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Institution · NeurAxon (Canada)

Most cited papers from NeurAxon (Canada)

NeurAxon (Canada)

What are the most cited papers from NeurAxon (Canada)?

The most cited paper from NeurAxon (Canada) is "Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers" (Milena De Felice, Michael H. Ossipov, R. Wang et al., 2010), with 125 citations. Next come "NXN-188, a selective nNOS inhibitor and a 5-HT 1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models" (55) and "Discovery ofcis-N-(1-(4-(Methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: A 1,6-Disubstituted Indoline Derivative as a Highly Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) without Any Cardiovascular Liabilities" (40).

Showing 21 of 21 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers Milena De Felice, Michael H. Ossipov, R. Wang et al. · Brain Open access 13 Jul 2010 125
2 NXN-188, a selective nNOS inhibitor and a 5-HT 1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models Deepak Kumar Bhatt, Saurabh Kumar Gupta, Inger Jansen‐Olesen et al. · Cephalalgia Open access 15 Nov 2012 55
3 Discovery ofcis-N-(1-(4-(Methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: A 1,6-Disubstituted Indoline Derivative as a Highly Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) without Any Cardiovascular Liabilities Subhash C. Annedi, Jailall Ramnauth, Shawn P. Maddaford et al. · Journal of Medicinal Chemistry Open access 16 Dec 2011 40
4 Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors Joanne Patman, Namrta Bhardwaj, Jailall Ramnauth et al. · Bioorganic & Medicinal Chemistry Letters Open access 9 Feb 2007 33
5 Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors Jailall Ramnauth, Joanne Speed, Shawn P. Maddaford et al. · Journal of Medicinal Chemistry Open access 23 Jun 2011 32
6 Chapter 2 Advancements in the Development of Nitric Oxide Synthase Inhibitors Shawn P. Maddaford, Subhash C. Annedi, Jailall Ramnauth et al. · Annual reports in medicinal chemistry Book chapter 2009 32
7 Discovery ofN-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain Subhash C. Annedi, Shawn P. Maddaford, Gabriela Mladenova et al. · Journal of Medicinal Chemistry Open access 5 Oct 2011 31
8 Applications of Organocatalytic Asymmetric Synthesis to Drug Prototypes—Dual Action and Selective Inhibitors of n-Nitric Oxide Synthase with Activity Against the 5-HT1D/1B Subreceptors Stephen Hanessian, Eli Stoffman, Xueling Mi et al. · Organic Letters 27 Jan 2011 26
9 In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450 Philippe Labrie, Shawn P. Maddaford, Jacques Lacroix et al. · Bioorganic & Medicinal Chemistry Open access 11 Aug 2006 25
10 Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine Subhash C. Annedi, Shawn P. Maddaford, Jailall Ramnauth et al. · European Journal of Medicinal Chemistry Open access 14 Jul 2012 23
11 NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with μ-Opioid Agonist Activity Paul Renton, Brenda J. Green, Shawn P. Maddaford et al. · ACS Medicinal Chemistry Letters Open access 30 Jan 2012 23
12 1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors Paul Renton, Joanne Speed, Shawn P. Maddaford et al. · Bioorganic & Medicinal Chemistry Letters 22 Jul 2011 20
13 Safety and pharmacokinetics of NXN-188 after single and multiple doses in five phase I, randomized, double-blind, parallel studies in healthy adult volunteers David P. Vaughan, Joanne Speed, Robert A. Medve et al. · Clinical Therapeutics 2010 20
14 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors Subhash C. Annedi, Shawn P. Maddaford, Jailall Ramnauth et al. · Bioorganic & Medicinal Chemistry Letters Open access 21 Jan 2012 18
15 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors Shawn P. Maddaford, Paul Renton, Joanne Speed et al. · Bioorganic & Medicinal Chemistry Letters 28 Jul 2011 17
16 A Medicinal Chemistry Perspective on Structure-Based Drug Design and Development Shawn P. Maddaford · Methods in molecular biology Book chapter 7 Dec 2011 16
17 First-in-Class, Dual-Action, 3,5-Disubstituted Indole Derivatives Having Human Nitric Oxide Synthase (nNOS) and Norepinephrine Reuptake Inhibitory (NERI) Activity for the Treatment of Neuropathic Pain Gabriela Mladenova, Subhash C. Annedi, Jailall Ramnauth et al. · Journal of Medicinal Chemistry Open access 15 Mar 2012 16
18 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: Lead Optimization Studies Resulting in the Identification ofN-(1-(2-(Methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a Preclinical Development Candidate Jailall Ramnauth, Paul Renton, Peter Dove et al. · Journal of Medicinal Chemistry Open access 15 Feb 2012 15
19 Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS) Subhash C. Annedi, Jailall Ramnauth, Michele Cossette et al. · Bioorganic & Medicinal Chemistry Letters Open access 9 Feb 2012 8
20 Glucocorticoid antagonists and depression John S. Andrews · Techniques in the behavioral and neural sciences Book chapter 2005 2
21 ChemInform Abstract: Discovery of a Potent, Orally Bioavailable and Highly Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitor, N‐(1‐(Piperidin‐4‐yl)indolin‐5‐yl)thiophene‐2‐carboximidamide as a Pre‐Clinical Development Candidate for the Treatment of Migraine. Subhash C. Annedi, et al. et al. · ChemInform 15 Jan 2013 0

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.