Institution · New Frontier
Most cited papers from New Frontier
What are the most cited papers from New Frontier?
The most cited paper from New Frontier is "Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior" (Takeshi Sakurai et al., 1998), with 5,551 citations. Next come "The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure" (4,686) and "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis" (3,317).
Showing 50 of 60 papers. Every paper with more than 491 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior Takeshi Sakurai et al. · Cell | Feb 1998 | 5,551 |
| 2 | The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure Milton Packer, Michael R. Bristow, Jay N. Cohn et al. · New England Journal of Medicine | 23 May 1996 | 4,686 |
| 3 | A protein kinase involved in the regulation of inflammatory cytokine biosynthesis John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature | Dec 1994 | 3,317 |
| 4 | The DNA damage response: putting checkpoints in perspective Bin‐Bing S. Zhou, Stephen J. Elledge · Nature | Nov 2000 | 3,230 |
| 5 | AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules David A. Pearlman, David Andrew Case, James W. Caldwell et al. · Computer Physics Communications | Sep 1995 | 3,156 |
| 6 | Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody Peter D. Kwong, Richard T. Wyatt, James E. Robinson et al. · Nature | Jun 1998 | 3,015 |
| 7 | Physiological Parameters in Laboratory Animals and Humans Brian E. Davies, Tim Morris · Pharmaceutical Research | Jul 1993 | 2,937 |
| 8 | Nasal Carriage as a Source ofStaphylococcus aureusBacteremia Christof von Eiff, Karsten Becker, Konstanze Machka et al. · New England Journal of Medicine | 4 Jan 2001 | 2,026 |
| 9 | Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia John B. Davis, Julie Gray, Martin J. Gunthorpe et al. · Nature | May 2000 | 1,770 |
| 10 | Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide Tiziana Bisogno, Lumír Hanuš, Luciano De Petrocellis et al. · British Journal of Pharmacology | Oct 2001 | 1,326 |
| 11 | International Union of Pharmacology nomenclature of adrenoceptors. Dan Bylund, D C Eikenberg, J. Paul Hieble et al. · Pharmacological Reviews | Jun 1994 | 1,222 |
| 12 | Chemical Amplification: Continuous-Flow PCR on a Chip Martin U. Kopp, Andrew J. de Mello, A. Manz · Science | 15 May 1998 | 1,212 |
| 13 | The antigenic structure of the HIV gp120 envelope glycoprotein Richard T. Wyatt, Peter D. Kwong, Elizabeth Desjardins et al. · Nature | Jun 1998 | 1,211 |
| 14 | Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL John G. Emery, Peter McDonnell, Michael Brigham Burke et al. · Journal of Biological Chemistry | Jun 1998 | 1,203 |
| 15 | Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase Ishrut Hussain, David J. Powell, David R Howlett et al. · Molecular and Cellular Neuroscience | Dec 1999 | 1,080 |
| 16 | Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics Frank C. Barone, Giora Feuerstein · Journal of Cerebral Blood Flow & Metabolism | Aug 1999 | 937 |
| 17 | Tumor Necrosis Factor-α Frank C. Barone, B. Mak Arvin, Ray F. White et al. · Stroke | Jun 1997 | 868 |
| 18 | Tumor necrosis factor-alpha expression in ischemic neurons. T Liu, Robert Clark, Peter McDonnell et al. · Stroke | Jul 1994 | 801 |
| 19 | Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 Robert S. Ames et al. · Nature | 16 Sep 1999 | 793 |
| 20 | The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1) D Smart, Martin J. Gunthorpe, Jeffrey C. Jerman et al. · British Journal of Pharmacology | 2000 | 781 |
| 21 | SK&F 96365, a novel inhibitor of receptor-mediated calcium entry J E Merritt, W P Armstrong, Christopher D. Benham et al. · Biochemical Journal | 15 Oct 1990 | 768 |
| 22 | Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli James F. Kane · Current Opinion in Biotechnology | 1995 | 766 |
| 23 | Variants in MTNR1B influence fasting glucose levels Inga Prokopenko et al. · Nature Genetics | 7 Dec 2008 | 755 |
| 24 | Vaccination against Lyme Disease with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein A with Adjuvant Allen C. Steere, Vijay K. Sikand, François Meurice et al. · New England Journal of Medicine | 23 Jul 1998 | 752 |
