| 1 |
Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma
Dominik Sturm et al. · Cancer Cell
Open access |
Oct 2012 |
1,881 |
| 2 |
Cortical demyelination and diffuse white matter injury in multiple sclerosis
Alexandra Kutzelnigg, Claudia Francesca Lucchinetti, Christine Stadelmann et al. · Brain
|
17 Oct 2005 |
1,857 |
| 3 |
Diagnostic criteria for malnutrition – An ESPEN Consensus Statement
Tommy Cederholm, Ingvar G. Bosaeus, Rocco Barazzoni et al. · Clinical Nutrition
Open access |
9 Mar 2015 |
1,770 |
| 4 |
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia
Willemijn J. Jansen et al. · JAMA
Open access129 authors |
19 May 2015 |
1,662 |
| 5 |
ESPEN expert group recommendations for action against cancer-related malnutrition
Jann Arends, Vickie Elaine Baracos, Hartmut Bertz et al. · Clinical Nutrition
Open access |
23 Jun 2017 |
1,326 |
| 6 |
Skin Wound Healing: An Update on the Current Knowledge and Concepts
Heiko Sorg, Daniel J. Tilkorn, Stephan Hager et al. · European Surgical Research
Open access |
14 Dec 2016 |
1,274 |
| 7 |
Adalimumab with or without Methotrexate in Juvenile Rheumatoid Arthritis
Daniel J. Lovell et al. · New England Journal of Medicine
Open access |
20 Aug 2008 |
635 |
| 8 |
High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial
Eckhard Thiel et al. · The Lancet Oncology
|
22 Oct 2010 |
626 |
| 9 |
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial
Andrés J.M. Ferreri et al. · The Lancet Haematology
Open access |
9 Apr 2016 |
612 |
| 10 |
Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke
Hannelore Ehrenreich et al. · Stroke
Open access |
15 Oct 2009 |
601 |
| 11 |
Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial
Martin Bendszus et al. · The Lancet
449 authors |
11 Oct 2023 |
473 |
| 12 |
Comparison of Basal Insulin Added to Oral Agents Versus Twice-Daily Premixed Insulin as Initial Insulin Therapy for Type 2 Diabetes
Hans Uwe Janka, G. Plewe, Matthew C. Riddle et al. · Diabetes Care
Open access |
Feb 2005 |
414 |
| 13 |
PET-guided treatment in patients with advanced-stage Hodgkin's lymphoma (HD18): final results of an open-label, international, randomised phase 3 trial by the German Hodgkin Study Group
Peter Borchmann et al. · The Lancet
|
23 Oct 2017 |
394 |
| 14 |
Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the International Extranodal Lymphoma Study Group-32 phase 2 trial
Andrés J.M. Ferreri et al. · The Lancet Haematology
Open access |
18 Oct 2017 |
390 |
| 15 |
Infection-Triggered Familial or Recurrent Cases of Acute Necrotizing Encephalopathy Caused by Mutations in a Component of the Nuclear Pore, RANBP2
Derek Neilson et al. · The American Journal of Human Genetics
Open access |
2009 |
368 |
| 16 |
ESPEN guideline on Clinical Nutrition in inflammatory bowel disease
Stephan C. Bischoff, Palle Bager, Johanna C. Escher et al. · Clinical Nutrition
Open access |
13 Jan 2023 |
365 |
| 17 |
Mutations in STRA6 Cause a Broad Spectrum of Malformations Including Anophthalmia, Congenital Heart Defects, Diaphragmatic Hernia, Alveolar Capillary Dysplasia, Lung Hypoplasia, and Mental Retardation
Francesca Pasutto et al. · The American Journal of Human Genetics
Open access |
5 Feb 2007 |
363 |
| 18 |
Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study
Klaus‐Peter Dieckmann et al. · Journal of Clinical Oncology
Open access |
15 Mar 2019 |
354 |
| 19 |
Indirect methods for reference interval determination – review and recommendations
Graham R.D. Jones, Rainer Haeckel, Tze Ping Loh et al. · Clinical Chemistry and Laboratory Medicine (CCLM)
|
19 Apr 2018 |
353 |
| 20 |
Outcome according to KRAS-, NRAS- and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by the AIO colorectal cancer study group
Dominik Paul Modest, Ingrid Ricard, Volker Heinemann et al. · Annals of Oncology
Open access |
29 Jun 2016 |
353 |
| 21 |
Effect of preoperative chemoradiation in addition to preoperative chemotherapy: a randomised trial in stage III non-small-cell lung cancer
Michael Thomas, Christian Rübe, Petra Hoffknecht et al. · The Lancet Oncology
|
25 Jun 2008 |
348 |
| 22 |
Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants
for the SAKK and the German CML Study Group et al. · Leukemia
Open access |
14 Aug 2017 |
342 |
| 23 |
Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study
Samantha Claudia Gouw et al. · Blood
|
4 Apr 2013 |
331 |
| 24 |
Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study
Jan Menne et al. · BMJ
Open access |
19 Jul 2012 |
310 |
| 25 |
A de novo gain-of-function mutation in SCN11A causes loss of pain perception
Enrico Leipold et al. · Nature Genetics
|
15 Sep 2013 |
309 |
| 26 |
Autosomal recessive hyperimmunoglobulin E syndrome: a distinct disease entity
Eleonore D. Renner, Jennifer M. Puck, Steven M. Holland et al. · The Journal of Pediatrics
|
2004 |
302 |
| 27 |
Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial
