Most cited papers in RNA Interference and Gene Delivery
What are the most cited papers in RNA Interference and Gene Delivery?
The most cited paper in RNA Interference and Gene Delivery is "Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays" (Tim R. Mosmann, 1983), with 56,216 citations. Next come "MicroRNAs: Target Recognition and Regulatory Functions" (20,551) and "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity" (17,763).
Showing 50 of 100 papers. Every paper with more than 2,810 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays Tim R. Mosmann · Journal of Immunological Methods | Dec 1983 | 56,216 |
| 2 | MicroRNAs: Target Recognition and Regulatory Functions David P. Bartel · Cell | 2009 | 20,551 |
| 3 | A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science | 29 Jun 2012 | 17,763 |
| 4 | Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Fernando P. Polack et al. · New England Journal of Medicine | 10 Dec 2020 | 15,741 |
| 5 | Apoptosis: A Review of Programmed Cell Death Susan A. Elmore · Toxicologic Pathology | Jun 2007 | 13,911 |
| 6 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Hadi Valadi, Karin M. Ekström, Apostolos Bossios et al. · Nature Cell Biology | 7 May 2007 | 13,088 |
| 7 | Genome engineering using the CRISPR-Cas9 system F. Ann Ran, Patrick D. Hsu, Jason B. Wright et al. · Nature Protocols | 24 Oct 2013 | 11,982 |
| 8 | The biology , function , and biomedical applications of exosomes Raghu K. Kalluri, Valerie S. LeBleu · Science | 6 Feb 2020 | 10,939 |
| 9 | Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine Lindsey R. Baden et al. · New England Journal of Medicine | 30 Dec 2020 | 10,910 |
| 10 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature | May 2001 | 9,461 |
| 11 | Shedding light on the cell biology of extracellular vesicles Guillaume van Niel, Gisela D’Angelo, Graça Raposo · Nature Reviews Molecular Cell Biology | 17 Jan 2018 | 8,693 |
| 12 | Nanocarriers as an emerging platform for cancer therapy Dan Peer, Jeffrey M. Karp, Seungpyo Hong et al. · Nature Nanotechnology | Dec 2007 | 8,681 |
| 13 | Engineering precision nanoparticles for drug delivery Michael J. Mitchell, Margaret M. Billingsley, Rebecca M. Haley et al. · Nature Reviews Drug Discovery | 4 Dec 2020 | 7,854 |
| 14 | Predicting effective microRNA target sites in mammalian mRNAs Vikram Agarwal, George W. Bell, Jin‐Wu Nam et al. · eLife | 12 Aug 2015 | 7,826 |
| 15 | Principles of nanoparticle design for overcoming biological barriers to drug delivery Elvin Blanco, Haifa Shen, Mauro Ferrari · Nature Biotechnology | Sep 2015 | 6,967 |
| 16 | A DNA-based method for rationally assembling nanoparticles into macroscopic materials Chad Alexander Mirkin, Robert L. Letsinger, Robert C. Mucic et al. · Nature | Aug 1996 | 6,698 |
| 17 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers Jeffrey Vieira, Joachim W. Messing · Gene | Oct 1982 | 6,134 |
| 18 | Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids Clotilde Théry, Sebastián Amigorena, Graça Raposo et al. · Current Protocols in Cell Biology | Mar 2006 | 5,870 |
| 19 | Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells Ophir Shalem, Neville E. Sanjana, Ella Hartenian et al. · Science | 12 Dec 2013 | 5,627 |
| 20 | A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V István Vermes, C. Haanen, Helga M. Steffens-nakken et al. · Journal of Immunological Methods | Jul 1995 | 5,471 |
| 21 | Exosomes: composition, biogenesis and function Clotilde Théry, Laurence Zitvogel, Sebastián Amigorena · Nature reviews. Immunology | Aug 2002 | 5,446 |
| 22 | Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression Lei Stanley Qi, Matthew H. Larson, Luke A. Gilbert et al. · Cell | Feb 2013 | 5,298 |
| 23 | Recent advances with liposomes as pharmaceutical carriers Vladimir P. Torchilin · Nature Reviews Drug Discovery | Feb 2005 | 5,273 |
| 24 | Prediction of Mammalian MicroRNA Targets Benjamin P. Lewis, I‐hung Shih, Matthew W. Jones-Rhoades et al. · Cell | Dec 2003 | 5,238 |
