| 1 |
Features and development of Coot
Paul Emsley, Bernhard Lohkamp, William G. Scott et al. · Acta Crystallographica Section D Biological Crystallography
Open access |
23 Mar 2010 |
30,245 |
| 2 |
International Physical Activity Questionnaire: 12-Country Reliability and Validity
Cora L. Craig, Alison L. Marshall, MICHAEL SJ??STR??M et al. · Medicine & Science in Sports & Exercise
|
Aug 2003 |
22,204 |
| 3 |
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici, Katarina Le Blanc, Ingo Mueller et al. · Cytotherapy
|
2006 |
18,014 |
| 4 |
Tissue-based map of the human proteome
Mathias Uhlén et al. · Science
Open access |
22 Jan 2015 |
16,343 |
| 5 |
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
Anna-Pelagia Magiorakos, Arjun Srinivasan, Roberta B. Carey et al. · Clinical Microbiology and Infection
Open access |
7 May 2011 |
14,554 |
| 6 |
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
Rafael Lozano et al. · The Lancet
Open access191 authors |
Dec 2012 |
14,344 |
| 7 |
Sarcopenia: revised European consensus on definition and diagnosis
Alfonso José Cruz-Jentoft et al. · Age and Ageing
Open access |
24 Sep 2018 |
14,151 |
| 8 |
A New Depression Scale Designed to be Sensitive to Change
Stuart Montgomery, Marie Åsberg · The British Journal of Psychiatry
|
Apr 1979 |
14,132 |
| 9 |
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013
Marie Ng et al. · The Lancet
Open access140 authors |
28 May 2014 |
12,158 |
| 10 |
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Clotilde Théry et al. · Journal of Extracellular Vesicles
Open access382 authors |
23 Nov 2018 |
11,535 |
| 11 |
MultiQC: summarize analysis results for multiple tools and samples in a single report
Philip Ewels, Måns Magnusson, Sverker Lundin et al. · Bioinformatics
Open access |
16 Jun 2016 |
11,105 |
| 12 |
2018 ESC/ESH Guidelines for the management of arterial hypertension
Bryan Williams et al. · European Heart Journal
Open access211 authors |
25 Aug 2018 |
10,602 |
| 13 |
Analysis of protein-coding genetic variation in 60,706 humans
Monkol Lek et al. · Nature
Open access |
Aug 2016 |
10,439 |
| 14 |
The mutational constraint spectrum quantified from variation in 141,456 humans
Konrad J. Karczewski et al. · Nature
Open access177 authors |
27 May 2020 |
10,422 |
| 15 |
CHARMM: The biomolecular simulation program
Bernard R. Brooks et al. · Journal of Computational Chemistry
Open access |
14 May 2009 |
9,331 |
| 16 |
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Christopher J L Murray et al. · The Lancet
Open access362 authors |
Dec 2012 |
9,055 |
| 17 |
Inflammation, Atherosclerosis, and Coronary Artery Disease
Göran K. Hansson · New England Journal of Medicine
|
20 Apr 2005 |
8,822 |
| 18 |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Theo Vos et al. · The Lancet
Open access358 authors |
Dec 2012 |
8,461 |
| 19 |
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke et al. · Nature
Open access297 authors |
Jul 2014 |
8,181 |
| 20 |
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Mohammad Hossein Forouzanfar et al. · The Lancet
Open access654 authors |
Oct 2016 |
7,829 |
| 21 |
Geant4 developments and applications
John E. Allison et al. · IEEE Transactions on Nuclear Science
Open access |
Feb 2006 |
7,047 |
| 22 |
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Lorenzo Galluzzi et al. · Cell Death and Differentiation
Open access169 authors |
23 Jan 2018 |
6,760 |
| 23 |
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
Werner Hacke, Markku Kaste, Erich Bluhmki et al. · New England Journal of Medicine
Open access |
24 Sep 2008 |
6,735 |
| 24 |
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
Theo Vos et al. · The Lancet
Open access679 authors |
7 Jun 2015 |
6,558 |
| 25 |
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015
Christina Fitzmaurice et al. · JAMA Oncology
Open access185 authors |
