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Topic · Genetics

Coagulation, Bradykinin, Polyphosphates, and Angioedema

Coagulation, Bradykinin, Polyphosphates, and Angioedema is a research topic within Genetics. Science Explorer counts 31k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the molecular mechanisms, pathophysiological consequences, and clinical management of Hereditary Angioedema. It covers topics such as the role of kinin receptors, coagulation factors XII and XI, polyphosphate, C1 inhibitor deficiency, and the use of bradykinin-receptor antagonists in the treatment of angioedema. Additionally, it explores the involvement of tissue kallikreins and the contact activation system in the disease pathology.

  • Hereditary Angioedema
  • Kinin Receptor Family
  • Coagulation Factor XII
  • Polyphosphate
  • C1 Inhibitor Deficiency
  • Bradykinin-Receptor Antagonist
  • Factor XI Antisense Oligonucleotide
  • Tissue Kallikreins
  • Contact Activation System
  • Thrombosis
Research works
31k
fractional, since 1950
In the world top 10%
3.1k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+12%
the tick is no change
Largest producer
United States
35% of the 10 largest, 2022-now
Coagulation, Bradykinin, Polyphosphates, and Angioedema

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Coagulation, Bradykinin, Polyphosphates, and Angioedema research?

By volume, the United States and China publish the most (1.1k and 454 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.1k works
  2. 2 China 454 works
  3. 3 Germany 273 works
  4. 4 Japan 267 works
  5. 5 Italy 203 works
  6. 6 France 199 works
  7. 7 India 195 works
  8. 8 United Kingdom 167 works
  9. 9 Spain 153 works
  10. 10 Türkiye 122 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 35.0%China: 14.5%Germany: 8.7%Japan: 8.6%6 others listed: 33.2%35%largest
United States1,095 · 35.0%China454 · 14.5%Germany273 · 8.7%Japan267 · 8.6%6 others listed1,038 · 33.2%

Shares of the rows listed above, not of the whole node.

Which institutions lead Coagulation, Bradykinin, Polyphosphates, and Angioedema research?

By volume in 2022-now, Harvard University publishes the most Coagulation, Bradykinin, Polyphosphates, and Angioedema research, followed by University of North Carolina at Chapel Hill and Mayo Clinic.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 36 works
  2. 2 University of North Carolina at Chapel HillUnited States 32 works
  3. 3 Mayo ClinicUnited States 28 works
  4. 4 InsermFrance 27 works
  5. 5 University of TorontoCanada 20 works
  6. 6 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 19 works
  7. 7 Université Paris CitéFrance 18 works
  8. 8 Takeda (Japan)Japan 17 works
  9. 9 Charité - Universitätsmedizin BerlinGermany 16 works
  10. 10 University College LondonUnited Kingdom 16 works

Who are the leading researchers in Coagulation, Bradykinin, Polyphosphates, and Angioedema?

The most-cited researchers publishing on Coagulation, Bradykinin, Polyphosphates, and Angioedema include John J.V. McMurray, Cyrus Cooper and Jun Wang.

  1. 1 John J.V. McMurray United Kingdom 349k citations
  2. 2 Cyrus Cooper United Kingdom 342k citations
  3. 3 Jun Wang China 340k citations
  4. 4 Giuseppe Remuzzi Italy 328k citations
  5. 5 Graeme J. Hankey Australia 316k citations
  6. 6 Gordon Henry Guyatt Canada 315k citations
  7. 7 Gregory Y.H. Lip United Kingdom 311k citations
  8. 8 Richard A. Gibbs United States 292k citations
  9. 9 Hagop M. Kantarjian United States 273k citations
  10. 10 Josef Coresh United States 272k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Coagulation, Bradykinin, Polyphosphates, and Angioedema?

The most cited paper in Coagulation, Bradykinin, Polyphosphates, and Angioedema is "TOR Signaling in Growth and Metabolism" (Stephan Wullschleger, Robbie Loewith, Michael N. Hall, 2006), with 5,827 citations. Next come "A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9" (3,177) and "A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis" (3,128).

Most cited papers
#PaperReleasedCitations
1 TOR Signaling in Growth and Metabolism Stephan Wullschleger, Robbie Loewith, Michael N. Hall · Cell Open access Feb 2006 5,827
2 A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9 Mary Donoghue, F. Hsieh, Elizabeth Baronas et al. · Circulation Research Open access Sep 2000 3,177
3 A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis SR Poort, FR Rosendaal, PH Reitsma et al. · Blood 15 Nov 1996 3,128
4 Complement Mark J. Walport · New England Journal of Medicine 5 Apr 2001 2,952
5 Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton Dos D. Sarbassov, Siraj Mahamed Ali, Do‐Hyung Kim et al. · Current Biology Open access Jul 2004 2,701
All 98 most cited papers, with filters and sorting

Where is Coagulation, Bradykinin, Polyphosphates, and Angioedema research done?

The largest centres of Coagulation, Bradykinin, Polyphosphates, and Angioedema research in 2022-now are Paris (France), Beijing (China), Tokyo (Japan) and London (United Kingdom).

Largest cities, 2022-now

  1. 1 ParisFrance 77 works
  2. 2 BeijingChina 69 works
  3. 3 TokyoJapan 61 works
  4. 4 LondonUnited Kingdom 57 works
  5. 5 New YorkUnited States 55 works
  6. 6 MadridSpain 49 works
  7. 7 BerlinGermany 44 works
  8. 8 BostonUnited States 39 works
  9. 9 ShanghaiChina 36 works
  10. 10 IstanbulTürkiye 36 works
See Coagulation, Bradykinin, Polyphosphates, and Angioedema on the map

Where is the best place to study Coagulation, Bradykinin, Polyphosphates, and Angioedema?

Among universities, judged by research, Harvard University, McMaster University and Humboldt-Universität zu Berlin score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 22.94%fractional works in this field (log) →share of work in the world top 10% →Humboldt-Universität…Oregon Health & Scie…McMaster UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 70.012.2%2.9×36 -5.0%
2McMaster UniversityCanada 69.722.4%6.8×15 +77.7%
3Humboldt-Universität zu BerlinGermany 69.132.9%7.1×10 +379.8%
4Oregon Health & Science UniversityUnited States 69.029.6%9.0×11 +30.8%
5University of TorontoCanada 67.219.0%2.5×20 +39.6%
6University of CincinnatiUnited States 66.328.6%6.2×14 +24.2%
7University College LondonUnited Kingdom 61.718.3%2.7×16 +3.0%
8Vanderbilt UniversityUnited States 61.220.9%4.5×12 +16.2%
9University of OttawaCanada 58.927.2%3.4×9 +27.3%
10University of LübeckGermany 57.618.3%27.3×15 -17.4%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Coagulation, Bradykinin, Polyphosphates, and Angioedema, country by country

Is Coagulation, Bradykinin, Polyphosphates, and Angioedema research growing?

Output in 2022-2025 was 12% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Coagulation, Bradykinin, Polyphosphates, and Angioedema.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Coagulation, Bradykinin, Polyphosphates, and Angioedema as a percentage of every work published that year, 0.019% in 2024.

still counting0.025%0.050%0.075%Coagulation, Bradykinin, Polyphosphates, and Angioedema0.020% in 202519801990200020102020

Fractional works of Coagulation, Bradykinin, Polyphosphates, and Angioedema over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Coagulation, Bradykinin, Polyphosphates, and Angioedema10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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