Science Explorer Back to mapMap
Discussion
Topic · Molecular Biology

RNA Interference and Gene Delivery

RNA Interference and Gene Delivery is a research topic within Molecular Biology. Science Explorer counts 83k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the mechanisms, delivery methods, and therapeutic applications of RNA interference (RNAi) in mammalian cells. It covers topics such as siRNA delivery, gene silencing, non-viral vectors, cell-penetrating peptides, lipid nanoparticles, and the potential of RNAi for gene therapy. The research also delves into the challenges and future directions of RNAi-based therapeutics.

  • RNA Interference
  • siRNA Delivery
  • Gene Silencing
  • Non-viral Vectors
  • Therapeutic RNAi
  • Cell-penetrating Peptides
  • Lipid Nanoparticles
  • siRNA Therapeutics
  • Gene Therapy
  • Nucleic Acid Delivery
Research works
83k
fractional, since 1950
In the world top 10%
8.2k
per year above
Top-10% rate
9.8%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+9%
the tick is no change
Largest producer
China
39% of the 10 largest, 2022-now
RNA Interference and Gene Delivery

Which countries lead RNA Interference and Gene Delivery research?

By volume, China and the United States publish the most (4.3k and 2.6k works in 2022-now).

By volume, 2022-now

  1. 1 China 4.3k works
  2. 2 United States 2.6k works
  3. 3 India 1.1k works
  4. 4 Japan 611 works
  5. 5 Germany 486 works
  6. 6 South Korea 410 works
  7. 7 Iran 395 works
  8. 8 United Kingdom 356 works
  9. 9 Italy 309 works
  10. 10 France 294 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 39.4%United States: 24.4%India: 9.8%Japan: 5.7%6 others listed: 20.8%39%largest
China4,253 · 39.4%United States2,632 · 24.4%India1,061 · 9.8%Japan611 · 5.7%6 others listed2,249 · 20.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead RNA Interference and Gene Delivery research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most RNA Interference and Gene Delivery research, followed by Sichuan University and Shanghai Jiao Tong University.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 223 works
  2. 2 Sichuan UniversityChina 134 works
  3. 3 Shanghai Jiao Tong UniversityChina 133 works
  4. 4 Centre National de la Recherche ScientifiqueFrance 108 works
  5. 5 Russian Academy of SciencesRussia 108 works
  6. 6 Sun Yat-sen UniversityChina 102 works
  7. 7 Harvard UniversityUnited States 101 works
  8. 8 Zhejiang UniversityChina 92 works
  9. 9 Fudan UniversityChina 71 works
  10. 10 Peking UniversityChina 64 works

Who are the leading researchers in RNA Interference and Gene Delivery?

The most-cited researchers publishing on RNA Interference and Gene Delivery include Eric S. Lander, Guido Kroemer and Bert Vogelstein.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Bert Vogelstein United States 373k citations
  4. 4 Elaine R. Mardis United States 346k citations
  5. 5 Shizuo Akira Japan 342k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 Yury G. Gogotsi United States 313k citations
  9. 9 Matthias Mann Germany 308k citations
  10. 10 Róbert Langer United States 303k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in RNA Interference and Gene Delivery?

The most cited paper in RNA Interference and Gene Delivery is "Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays" (Tim R. Mosmann, 1983), with 56,216 citations. Next come "MicroRNAs: Target Recognition and Regulatory Functions" (20,551) and "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity" (17,763).

Most cited papers
#PaperReleasedCitations
1 Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays Tim R. Mosmann · Journal of Immunological Methods Dec 1983 56,216
2 MicroRNAs: Target Recognition and Regulatory Functions David P. Bartel · Cell Open access 2009 20,551
3 A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science Open access 29 Jun 2012 17,763
4 Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Fernando P. Polack et al. · New England Journal of Medicine Open access 10 Dec 2020 15,741
5 Apoptosis: A Review of Programmed Cell Death Susan A. Elmore · Toxicologic Pathology Open access Jun 2007 13,911
All 100 most cited papers, with filters and sorting

Where is RNA Interference and Gene Delivery research done?

The largest centres of RNA Interference and Gene Delivery research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Chengdu.

Largest cities, 2022-now

  1. 1 BeijingChina 565 works
  2. 2 ShanghaiChina 405 works
  3. 3 GuangzhouChina 258 works
  4. 4 NanjingChina 229 works
  5. 5 HangzhouChina 199 works
  6. 6 SeoulSouth Korea 198 works
  7. 7 WuhanChina 176 works
  8. 8 TokyoJapan 176 works
  9. 9 ChengduChina 171 works
  10. 10 TehranIran 155 works

Where it is the local speciality

  1. Chengdu22.7 works9.8×
← less than its size predicts1×more →

Location quotient: how much more of its research is in RNA Interference and Gene Delivery than the world average.

See RNA Interference and Gene Delivery on the map

Where is the best place to study RNA Interference and Gene Delivery?

Among universities, judged by research, Sichuan University, Harvard University and Massachusetts Institute of Technology score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 19.28%fractional works in this field (log) →share of work in the world top 10% →Massachusetts Instit…Harvard UniversitySichuan UniversityShanghai Jiao Tong U…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sichuan UniversityChina 70.018.7%5.0×134 +24.0%
2Harvard UniversityUnited States 69.821.1%2.7×101 -7.3%
3Massachusetts Institute of TechnologyUnited States 68.127.0%3.8×32 -9.1%
4Shanghai Jiao Tong UniversityChina 66.115.8%3.9×133 +28.4%
5Zhejiang UniversityChina 65.220.6%2.9×92 +32.3%
6University of PennsylvaniaUnited States 65.026.9%3.1×40 +52.2%
7Sun Yat-sen UniversityChina 61.214.3%4.1×102 +32.4%
8Fudan UniversityChina 57.814.2%3.7×71 +45.6%
9University of British ColumbiaCanada 56.818.7%2.1×31 +32.3%
10University of Chinese Academy of SciencesChina 56.515.5%2.6×51 +16.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in RNA Interference and Gene Delivery, country by country

Is RNA Interference and Gene Delivery research growing?

Output in 2022-2025 was 9% higher than in 2018-2021, peaking in 2024. The fastest-growing topics are RNA Interference and Gene Delivery.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is RNA Interference and Gene Delivery as a percentage of every work published that year, 0.062% in 2024.

still counting0.050%0.10%0.15%RNA Interference and Gene Delivery0.057% in 202519801990200020102020

Fractional works of RNA Interference and Gene Delivery over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%RNA Interference and Gene Delivery9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

Ask a question or share a note about RNA Interference and Gene Delivery. Posts are plain text and can be reported.