Most cited papers in Hemoglobinopathies and Related Disorders
What are the most cited papers in Hemoglobinopathies and Related Disorders?
The most cited paper in Hemoglobinopathies and Related Disorders is "Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent" (Jozef Sedlak, Raymond H. Lindsay, 1968), with 8,107 citations. Next come "Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization" (4,836) and "Avoiding bias from weak instruments in Mendelian randomization studies" (4,293).
Showing 50 of 99 papers. Every paper with more than 987 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Jozef Sedlak, Raymond H. Lindsay · Analytical Biochemistry | 1968 | 8,107 |
| 2 | Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization Elizabeta Nemeth, Marie S. Tuttle, Julie Powelson et al. · Science | 28 Oct 2004 | 4,836 |
| 3 | Avoiding bias from weak instruments in Mendelian randomization studies Stephen Burgess, Simon G. Thompson · International Journal of Epidemiology | 16 Mar 2011 | 4,293 |
| 4 | Anemia of Chronic Disease Günter Weiß, Lawrence T. Goodnough · New England Journal of Medicine | 9 Mar 2005 | 3,793 |
| 5 | A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis John N. Feder et al. · Nature Genetics | Aug 1996 | 3,727 |
| 6 | Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death Orah S. Platt, Donald J. Brambilla, Wendell F. Rosse et al. · New England Journal of Medicine | 9 Jun 1994 | 3,370 |
| 7 | Sickle-cell disease David C. Rees, Thomas Neil Williams, Mark T. Gladwin · The Lancet | Dec 2010 | 2,398 |
| 8 | Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia Samuel Charache, Michael L. Terrin, Richard D. Moore et al. · New England Journal of Medicine | 18 May 1995 | 2,361 |
| 9 | The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype Sheng Zhou, John D. Schuetz, Kevin D. Bunting et al. · Nature Medicine | Sep 2001 | 2,286 |
| 10 | Two to Tango: Regulation of Mammalian Iron Metabolism Matthias W. Hentze, Martina Ulrike Muckenthaler, Bruno Galy et al. · Cell | Jul 2010 | 2,142 |
| 11 | Disorders of Iron Metabolism Nancy C. Andrews · New England Journal of Medicine | 23 Dec 1999 | 2,127 |
| 12 | A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease Marc A. Pfeffer, Emmanuel A. Burdmann, Chao Yin Chen et al. · New England Journal of Medicine | 30 Oct 2009 | 2,110 |
| 13 | Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency Stefan D. Anker, Josep Comín Colet, Gerasimos S Filippatos et al. · New England Journal of Medicine | 17 Nov 2009 | 2,090 |
| 14 | SNPStats: a web tool for the analysis of association studies Xavier Solé, Elisabet Guinó, Joan Valls et al. · Bioinformatics | 23 May 2006 | 2,058 |
| 15 | Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data Gretchen A Stevens, Mariel McKenzie Finucane, Luz Maria De‐Regil et al. · The Lancet Global Health | 25 Jun 2013 | 1,983 |
| 16 | CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia Haydar Frangoul et al. · New England Journal of Medicine | 5 Dec 2020 | 1,969 |
| 17 | Global epidemiology of haemoglobin disorders and derived service indicators Bernadette Modell · Bulletin of the World Health Organization | Jun 2008 | 1,934 |
| 18 | Prevention of a First Stroke by Transfusions in Children with Sickle Cell Anemia and Abnormal Results on Transcranial Doppler Ultrasonography Robert J. Adams et al. · New England Journal of Medicine | 2 Jul 1998 | 1,892 |
| 19 | AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis Tsukasa Okuda, Jan M. van Deursen, Scott W. Hiebert et al. · Cell | 1996 | 1,882 |
| 20 | Balancing Acts Matthias W. Hentze, Martina Ulrike Muckenthaler, Nancy C. Andrews · Cell | Apr 2004 | 1,736 |
| 21 | Identification of the haemoglobin scavenger receptor Mette Kristiansen, Jonas Heilskov Graversen, Christian Borch Jacobsen et al. · Nature | 2001 | 1,728 |
| 22 | Cerebrovascular accidents in sickle cell disease: rates and risk factors. Kwaku Ohene‐Frempong, Steven J. Weiner, Lynn A. Sleeper et al. · PubMed | 1998 | 1,718 |
| 23 | A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload Christelle Pigeon, Gennady P. Ilyin, Brice Courselaud et al. · Journal of Biological Chemistry | Mar 2001 | 1,711 |