| 25 | Efficient selection for high-expression transfectants with a novel eukaryotic vector Hitoshi Niwa, Ken‐ichi Yamamura, Jun‐ichi Miyazaki · Gene | Dec 1991 | 5,233 |
| 26 | Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c Xuesong Liu, Caryn Naekyung Kim, Jie Yang et al. · Cell | Jul 1996 | 5,207 |
| 27 | The nuclear RNase III Drosha initiates microRNA processing Yoontae Lee, Chiyoung Ahn, Jinju Han et al. · Nature | Sep 2003 | 5,144 |
| 28 | Origins and Mechanisms of miRNAs and siRNAs Richard W. Carthew, Erik J. Sontheimer · Cell | Feb 2009 | 5,095 |
| 29 | Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Johan Skog, Tom Würdinger, Sjoerd van Rijn et al. · Nature Cell Biology | 16 Nov 2008 | 5,078 |
| 30 | Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Philip Louis Felgner, Thomas R. Gadek, Mai Marie Holm et al. · Proceedings of the National Academy of Sciences | Nov 1987 | 5,011 |
| 31 | Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes Lydia Alvarez‐Erviti, Yiqi Seow, HaiFang Yin et al. · Nature Biotechnology | 20 Mar 2011 | 4,972 |
| 32 | A simple, rapid, and sensitive DNA assay procedure Cesar G. Labarca, Kenneth Paigen · Analytical Biochemistry | Mar 1980 | 4,971 |
| 33 | In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector Luigi Naldini, Ulrike Blömer, Philippe A. Gallay et al. · Science | 12 Apr 1996 | 4,952 |
| 34 | Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5 Frank L. Graham, W. C. Russell, James R. Smiley et al. · Journal of General Virology | Jul 1977 | 4,887 |
| 35 | Liposomal drug delivery systems: From concept to clinical applications Theresa M. Allen, Pieter R. Cullis · Advanced Drug Delivery Reviews | Oct 2012 | 4,816 |
| 36 | The BCL-2 protein family: opposing activities that mediate cell death Richard J. Youle, Andreas Strasser · Nature Reviews Molecular Cell Biology | 21 Dec 2007 | 4,708 |
| 37 | mRNA vaccines — a new era in vaccinology Norbert Pardi, Michael J. Hogan, Frederick Porter et al. · Nature Reviews Drug Discovery | 12 Jan 2018 | 4,701 |
| 38 | A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry Ildo Nicoletti, Graziella Migliorati, Maria Cristina Pagliacci et al. · Journal of Immunological Methods | Jun 1991 | 4,648 |
| 39 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation A H Wyllie · Nature | Apr 1980 | 4,548 |
| 40 | Drug Delivery Systems: Entering the Mainstream Theresa M. Allen, Pieter R. Cullis · Science | 19 Mar 2004 | 4,545 |
| 41 | PEGylation as a strategy for improving nanoparticle-based drug and gene delivery Jung Soo Suk, Qingguo Xu, Nam‐Ho Kim et al. · Advanced Drug Delivery Reviews | 19 Oct 2015 | 4,511 |
| 42 | Cellular senescence: when bad things happen to good cells Judith Campisi, Fabrizio d’Adda di Fagagna · Nature Reviews Molecular Cell Biology | Aug 2007 | 4,475 |
| 43 | A System for Stable Expression of Short Interfering RNAs in Mammalian Cells Thijn R. Brummelkamp, René Bernards, Reuven Agami · Science | 19 Apr 2002 | 4,319 |
| 44 | Chromosome preparations of leukocytes cultured from human peripheral blood Paul S. Moorhead, Peter C. Nowell̀, William J. Mellman et al. · Experimental Cell Research | Sep 1960 | 4,247 |
| 45 | Direct Gene Transfer into Mouse Muscle in Vivo Jon A. Wolff, Robert W. Malone, Phillip A. Williams et al. · Science | 23 Mar 1990 | 4,189 |
| 46 | Molecular characterization of mitochondrial apoptosis-inducing factor Santos A. Susín, Hans Kristian Lorenzo, Naoufal Zamzami et al. · Nature | Feb 1999 | 4,082 |
| 47 | Lipid nanoparticles for mRNA delivery Xucheng Hou, Tal Z. Zaks, Róbert Langer et al. · Nature Reviews Materials | 10 Aug 2021 | 3,994 |
| 48 | Mammalian microRNAs predominantly act to decrease target mRNA levels Huili Guo, Nicholas T. Ingolia, Jonathan S. Weissman et al. · Nature | Aug 2010 | 3,989 |
| 49 | Silencing of microRNAs in vivo with ‘antagomirs’ Jan Krützfeldt, Nikolaus Rajewsky, Ravi S Braich et al. · Nature | 30 Oct 2005 | 3,987 |
| 50 | Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 Florian Heil, Hiroaki Hemmi, Hubertus Hochrein et al. · Science | 23 Feb 2004 | 3,973 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.