Most cited papers from Medivir (Sweden)

Medivir (Sweden)

What are the most cited papers from Medivir (Sweden)?

The most cited paper from Medivir (Sweden) is "MAIT cells are activated during human viral infections" (Bonnie van Wilgenburg et al., 2016), with 532 citations. Next come "Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs" (238) and "Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor" (217).

Published TypeFieldAccessCitations

Showing 50 of 59 papers. Every paper with more than 42 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	MAIT cells are activated during human viral infections Bonnie van Wilgenburg et al. · Nature Communications Open access	23 Jun 2016	532
2	Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs Staffan Eriksson, Borys Kierdaszuk, Birgitte Munch‐Petersen et al. · Biochemical and Biophysical Research Communications	Apr 1991	238
3	Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor Åsa Rosenquist, Bertil Samuelsson, Per-Ola Johansson et al. · Journal of Medicinal Chemistry	21 Jan 2014	217
4	In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435 Oliver Lenz, Thierry Verbinnen, Tse‐I Lin et al. · Antimicrobial Agents and Chemotherapy Open access	23 Feb 2010	211
5	Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4 Peishen Zhao, TinaMarie Lieu, Nicholas Barlow et al. · Journal of Biological Chemistry Open access	13 Aug 2014	191
6	In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor Tse‐I Lin, Oliver Lenz, Gregory C. Fanning et al. · Antimicrobial Agents and Chemotherapy Open access	27 Jan 2009	190
7	Plasmepsins as potential targets for new antimalarial therapy Karolina Ersmark, Bertil Samuelsson, Anders Hallberg · Medicinal Research Reviews	2006	168
8	HIV-1-Specific Reverse Transcriptase Inhibitors Show Differential Activity against HIV-1 Mutant Strains Containing Different Amino Acid Substitutions in the Reverse Transcriptase Jan M. Balzarini, Anna Karlsson, María‐Jesús Pérez‐Pérez et al. · Virology	1993	153
9	Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus M. Azim Ansari et al. · Nature Genetics Open access	10 Apr 2017	151
10	Relationships between Structure and Interaction Kinetics for HIV-1 Protease Inhibitors Per-Olof Markgren, Wesley Schaal, Markku Hämäläinen et al. · Journal of Medicinal Chemistry Open access	25 Oct 2002	150
11	Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis Philip G. Conaghan, M.A. Bowes, Sarah R. Kingsbury et al. · Annals of Internal Medicine	30 Dec 2019	149
12	Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350 Pierre Raboisson et al. · Bioorganic & Medicinal Chemistry Letters	25 Jul 2008	141
13	Structural basis for the inhibitory efficacy of efavirenz (DMP‐266), MSC194 and PNU142721 towards the HIV‐1 RT K103N mutant Jimmy Lindberg, Snævar Sigurðsson, Seved Löwgren et al. · European Journal of Biochemistry Open access	14 Mar 2002	137
14	Effects of GABA agonists on body temperature regulation in GABAB(1)−/− mice Christophe Quéva, Marianne Bremner‐Danielsen, ANDERS EDLUND et al. · British Journal of Pharmacology Open access	Sep 2003	120
15	Phenethylthiazolylthiourea (PETT) Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 2. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogs Amanda S. Cantrell, Per Engelhardt, Marita Högberg et al. · Journal of Medicinal Chemistry Open access	1996	113
16	Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase): A comparative study of different C-terminals Anja Johansson, Anton Poliakov, Eva B. Akerblom et al. · Bioorganic & Medicinal Chemistry	19 May 2003	110
17	Potent Inhibitors of the Plasmodium falciparum Enzymes Plasmepsin I and II Devoid of Cathepsin D Inhibitory Activity Karolina Ersmark, Isabella Feierberg, Sinisa Bjelic et al. · Journal of Medicinal Chemistry Open access	9 Dec 2003	107
18	dUTPase as a Platform for Antimalarial Drug Design: Structural Basis for the Selectivity of a Class of Nucleoside Inhibitors Jean L. Whittingham, Isabel Leal, Corinne Nguyen et al. · Structure Open access	Feb 2005	99
19	The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine David B. Smith, Genadiy Kalayanov, Christian J. Sund et al. · Journal of Medicinal Chemistry	2 Apr 2009	99
20	Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target Maxwell D. Cummings, Jimmy Lindberg, Tse‐I Lin et al. · Angewandte Chemie International Edition	17 Feb 2010	96
21	2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups Klaus Klumpp et al. · Journal of Biological Chemistry Open access	15 Nov 2007	96
22	Prevention of simian immunodeficiency virus, SIVsm, or HIV-2 infection in cynomolgus monkeys by pre- and postexposure administration of BEA-005 Disa Böttiger, Nils‐Gunnar Johansson, Bengt O. Samuelsson et al. · AIDS	Feb 1997	95
23	Support Vector Machines for the Estimation of Aqueous Solubility Peter Lind, Tatiana V. Maltseva · Journal of Chemical Information and Computer Sciences	17 Oct 2003	94
24	Urea−PETT Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 3. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogues Marita Högberg, Christer Sahlberg, Per Engelhardt et al. · Journal of Medicinal Chemistry Open access	14 Sep 1999	89
