Topic · Complement system in diseases
Most cited papers in Complement system in diseases
What are the most cited papers in Complement system in diseases?
The most cited paper in Complement system in diseases is "Complement Factor H Polymorphism in Age-Related Macular Degeneration" (Robert J. Klein, Caroline J. Zeiss, Emily Y. Chew et al., 2005), with 4,552 citations. Next come "A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis" (3,727) and "Complement: a key system for immune surveillance and homeostasis" (3,686).
Showing 50 of 99 papers. Every paper with more than 813 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Complement Factor H Polymorphism in Age-Related Macular Degeneration Robert J. Klein, Caroline J. Zeiss, Emily Y. Chew et al. · Science | 10 Mar 2005 | 4,552 |
| 2 | A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis John N. Feder et al. · Nature Genetics | Aug 1996 | 3,727 |
| 3 | Complement: a key system for immune surveillance and homeostasis Daniel Ricklin, George Hajishengallis, Kun Yang et al. · Nature Immunology | 19 Aug 2010 | 3,686 |
| 4 | A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes Philipp E. Scherer, Suzanne P. Williams, Michael Fogliano et al. · Journal of Biological Chemistry | Nov 1995 | 3,253 |
| 5 | Complement Mark J. Walport · New England Journal of Medicine | 5 Apr 2001 | 2,952 |
| 6 | Schizophrenia risk from complex variation of complement component 4 Aswin Sekar, Allison R. Bialas, Heather de Rivera et al. · Nature | 26 Jan 2016 | 2,592 |
| 7 | Complement Factor H Polymorphism and Age-Related Macular Degeneration Albert O. Edwards, Robert Ritter, Kenneth J. Abel et al. · Science | 10 Mar 2005 | 2,467 |
| 8 | Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases CYNTHIA M.J. MAGRO, Joseph Justin Mulvey, David Berlin et al. · Translational research | 15 Apr 2020 | 2,263 |
| 9 | Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue Anand Padmanabhan, Laura S. Connelly‐Smith, Nicole A. Aqui et al. · Journal of Clinical Apheresis | Jun 2019 | 2,235 |
| 10 | Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles Bence György, Tamás Géza Szabó, Mária Pásztói et al. · Cellular and Molecular Life Sciences | 10 May 2011 | 2,104 |
| 11 | Dietary Protein Intake and the Progressive Nature of Kidney Disease: Franklin H. Epstein, Barry Morton Brenner, Timothy W. Meyer et al. · New England Journal of Medicine | 9 Sep 1982 | 2,087 |
| 12 | Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins Michael P. Bevilacqua, Siegfried Stengelin, Michael A. Gimbrone et al. · Science | 3 Mar 1989 | 2,036 |
| 13 | Disseminated Intravascular Coagulation Marcel M Levi, Hugo Ten Cate · New England Journal of Medicine | 19 Aug 1999 | 2,005 |
| 14 | Complement and its role in innate and adaptive immune responses Jason Dunkelberger, Wen‐Chao Song · Cell Research | 15 Dec 2009 | 1,994 |
| 15 | A common haplotype in the complement regulatory gene factor H ( HF1/CFH ) predisposes individuals to age-related macular degeneration Gregory S. Hageman et al. · Proceedings of the National Academy of Sciences | 3 May 2005 | 1,979 |
| 16 | Comparison of Plasma Exchange with Plasma Infusion in the Treatment of Thrombotic Thrombocytopenic Purpura G. A. Rock, Kenneth H. Shumak, Noel A. Buskard et al. · New England Journal of Medicine | 8 Aug 1991 | 1,940 |
| 17 | C-reactive Protein Stephen Alan Black, Irving Kushner, David R. Samols · Journal of Biological Chemistry | 27 Aug 2004 | 1,854 |
| 18 | Antibodies to von Willebrand Factor–Cleaving Protease in Acute Thrombotic Thrombocytopenic Purpura Han‐Mou Tsai, Eric Chun‐Yet Lian · New England Journal of Medicine | 26 Nov 1998 | 1,781 |
| 19 | Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome Phillip I. Tarr, Carrie A. Gordon, Wayne Leslie Chandler · The Lancet | Mar 2005 | 1,776 |
| 20 | Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura Gallia G. Levy, William C. Nichols, Eric C.‐Y. Lian et al. · Nature | 4 Oct 2001 | 1,764 |
| 21 | von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome Miha Furlan, Rodolfo Robles, Miriam Galbusera et al. · New England Journal of Medicine | 26 Nov 1998 | 1,676 |
| 22 | HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN FOR IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDHOOD Paul A. Imbach, Vincenzo D’Apuzzo, Andreas Hirt et al. · The Lancet | Jun 1981 | 1,672 |
