Topic · RNA regulation and disease
Most cited papers in RNA regulation and disease
What are the most cited papers in RNA regulation and disease?
The most cited paper in RNA regulation and disease is "TopHat: discovering splice junctions with RNA-Seq" (Cole Trapnell, Lior S. Pachter, Steven L. Salzberg, 2009), with 12,264 citations. Next come "In vitro selection of RNA molecules that bind specific ligands" (9,885) and "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage" (5,677).
Showing 50 of 100 papers. Every paper with more than 1,444 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | TopHat: discovering splice junctions with RNA-Seq Cole Trapnell, Lior S. Pachter, Steven L. Salzberg · Bioinformatics | 16 Mar 2009 | 12,264 |
| 2 | In vitro selection of RNA molecules that bind specific ligands Andrew D. Ellington, Jack W. Szostak · Nature | Aug 1990 | 9,885 |
| 3 | Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage Alexis C. Komor, Y. Bill Kim, Michael S. Packer et al. · Nature | 19 Apr 2016 | 5,677 |
| 4 | Novel Proteinaceous Infectious Particles Cause Scrapie Stanley Ben Prusiner · Science | 9 Apr 1982 | 5,188 |
| 5 | Search-and-replace genome editing without double-strand breaks or donor DNA Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature | 21 Oct 2019 | 4,928 |
| 6 | XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor Hiderou Yoshida, Toshie Matsui, Akira Yamamoto et al. · Cell | Dec 2001 | 4,139 |
| 7 | The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology | 20 Jun 2004 | 3,949 |
| 8 | Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Hiroki Kato, Osamu Takeuchi, Shintaro Sato et al. · Nature | 9 Apr 2006 | 3,913 |
| 9 | CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes Luke A. Gilbert, Matthew H. Larson, Leonardo Morsut et al. · Cell | Jul 2013 | 3,892 |
| 10 | RAS Is Regulated by the let-7 MicroRNA Family Steven Johnson, Helge Großhans, Jaclyn Shingara et al. · Cell | Mar 2005 | 3,692 |
| 11 | Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1 Enza Maria Valente et al. · Science | 19 Apr 2004 | 3,521 |
| 12 | Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan et al. · Cell | Sep 2000 | 3,503 |
| 13 | Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase Heather P. Harding, Yuhong Zhang, David Ron · Nature | 21 Jan 1999 | 3,379 |
| 14 | Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells Heather P. Harding, Isabel Novoa, Yuhong Zhang et al. · Molecular Cell | Nov 2000 | 3,335 |
| 15 | Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. Yasumasa Ishida, Yasutoshi Agata, Kei‐ichi Shibahara et al. · The EMBO Journal | Nov 1992 | 3,261 |
| 16 | CRISPR-Cas systems for editing, regulating and targeting genomes Jeffry D. Sander, J. Keith Joung · Nature Biotechnology | 2 Mar 2014 | 3,227 |
| 17 | Cloning and characterization of a mammalian proton-coupled metal-ion transporter Hiromi Gunshin, Bryan Mackenzie, Urs V. Berger et al. · Nature | 31 Jul 1997 | 3,203 |
| 18 | Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology Alexander A. Zimprich et al. · Neuron | Nov 2004 | 3,086 |
| 19 | Routes and mechanisms of extracellular vesicle uptake Laura Ann Mulcahy, Ryan Charles Pink, David Raul Francisco Carter · Journal of Extracellular Vesicles | 2014 | 2,870 |
| 20 | Roles of CHOP/GADD153 in endoplasmic reticulum stress Seiichi Oyadomari, Masataka Mori · Cell Death and Differentiation | 19 Dec 2003 | 2,860 |
| 21 | The Calpain System Darrel E. Goll, Valery F. Thompson, Hongqi Li et al. · Physiological Reviews | Jul 2003 | 2,837 |
| 22 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences Ranjan Sen, David Baltimore · Cell | Aug 1986 | 2,815 |
| 23 | Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member J. David Brook et al. · Cell | Feb 1992 | 2,808 |
| 24 | The integrated stress response Karolina Pakos‐Zebrucka, Izabela Koryga, Katarzyna Mnich et al. · EMBO Reports | 14 Sep 2016 | 2,803 |
