| 1 |
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke et al. · Nature
Open access297 authors |
Jul 2014 |
8,181 |
| 2 |
Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials
Mayank Goyal et al. · The Lancet
Review |
20 Feb 2016 |
7,859 |
| 3 |
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray et al. · Immunity
Open access |
Jul 2014 |
6,444 |
| 4 |
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
Donald B. Smith, Kevin Scot Johnson · Gene
|
Jul 1988 |
5,982 |
| 5 |
Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection
Bruce C.V. Campbell et al. · New England Journal of Medicine
Open access |
11 Feb 2015 |
5,898 |
| 6 |
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
Raul G. Nogueira et al. · New England Journal of Medicine
Open access |
11 Nov 2017 |
5,684 |
| 7 |
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda et al. · Science Translational Medicine
Open access |
19 Feb 2014 |
5,211 |
| 8 |
Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
John W. Devlin et al. · Critical Care Medicine
Open access |
16 Aug 2018 |
4,050 |
| 9 |
The Bcl2 family: regulators of the cellular life-or-death switch
Suzanne Cory, Jerry M. Adams · Nature reviews. Cancer
Review |
Sep 2002 |
4,029 |
| 10 |
Our future: a Lancet commission on adolescent health and wellbeing
George Patton et al. · The Lancet
Open access |
9 May 2016 |
3,864 |
| 11 |
The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
Marita Cross, Emma U.R. Smith, Damian Hoy et al. · Annals of the Rheumatic Diseases
|
20 Feb 2014 |
3,624 |
| 12 |
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Jane E. Visvader, Geoffrey J. Lindeman · Nature reviews. Cancer
Review |
11 Sep 2008 |
3,485 |
| 13 |
Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis
Arnoud J. Templeton, Mairead Geraldine McNamara, Boštjan Šeruga et al. · JNCI Journal of the National Cancer Institute
Review |
29 May 2014 |
3,385 |
| 14 |
Bone marrow transplant
Jeff Szer · The Medical Journal of Australia
|
Mar 1999 |
3,378 |
| 15 |
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
Hartmut Döhner et al. · Blood
Open access |
7 Jul 2022 |
3,286 |
| 16 |
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
David Lawrence Vaux, Suzanne Cory, Jerry M. Adams · Nature
|
Sep 1988 |
3,258 |
| 17 |
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew James Souers et al. · Nature Medicine
|
6 Jan 2013 |
3,089 |
| 18 |
Network-based statistic: Identifying differences in brain networks
Andrew Zalesky, Alex Fornito, Edward Thomas Bullmore · NeuroImage
|
26 Jun 2010 |
2,938 |
| 19 |
T cell receptor antagonist peptides induce positive selection
Kristin Ann Hogquist, Stephen C. Jameson, William R. Heath et al. · Cell
|
1994 |
2,922 |
| 20 |
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
Daniel A. Arber et al. · Blood
Open access |
29 Jun 2022 |
2,906 |
| 21 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Vassily Vladimirovich Trubetskoy et al. · Nature
Open access613 authors |
8 Apr 2022 |
2,894 |
| 22 |
Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
Michael James Overman, Ray McDermott, Joseph L. Leach et al. · The Lancet Oncology
Open access |
19 Jul 2017 |
2,883 |
| 23 |
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
Hugh G Calkins et al. · Heart Rhythm
Open access |
12 May 2017 |
2,780 |
| 24 |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Stephen J. Sawcer et al. · Nature
Open access241 authors |
Aug 2011 |
2,772 |
| 25 |
Fatigue-free ferroelectric capacitors with platinum electrodes
C. A-Paz de Araujo, Joe D. Cuchiaro, L. D. McMillan et al. · Nature
|
Apr 1995 |
2,629 |
| 26 |
Prevalence of obstructive sleep apnea in the general population: A systematic review
