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Topic · Immunology

Complement system in diseases

Complement system in diseases is a research topic within Immunology. Science Explorer counts 24k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of the complement system in immune response, focusing on its involvement in thrombotic microangiopathies, hemolytic uremic syndrome, and inflammatory diseases. It delves into the genetics, regulation, and therapeutic interventions such as Eculizumab for managing complement-related disorders.

  • Complement
  • Immune
  • Thrombotic Microangiopathies
  • Hemolytic Uremic Syndrome
  • Eculizumab
  • Innate Immunity
  • ADAMTS13
  • Regulation
  • Inflammatory Diseases
  • Genetics
Research works
24k
fractional, since 1950
In the world top 10%
2.4k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+18%
the tick is no change
Largest producer
United States
38% of the 10 largest, 2022-now
Complement system in diseases

Which countries lead Complement system in diseases research?

By volume, the United States and China publish the most (1.2k and 591 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.2k works
  2. 2 China 591 works
  3. 3 Japan 220 works
  4. 4 United Kingdom 206 works
  5. 5 Germany 199 works
  6. 6 India 189 works
  7. 7 France 184 works
  8. 8 Italy 154 works
  9. 9 Spain 116 works
  10. 10 Canada 92 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 37.6%China: 18.9%Japan: 7.0%United Kingdom: 6.6%6 others listed: 29.9%38%largest
United States1,174 · 37.6%China591 · 18.9%Japan220 · 7.0%United Kingdom206 · 6.6%6 others listed933 · 29.9%

Shares of the rows listed above, not of the whole node.

Which institutions lead Complement system in diseases research?

By volume in 2022-now, Harvard University publishes the most Complement system in diseases research, followed by Inserm and Peking University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 40 works
  2. 2 InsermFrance 31 works
  3. 3 Peking UniversityChina 27 works
  4. 4 Mayo ClinicUnited States 27 works
  5. 5 Université Paris CitéFrance 25 works
  6. 6 Johns Hopkins UniversityUnited States 23 works
  7. 7 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 22 works
  8. 8 Novartis (Switzerland)Switzerland 22 works
  9. 9 National Institutes of HealthUnited States 22 works
  10. 10 University of TorontoCanada 21 works

Who are the leading researchers in Complement system in diseases?

The most-cited researchers publishing on Complement system in diseases include George Davey Smith, Mark J. Daly and Guido Kroemer.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 Elaine R. Mardis United States 346k citations
  5. 5 Shizuo Akira Japan 342k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 Gregory Y.H. Lip United Kingdom 311k citations
  9. 9 Gonçalo R. Abecasis United States 300k citations
  10. 10 Richard A. Gibbs United States 292k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Complement system in diseases?

The most cited paper in Complement system in diseases is "Complement Factor H Polymorphism in Age-Related Macular Degeneration" (Robert J. Klein, Caroline J. Zeiss, Emily Y. Chew et al., 2005), with 4,552 citations. Next come "A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis" (3,727) and "Complement: a key system for immune surveillance and homeostasis" (3,686).

Most cited papers
#PaperReleasedCitations
1 Complement Factor H Polymorphism in Age-Related Macular Degeneration Robert J. Klein, Caroline J. Zeiss, Emily Y. Chew et al. · Science Open access 10 Mar 2005 4,552
2 A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis John N. Feder et al. · Nature Genetics Aug 1996 3,727
3 Complement: a key system for immune surveillance and homeostasis Daniel Ricklin, George Hajishengallis, Kun Yang et al. · Nature Immunology Open access 19 Aug 2010 3,686
4 A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes Philipp E. Scherer, Suzanne P. Williams, Michael Fogliano et al. · Journal of Biological Chemistry Open access Nov 1995 3,253
5 Complement Mark J. Walport · New England Journal of Medicine 5 Apr 2001 2,952
All 99 most cited papers, with filters and sorting

Where is Complement system in diseases research done?

The largest centres of Complement system in diseases research in 2022-now are Beijing (China), Paris (France), London (United Kingdom) and Tokyo (Japan). Among places with at least 20 works in it, it is an unusually large share of all research in Basel.

Largest cities, 2022-now

  1. 1 BeijingChina 101 works
  2. 2 ParisFrance 96 works
  3. 3 LondonUnited Kingdom 64 works
  4. 4 TokyoJapan 54 works
  5. 5 New YorkUnited States 52 works
  6. 6 BostonUnited States 44 works
  7. 7 ShanghaiChina 44 works
  8. 8 MadridSpain 41 works
  9. 9 GuangzhouChina 38 works
  10. 10 MilanItaly 35 works

Where it is the local speciality

  1. BaselCH · 23.8 works9.3×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Complement system in diseases than the world average.

See Complement system in diseases on the map

Where is the best place to study Complement system in diseases?

Among universities, judged by research, Harvard University, Université Paris Cité and Newcastle University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 18.45%fractional works in this field (log) →share of work in the world top 10% →Newcastle UniversityJohns Hopkins Univer…Université Paris CitéHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 74.713.3%3.5×40 -1.0%
2Université Paris CitéFrance 72.115.5%8.9×25 +12.7%
3Newcastle UniversityUnited Kingdom 68.525.2%6.0×10 +44.9%
4Johns Hopkins UniversityUnited States 66.716.7%4.0×23 +10.2%
5Columbia UniversityUnited States 65.024.6%2.8×11 +24.2%
6University of OxfordUnited Kingdom 64.818.4%2.5×13 +11.0%
7Stanford UniversityUnited States 63.615.7%2.6×14 +117.0%
8Washington University in St. LouisUnited States 61.816.5%5.8×15 +17.2%
9University of Colorado Anschutz Medical CampusUnited States 56.517.5%9.5×9 +13.0%
10The University of QueenslandAustralia 55.821.1%3.3×12 -11.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Complement system in diseases, country by country

Is Complement system in diseases research growing?

Output in 2022-2025 was 18% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Complement system in diseases.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Complement system in diseases as a percentage of every work published that year, 0.015% in 2024.

still counting0.020%0.040%0.060%Complement system in diseases0.018% in 202519801990200020102020

Fractional works of Complement system in diseases over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Complement system in diseases9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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