| 1 |
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Clotilde Théry et al. · Journal of Extracellular Vesicles
Open access382 authors |
23 Nov 2018 |
11,535 |
| 2 |
Genome-wide association study identifies five new schizophrenia loci
Stephan Ripke et al. · Nature Genetics
Open access196 authors |
18 Sep 2011 |
1,966 |
| 3 |
Single-copy insertion of transgenes in Caenorhabditis elegans
Christian Frøkjær‐Jensen, M. Wayne Davis, Christopher E. Hopkins et al. · Nature Genetics
Open access |
26 Oct 2008 |
1,319 |
| 4 |
The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction
J∅gen Scheel-Krüger · Journal of Chemical Neuroanatomy
|
Sep 1993 |
1,278 |
| 5 |
Ligands for Glutamate Receptors: Design and Therapeutic Prospects
Hans Bräuner‐Osborne, Jan Egebjerg, Elsebet Østergaard Nielsen et al. · Journal of Medicinal Chemistry
Open access |
Jul 2000 |
526 |
| 6 |
Modification of activity‐dependent increases of cerebral blood flow by excitatory synaptic activity and spikes in rat cerebellar cortex
Claus Mathiesen, Kirsten Caesar, Nuran Akgören et al. · The Journal of Physiology
Open access |
Oct 1998 |
378 |
| 7 |
Effect of Mutant α-Synuclein on Dopamine Homeostasis in a New Human Mesencephalic Cell Line
Julie Lotharius, Julie Lotharius, Sebastian Barg et al. · Journal of Biological Chemistry
Open access |
Oct 2002 |
360 |
| 8 |
pH Dependency and Desensitization Kinetics of Heterologously Expressed Combinations of Acid-sensing Ion Channel Subunits
Mette Hesselager, Daniel Brunicardi Timmermann, Philip Kiær Ahring · Journal of Biological Chemistry
Open access |
Mar 2004 |
321 |
| 9 |
Modulation of anxiety circuits by serotonergic systems
Christopher A. Lowry, Philip L. Johnson, Anders Hay‐Schmidt et al. · Stress
Open access |
2005 |
310 |
| 10 |
Selective activation of Ca2+ -dependent K+ channels by novel benzimidazolone
Søren‐Peter Olesen, Ellen Munch, Peter Moldt et al. · European Journal of Pharmacology
|
1994 |
303 |
| 11 |
The KCNQ1 Potassium Channel: From Gene to Physiological Function
Thomas Jespersen, Morten Grunnet, Søren‐Peter Olesen · Physiology
|
15 Nov 2005 |
278 |
| 12 |
Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters
Florent G. Revel, Michel Saboureau, Mireille Masson-Pévet et al. · Current Biology
Open access |
Sep 2006 |
276 |
| 13 |
Novel Potent Ligands for the Central Nicotinic Acetylcholine Receptor: Synthesis, Receptor Binding, and 3D-QSAR Analysis
Simon Feldbæk Nielsen, Elsebet Østergaard Nielsen, Gunnar M. Olsen et al. · Journal of Medicinal Chemistry
Open access |
5 May 2000 |
245 |
| 14 |
BMS‐204352: A Potassium Channel Opener Developed for the Treatment of Stroke
Bo Jensen · CNS Drug Reviews
Open access |
Dec 2002 |
224 |
| 15 |
Characterization of the cloned human intermediate-conductance Ca 2+ -activated K + channel
Bo Jensen, Dorte Strøbæk, Palle Christophersen et al. · American Journal of Physiology-Cell Physiology
|
Sep 1998 |
222 |
| 16 |
An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo
Daniel Brunicardi Timmermann, Jens Halvard Grønlien, Kathy L. Kohlhaas et al. · Journal of Pharmacology and Experimental Therapeutics
|
12 Jul 2007 |
216 |
| 17 |
The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain
Gordon Blackburn-Munro, Bo Jensen · European Journal of Pharmacology
|
