| 1 |
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke et al. · Nature
Open access297 authors |
Jul 2014 |
8,181 |
| 2 |
Cu-Catalyzed Azide−Alkyne Cycloaddition
Morten Meldal, Christian Wenzel Tornøe · Chemical Reviews
Review |
Aug 2008 |
4,612 |
| 3 |
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup
Clifford R. Jack, Jeffrey Scott Andrews, Thomas G. Beach et al. · Alzheimer s & Dementia
Open access |
27 Jun 2024 |
2,670 |
| 4 |
Four deaths and a funeral: from caspases to alternative mechanisms
Marcel Leist, Marja Jäättelä · Nature Reviews Molecular Cell Biology
ReviewOpen access |
Aug 2001 |
1,599 |
| 5 |
Community-led, integrated, reproducible multi-omics with anvi’o
A. Murat Eren et al. · Nature Microbiology
Open access |
21 Dec 2020 |
1,028 |
| 6 |
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
Christian Hansen, Élodie Angot, Ann‐Louise Bergström et al. · Journal of Clinical Investigation
Open access |
18 Jan 2011 |
854 |
| 7 |
Global mapping of pharmacological space
Gaia Valeria Paolini, Richard H B Shapland, Willem P. van Hoorn et al. · Nature Biotechnology
|
Jul 2006 |
820 |
| 8 |
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Colm T. O'Dushlaine et al. · Nature Neuroscience
Open access375 authors |
19 Jan 2015 |
807 |
| 9 |
Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic
Marcel Leist et al. · Science
Open access |
8 Jul 2004 |
805 |
| 10 |
SCH 23390—The first selective dopamine D-1 antagonist
John Hyttel · European Journal of Pharmacology
|
Jul 1983 |
740 |
| 11 |
CNVs conferring risk of autism or schizophrenia affect cognition in controls
Hreinn Stefánsson et al. · Nature
Open access |
18 Dec 2013 |
737 |
| 12 |
Recent Advances in Wave Function-Based Methods of Molecular-Property Calculations
Trygve Ulf Helgaker, Sonia Coriani, Poul Jørgensen et al. · Chemical Reviews
Review |
11 Jan 2012 |
734 |
| 13 |
Lysosomes in cell death
Maria Eugenia Guicciardi, Marcel Leist, Gregory James Gores · Oncogene
Open access |
12 Apr 2004 |
719 |
| 14 |
Do Novel Antipsychotics Have Similar Pharmacological Characteristics? A Review of the Evidence
J�rn Arnt · Neuropsychopharmacology
Open access |
Feb 1998 |
716 |
| 15 |
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Inge R. Holtman, Divya D. A. Raj, Jeremy A. Miller et al. · Acta Neuropathologica Communications
Open access |
21 May 2015 |
694 |
| 16 |
Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor
Lasse Foghsgaard, Dorte Wissing, Daniel Mauch et al. · The Journal of Cell Biology
Open access |
21 May 2001 |
631 |
| 17 |
Influence of microemulsions on cutaneous drug delivery
Mads Kreilgaard · Advanced Drug Delivery Reviews
Review |
Nov 2002 |
626 |
| 18 |
Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles
Ralf Baron et al. · Pain
Open access |
3 Nov 2016 |
620 |
| 19 |
Pre‐operative radiotherapy prolongs survival in operable esophageal carcinoma: A randomized, multicenter study of pre‐operative radiotherapy and chemotherapy. The second scandinavian trial in esophageal cancer
Knut Nygaard, Steinar Hagen, Hanne Sand Hansen et al. · World Journal of Surgery
|
Nov 1992 |
620 |
| 20 |
Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder
Benny Bang‐Andersen, Thomas M. Ruhland, Morten Jørgensen et al. · Journal of Medicinal Chemistry
Open access |
12 Apr 2011 |
604 |
| 21 |
Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity
John Hyttel · Progress in Neuro-Psychopharmacology and Biological Psychiatry
|
1982 |
587 |
| 22 |
The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional
Joshua D. Shrout, David L. Chopp, Collin L. Just et al. · Molecular Microbiology
Open access |
24 Oct 2006 |
585 |
| 23 |
Vortioxetine, a novel antidepressant with multimodal activity: Review of preclinical and clinical data
Connie Sánchez, Karen E. Asin, Francesc Artigas · Pharmacology & Therapeutics
Open access |
9 Jul 2014 |
545 |
| 24 |
Efficient ancestry and mutation simulation with msprime 1.0
Franz Baumdicker et al. · Genetics
Open access |
13 Dec 2021 |
543 |
| 25 |
The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways
Günaj Rakipovski, Bidda Rolin, Jane Nøhr et al. · JACC Basic to Translational Science
Open access |
21 Nov 2018 |
517 |
| 26 |
Oxidative stress and inflammation in Parkinson's disease: is there a causal link?
Andreas Hald, Julie Lotharius · Experimental Neurology
|
4 Mar 2005 |
510 |
| 27 |
Chronic Pain, Chronic Stress and Depression: Coincidence or Consequence?