Chamara V. Senaratna, Jennifer L. Perret, Caroline Lodge et al. · Sleep Medicine Reviews
Review |
18 Jul 2016 |
2,605 |
| 27 |
Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015
Mohammad Hossein Forouzanfar et al. · JAMA
Open access |
10 Jan 2017 |
2,464 |
| 28 |
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
Anne M. Verhagen, Paul G. Ekert, Miha Pakusch et al. · Cell
Open access |
Jul 2000 |
2,371 |
| 29 |
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton et al. · Nature
Open access239 authors |
27 May 2007 |
2,342 |
| 30 |
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
M. William Audeh, James Carmichael, Richard T. Penson et al. · The Lancet
|
Jul 2010 |
2,298 |
| 31 |
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
Leon Caly, Julian D Druce, Mike G Catton et al. · Antiviral Research
Open access |
3 Apr 2020 |
2,278 |
| 32 |
Stroke
Geoffrey Alan Donnan, Marc Fisher, Malcolm Robert Macleod et al. · The Lancet
|
May 2008 |
2,224 |
| 33 |
Epilepsy in adults
Roland D. Thijs, Rainer Surges, Terence John O'Brien et al. · The Lancet
|
26 Jan 2019 |
2,198 |
| 34 |
Phase behaviour of concentrated suspensions of nearly hard colloidal spheres
P. N. Pusey, W. van Megen · Nature
|
Mar 1986 |
2,179 |
| 35 |
Clinical applications of visual analogue scales: a critical review
Heather M. McCormack, David J. de L. Horne, Simon J. Sheather · Psychological Medicine
|
Nov 1988 |
2,129 |
| 36 |
Analysis of shared heritability in common disorders of the brain
Verneri Anttila et al. · Science
Open access577 authors |
21 Jun 2018 |
2,056 |
| 37 |
The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level
Tomi Akinyemiju et al. · JAMA Oncology
Open access |
5 Oct 2017 |
2,044 |
| 38 |
Generation of a functional mammary gland from a single stem cell
Mark J. Shackleton, François Vaillant, Kaylene J. Simpson et al. · Nature
|
2006 |
2,017 |
| 39 |
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
R. Lindsay Williams, Douglas J. Hilton, Shirley Pease et al. · Nature
|
Dec 1988 |
2,016 |
| 40 |
Genome-wide association study identifies five new schizophrenia loci
Stephan Ripke et al. · Nature Genetics
Open access196 authors |
18 Sep 2011 |
1,966 |
| 41 |
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
Andrew Warwick Roberts, Matthew Steven Davids, John M. Pagel et al. · New England Journal of Medicine
Open access |
6 Dec 2015 |
1,929 |
| 42 |
Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock
James A. Russell, Keith R. Walley, Joel Singer et al. · New England Journal of Medicine
Open access |
27 Feb 2008 |
1,925 |
| 43 |
Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
Jonathan A. Ledermann, Philipp Harter, Charlie Gourley et al. · New England Journal of Medicine
|
27 Mar 2012 |
1,916 |
| 44 |
Brain charts for the human lifespan
Richard A. I. Bethlehem et al. · Nature
Open access223 authors |
6 Apr 2022 |
1,896 |
| 45 |
Hyaluronan 1
Torvard C. Laurent, J. R. E. Fraser · The FASEB Journal
|
Apr 1992 |
1,876 |
| 46 |
The connectomics of brain disorders
Alex Fornito, Andrew Zalesky, Michael J Breakspear · Nature reviews. Neuroscience
Review |
20 Feb 2015 |
1,860 |
| 47 |
Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke
Joseph P. Broderick et al. · New England Journal of Medicine
Open access |
7 Feb 2013 |
1,819 |
| 48 |
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Jerry M. Adams, A. W. Harris, Carl A. Pinkert et al. · Nature
|
Dec 1985 |
1,802 |
| 49 |
Ischaemic stroke
Bruce C.V. Campbell, Deidre Anne De Silva, Malcolm Robert Macleod et al. · Nature Reviews Disease Primers
Review |
10 Oct 2019 |
1,800 |
| 50 |
The vascular territories (angiosomes) of the body: experimental study and clinical applications
G. Ian Taylor, John H. C. Palmer · British Journal of Plastic Surgery
|
Mar 1987 |
1,799 |