniversityChina 59.513.6%4.2×42 +45.4%
5University of PennsylvaniaUnited States 59.115.9%4.9×25 +32.2%
6Johns Hopkins UniversityUnited States 57.618.1%3.1×23 +12.8%
7China Agricultural UniversityChina 57.323.7%5.3×14 +199.2%
8Rockefeller UniversityUnited States 55.314.9%27.7×8 +123.4%
9Fudan UniversityChina 54.815.6%3.7×28 +57.4%
10McGill UniversityCanada 53.811.9%4.4×21 +17.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in RNA regulation and disease, country by country

Is RNA regulation and disease research growing?

Output in 2022-2025 was 14% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are RNA regulation and disease.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is RNA regulation and disease as a percentage of every work published that year, 0.024% in 2024.

still counting0.020%0.040%RNA regulation and disease0.024% in 202519801990200020102020

Fractional works of RNA regulation and disease over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%RNA regulation and disease10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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