Gordon Blackburn-Munro, Ruth E. Blackburn-Munro · Journal of Neuroendocrinology
|
Dec 2001 |
502 |
| 28 |
Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)
John Hyttel · International Clinical Psychopharmacology
|
Mar 1994 |
495 |
| 29 |
The impact of the prolonged COVID-19 pandemic on stress resilience and mental health: A critical review across waves
Mirko Manchia, Anouk W. Gathier, Hale Yapıcı Eser et al. · European Neuropsychopharmacology
Open access |
29 Oct 2021 |
492 |
| 30 |
Extending the Treatment Options in Alcohol Dependence: A Randomized Controlled Study of As-Needed Nalmefene
Karl F Mann, Anna Bladström, Lars Torup et al. · Biological Psychiatry
|
10 Dec 2012 |
482 |
| 31 |
Influence of Phasic and Tonic Dopamine Release on Receptor Activation
Jakob Kisbye Dreyer, Kjartan Frisch Herrik, Rune W. Berg et al. · Journal of Neuroscience
Open access |
20 Oct 2010 |
445 |
| 32 |
A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder
Cornelius Katona, Thomas Michael Hansen, Christina Kurre Olsen · International Clinical Psychopharmacology
|
8 May 2012 |
444 |
| 33 |
A Common Reference Framework for Analyzing/Comparing Proteins and Ligands. Fingerprints for Ligands And Proteins (FLAP): Theory and Application
Massimo Baroni, Gabriele Cruciani, Simone Sciabola et al. · Journal of Chemical Information and Modeling
|
9 Jan 2007 |
442 |
| 34 |
The effect of oxcarbazepine in peripheral neuropathic pain depends on pain phenotype: A randomised, double-blind, placebo-controlled phenotype-stratified study
Dyveke T. Demant, Karen Lund, Jan Vollert et al. · Pain
|
16 Aug 2014 |
442 |
| 35 |
Long-term temporal and spatial trends in eutrophication status of the Baltic Sea
Jesper H. Andersen, Jacob Carstensen, Daniel J. Conley et al. · Biological reviews/Biological reviews of the Cambridge Philosophical Society
ReviewOpen access |
14 Oct 2015 |
441 |
| 36 |
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Serhat Erbayraktar et al. · Proceedings of the National Academy of Sciences
Open access |
13 May 2003 |
437 |
| 37 |
A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults
Roger S. McIntyre, Søren Lophaven, Christina Kurre Olsen · The International Journal of Neuropsychopharmacology
Open access |
30 Apr 2014 |
437 |
| 38 |
Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial
Murat Emre, Magda Tsolaki, Ubaldo Bonuccelli et al. · The Lancet Neurology
|
22 Aug 2010 |
436 |
| 39 |
Comparison of the Effects of Antidepressants and Their Metabolites on Reuptake of Biogenic Amines and on Receptor Binding
Connie Sánchez, John Hyttel · Cellular and Molecular Neurobiology
Open access |
Aug 1999 |
434 |
| 40 |
Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: A prospective multicenter trial of the scandinavian glioblastoma study group
Kristian Uldall Kristiansen, Suzanne Hagen, T Kollevold et al. · Cancer
|
15 Feb 1981 |
422 |
| 41 |
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits
Dennis R. Sparta, Alice M. Stamatakis, Jana L. Phillips et al. · Nature Protocols
Open access |
8 Dec 2011 |
416 |
| 42 |
Kynurenines in CNS disease: regulation by inflammatory cytokines
Brian Campbell, Erik I. Charych, Anna W. Lee et al. · Frontiers in Neuroscience
Open access |
2014 |
416 |
| 43 |
A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence
Antoni Gual, Yuan He, Lars Torup et al. · European Neuropsychopharmacology
|
4 Apr 2013 |
404 |
| 44 |
Why still in hospital after fast-track hip and knee arthroplasty?
Henrik Husted, Troels Haxholdt Lunn, Anders Troelsen et al. · Acta Orthopaedica
Open access |
9 Nov 2011 |
404 |
| 45 |
Reduced signal for polygenic adaptation of height in UK Biobank
Jeremy J. Berg, Arbel Harpak, Nasa Sinnott-Armstrong et al. · eLife
Open access |
20 Mar 2019 |
395 |
| 46 |
Use of pharmaceutical salts and cocrystals to address the issue of poor solubility
David P. Elder, René Holm, Heidi Lopez de Diego · International Journal of Pharmaceutics
|
24 Nov 2012 |
393 |
| 47 |
Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics
Anne Vibeke Christensen, J�rn Arnt, John Hyttel et al. · Life Sciences
|
Apr 1984 |
376 |
| 48 |
In vitro models for the prediction of in vivo performance of oral dosage forms
Edmund S. Kostewicz, Bertil Abrahamsson, Marcus Eli Brewster et al. · European Journal of Pharmaceutical Sciences
Open access |
27 Aug 2013 |
372 |
| 49 |
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Pascal Steullet, J-H Cabungcal, Joseph T. Coyle et al. · Molecular Psychiatry
Open access |
21 Mar 2017 |
370 |
| 50 |
Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator
Kenji Maeda, Haruhiko Sugino, Hitomi Akazawa et al. · Journal of Pharmacology and Experimental Therapeutics
|
20 Jun 2014 |
369 |