| 1 |
Initial sequencing and analysis of the human genome
Eric S. Lander et al. · Nature
Open access252 authors |
Feb 2001 |
24,745 |
| 2 |
A molecular dynamics method for simulations in the canonical ensemble
Shūichi Nosé · Molecular Physics
|
10 Jun 1984 |
10,260 |
| 3 |
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Tomoya Baba, Takeshi Ara, Miki Launois Hasegawa et al. · Molecular Systems Biology
Open access |
21 Feb 2006 |
8,362 |
| 4 |
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes et al. · Intensive Care Medicine
Open access |
18 Jan 2017 |
6,868 |
| 5 |
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al. · Autophagy
Open access2,467 authors |
2 Jan 2016 |
6,023 |
| 6 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update
Josef S Smolen et al. · Annals of the Rheumatic Diseases
Open access |
6 Mar 2017 |
5,808 |
| 7 |
Mersenne twister
Makoto Matsumoto, Takuji Nishimura · ACM Transactions on Modeling and Computer Simulation
|
1998 |
5,805 |
| 8 |
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Yukihiro Furusawa et al. · Nature
|
13 Nov 2013 |
5,575 |
| 9 |
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature
|
Apr 1998 |
5,278 |
| 10 |
Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
Juri Rappsilber, Matthias Mann, Yasushi Ishihama · Nature Protocols
|
Aug 2007 |
5,019 |
| 11 |
The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer
Peter Goldstraw et al. · Journal of Thoracic Oncology
Open access152 authors |
2016 |
4,749 |
| 12 |
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara, Kenji D. Nakamura, Makoto Matsui et al. · Nature
|
19 Apr 2006 |
3,905 |
| 13 |
The repertoire of mutational signatures in human cancer
Ludmil B. Alexandrov et al. · Nature
Open access1,384 authors |
5 Feb 2020 |
3,854 |
| 14 |
A bacterium that degrades and assimilates poly(ethylene terephthalate)
Shosuke Yoshida, Kazumi Hiraga, Toshihiko Takehana et al. · Science
|
10 Mar 2016 |
3,416 |
| 15 |
TFOS DEWS II Definition and Classification Report
Jennifer P. Craig, Kelly Kinney Nichols, Esen K. Akpek et al. · The Ocular Surface
|
Jul 2017 |
3,402 |
| 16 |
Pan-cancer analysis of whole genomes
Lauri A. Aaltonen et al. · Nature
Open access1,324 authors |
5 Feb 2020 |
3,360 |
| 17 |
Fundamental analysis for visible-light communication system using LED lights
Toshihiko Komine, Masaki Nakagawa · IEEE Transactions on Consumer Electronics
|
Feb 2004 |
3,350 |
| 18 |
Biogenesis of small RNAs in animals
V. Narry Kim, Jinju Han, Mikiko C. Siomi · Nature Reviews Molecular Cell Biology
Review |
23 Jan 2009 |
3,201 |
| 19 |
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi et al. · Nature
|
11 Jun 2003 |
3,196 |
| 20 |
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
Michael Hucka et al. · Bioinformatics
Open access |
28 Feb 2003 |
3,190 |
| 21 |
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Koji Atarashi et al. · Nature
|
9 Jul 2013 |
2,965 |
| 22 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update
Josef S Smolen et al. · Annals of the Rheumatic Diseases
Open access |
22 Jan 2020 |
2,807 |
| 23 |
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi, Michael Karin · Nature reviews. Immunology
Review |
22 Jan 2018 |
2,765 |
| 24 |
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Daniel J. Klionsky et al. · Autophagy
Open access2,930 authors |
2 Jan 2021 |
2,743 |
| 25 |
Cross-national prevalence and risk factors for suicidal ideation, plans and attempts
Matthew K. Nock et al. · The British Journal of Psychiatry
Open access |
31 Jan 2008 |
2,701 |
| 26 |
TFOS DEWS II Epidemiology Report
Fiona Jane Stapleton, Mônica Alves, Vatinee Y. Bunya et al. · The Ocular Surface
Open access |
Jul 2017 |