Dieter F. Hoelzer et al. · Blood
Open access |
31 Oct 2014 |
299 |
| 28 |
ESPEN guideline on clinical nutrition in acute and chronic pancreatitis
Marianna Arvanitakis, Johann Ockenga, Mihailo Bezmarević et al. · Clinical Nutrition
Open access |
22 Jan 2020 |
291 |
| 29 |
Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD
Richard F. Schlenk et al. · Blood
Open access |
18 Dec 2018 |
290 |
| 30 |
Cerebral Microbleeds in CADASIL
Martin Dichgans, Markus Holtmannspötter, Jürgen Herzog et al. · Stroke
Open access |
2002 |
288 |
| 31 |
Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels
Marios‐Nikos Psychogios et al. · New England Journal of Medicine
Open access |
5 Feb 2025 |
260 |
| 32 |
Treatment and prognostic impact of transient leukemia in neonates with Down syndrome
Jan‐Henning Klusmann, Ursula Creutzig, Martin Zimmermann et al. · Blood
Open access |
9 Jan 2008 |
259 |
| 33 |
Functional Outcome Following Stroke Thrombectomy in Clinical Practice
Frank Arne Wollenweber et al. · Stroke
Open access |
24 Jul 2019 |
255 |
| 34 |
S3-Leitlinie – Kolorektales Karzinom
Wolff Schmiegel, Barbara Buchberger, Markus Follmann et al. · Zeitschrift für Gastroenterologie
Open access |
Dec 2017 |
244 |
| 35 |
Cetuximab plus cisplatin–5-fluorouracil versus cisplatin–5-fluorouracil alone in first-line metastatic squamous cell carcinoma of the esophagus: a randomized phase II study of the Arbeitsgemeinschaft Internistische Onkologie
Sylvie Lorenzen, Tibor Schuster, Rainer Porschen et al. · Annals of Oncology
Open access |
24 Jun 2009 |
243 |
| 36 |
Agreement of different methods for assessing sleep characteristics: a comparison of two actigraphs, wrist and hip placement, and self-report with polysomnography
Melanie Zinkhan, Klaus Berger, Sabrina Hense et al. · Sleep Medicine
|
28 May 2014 |
243 |
| 37 |
Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
Huriye Cin et al. · Acta Neuropathologica
|
19 Mar 2011 |
240 |
| 38 |
Man against machine reloaded: performance of a market-approved convolutional neural network in classifying a broad spectrum of skin lesions in comparison with 96 dermatologists working under less artificial conditions
Holger Andreas Haenssle et al. · Annals of Oncology
Open access |
2020 |
239 |
| 39 |
Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic–uraemic syndrome: an analysis of the German STEC-HUS registry
Jan Thomas Kielstein et al. · Nephrology Dialysis Transplantation
|
Oct 2012 |
239 |
| 40 |
Positron Emission Tomography–Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group
Michael Fuchs et al. · Journal of Clinical Oncology
|
9 Sep 2019 |
233 |
| 41 |
PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups
Lars Henning Schmidt, Andreas Kümmel, Dennis Görlich et al. · PLoS ONE
Open access |
27 Aug 2015 |
232 |
| 42 |
Working memory related gamma oscillations in schizophrenia patients
Canan Başar‐Eroğlu, Andreas Brand, Helmut Hildebrandt et al. · International Journal of Psychophysiology
|
8 Sep 2006 |
229 |
| 43 |
e-ASPECTS software is non-inferior to neuroradiologists in applying the ASPECT score to computed tomography scans of acute ischemic stroke patients
Simon Nagel et al. · International Journal of Stroke
Open access |
29 Nov 2016 |
218 |
| 44 |
Retinopathy and Vision Loss in Insulin-dependent Diabetes in Europe
Anne Katrin Sjølie et al. · Ophthalmology
127 authors |
Feb 1997 |
216 |
| 45 |
Distinguishing reference intervals and clinical decision limits – A review by the IFCC Committee on Reference Intervals and Decision Limits
Yeşim Özarda, Ken A. Sikaris, Thomas Streichert et al. · Critical Reviews in Clinical Laboratory Sciences
Review |
26 Jul 2018 |
212 |
| 46 |
Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein for Differentiating Intracerebral Hemorrhage and Cerebral Ischemia in Patients with Symptoms of Acute Stroke
Christian Foerch, Marion Niessner, Tobias Back et al. · Clinical Chemistry
|
29 Nov 2011 |
211 |
| 47 |
Serum Levels of MicroRNA miR-371a-3p: A Sensitive and Specific New Biomarker for Germ Cell Tumours
Klaus‐Peter Dieckmann, Arlo Radtke, Meike Spiekermann et al. · European Urology
Open access |
3 Aug 2016 |
210 |
| 48 |
Quality of Life in orthognathic surgery patients: Post-surgical improvements in aesthetics and self-confidence
Jan Rustemeyer, Johanne Gregersen · Journal of Cranio-Maxillofacial Surgery
|
28 Aug 2011 |
200 |
| 49 |
18F-FDG PET for Mediastinal Staging of Lung Cancer: Which SUV Threshold Makes Sense?
Dirk Hellwig, Thomas P Graeter, D. Ukena et al. · Journal of Nuclear Medicine
Open access |
17 Oct 2007 |
199 |
| 50 |
Pathway-controlled fast-track rehabilitation after total knee arthroplasty: a randomized prospective clinical study evaluating the recovery pattern, drug consumption, and length of stay
Adrianus den Hertog, Kerstin Gliesche, Jürgen Timm et al. · Archives of Orthopaedic and Trauma Surgery
Open access |
27 May 2012 |
198 |