| 25 | In vivo genome editing using Staphylococcus aureus Cas9 F. Ann Ran, Le Dinh Công, Winston X. Yan et al. · Nature | 31 Mar 2015 | 2,785 |
| 26 | Antiviral Actions of Interferons Charles E. Samuel · Clinical Microbiology Reviews | Oct 2001 | 2,780 |
| 27 | REGULATORY SEQUENCES INVOLVED IN THE PROMOTION AND TERMINATION OF RNA TRANSCRIPTION Martin J. Rosenberg, Donald Court · Annual Review of Genetics | Dec 1979 | 2,726 |
| 28 | RNAi Phillip D. Zamore, Thomas Tuschl, Phillip A. Sharp et al. · Cell | Mar 2000 | 2,662 |
| 29 | Widespread transcription at neuronal activity-regulated enhancers Tae-Kyung Kim, Martin Hemberg, Jesse M. Gray et al. · Nature | 13 Apr 2010 | 2,577 |
| 30 | Mechanisms of gene silencing by double-stranded RNA Gunter Meister, Thomas Tuschl · Nature | Sep 2004 | 2,569 |
| 31 | Genomic Analysis of Reactive Astrogliosis Jennifer L. Zamanian, Lijun Xu, Lynette C. Foo et al. · Journal of Neuroscience | 2 May 2012 | 2,525 |
| 32 | Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases Sangsu Bae, Jeongbin Park, Jin‐Soo Kim · Bioinformatics | 24 Jan 2014 | 2,519 |
| 33 | Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus Etienne Meylan, Joseph Alphonsus Curran, Kay Hofmann et al. · Nature | 21 Sep 2005 | 2,402 |
| 34 | GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen et al. · Nature Biotechnology | 16 Dec 2014 | 2,398 |
| 35 | A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus Éric Vivès, Priscille M Brodin, Bernard Lebleu · Journal of Biological Chemistry | Jun 1997 | 2,384 |
| 36 | MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts Thomas Thum et al. · Nature | 30 Nov 2008 | 2,368 |
| 37 | Dynamic regulation of genome-wide pre-mRNA splicing and stress tolerance by the Sm-like protein LSm5 in Arabidopsis Peng Cui, Shoudong Zhang, Feng Hua Ding et al. · Genome biology | 6 Jan 2014 | 2,339 |
| 38 | A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins Jie Wang, Jeong‐Mo Choi, Alex S. Holehouse et al. · Cell | 28 Jun 2018 | 2,327 |
| 39 | CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing Kornel Labun, Tessa G. Montague, Maximilian Krause et al. · Nucleic Acids Research | 6 May 2019 | 2,317 |
| 40 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls Randal J. Kaufman · Genes & Development | 15 May 1999 | 2,267 |
| 41 | The microRNA Registry Sam Griffiths‐Jones · Nucleic Acids Research | 18 Dec 2003 | 2,262 |
| 42 | RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates Andreas Pichlmair, Oliver Schulz, Choon Ping Tan et al. · Science | 13 Oct 2006 | 2,223 |
| 43 | RNA targeting with CRISPR–Cas13 Omar O. Abudayyeh, Jonathan S. Gootenberg, Patrick Essletzbichler et al. · Nature | Oct 2017 | 2,185 |
| 44 | Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels Masato Kato, Tina Wei Han, Shanhai Xie et al. · Cell | May 2012 | 2,146 |
| 45 | Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products Susan Amara, Vivian Jonas, Michael G. Rosenfeld et al. · Nature | Jul 1982 | 2,138 |
| 46 | 30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology Qian Zhang, Michael J. Lenardo, David Baltimore · Cell | 2017 | 2,095 |
| 47 | Structure, Regulation and Function of NF-kappaB Ulrich K. Siebenlist, Guido Franzoso, Keith D. Brown · Annual Review of Cell Biology | Nov 1994 | 2,088 |
| 48 | Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress Kyosuke Haze, Hiderou Yoshida, Hideki Yanagi et al. · Molecular Biology of the Cell | Nov 1999 | 2,079 |
| 49 | Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response Heather P. Harding, Yuhong Zhang, Anne Bertolotti et al. · Molecular Cell | May 2000 | 2,055 |
| 50 | Transport Between the Cell Nucleus and the Cytoplasm Dirk Görlich, Ulrike Kutay · Annual Review of Cell and Developmental Biology | Nov 1999 | 2,054 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.