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Institution · Medicina

Most cited papers from Medicina

What are the most cited papers from Medicina?

The most cited paper from Medicina is "GW190521: A Binary Black Hole Merger with a Total Mass of 150 M ⊙" (R. Abbott et al., 2020), with 1,354 citations. Next come "Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications" (1,034) and "Modular Organization of Genes Required for Complex Polyketide Biosynthesis" (914).

Showing 50 of 60 papers. Every paper with more than 147 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 GW190521: A Binary Black Hole Merger with a Total Mass of 150 M ⊙ R. Abbott et al. · Physical Review Letters Open access1,256 authors 2 Sep 2020 1,354
2 Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications Javad Sharifi‐Rad et al. · Frontiers in Pharmacology Open access 15 Sep 2020 1,034
3 Modular Organization of Genes Required for Complex Polyketide Biosynthesis Stefano Donadio, Michael J. Staver, James B. McAlpine et al. · Science 3 May 1991 914
4 Accelerated reaction of nitric oxide with O 2 within the hydrophobic interior of biological membranes Xiaoping Liu, Mark J.S. Miller, Mahesh S. Joshi et al. · Proceedings of the National Academy of Sciences Open access 3 Mar 1998 600
5 Recent advances in employing homoenolates generated by N-heterocyclic carbene (NHC) catalysis in carbon–carbon bond-forming reactions Rajeev S. Menon, Akkattu T. Biju, Vijay Nair · Chemical Society Reviews Review 2015 597
6 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis Peter C. Grayson et al. · Annals of the Rheumatic Diseases Open access153 authors 2 Feb 2022 556
7 Generic GPCR residue numbers – aligning topology maps while minding the gaps Vignir Ísberg, Chris de Graaf, Andrea Bortolato et al. · Trends in Pharmacological Sciences ReviewOpen access 22 Dec 2014 518
8 Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes Travis T. Wager, Ramalakshmi Yegna Chandrasekaran, Xinjun Hou et al. · ACS Chemical Neuroscience Open access 25 Mar 2010 492
9 p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. R M Hudziak, G D Lewis, M Winget et al. · Molecular and Cellular Biology Mar 1989 489
10 A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam Susan J. Murch, Paul Alan Cox, Sandra Anne Banack · Proceedings of the National Academy of Sciences Open access 4 Aug 2004 417
11 Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening Maria A. Loane et al. · European Journal of Human Genetics Open access 20 Jun 2012 377
12 Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats Laura Gabriela Sánchez‐Lozada, Edilia Tapia, Adriana Jiménez et al. · American Journal of Physiology-Renal Physiology 30 Aug 2006 356
13 Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1 Lisa A. Ridnour, Jeffrey Scott Isenberg, Michael Graham Espey et al. · Proceedings of the National Academy of Sciences Open access 2 Sep 2005 323
14 Identification of Cytochrome P450 2E1 as the Predominant Enzyme Catalyzing Human Liver Microsomal Defluorination of Sevoflurane, Isoflurane, and Methoxyflurane Evan D. Kharasch, Kenneth E. Thummel · Anesthesiology Open access Oct 1993 318
15 Epidemiology of congenital diaphragmatic hernia in Europe: a register-based study M McGivern et al. · Archives of Disease in Childhood Fetal & Neonatal 19 Nov 2014 317
16 Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia Laura Gabriela Sánchez‐Lozada, Virgilia Soto, Edilia Tapia et al. · American Journal of Physiology-Renal Physiology Open access Oct 2008 309
17 Late-stage [ 18 F]fluorination: new solutions to old problems Allen F. Brooks, Joseph J. Topczewski, Naoko Ichiishi et al. · Chemical Science Open access 2014 308
18 Modifications of dietary flavonoids towards improved bioactivity: An update on structure–activity relationship Lei Chen, Hui Teng, Zhenglu Xie et al. · Critical Reviews in Food Science and Nutrition Open access 20 Jul 2016 293
19 Countercurrent Separation of Natural Products: An Update J. Brent Friesen, James B. McAlpine, Shao‐Nong Chen et al. · Journal of Natural Products Open access 15 Jul 2015 293
20 Mechanistic insights and perspectives involved in neuroprotective action of quercetin Amarjot Kaur Grewal, Thakur Gurjeet Singh, Deepak Sharma et al. · Biomedicine & Pharmacotherapy Open access 24 May 2021 288
21 Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance Phillip A. Schwartz, Petr Kuzmič, James E. Solowiej et al. · Proceedings of the National Academy of Sciences Open access 17 Dec 2013 284
22 Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview Sankalan Mondal, Gautam Panda · RSC Advances Open access 2014 278
23 PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations Helen Y. Zou et al. · Proceedings of the National Academy of Sciences Open access 2 Mar 2015 271
24 Facile elaboration of porphyrins via metal-mediated cross-coupling Stephen G. DiMagno, Victor S.‐Y. Lin, Michael J. Therien · The Journal of Organic Chemistry Oct 1993 265