| 24 | Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload Lisa Anderson · European Heart Journal | Dec 2001 | 1,687 |
| 25 | Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Adriana Donovan, Alison Brownlie, Yi Zhou et al. · Nature | Feb 2000 | 1,673 |
| 26 | Iron-Deficiency Anemia Clara Camaschella · New England Journal of Medicine | 6 May 2015 | 1,658 |
| 27 | The Missing Diversity in Human Genetic Studies Giorgio Sirugo, Scott M. Williams, Sarah A. Tishkoff · Cell | Mar 2019 | 1,625 |
| 28 | Management of Sickle Cell Disease Barbara P. Yawn, George R. Buchanan, Araba Afenyi‐Annan et al. · JAMA | 9 Sep 2014 | 1,608 |
| 29 | Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Tomas Ganz · Blood | 31 Mar 2003 | 1,561 |
| 30 | Pain in Sickle Cell Disease Orah S. Platt, Bruce D. Thorington, Donald J. Brambilla et al. · New England Journal of Medicine | 4 Jul 1991 | 1,559 |
| 31 | Artificial Hallucinations in ChatGPT: Implications in Scientific Writing Hussam R Alkaissi, Samy I. McFarlane · Cureus | 19 Feb 2023 | 1,556 |
| 32 | The Clinical Sequelae of Intravascular Hemolysis and Extracellular Plasma Hemoglobin Russell P. Rother, Leonard B. Bell, Peter Hillmen et al. · JAMA | 6 Apr 2005 | 1,555 |
| 33 | Iron deficiency anaemia Anthony C. Lopez, P. Cacoub, Iain C. Macdougall et al. · The Lancet | 25 Aug 2015 | 1,506 |
| 34 | Abnormal human haemoglobins J. B. Clegg, Michael A. Naughton, David John Weatherall · Journal of Molecular Biology | Aug 1966 | 1,496 |
| 35 | Beta-thalassemia Renzo Galanello, Raffaella Origa · Orphanet Journal of Rare Diseases | 21 May 2010 | 1,490 |
| 36 | Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia Jack M. Guralnik, Richard S. Eisenstaedt, Luigi Ferrucci et al. · Blood | 6 Jul 2004 | 1,469 |
| 37 | A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation Andrew Tristan McKie, Paola Marciani, Andreas Rolfs et al. · Molecular Cell | Feb 2000 | 1,430 |
| 38 | Sickle cell disease Gregory James Kato, Frédéric B. Piel, Clarice D. Reid et al. · Nature Reviews Disease Primers | 14 Mar 2018 | 1,422 |
| 39 | Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury Michael L. Brines, Pietro Ghezzi, Sonja Keenan et al. · Proceedings of the National Academy of Sciences | 12 Sep 2000 | 1,419 |
| 40 | Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Elizabeta Nemeth, Erika V. Valore, Mary Territo et al. · Blood | 17 Mar 2003 | 1,418 |
| 41 | The structure and evolution of the human β-globin gene family Argiris Efstratiadis · Cell | Oct 1980 | 1,408 |
| 42 | A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. Coli I. Purification and characterization of alkaline phosphatase Alan Garen, Cyrus Levinthal · Biochimica et Biophysica Acta | 1960 | 1,407 |
| 43 | Sickle Cell Disease Frédéric B. Piel, Martin H. Steinberg, David C. Rees · New England Journal of Medicine | 19 Apr 2017 | 1,384 |
| 44 | Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide Charlotte Friend, William Scher, J. G. Holland et al. · Proceedings of the National Academy of Sciences | Feb 1971 | 1,373 |
| 45 | Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease LaTonya J. Hickson et al. · EBioMedicine | Sep 2019 | 1,371 |
| 46 | Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 Larysa Pevny, M C Simon, Elizabeth J. Robertson et al. · Nature | 1991 | 1,358 |
| 47 | Structure of Hæmoglobin: A Three-Dimensional Fourier Synthesis at 5.5-Å. Resolution, Obtained by X-Ray Analysis Max Ferdinand Perutz, Michael George Rossmann, Ann F. Cullis et al. · Nature | Feb 1960 | 1,357 |
| 48 | Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis Jasbir S. Makker, Ahmad Hanif, Bharat Bajantri et al. · Case Reports in Gastroenterology | 15 Jan 2015 | 1,355 |
| 49 | A Red Carpet for Iron Metabolism Martina Ulrike Muckenthaler, Stefano B. Rivella, Matthias W. Hentze et al. · Cell | 2017 | 1,351 |
| 50 | Anaemia in low-income and middle-income countries Yarlini Balarajan, Usha Ramakrishnan, Emre Özaltin et al. · The Lancet | 3 Aug 2011 | 1,334 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.