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Hemoglobinopathies and Related Disorders

Hemoglobinopathies and Related Disorders is a research topic within Genetics. Science Explorer counts 54k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the genetic, clinical, and epidemiological aspects of hemoglobin disorders, including sickle-cell disease and thalassemia. It covers topics such as hemolysis, fetal hemoglobin regulation, iron overload, pulmonary hypertension, and the use of transfusion therapy. The genetic regulation of erythropoiesis by factors like GATA1 and BCL11A is also a focus of several papers.

  • Sickle-cell Disease
  • Thalassemia
  • Hemolysis
  • Fetal Hemoglobin
  • Iron Overload
  • Genetic Regulation
  • Pulmonary Hypertension
  • Transfusion Therapy
  • GATA Factor
  • Epidemiology
Research works
54k
fractional, since 1950
In the world top 10%
5.5k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+17%
the tick is no change
Largest producer
United States
42% of the 10 largest, 2022-now
Hemoglobinopathies and Related Disorders

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Hemoglobinopathies and Related Disorders research?

By volume, the United States and India publish the most (2.8k and 930 works in 2022-now).

By volume, 2022-now

  1. 1 United States 2.8k works
  2. 2 India 930 works
  3. 3 China 682 works
  4. 4 Brazil 595 works
  5. 5 United Kingdom 327 works
  6. 6 Italy 291 works
  7. 7 Pakistan 282 works
  8. 8 France 281 works
  9. 9 Nigeria 250 works
  10. 10 Saudi Arabia 214 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 41.8%India: 14.1%China: 10.3%Brazil: 9.0%6 others listed: 24.8%42%largest
United States2,768 · 41.8%India930 · 14.1%China682 · 10.3%Brazil595 · 9.0%6 others listed1,645 · 24.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead Hemoglobinopathies and Related Disorders research?

By volume in 2022-now, Harvard University publishes the most Hemoglobinopathies and Related Disorders research, followed by All India Institute of Medical Sciences and Emory University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 74 works
  2. 2 All India Institute of Medical SciencesIndia 71 works
  3. 3 Emory UniversityUnited States 70 works
  4. 4 National Institutes of HealthUnited States 64 works
  5. 5 University of North Carolina at Chapel HillUnited States 54 works
  6. 6 University of CincinnatiUnited States 50 works
  7. 7 Johns Hopkins UniversityUnited States 50 works
  8. 8 InsermFrance 48 works
  9. 9 University of TorontoCanada 43 works
  10. 10 University of PittsburghUnited States 41 works

Who are the leading researchers in Hemoglobinopathies and Related Disorders?

The most-cited researchers publishing on Hemoglobinopathies and Related Disorders include Christopher J L Murray, Eric S. Lander and Simon Iain Hay.

  1. 1 Christopher J L Murray United States 583k citations
  2. 2 Eric S. Lander United States 524k citations
  3. 3 Simon Iain Hay United States 452k citations
  4. 4 George Davey Smith United Kingdom 435k citations
  5. 5 Ali H. Mokdad United States 429k citations
  6. 6 Walter Churchill Willett United States 411k citations
  7. 7 Mark J. Daly United States 403k citations
  8. 8 Stacey L. Gabriel United States 402k citations
  9. 9 Zulfiqar Ahmed Bhutta Pakistan 371k citations
  10. 10 John J.V. McMurray United Kingdom 349k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Hemoglobinopathies and Related Disorders?

The most cited paper in Hemoglobinopathies and Related Disorders is "Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent" (Jozef Sedlak, Raymond H. Lindsay, 1968), with 8,107 citations. Next come "Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization" (4,836) and "Avoiding bias from weak instruments in Mendelian randomization studies" (4,293).

Most cited papers
#PaperReleasedCitations
1 Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Jozef Sedlak, Raymond H. Lindsay · Analytical Biochemistry 1968 8,107
2 Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization Elizabeta Nemeth, Marie S. Tuttle, Julie Powelson et al. · Science 28 Oct 2004 4,836
3 Avoiding bias from weak instruments in Mendelian randomization studies Stephen Burgess, Simon G. Thompson · International Journal of Epidemiology 16 Mar 2011 4,293
4 Anemia of Chronic Disease Günter Weiß, Lawrence T. Goodnough · New England Journal of Medicine 9 Mar 2005 3,793
5 A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis John N. Feder et al. · Nature Genetics Aug 1996 3,727
All 99 most cited papers, with filters and sorting

Where is Hemoglobinopathies and Related Disorders research done?

The largest centres of Hemoglobinopathies and Related Disorders research in 2022-now are Paris (France), London (United Kingdom), São Paulo (Brazil) and New York (United States). Among places with at least 20 works in it, it is an unusually large share of all research in Kinshasa and Memphis.

Largest cities, 2022-now

  1. 1 ParisFrance 151 works
  2. 2 LondonUnited Kingdom 141 works
  3. 3 São PauloBrazil 133 works
  4. 4 New YorkUnited States 131 works
  5. 5 BostonUnited States 107 works
  6. 6 AtlantaUnited States 94 works
  7. 7 New DelhiIndia 90 works
  8. 8 PhiladelphiaUnited States 90 works
  9. 9 RiyadhSaudi Arabia 85 works
  10. 10 ChicagoUnited States 78 works

Where it is the local speciality

  1. KinshasaCD · 21.6 works15×
  2. MemphisUS · 57.9 works12×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Hemoglobinopathies and Related Disorders than the world average.

See Hemoglobinopathies and Related Disorders on the map

Where is the best place to study Hemoglobinopathies and Related Disorders?

Among universities, judged by research, Harvard University, Emory University and Kampala International University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 21.47%fractional works in this field (log) →share of work in the world top 10% →Kampala Internationa…Harvard UniversityEmory UniversityUniversity of Cincin…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 76.319.7%2.7×74 +8.9%
2Emory UniversityUnited States 75.317.7%10.2×70 +46.5%
3Kampala International UniversityUganda 74.730.9%35.2×21 -
4University of CincinnatiUnited States 68.016.1%9.9×50 +20.4%
5Johns Hopkins UniversityUnited States 65.416.6%3.8×50 +7.2%
6University of PittsburghUnited States 63.313.2%6.0×41 +34.5%
7University of MilanItaly 62.433.1%2.5×14 +18.8%
8University of PennsylvaniaUnited States 61.321.5%3.3×30 +16.5%
9Duke UniversityUnited States 60.922.5%4.2×29 +9.4%
10University of California, San FranciscoUnited States 60.623.4%4.3×26 +2.0%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Hemoglobinopathies and Related Disorders, country by country

Is Hemoglobinopathies and Related Disorders research growing?

Output in 2022-2025 was 17% higher than in 2018-2021, peaking in 2024. The fastest-growing topics are Hemoglobinopathies and Related Disorders.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Hemoglobinopathies and Related Disorders as a percentage of every work published that year, 0.044% in 2024.

still counting0.050%0.10%0.15%Hemoglobinopathies and Related Disorders0.039% in 202519801990200020102020

Fractional works of Hemoglobinopathies and Related Disorders over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Hemoglobinopathies and Related Disorders10.6% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Questions people ask

Who is researching a cure for sickle cell disease?

By volume in 2022-now, Harvard University publishes the most Hemoglobinopathies and Related Disorders research, followed by All India Institute of Medical Sciences and Emory University. By volume, the United States and India publish the most (2.8k and 930 works in 2022-now).

All 1,273 questions in the Question Catalogue

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