| 25 | Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats Anne M. Romanic, Raymond Frederick Martin White, Anthony J. Arleth et al. · Stroke | May 1998 | 740 |
| 26 | Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects Panayiotis P. Constantinides · Pharmaceutical Research | Nov 1995 | 740 |
| 27 | International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. J. Paul Hieble, Dan Bylund, David E. Clarke et al. · Pharmacological Reviews | Jun 1995 | 719 |
| 28 | Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts Fred H. Drake, Robert A. Dodds, Ian E. James et al. · Journal of Biological Chemistry | May 1996 | 718 |
| 29 | Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides Tobias Hartmann, Sophie C. Bieger, Babara Brühl et al. · Nature Medicine | Sep 1997 | 715 |
| 30 | Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures Narayan R. Bhat, Peisheng Zhang, John C. Lee et al. · Journal of Neuroscience | Mar 1998 | 715 |
| 31 | Functional antioxidant responsive elements Wyeth W. Wasserman, William E. Fahl · Proceedings of the National Academy of Sciences | 13 May 1997 | 712 |
| 32 | The codependence of angiogenesis and chronic inflammation Jeffrey R. Jackson, Michael P. Seed, Charles H. Kircher et al. · The FASEB Journal | May 1997 | 701 |
| 33 | Regression Analysis of Count Data John J. Peterson, A. Colin Cameron, Pravin K. Trivedi · Technometrics | Nov 1999 | 696 |
| 34 | Phosphodiesterase Isozymes: Molecular Targets for Novel Antiasthma Agents Theodore J. Torphy · American Journal of Respiratory and Critical Care Medicine | Feb 1998 | 662 |
| 35 | DNA microarrays in drug discovery and development Christine M. Debouck, Peter Neville Goodfellow · Nature Genetics | 1999 | 657 |
| 36 | Transforming cabbage into turnip Sridhar Hannenhalli, Pavel A. Pevzner · Journal of the ACM | 1999 | 655 |
| 37 | The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases Patrick Garnero, Olivier Borel, I. Byrjalsen et al. · Journal of Biological Chemistry | Nov 1998 | 644 |
| 38 | Membrane protein secretases Nigel M. Hooper, Eric H. Karran, Anthony J. Turner · Biochemical Journal | 15 Jan 1997 | 624 |
| 39 | Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean John C. Clapham et al. · Nature | Jul 2000 | 616 |
| 40 | Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase Valerie B. O’Donnell, David G. Tew, Owen T.G. Jones et al. · Biochemical Journal | 15 Feb 1993 | 593 |
| 41 | Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. Robert Bals, Xuemin Wang, Zhihong Wu et al. · Journal of Clinical Investigation | Sep 1998 | 577 |
| 42 | Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site Peter R. Young, Megan M. McLaughlin, Sanjay Kumar et al. · Journal of Biological Chemistry | May 1997 | 574 |
| 43 | Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. G.W. Roberts, Stephen M. Gentleman, Aoibhinn Lynch et al. · Journal of Neurology Neurosurgery & Psychiatry | Apr 1994 | 574 |
| 44 | Crystal structure of an HIV-binding recombinant fragment of human CD4 Seong-Eon Ryu, Peter D. Kwong, Alemseged Truneh et al. · Nature | Nov 1990 | 560 |
| 45 | Determination of Rate and Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods Daniel John O'Shannessy, Michael R Brigham-Burke, K. Karl Soneson et al. · Analytical Biochemistry | Aug 1993 | 552 |
| 46 | Frequent Alternative Splicing of Human Genes Andrey A. Mironov, James Wildon Fickett, Mikhail Sergeevich Gelfand · Genome Research | Dec 1999 | 550 |
| 47 | High-throughput screening: new technology for the 21st century Robert Hertzberg, Andrew J. Pope · Current Opinion in Chemical Biology | Aug 2000 | 546 |
| 48 | Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man Adrian Mark Owen, Barbara Jacquelyn Sahakian, James M. Semple et al. · Neuropsychologia | 1995 | 535 |
| 49 | soluble form of CD4 (T4) protein inhibits AIDS virus infection Keith C. Deen, J. Steven McDougal, Richard Inacker et al. · Nature | 1988 | 527 |
| 50 | SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist G.A. Kennett, Martyn D. Wood, Fiona Bright et al. · Neuropharmacology | Apr 1997 | 525 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.