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Topic · Immunology

Mast cells and histamine

Mast cells and histamine is a research topic within Immunology. Science Explorer counts 26k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the diverse roles of mast cells in allergic disease, immune responses, and inflammation. It covers topics such as the activation and regulation of mast cells, their interactions with other immune cells, their involvement in allergic and non-allergic immune responses, and their significance in diseases such as mastocytosis. The cluster also delves into the molecular mechanisms, signaling pathways, and therapeutic implications related to mast cell biology.

  • Mast Cells
  • Allergic Disease
  • Immune Responses
  • Histamine
  • Basophils
  • T Cell Activation
  • Inflammation
  • Cytokines
  • Receptor Tyrosine Kinase
  • Mastocytosis
Research works
26k
fractional, since 1950
In the world top 10%
2.6k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+4%
the tick is no change
Largest producer
United States
31% of the 10 largest, 2022-now
Mast cells and histamine

Which countries lead Mast cells and histamine research?

By volume, the United States and China publish the most (778 and 565 works in 2022-now).

By volume, 2022-now

  1. 1 United States 778 works
  2. 2 China 565 works
  3. 3 Japan 200 works
  4. 4 Germany 182 works
  5. 5 India 175 works
  6. 6 Italy 152 works
  7. 7 France 127 works
  8. 8 United Kingdom 107 works
  9. 9 South Korea 95 works
  10. 10 Spain 92 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 31.5%China: 22.8%Japan: 8.1%Germany: 7.4%6 others listed: 30.3%31%largest
United States778 · 31.5%China565 · 22.8%Japan200 · 8.1%Germany182 · 7.4%6 others listed748 · 30.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Mast cells and histamine research?

By volume in 2022-now, Harvard University publishes the most Mast cells and histamine research, followed by Xi'an Jiaotong University and National Institutes of Health.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 35 works
  2. 2 Xi'an Jiaotong UniversityChina 21 works
  3. 3 National Institutes of HealthUnited States 20 works
  4. 4 InsermFrance 19 works
  5. 5 Mayo ClinicUnited States 19 works
  6. 6 Johns Hopkins UniversityUnited States 18 works
  7. 7 Charité - Universitätsmedizin BerlinGermany 16 works
  8. 8 Centre National de la Recherche ScientifiqueFrance 15 works
  9. 9 University of MichiganUnited States 15 works
  10. 10 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 14 works

Who are the leading researchers in Mast cells and histamine?

The most-cited researchers publishing on Mast cells and histamine include George Davey Smith, Mark J. Daly and Guido Kroemer.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 Shizuo Akira Japan 342k citations
  5. 5 Giuseppe Remuzzi Italy 328k citations
  6. 6 Gonçalo R. Abecasis United States 300k citations
  7. 7 Ted R. Miller United States 279k citations
  8. 8 Hagop M. Kantarjian United States 273k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Mast cells and histamine?

The most cited paper in Mast cells and histamine is "Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors" (Seiichi Hirota, Koji Isozaki, Yasuhiro Moriyama et al., 1998), with 4,517 citations. Next come "A fluorometric method for determination of oxidized and reduced glutathione in tissues" (4,127) and "Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor" (2,507).

Most cited papers
#PaperReleasedCitations
1 Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors Seiichi Hirota, Koji Isozaki, Yasuhiro Moriyama et al. · Science 23 Jan 1998 4,517
2 A fluorometric method for determination of oxidized and reduced glutathione in tissues Paul J. Hissin, Russell Hilf · Analytical Biochemistry Jul 1976 4,127
3 Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor Carl‐Henrik Heldin, Bengt Westermark · Physiological Reviews Review 10 Jan 1999 2,507
4 Inositol phospholipids and cell surface receptor function Robert Hall Michell · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes Mar 1975 2,479
5 Establishment and characterization of a human histiocytic lymphoma cell line (U‐937) Christer Sundström, Kenneth Nilsson · International Journal of Cancer 15 May 1976 2,436
All 100 most cited papers, with filters and sorting

Where is Mast cells and histamine research done?

The largest centres of Mast cells and histamine research in 2022-now are Beijing (China), Tokyo (Japan), Paris (France) and London (United Kingdom). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda.

Largest cities, 2022-now

  1. 1 BeijingChina 75 works
  2. 2 TokyoJapan 62 works
  3. 3 ParisFrance 57 works
  4. 4 LondonUnited Kingdom 41 works
  5. 5 ShanghaiChina 41 works
  6. 6 New YorkUnited States 40 works
  7. 7 BerlinGermany 39 works
  8. 8 MoscowRussia 38 works
  9. 9 SeoulSouth Korea 37 works
  10. 10 Xi'anChina 33 works

Where it is the local speciality

  1. BethesdaUS · 23.0 works5.6×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Mast cells and histamine than the world average.

See Mast cells and histamine on the map

Where is the best place to study Mast cells and histamine?

Among universities, judged by research, Harvard University, Karolinska Institutet and Humboldt-Universität zu Berlin score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.67%fractional works in this field (log) →share of work in the world top 10% →Central South Univer…Humboldt-Universität…Karolinska InstitutetHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 74.813.8%3.7×36 -16.6%
2Karolinska InstitutetSweden 68.620.0%7.9×14 +88.2%
3Humboldt-Universität zu BerlinGermany 65.722.4%9.8×11 +304.4%
4Central South UniversityChina 61.526.3%2.2×13 +93.5%
5Johns Hopkins UniversityUnited States 60.420.2%3.8×18 -16.0%
6Medical University of ViennaAustria 56.615.5%11.7×11 +4.6%
7Heidelberg UniversityGermany 51.414.2%5.2×12 +23.3%
8University of PennsylvaniaUnited States 50.613.2%3.4×11 +12.3%
9Stanford UniversityUnited States 47.619.1%1.9×9 -27.7%
10Xi'an Jiaotong UniversityChina 46.612.0%3.9×21 -4.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Mast cells and histamine, country by country

Is Mast cells and histamine research growing?

Output in 2022-2025 was 4% higher than in 2018-2021, peaking in 2009. The fastest-growing topics are Mast cells and histamine.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Mast cells and histamine as a percentage of every work published that year, 0.014% in 2024.

still counting0.020%0.040%0.060%Mast cells and histamine0.014% in 202519801990200020102020

Fractional works of Mast cells and histamine over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Mast cells and histamine10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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