5 Dec 2016 |
6,333 |
| 26 |
Neuroinflammation in Alzheimer's disease
Michael Thomas Heneka et al. · The Lancet Neurology
Open access |
16 Mar 2015 |
6,318 |
| 27 |
ILAE Official Report: A practical clinical definition of epilepsy
Robert S. Fisher, Carlos Alberto Acevedo, Alexis A. Arzimanoglou et al. · Epilepsia
Open access |
Apr 2014 |
6,110 |
| 28 |
Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science
Emily Alexandra Holmes et al. · The Lancet Psychiatry
Open access |
15 Apr 2020 |
6,092 |
| 29 |
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al. · Autophagy
Open access2,467 authors |
2 Jan 2016 |
6,023 |
| 30 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update
Josef S Smolen et al. · Annals of the Rheumatic Diseases
Open access |
6 Mar 2017 |
5,808 |
| 31 |
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
Bertrand Routy et al. · Science
|
2 Nov 2017 |
5,679 |
| 32 |
European Position Paper on Rhinosinusitis and Nasal Polyps 2020
W.J. Fokkens et al. · Rhinology Journal
Open access148 authors |
Feb 2020 |
5,610 |
| 33 |
HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis
Jan‐Inge Henter, AnnaCarin Horne, Maurizio Aricò et al. · Pediatric Blood & Cancer
|
25 Aug 2006 |
5,452 |
| 34 |
Alternative isoform regulation in human tissue transcriptomes
Eric T. Wang, Rickard Sandberg, Shujun J. Luo et al. · Nature
Open access |
Nov 2008 |
5,451 |
| 35 |
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
Björn Dahlöf, Richard B. Devereux, Sverre Erik Kjeldsen et al. · The Lancet
|
Mar 2002 |
5,432 |
| 36 |
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus
Michelle Petri et al. · Arthritis & Rheumatism
Open access |
2 May 2012 |
5,385 |
| 37 |
Global prevalence of dementia: a Delphi consensus study
Cleusa P. Ferri, Martin James Prince, Carol Brayne et al. · The Lancet
Open access |
Dec 2005 |
5,347 |
| 38 |
Tumour exosome integrins determine organotropic metastasis
Ayuko Hoshino et al. · Nature
Open access |
28 Oct 2015 |
5,240 |
| 39 |
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda et al. · Science Translational Medicine
Open access |
19 Feb 2014 |
5,211 |
| 40 |
External review and validation of the Swedish national inpatient register
Jonas Filip Ludvigsson, Eva Andersson, Anders Ekbom et al. · BMC Public Health
Open access |
9 Jun 2011 |
5,148 |
| 41 |
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee, Chiyoung Ahn, Jinju Han et al. · Nature
|
Sep 2003 |
5,144 |
| 42 |
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Shaun Purcell et al. · Nature
Open access |
Jul 2009 |
5,082 |
| 43 |
Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patients
Sam Schulman, Clive Kearon · Journal of Thrombosis and Haemostasis
Open access |
Apr 2005 |
5,063 |
| 44 |
ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology
Ingrid Eileen Scheffer, Samuel Frank Berkovic, Giuseppe Capovilla et al. · Epilepsia
Open access |
8 Mar 2017 |
5,051 |
| 45 |
Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
Bengt G. Winblad et al. · Journal of Internal Medicine
Open access |
20 Aug 2004 |
5,036 |
| 46 |
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma
S. Vincent Rajkumar et al. · The Lancet Oncology
Open access |
26 Oct 2014 |
5,031 |
| 47 |
Gastric cancer
Elizabeth Catherine Smyth, Magnus Nilsson, Heike Irmgard Grabsch et al. · The Lancet
|
Aug 2020 |
5,024 |
| 48 |
The global prevalence of dementia: A systematic review and metaanalysis
Martin James Prince, Renata Bryce, Emiliano Albanese et al. · Alzheimer s & Dementia
ReviewOpen access |
2013 |
4,986 |
| 49 |
Genetic studies of body mass index yield new insights for obesity biology
The LifeLines Cohort Study et al. · Nature
Open access487 authors |
10 Feb 2015 |
4,954 |
| 50 |
2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD
Francesco Cosentino et al. · European Heart Journal
Open access172 authors |
31 Aug 2019 |
4,930 |