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Most cited papers from Netherlands Bioinformatics Centre

What are the most cited papers from Netherlands Bioinformatics Centre?

The most cited paper from Netherlands Bioinformatics Centre is "Human gut microbes impact host serum metabolome and insulin sensitivity" (Helle Pedersen et al., 2016), with 2,204 citations. Next come "A series of PDB related databases for everyday needs" (1,386) and "Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces" (1,205).

Showing 50 of 61 papers. Every paper with more than 107 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Human gut microbes impact host serum metabolome and insulin sensitivity Helle Pedersen et al. · Nature Open access Jul 2016 2,204
2 A series of PDB related databases for everyday needs Robbie P. Joosten, Tim A. H. te Beek, Elmar Krieger et al. · Nucleic Acids Research Open access 11 Nov 2010 1,386
3 Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces Hanka Venselaar, Tim AH te Beek, Remko K. P. Kuipers et al. · BMC Bioinformatics Open access 8 Nov 2010 1,205
4 A community-driven global reconstruction of human metabolism Ines Thiele et al. · Nature Biotechnology Open access 3 Mar 2013 1,087
5 Marine DNA Viral Macro- and Microdiversity from Pole to Pole Ann Gregory et al. · Cell Open access 25 Apr 2019 923
6 Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells Jessica Zuin, Jesse R. Dixon, Michael I. J. A. van der Reijden et al. · Proceedings of the National Academy of Sciences Open access 13 Dec 2013 847
7 Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits Frank M. Johannes, Emmanuelle Porcher, Felipe Karam Teixeira et al. · PLoS Genetics Open access 25 Jun 2009 837
8 Whole-genome sequence variation, population structure and demographic history of the Dutch population Laurent C. Francioli et al. · Nature Genetics Open access 29 Jun 2014 732
9 Molecular and Evolutionary Determinants of Bacteriophage Host Range Patrick A. de Jonge, Franklin L. Nóbrega, Stan J. J. Brouns et al. · Trends in Microbiology ReviewOpen access Sep 2018 514
10 Toward interoperable bioscience data Susanna‐Assunta Sansone et al. · Nature Genetics Open access 27 Jan 2012 473
11 The European ST-T database: standard for evaluating systems for the analysis of ST-T changes in ambulatory electrocardiography Antonio Taddei, G Distante, Michele Emdin et al. · European Heart Journal Sep 1992 443
12 Spiral wave structure in pre-biotic evolution: Hypercycles stable against parasites Maarten C. Boerlijst, Paulien Hogeweg · Physica D Nonlinear Phenomena Feb 1991 381
13 Open PHACTS: semantic interoperability for drug discovery Antony John Williams, Lee Harland, Paul Thomas Groth et al. · Drug Discovery Today Open access 7 Jun 2012 339
14 The anatomy of a nanopublication Paul Thomas Groth, Andrew A. P. Gibson, Jan Velterop · Information Services & Use Open access Feb 2010 323
15 Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines Antoinette Hollestelle et al. · Breast Cancer Research and Treatment 10 Jul 2009 313
16 De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology Jurgen F. Nijkamp, Marcel van den Broek, Erwin Datema et al. · Microbial Cell Factories Open access 26 Mar 2012 304
17 Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories Peter A.C. ’t Hoen, Marc R. Friedländer, Jonas Carlsson Almlöf et al. · Nature Biotechnology Open access 15 Sep 2013 291
18 The Genome of the Netherlands: design, and project goals Dorret Irene Boomsma et al. · European Journal of Human Genetics Open access 29 May 2013 286
19 The alignment of sets of sequences and the construction of phyletic trees: An integrated method Paulien Hogeweg, B. Hesper · Journal of Molecular Evolution Jun 1984 268
20 The Specificity and Topology of Chromatin Interaction Pathways in Yeast Tineke Laura Lenstra, Joris J. Benschop, Tae Soo Kim et al. · Molecular Cell Open access May 2011 260
21 Cellular automata as a paradigm for ecological modeling Paulien Hogeweg · Applied Mathematics and Computation Jul 1988 242
22 Time‐Course of Cytokines During Delirium in Elderly Patients with Hip Fractures Barbara C. Van Munster, Johanna C. Korevaar, Aeilko Having Zwinderman et al. · Journal of the American Geriatrics Society 6 Aug 2008 238
23 Impact of soil heat on reassembly of bacterial communities in the rhizosphere microbiome and plant disease suppression Menno van der Voort, Marcel Kempenaar, Marc van Driel et al. · Ecology Letters Open access Feb 2016 236
24 Open software for biologists: from famine to feast Dawn Field, Bela Tiwari, Tim Booth et al. · Nature Biotechnology Jul 2006 207
25 Inferring patient to patient transmission of Mycobacterium tuberculosisfrom whole genome sequencing data Josephine M. Bryant, Anita C. Schürch, Henk van Deutekom et al. · BMC Infectious Diseases Open access 27 Feb 2013 204