| 23 | Complement System Part I – Molecular Mechanisms of Activation and Regulation Nicolas S. Merle, S. Church, Véronique Frémeaux‐Bacchi et al. · Frontiers in Immunology | 2 Jun 2015 | 1,618 |
| 24 | F4/80, a monoclonal antibody directed specifically against the mouse macrophage Jonathan M. Austyn, Siamon Gordon · European Journal of Immunology | 1981 | 1,616 |
| 25 | Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome Christophe M. Legendre et al. · New England Journal of Medicine | 5 Jun 2013 | 1,590 |
| 26 | Common West African HLA antigens are associated with protection from severe malaria Adrian V. S. Hill, Catherine E. M. Allsopp, Dominic P. Kwiatkowski et al. · Nature | 15 Aug 1991 | 1,578 |
| 27 | VEGF Inhibition and Renal Thrombotic Microangiopathy Vera Eremina, J. Ashley Jefferson, Jolanta Kowalewska et al. · New England Journal of Medicine | 12 Mar 2008 | 1,514 |
| 28 | Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles Marina Colombo, Catarina Ferreira Moita, Guillaume van Niel et al. · Journal of Cell Science | 2013 | 1,488 |
| 29 | Complement Mark J. Walport · New England Journal of Medicine | 12 Apr 2001 | 1,483 |
| 30 | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection Yunlong Cao et al. · Nature | 17 Jun 2022 | 1,460 |
| 31 | Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies Marina Botto, Chiara Dell' Agnola, Anne E. Bygrave et al. · Nature Genetics | May 1998 | 1,437 |
| 32 | Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin Richard J. Ulevitch, Peter S. Tobias · Annual Review of Immunology | Apr 1995 | 1,435 |
| 33 | The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition David H. Goetz, Margaret A. Holmes, Niels Borregaard et al. · Molecular Cell | Nov 2002 | 1,362 |
| 34 | Exosomal-like vesicles are present in human blood plasma Marie-Pierre Caby, Danielle Lankar, Claude Vincendeau-Scherrer et al. · International Immunology | 20 May 2005 | 1,347 |
| 35 | Atypical Hemolytic–Uremic Syndrome Marina Noris, Giuseppe Remuzzi · New England Journal of Medicine | 21 Oct 2009 | 1,346 |
| 36 | The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria Peter Hillmen, Neal S. Young, Jörg E. A. Schubert et al. · New England Journal of Medicine | 21 Sep 2006 | 1,305 |
| 37 | Complement regulators and inhibitory proteins Peter F. Zipfel, Christine Skerka · Nature reviews. Immunology | 4 Sep 2009 | 1,285 |
| 38 | Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression Giovanna Borsellino, Markus Kleinewietfeld, Diletta Di Mitri et al. · Blood | 20 Apr 2007 | 1,283 |
| 39 | Syndromes of Thrombotic Microangiopathy James N. George, Carla Nester · New England Journal of Medicine | 13 Aug 2014 | 1,282 |
| 40 | The roles of extracellular vesicles in the immune system Edit I. Buzás · Nature reviews. Immunology | 4 Aug 2022 | 1,247 |
| 41 | Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes Jean-Michel Escola, Monique J. Kleijmeer, Willem Stoorvogel et al. · Journal of Biological Chemistry | Aug 1998 | 1,232 |
| 42 | Thrombotic Microangiopathies Joel L. Moake · New England Journal of Medicine | 22 Aug 2002 | 1,221 |
| 43 | Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. Marcel Loetscher, Basil O. Gerber, Pius Loetscher et al. · The Journal of Experimental Medicine | Sep 1996 | 1,205 |
| 44 | Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria William Leo McGuire, Adrian V. S. Hill, Catherine E. M. Allsopp et al. · Nature | Oct 1994 | 1,183 |
| 45 | The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease Alexander H. Stephan, Ben A. Barres, Beth A. Stevens · Annual Review of Neuroscience | 21 Jun 2012 | 1,165 |
| 46 | C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells Carol Anne Ogden, Aimee M. deCathelineau, Peter R. Hoffmann et al. · The Journal of Experimental Medicine | 17 Sep 2001 | 1,150 |
| 47 | Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system I. E. C. Sommer, M. Schachner · Developmental Biology | Apr 1981 | 1,131 |
| 48 | Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta Michal Fried, Patrick Emmet Duffy · Science | 7 Jun 1996 | 1,126 |
| 49 | Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage. T Sacks, Charles F. Moldow, P R Craddock et al. · Journal of Clinical Investigation | May 1978 | 1,114 |
| 50 | Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma Mark Ping Chao, Ash A. Alizadeh, Chad Z. Tang et al. · Cell | Sep 2010 | 1,101 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.