2003 |
210 |
| 18 |
Pharmacological characterisation of the spared nerve injury model of neuropathic pain
Helle Kirstein Erichsen, Gordon Blackburn-Munro · Pain
|
Jul 2002 |
210 |
| 19 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain
Signe F. Bomholt, Jens D. Mikkelsen, Gordon Blackburn-Munro · Neuropharmacology
|
6 Dec 2004 |
207 |
| 20 |
RFamide-Related Peptide Gene Is a Melatonin-Driven Photoperiodic Gene
Florent G. Revel, Michel Saboureau, Paul Pévet et al. · Endocrinology
|
13 Dec 2007 |
204 |
| 21 |
Coupling and uncoupling of activity‐dependent increases of neuronal activity and blood flow in rat somatosensory cortex
Alexander Norup Nielsen, Martin Lauritzen · The Journal of Physiology
Open access |
Jun 2001 |
202 |
| 22 |
Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs
J.K. Abrams, Philip L. Johnson, Anders Hay‐Schmidt et al. · Neuroscience
|
2005 |
200 |
| 23 |
Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome
Yanzong Yang et al. · The American Journal of Human Genetics
Open access |
Jun 2010 |
200 |
| 24 |
Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)
Dorte Strøbæk, Lene Teuber, Tino D. Jørgensen et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes
Open access |
27 Aug 2004 |
200 |
| 25 |
Delineation of an endogenous zinc‐binding site in the human dopamine transporter
Lene Nørregaard, Dorte Frederiksen, Elsebet Ø. Nielsen et al. · The EMBO Journal
Open access |
3 Aug 1998 |
195 |
| 26 |
Inhibition of Small-Conductance Ca 2+ -Activated K + Channels Terminates and Protects Against Atrial Fibrillation
Jonas Goldin Diness, Ulrik S. Sørensen, Jakob D. Nissen et al. · Circulation Arrhythmia and Electrophysiology
Open access |
20 Jun 2010 |
190 |
| 27 |
Broad-Spectrum Efficacy across Cognitive Domains by α7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways
Robert S. Bitner et al. · Journal of Neuroscience
Open access |
26 Sep 2007 |
186 |
| 28 |
Pharmacological characterization of small‐conductance Ca2+‐activated K+ channels stably expressed in HEK 293 cells
Dorte Strøbæk, Tino D Jørgensen, Palle Christophersen et al. · British Journal of Pharmacology
Open access |
Mar 2000 |
183 |
| 29 |
A simple procedure for quantification of neurite outgrowth based on stereological principles
Lars Christian B. Rønn, Igor Ralets, Barbara P. Hartz et al. · Journal of Neuroscience Methods
|
Jul 2000 |
175 |
| 30 |
Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial
Justo García de Yébenes, G. Bernhard Landwehrmeyer, Ferdinando Squitieri et al. · The Lancet Neurology
|
8 Nov 2011 |
174 |
| 31 |
Endogenous Unsaturated C18 N-Acylethanolamines Are Vanilloid Receptor (TRPV1) Agonists
Pouya Movahed, Bo Jönsson, Bryndis Birnir et al. · Journal of Biological Chemistry
Open access |
4 Aug 2005 |
174 |
| 32 |
Specific Enhancement of SK Channel Activity Selectively Potentiates the Afterhyperpolarizing Current IAHP and Modulates the Firing Properties of Hippocampal Pyramidal Neurons
Paola Pedarzani, James E. McCutcheon, Gregor Rogge et al. · Journal of Biological Chemistry
Open access |
26 Oct 2005 |
161 |
| 33 |
Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines
Jakob Bondo Hansen et al. · Cell Metabolism
Open access |
20 Sep 2012 |
158 |
| 34 |
Pain-like behaviours in animals – how human are they?