25 European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients Olga P. Nyssen et al. · Gut Open access 21 Sep 2020 263
26 The Chemokine Receptor CCR7 Activates in Dendritic Cells Two Signaling Modules That Independently Regulate Chemotaxis and Migratory Speed Lorena Riol‐Blanco, Noelia Sánchez‐Sánchez, A.L. Torres et al. · The Journal of Immunology Apr 2005 261
27 Common mental disorders in Santiago, Chile Ricardo Araya, Graciela Rojas, Rosemarie Fritsch et al. · The British Journal of Psychiatry Open access Mar 2001 260
28 Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery? Jonathan Bisson, James B. McAlpine, J. Brent Friesen et al. · Journal of Medicinal Chemistry Open access 27 Oct 2015 251
29 The Biphasic Nature of Nitric Oxide Responses in Tumor Biology Lisa A. Ridnour, Douglas D. Thomas, Sonia Donzelli et al. · Antioxidants and Redox Signaling Jul 2006 247
30 Copy-Number Disorders Are a Common Cause of Congenital Kidney Malformations Simone Sanna‐Cherchi et al. · The American Journal of Human Genetics Open access 15 Nov 2012 242
31 Crystal Structure of Human Squalene Synthase Jayvardhan Pandit, Dennis E. Danley, Gayle K. Schulte et al. · Journal of Biological Chemistry Open access Sep 2000 241
32 The relationship between phenolic compounds from diet and microbiota: impact on human health Lorena Valdés, Amable J. Valdés Cuervo, Nuria Salazar et al. · Food & Function Open access 2015 237
33 Recent advances in deep-sea natural products Danielle Skropeta, Liangqian Wei · Natural Product Reports 2014 233
34 Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells. Wen Gao, T Shirasaka, David G. Johns et al. · Journal of Clinical Investigation Open access May 1993 233
35 Guest Molecule-Responsive Functional Calcium Phosphonate Frameworks for Tuned Proton Conductivity Montse Bazaga-García, Rosario M. P. Colodrero, Maria I. Papadaki et al. · Journal of the American Chemical Society Open access 18 Mar 2014 230
36 GPCRdb: the G protein‐coupled receptor database – an introduction Christian Munk, Vignir Ísberg, Stefan Mordalski et al. · British Journal of Pharmacology Open access 8 May 2016 218
37 Polyamines and their possible mechanisms involved in plant physiological processes and elicitation of secondary metabolites Seyed Hamid Mustafavi, H Naghdi Badi, Agnieszka Sękara et al. · Acta Physiologiae Plantarum 3 May 2018 214
38 Two Group A Streptococcal Peptide Pheromones Act through Opposing Rgg Regulators to Control Biofilm Development Jennifer C. Chang, Breah LaSarre, Juan Cristobal Jimenez et al. · PLoS Pathogens Open access 4 Aug 2011 211
39 Production of the Neurotoxin BMAA by a Marine Cyanobacterium Sandra Anne Banack, Holly E. Johnson, Ran Cheng et al. · Marine Drugs Open access 6 Dec 2007 189
40 International Variations in Harsh Child Discipline Desmond K. Runyan, V. Shankar, Fatma Hassan et al. · PEDIATRICS Open access 3 Aug 2010 184
41 Multi-functional analysis ofKlebsiella pneumoniaefimbrial types in adherence and biofilm formation Marı́a Dolores Alcántar-Curiel, Dana Blackburn, Zeus Saldaña‐Ahuactzi et al. · Virulence Open access 7 Feb 2013 184
42 An erythromycin analog produced by reprogramming of polyketide synthesis. Stefano Donadio, James B. McAlpine, P Sheldon et al. · Proceedings of the National Academy of Sciences Open access Aug 1993 183
43 Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms STACIE E. GELLER, LEE P. SHULMAN, Richard Bruce van Breemen et al. · Menopause The Journal of The North American Menopause Society Open access Nov 2009 179
44 Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial José Antonio Pérez‐Simón, Olga López‐Villar, Enrique José Andreu et al. · Haematologica Open access 10 Mar 2011 177
45 The Evolution of Vivipary in Flowering Plants Thomas Elmqvist, Paul Alan Cox · Oikos Oct 1996 177
46 Cardiopulmonary Exercise Test: Fundamentals, Applicability and Interpretation Artur Haddad Herdy, Luiz Eduardo Fonteles Ritt, Ricardo Stein et al. · Arquivos Brasileiros de Cardiologia Open access 2016 173
47 Psychosine Accumulates in Membrane Microdomains in the Brain of Krabbe Patients, Disrupting the Raft Architecture Adam B. White, Maria Irene Givogri, Aurora Lopez‐Rosas et al. · Journal of Neuroscience Open access 13 May 2009 173
48 A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications Awais Ahmad, Nabisab Mujawar Mubarak, Fakiha Tul Jannat et al. · Processes Open access 11 Jan 2021 172
49 Methods for the stereoselective cis-cyanohydroxylation and -carboxyhydroxylation of olefins Alan P. Kozikowski, Maciej Adamcz · The Journal of Organic Chemistry Feb 1983 171
50 Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide Michael Graham Espey, Douglas D. Thomas, Katrina M. Miranda et al. · Proceedings of the National Academy of Sciences Open access 12 Aug 2002 170

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.