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Topic · Immunology

T-cell and B-cell Immunology

T-cell and B-cell Immunology is a research topic within Immunology. Science Explorer counts 82k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the development, function, and regulation of regulatory T cells (Tregs), particularly emphasizing the role of transcription factor Foxp3, TGF-ß induction, immune tolerance, thymic selection, memory T cells, IL-2 signaling, and their involvement in tumor immunity and immunological surveillance. The cluster also explores the implications of Tregs in autoimmunity and their potential for therapeutic interventions.

  • Foxp3
  • TGF-ß
  • CD4+CD25+
  • Immune Tolerance
  • Autoimmunity
  • Thymic Selection
  • Memory T Cells
  • IL-2
  • Tumor Immunity
  • Immunological Surveillance
Research works
82k
fractional, since 1950
In the world top 10%
8.1k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-9%
the tick is no change
Largest producer
United States
41% of the 10 largest, 2022-now
T-cell and B-cell Immunology

Which countries lead T-cell and B-cell Immunology research?

By volume, the United States and China publish the most (2.6k and 1.4k works in 2022-now).

By volume, 2022-now

  1. 1 United States 2.6k works
  2. 2 China 1.4k works
  3. 3 Germany 487 works
  4. 4 Japan 388 works
  5. 5 United Kingdom 372 works
  6. 6 France 369 works
  7. 7 Australia 191 works
  8. 8 Canada 189 works
  9. 9 Italy 177 works
  10. 10 Spain 172 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 41.1%China: 22.1%Germany: 7.6%Japan: 6.1%6 others listed: 23.1%41%largest
United States2,616 · 41.1%China1,404 · 22.1%Germany487 · 7.6%Japan388 · 6.1%6 others listed1,471 · 23.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead T-cell and B-cell Immunology research?

By volume in 2022-now, Harvard University publishes the most T-cell and B-cell Immunology research, followed by National Institutes of Health and Centre National de la Recherche Scientifique.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 163 works
  2. 2 National Institutes of HealthUnited States 114 works
  3. 3 Centre National de la Recherche ScientifiqueFrance 79 works
  4. 4 InsermFrance 73 works
  5. 5 Peking UniversityChina 52 works
  6. 6 Emory UniversityUnited States 51 works
  7. 7 University of PennsylvaniaUnited States 50 works
  8. 8 Shanghai Jiao Tong UniversityChina 49 works
  9. 9 University College LondonUnited Kingdom 48 works
  10. 10 Karolinska InstitutetSweden 47 works

Who are the leading researchers in T-cell and B-cell Immunology?

The most-cited researchers publishing on T-cell and B-cell Immunology include Eric S. Lander, Mark J. Daly and Robert John Tibshirani.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Robert John Tibshirani United States 396k citations
  4. 4 Guido Kroemer France 386k citations
  5. 5 Bert Vogelstein United States 373k citations
  6. 6 Gad A. Getz United States 364k citations
  7. 7 Elaine R. Mardis United States 346k citations
  8. 8 Hermann Brenner Germany 343k citations
  9. 9 Shizuo Akira Japan 342k citations
  10. 10 Cyrus Cooper United Kingdom 342k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in T-cell and B-cell Immunology?

The most cited paper in T-cell and B-cell Immunology is "Integrated analysis of multimodal single-cell data" (Yuhan Hao et al., 2021), with 16,879 citations. Next come "Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities" (14,980) and "Dendritic cells and the control of immunity" (14,440).

Most cited papers
#PaperReleasedCitations
1 Integrated analysis of multimodal single-cell data Yuhan Hao et al. · Cell Open access 31 May 2021 16,879
2 Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities Sven Heinz, Christopher W. Benner, Nathanael J. Spann et al. · Molecular Cell Open access May 2010 14,980
3 Dendritic cells and the control of immunity Jacques Banchereau, Ralph M. Steinman · Nature Mar 1998 14,440
4 Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science 13 Feb 2003 8,213
5 Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Jason D. Fontenot, Marc A. Gavin, Alexander Yu Rudensky · Nature Immunology 3 Mar 2003 7,778
All 100 most cited papers, with filters and sorting

Where is T-cell and B-cell Immunology research done?

The largest centres of T-cell and B-cell Immunology research in 2022-now are Beijing (China), Paris (France), London (United Kingdom) and New York (United States). Among places with at least 20 works in it, it is an unusually large share of all research in Kirov, Hualien City and Bethesda.

Largest cities, 2022-now

  1. 1 BeijingChina 223 works
  2. 2 ParisFrance 185 works
  3. 3 LondonUnited Kingdom 149 works
  4. 4 New YorkUnited States 142 works
  5. 5 ShanghaiChina 131 works
  6. 6 BethesdaUnited States 105 works
  7. 7 BostonUnited States 103 works
  8. 8 TokyoJapan 100 works
  9. 9 CambridgeUnited States 97 works
  10. 10 SeoulSouth Korea 95 works

Where it is the local speciality

  1. KirovRU · 35.1 works66×
  2. Hualien CityTW · 23.1 works23×
  3. BethesdaUS · 105.2 works11×
← less than its size predicts1×more →

Location quotient: how much more of its research is in T-cell and B-cell Immunology than the world average.

See T-cell and B-cell Immunology on the map

Where is the best place to study T-cell and B-cell Immunology?

Among universities, judged by research, Harvard University, Rockefeller University and Stanford University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 16.02%fractional works in this field (log) →share of work in the world top 10% →Rockefeller UniversityStanford UniversityHarvard UniversityUniversity of Pennsy…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 68.417.7%7.2×162 -15.8%
2Rockefeller UniversityUnited States 64.025.3%26.1×11 +13.4%
3Stanford UniversityUnited States 55.521.3%4.4×46 -21.8%
4University of PennsylvaniaUnited States 53.316.6%6.7×50 -4.0%
5Emory UniversityUnited States 52.89.6%8.9×51 +11.0%
6Washington University in St. LouisUnited States 52.715.0%6.8×35 +3.7%
7Cornell UniversityUnited States 52.215.2%4.2×39 +9.6%
8Karolinska InstitutetSweden 52.010.6%11.8×47 -9.9%
9University College LondonUnited Kingdom 51.89.8%4.3×48 +6.3%
10University of California, San FranciscoUnited States 51.419.1%6.2×31 -43.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in T-cell and B-cell Immunology, country by country

Is T-cell and B-cell Immunology research growing?

Output in 2022-2025 was 9% lower than in 2018-2021, peaking in 2009.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is T-cell and B-cell Immunology as a percentage of every work published that year, 0.031% in 2024.

still counting0.10%0.20%T-cell and B-cell Immunology0.032% in 202519801990200020102020

Fractional works of T-cell and B-cell Immunology over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%T-cell and B-cell Immunology9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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