25	Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in Plasmodium falciparum-Infected Cultured Human Erythrocytes Daniel Nöteberg, Elizabeth Hamelink, Johan Hultén et al. · Journal of Medicinal Chemistry Open access	22 Jan 2003	88
26	The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis Erik Lindström, Biljana Rizoska, Karin Tunblad et al. · Journal of Translational Medicine Open access	9 Mar 2018	82
27	Direct Epoxidation in Candida antarctica Lipase B Studied by Experiment and Theory Maria Svedendahl Humble, Peter Carlqvist, Cecilia Branneby et al. · ChemBioChem Open access	6 Oct 2008	81
28	Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein Oscar Belda, Paul Targett‐Adams · Virus Research	23 Sep 2012	80
29	Acridine/acridone: a simple scaffold with a wide range of application in oncology Philippe Belmont, Ismet B. Dorange · Expert Opinion on Therapeutic Patents	29 Oct 2008	76
30	Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work Anna-Karin Sohlenius-Sternbeck, Ylva Terelius · Drug Metabolism and Disposition Open access	8 Nov 2021	72
31	Structure-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases. Nils Gunnar Johansson, S. Eriksson · PubMed	1996	72
32	The optimal DFT approach in DP4 NMR structure analysis – pushing the limits of relative configuration elucidation Kristaps Ermanis, Kevin E. B. Parkes, Tatiana Agback et al. · Organic & Biomolecular Chemistry Open access	2019	70
33	Doubling the power of DP4 for computational structure elucidation Kristaps Ermanis, Kevin E. B. Parkes, Tatiana Agback et al. · Organic & Biomolecular Chemistry Open access	2017	69
34	High-Speed Optimization of Inhibitors of the Malarial Proteases Plasmepsin I and II Daniel Nöteberg, Wesley Schaal, Elizabeth Hamelink et al. · Journal of Combinatorial Chemistry Open access	17 May 2003	69
35	Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S Silke Haerteis, Matteus Krappitz, Marko Bertog et al. · Pflügers Archiv - European Journal of Physiology Open access	4 Aug 2012	68
36	Double-Blind, Randomized, Placebo-Controlled Study of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of UV Radiation-Induced Herpes Labialis Thomas G. Evans, David I. Bernstein, G. Wayne Raborn et al. · Antimicrobial Agents and Chemotherapy Open access	Jun 2002	67
37	Synthesis of Malarial Plasmepsin Inhibitors and Prediction of Binding Modes by Molecular Dynamics Simulations Karolina Ersmark, Martin Nervall, Elizabeth Hamelink et al. · Journal of Medicinal Chemistry Open access	23 Aug 2005	64
38	Achievements and Challenges in Antiviral Drug Discovery Eddy Littler, Bo F. Öberg · Antiviral chemistry & chemotherapy	Jun 2005	63
39	Rational design of polymerase inhibitors as antiviral drugs Bo F. Öberg · Antiviral Research	7 Jun 2006	61
40	Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice Lena Svelander, Helena Erlandsson-Harris, Leif Astner et al. · European Journal of Pharmacology	8 Apr 2009	58
41	Effect of the Protonation State of the Titratable Residues on the Inhibitor Affinity to BACE-1 José Luís Domínguez‐García, Tony Christopeit, M. Carmen Villaverde et al. · Biochemistry	26 Jul 2010	57
42	Changes in vascular permeability in the spinal cord contribute to chemotherapy-induced neuropathic pain Karli Montague-Cardoso, Thomas Pitcher, Kim Chisolm et al. · Brain Behavior and Immunity Open access	24 Oct 2019	56
43	2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase Tim H. M. Jonckers et al. · Journal of Medicinal Chemistry	29 Oct 2010	55
44	Criteria for confirming sequence periodicity identified by Fourier transform analysis: Application to GCR2, a candidate plant GPCR? Christopher J. R. Illingworth, Kevin E. Parkes, Christopher R. Snell et al. · Biophysical Chemistry Open access	27 Nov 2007	55
45	Expanding DP4: application to drug compounds and automation Kristaps Ermanis, Kevin E. B. Parkes, Tatiana Agback et al. · Organic & Biomolecular Chemistry Open access	2016	52
46	Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library Helena Nordström, Thomas Gossas, Markku Hämäläinen et al. · Journal of Medicinal Chemistry Open access	22 May 2008	52
47	Design and Synthesis of Potent Inhibitors of the Malaria Aspartyl Proteases Plasmepsin I and II. Use of Solid-Phase Synthesis to Explore Novel Statine Motifs Per-Ola Johansson, Yantao Chen, Anna Karin Belfrage et al. · Journal of Medicinal Chemistry Open access	26 May 2004	51
48	C2-Symmetric inhibitors of Plasmodium falciparum plasmepsin II: synthesis and theoretical predictions Karolina Ersmark, Isabella Feierberg, Sinisa Bjelic et al. · Bioorganic & Medicinal Chemistry	16 Jul 2003	50
49	Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic Xiongyu Wu, Per Öhrngren, Jenny K. Ekegren et al. · Journal of Medicinal Chemistry Open access	24 Jan 2008	48
50	Microwave-Accelerated Synthesis of P1‘-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold Jenny K. Ekegren, Nina Ginman, Åsa Johansson et al. · Journal of Medicinal Chemistry Open access	11 Feb 2006	47

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.