Gordon Blackburn-Munro · Trends in Pharmacological Sciences
Review |
13 May 2004 |
157 |
| 35 |
Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension
Thomas A. Jepps, Preet S. Chadha, Alison J. Davis et al. · Circulation
Open access |
12 Jul 2011 |
157 |
| 36 |
Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca 2+ ‐activated K + channels
Charlotte Ørsted Hougaard, Birgitte Langer Eriksen, Sine Wanda Jørgensen et al. · British Journal of Pharmacology
Open access |
8 May 2007 |
157 |
| 37 |
Xanomeline and the Antipsychotic Potential of Muscarinic Receptor Subtype Selective Agonists
Naheed Rohman Mirza, Dan Peters, Robin G. Sparks · CNS Drug Reviews
Open access |
Jun 2003 |
156 |
| 38 |
Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex
Martin Ejler Fabricius, Leif Helth Jensen, Martin Lauritzen · Brain Research
|
May 1993 |
155 |
| 39 |
Acidification of the Osteoclastic Resorption Compartment Provides Insight into the Coupling of Bone Formation to Bone Resorption
M.A. Karsdal, Kim Henriksen, Mette Grøndahl Sørensen et al. · American Journal Of Pathology
Open access |
Feb 2005 |
155 |
| 40 |
Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors
Kasper Harpsøe, Philip Kiær Ahring, J. K. Christensen et al. · Journal of Neuroscience
Open access |
27 Jul 2011 |
152 |
| 41 |
Selective Positive Modulator of Calcium-Activated Potassium Channels Exerts Beneficial Effects in a Mouse Model of Spinocerebellar Ataxia Type 2
Adebimpe W. Kasumu, Charlotte Ørsted Hougaard, Frederik Rode et al. · Chemistry & Biology
Open access |
Oct 2012 |
149 |
| 42 |
In Vivo Protection of Nigral Dopamine Neurons by Lentiviral Gene Transfer of the Novel GDNF-Family Member Neublastin/Artemin
Carl Rosenblad, Mette Grønborg, Claus Hansen et al. · Molecular and Cellular Neuroscience
Open access |
Feb 2000 |
148 |
| 43 |
BK Channel Modulators: A Comprehensive Overview
Antônio Egídio Nardi, Søren‐Peter Olesen · Current Medicinal Chemistry
|
30 Apr 2008 |
148 |
| 44 |
The Chloride Channel Inhibitor NS3736 Prevents Bone Resorption in Ovariectomized Rats Without Changing Bone Formation
Sophie Schaller, Kim Henriksen, Christina Sveigaard et al. · Journal of Bone and Mineral Research
Open access |
Jul 2004 |
147 |
| 45 |
Activation of Human ether-a-go-go-Related Gene Potassium Channels by the Diphenylurea 1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)
Rie Schultz Hansen, Thomas Goldin Diness, Torsten Christ et al. · Molecular Pharmacology
|
12 Oct 2005 |
145 |
| 46 |
The Suzuki Reaction Under Solvent-Free Conditions
Simon Feldbæk Nielsen, Dan Peters, Oskar Axelsson · Synthetic Communications
|
Oct 2000 |
143 |
| 47 |
Nitric oxide promotes seizure activity in kainate-treated rats
Alexander Mülsch, Rudi Busse, Peter I. Mordvintcev et al. · Neuroreport
|
Nov 1994 |
143 |
| 48 |
Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat
Jacob P. R. Jacobsen, Arne Mørk · Brain Research
|
2 Aug 2006 |
141 |
| 49 |
The neuroanatomy of the kisspeptin system in the mammalian brain
Jens Damsgaard Mikkelsen, Valérie Simonneaux · Peptides
|
19 Sep 2008 |
138 |
| 50 |
Melatonin Regulates Type 2 Deiodinase Gene Expression in the Syrian Hamster
Florent G. Revel, Michel Saboureau, Paul Pévet et al. · Endocrinology
|
28 Jul 2006 |
138 |