26 Comparative Genome Analysis of Lactococcus lactis Indicates Niche Adaptation and Resolves Genotype/Phenotype Disparity Michiel Wels, Roland J. Siezen, Sacha A. F. T. van Hijum et al. · Frontiers in Microbiology Open access 31 Jan 2019 178
27 CGtag: complete genomics toolkit and annotation in a cloud-based Galaxy Saskia Hiltemann, Hailiang Mei, Mattias de Hollander et al. · GigaScience Open access 24 Jan 2014 175
28 MADMAX – Management and analysis database for multiple ~omics experiments Ke Lin, Harrie J. Kools, Philip J. de Groot et al. · Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics Open access Jun 2011 169
29 Dissecting Kawasaki disease: a state-of-the-art review Siobhan M. Dietz, D. van Stijn, David Paul Burgner et al. · European Journal of Pediatrics Open access 27 Jun 2017 169
30 Lactobacillus paracasei Comparative Genomics: Towards Species Pan-Genome Definition and Exploitation of Diversity Tamara Smokvina, Michiel Wels, Justyna Urszula Polka et al. · PLoS ONE Open access 19 Jul 2013 164
31 The MOLGENIS toolkit: rapid prototyping of biosoftware at the push of a button Morris A. Swertz, Martijn Dijkstra, Tomasz Adamusiak et al. · BMC Bioinformatics Open access Dec 2010 161
32 Human Papillomavirus Deregulates the Response of a Cellular Network Comprising of Chemotactic and Proinflammatory Genes Rezaul Karim, Craig Meyers, Claude Backendorf et al. · PLoS ONE Open access 14 Mar 2011 160
33 Rates of Lateral Gene Transfer in Prokaryotes: High but Why? Michiel Vos, Matthijn C. Hesselman, Tim AH Te Beek et al. · Trends in Microbiology ReviewOpen access Oct 2015 158
34 The value of data Barend Mons, Herman van Haagen, Christine H. Chichester et al. · Nature Genetics Open access 29 Mar 2011 156
35 ESSENTIALS: Software for Rapid Analysis of High Throughput Transposon Insertion Sequencing Data Aldert Zomer, Peter Burghout, Hester J. Bootsma et al. · PLoS ONE Open access 10 Aug 2012 153
36 On loopfolding in nucleic acid hairpin-type structures29 Cornelis A. G. HAASNOOT, Cornelis W. Hilbers, G. A. VAN DER MAREL et al. · Journal of Biomolecular Structure and Dynamics Apr 1986 152
37 A Critical Assessment of Feature Selection Methods for Biomarker Discovery in Clinical Proteomics Christin Christin, Huub C. J. Hoefsloot, Age K. Smilde et al. · Molecular & Cellular Proteomics Open access Nov 2012 150
38 Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions Ralph Stadhouders, Petros Kolovos, Rutger W. W. Brouwer et al. · Nature Protocols 14 Feb 2013 150
39 Massively parallel sequencing of short tandem repeats—Population data and mixture analysis results for the PowerSeq™ system Kristiaan J. van der Gaag, Rick H. de Leeuw, Jerry Hoogenboom et al. · Forensic Science International Genetics Open access 7 Jun 2016 148
40 The ontogeny of the interaction structure in bumble bee colonies: A MIRROR model Paulien Hogeweg, B. Hesper · Behavioral Ecology and Sociobiology Jul 1983 146
41 A footprint of desiccation tolerance in the genome of Xerophyta viscosa Maria-Cecília D. Costa, Mariana A S Artur, Júlio Maia et al. · Nature Plants Open access 27 Mar 2017 142
42 Protein Secondary Structure Prediction Walter Pirovano, Jaap Heringa · Methods in molecular biology Book chapter 30 Oct 2009 138
43 Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways Sake van Wageningen et al. · Cell Open access Dec 2010 135
44 Complete Resequencing and Reannotation of the Lactobacillus plantarum WCFS1 Genome Roland J. Siezen, Christof Francke, B.A.M. Renckens et al. · Journal of Bacteriology Open access 7 Dec 2011 134
45 Comparative genomics of Lactobacillus Ravi Kant, Jochen Blom, Airi M. Palva et al. · Microbial Biotechnology Open access 21 Oct 2010 133
46 Contribution of rare and common variants determine complex diseases—Hirschsprung disease as a model Maria M. Alves, Yunia Sribudiani, Rutger W. W. Brouwer et al. · Developmental Biology Open access 23 May 2013 130
47 Safety of the Surrogate Microorganism Enterococcus faecium NRRL B-2354 for Use in Thermal Process Validation Lauren M. Kopit, Eun Bae Kim, Roland J. Siezen et al. · Applied and Environmental Microbiology Open access 11 Jan 2014 128
48 Involvement of the TGF-β and β-Catenin Pathways in Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer Maartje G. Noordhuis, Rudolf S.N. Fehrmann, G. Bea A. Wisman et al. · Clinical Cancer Research 8 Mar 2011 125
49 Profiling of N-Acetylated Protein Termini Provides In-depth Insights into the N-terminal Nature of the Proteome Andreas O. Helbig, Sharon Gauci, Reinout Raijmakers et al. · Molecular & Cellular Proteomics Open access 8 Jan 2010 125
50 Topology of molecular interaction networks Wynand Winterbach, Piet Van Mieghem, Marcel J. T. Reinders et al. · BMC Systems Biology Open access 2013 123

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.