2,656 |
| 27 |
MassBank: a public repository for sharing mass spectral data for life sciences
Hisayuki Horai et al. · Journal of Mass Spectrometry
Open access |
Jul 2010 |
2,595 |
| 28 |
Initial Invasive or Conservative Strategy for Stable Coronary Disease
David Joel Maron et al. · New England Journal of Medicine
Open access |
30 Mar 2020 |
2,464 |
| 29 |
Traumatic spinal cord injury
Christopher S. Ahuja, Jefferson R. Wilson, Satoshi Nori et al. · Nature Reviews Disease Primers
Review |
26 Apr 2017 |
2,463 |
| 30 |
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial
Yoon‐Koo Kang et al. · The Lancet
Open access |
12 Oct 2017 |
2,317 |
| 31 |
Observation of the spin Seebeck effect
Ken‐ichi Uchida, S. Takahashi, Kazuya Harii et al. · Nature
|
Oct 2008 |
2,263 |
| 32 |
Direct observation of the rotation of F1-ATPase
Hiroyuki Noji, Ryohei Yasuda, Masasuke Yoshida et al. · Nature
|
Mar 1997 |
2,260 |
| 33 |
Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases
Hidefumi Aoyama, Hiroki Shirato, Masao Tago et al. · JAMA
|
6 Jun 2006 |
2,226 |
| 34 |
A promoter-level mammalian expression atlas
Alistair R. R. Forrest et al. · Nature
Open access261 authors |
Mar 2014 |
2,221 |
| 35 |
Conversion of spin current into charge current at room temperature: Inverse spin-Hall effect
Eiji Saitoh, Masahito Ueda, H. Miyajima et al. · Applied Physics Letters
|
May 2006 |
2,175 |
| 36 |
Innate Lymphoid Cells: 10 Years On
Eric D. Vivier, David Artis, Marco Colonna et al. · Cell
Open access |
Aug 2018 |
2,174 |
| 37 |
TFOS DEWS II Diagnostic Methodology report
James S. Wolffsohn, Reiko Arita, Robin L. Chalmers et al. · The Ocular Surface
|
Jul 2017 |
2,152 |
| 38 |
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
Chen Wang, Li Deng, Mei Hong et al. · Nature
|
19 Jul 2001 |
2,134 |
| 39 |
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
Franck Pagès et al. · The Lancet
|
May 2018 |
2,133 |
| 40 |
Violent video game effects on aggression, empathy, and prosocial behavior in Eastern and Western countries: A meta-analytic review.
Craig A. Anderson, Akiko Shibuya, Nobuko Ihori et al. · Psychological Bulletin
|
2010 |
2,046 |
| 41 |
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo et al. · Nature Genetics
|
Jul 2000 |
2,029 |
| 42 |
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
Kazuyo Moro, Taketo Yamada, M. Tanabe et al. · Nature
|
20 Dec 2009 |
2,003 |
| 43 |
A framework for quality management research and an associated measurement instrument
Barbara Bechler Flynn, Roger G. Schroeder, Sadao Sakakibara · Journal of Operations Management
|
Mar 1994 |
1,975 |
| 44 |
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Fumio Arai, Atsushi Hirao, Masako Ohmura et al. · Cell
Open access |
Jul 2004 |
1,960 |
| 45 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update
Josef S Smolen et al. · Annals of the Rheumatic Diseases
Open access |
10 Nov 2022 |
1,921 |
| 46 |
How mental health care should change as a consequence of the COVID-19 pandemic
Carmen Moreno et al. · The Lancet Psychiatry
Open access |
16 Jul 2020 |
1,919 |
| 47 |
Cardiomyocytes can be generated from marrow stromal cells in vitro
Shinji Makino, Keiichi Fukuda, Shunichirou Miyoshi et al. · Journal of Clinical Investigation
Open access |
Mar 1999 |
1,889 |
| 48 |
Motion control for advanced mechatronics
Kouhei Ohnishi, Mizuho Shibata, Toshiyuki Murakami · IEEE/ASME Transactions on Mechatronics
|
Mar 1996 |
1,882 |
| 49 |
The microbiota in adaptive immune homeostasis and disease
Kenya Honda, Dan R. Littman · Nature
|
5 Jul 2016 |
1,880 |
| 50 |
TFOS DEWS II pathophysiology report
Anthony J. Bron, Cintia Sade de Paiva, Sunil K. Chauhan et al. · The Ocular Surface
|
Jul 2017 |
1,822 |