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Topic · Immunology

Macrophage Migration Inhibitory Factor

Macrophage Migration Inhibitory Factor is a research topic within Immunology. Science Explorer counts 9.7k research works in it since 1952. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of Macrophage Migration Inhibitory Factor (MIF) in innate immunity, inflammatory responses, atherosclerosis, autoimmune diseases, cancer, cell survival, angiogenesis, and inflammation. The papers explore MIF as a cytokine involved in modulating immune responses, promoting cell survival, regulating inflammatory pathways, and contributing to the pathogenesis of various diseases.

  • Innate Immunity
  • Inflammatory Response
  • Toll-like Receptor
  • Atherosclerosis
  • Cytokine
  • Autoimmune Diseases
  • Cancer
  • Cell Survival
  • Angiogenesis
  • Inflammation
Research works
9.7k
fractional, since 1952
In the world top 10%
981
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+6%
the tick is no change
Largest producer
China
49% of the 10 largest, 2022-now
Macrophage Migration Inhibitory Factor

Which countries lead Macrophage Migration Inhibitory Factor research?

By volume, China and the United States publish the most (573 and 256 works in 2022-now).

By volume, 2022-now

  1. 1 China 573 works
  2. 2 United States 256 works
  3. 3 India 63 works
  4. 4 Germany 61 works
  5. 5 Japan 48 works
  6. 6 South Korea 38 works
  7. 7 Russia 34 works
  8. 8 United Kingdom 33 works
  9. 9 France 31 works
  10. 10 Brazil 31 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 49.0%United States: 22.0%India: 5.4%Germany: 5.2%6 others listed: 18.4%49%largest
China573 · 49.0%United States256 · 22.0%India63 · 5.4%Germany61 · 5.2%6 others listed214 · 18.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Macrophage Migration Inhibitory Factor research?

By volume in 2022-now, Sun Yat-sen University publishes the most Macrophage Migration Inhibitory Factor research, followed by Nanjing Medical University and Shanghai Jiao Tong University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 18 works
  2. 2 Nanjing Medical UniversityChina 15 works
  3. 3 Shanghai Jiao Tong UniversityChina 15 works
  4. 4 Central South UniversityChina 13 works
  5. 5 Harvard UniversityUnited States 13 works
  6. 6 Anhui Medical UniversityChina 12 works
  7. 7 Sichuan UniversityChina 10 works
  8. 8 Yale UniversityUnited States 10 works
  9. 9 Zhejiang UniversityChina 10 works
  10. 10 Capital Medical UniversityChina 9 works

Who are the leading researchers in Macrophage Migration Inhibitory Factor?

The most-cited researchers publishing on Macrophage Migration Inhibitory Factor include Mark J. Daly, John J.V. McMurray and Shizuo Akira.

  1. 1 Mark J. Daly United States 403k citations
  2. 2 John J.V. McMurray United Kingdom 349k citations
  3. 3 Shizuo Akira Japan 342k citations
  4. 4 Giuseppe Remuzzi Italy 328k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Macrophage Migration Inhibitory Factor?

The most cited paper in Macrophage Migration Inhibitory Factor is "Matrix Metalloproteinases" (Hideaki Nagase, J. Frederick Woessner, 1999), with 3,917 citations. Next come "IL-10 inhibits cytokine production by activated macrophages" (2,923) and "Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver" (2,775).

Most cited papers
#PaperReleasedCitations
1 Matrix Metalloproteinases Hideaki Nagase, J. Frederick Woessner · Journal of Biological Chemistry Open access Jul 1999 3,917
2 IL-10 inhibits cytokine production by activated macrophages David Franklin Fiorentino, Albert Zlotnik, Tim R. Mosmann et al. · The Journal of Immunology Open access Dec 1991 2,923
3 Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver Bruno Costa‐Silva et al. · Nature Cell Biology Open access 18 May 2015 2,775
4 The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies Lynne Bingle, Nicola Jane Brown, Claire E. Lewis · The Journal of Pathology 22 Jan 2002 2,055
5 Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. Carl Nathan, Henry W. Murray, Michael E. Wiebe et al. · The Journal of Experimental Medicine Open access Sep 1983 1,973
All 99 most cited papers, with filters and sorting

Where is Macrophage Migration Inhibitory Factor research done?

The largest centres of Macrophage Migration Inhibitory Factor research in 2022-now are Beijing (China), Guangzhou (China), Shanghai (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Guangzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 50 works
  2. 2 GuangzhouChina 42 works
  3. 3 ShanghaiChina 40 works
  4. 4 NanjingChina 29 works
  5. 5 WuhanChina 23 works
  6. 6 ChangshaChina 18 works
  7. 7 HangzhouChina 18 works
  8. 8 HefeiChina 16 works
  9. 9 ChengduChina 15 works
  10. 10 JinanChina 14 works

Where it is the local speciality

  1. GuangzhouCN · 41.7 works3.2×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Macrophage Migration Inhibitory Factor than the world average.

See Macrophage Migration Inhibitory Factor on the map

Where is the best place to study Macrophage Migration Inhibitory Factor?

Among universities, judged by research, Sun Yat-sen University, Harvard University and Anhui Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 14.2%fractional works in this field (log) →share of work in the world top 10% →Anhui Medical Univer…Sun Yat-sen UniversityNanjing Medical Univ…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sun Yat-sen UniversityChina 79.517.0%6.4×18 +5.9%
2Harvard UniversityUnited States 73.69.4%3.0×13 +13.3%
3Anhui Medical UniversityChina 70.517.4%19.7×12 +121.2%
4Nanjing Medical UniversityChina 64.912.4%12.9×15 +61.6%
5Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 55.618.0%6.0×8 +19.5%
6Huazhong University of Science and TechnologyChina 54.416.9%3.5×8 +31.4%
7Zhejiang UniversityChina 53.516.7%2.7×10 +2.0%
8Shanghai Jiao Tong UniversityChina 51.411.4%3.9×15 +13.2%
9Sichuan UniversityChina 47.214.9%3.3×10 +100.3%
10Yale UniversityUnited States 45.87.9%6.8×10 -50.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Macrophage Migration Inhibitory Factor, country by country

Is Macrophage Migration Inhibitory Factor research growing?

Output in 2022-2025 was 6% higher than in 2018-2021, peaking in 2024. The fastest-growing topics are Macrophage Migration Inhibitory Factor.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Macrophage Migration Inhibitory Factor as a percentage of every work published that year, 0.0069% in 2024.

still counting0.020%0.040%0.060%Macrophage Migration Inhibitory Factor0.0065% in 202519801990200020102020

Fractional works of Macrophage Migration Inhibitory Factor over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Macrophage Migration Inhibitory Factor10.3% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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