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Most cited papers from Nobel Foundation

What are the most cited papers from Nobel Foundation?

The most cited paper from Nobel Foundation is "Physiological functions of thioredoxin and thioredoxin reductase" (Elias S.J. Arnér, Arne Holmgren, 2000), with 2,553 citations. Next come "Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents" (1,569) and "From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health" (1,344).

Showing 50 of 60 papers. Every paper with more than 266 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Physiological functions of thioredoxin and thioredoxin reductase Elias S.J. Arnér, Arne Holmgren · European Journal of Biochemistry Open access Oct 2000 2,553
2 Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents Adam C. Sedgwick, Luling Wu, Hai‐Hao Han et al. · Chemical Society Reviews ReviewOpen access 2018 1,569
3 From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health Laura V. Papp, Jun Lu, Arne Holmgren et al. · Antioxidants and Redox Signaling 18 May 2007 1,344
4 Generalized Potential of Adult Neural Stem Cells Diana L. Clarke, Clas B. Johansson, Johannes H. Wilbertz et al. · Science 2 Jun 2000 1,076
5 Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents Luling Wu, Chusen Huang, Ben P. Emery et al. · Chemical Society Reviews ReviewOpen access 2020 1,031
6 Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein Keiji Tanimoto, Yuichi Makino, Teresa Pereira et al. · The EMBO Journal Open access 15 Aug 2000 963
7 [21] Thioredoxin and thioredoxin reductase Arne Holmgren, Mikael Björnstedt · Methods in enzymology on CD-ROM/Methods in enzymology Book chapter 1995 946
8 Respiratory Enzymes in Oxidative Phosphorylation Britton Chance, Herrick Baltscheffsky · Journal of Biological Chemistry Open access Sep 1958 896
9 Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction Göran Bertilsson, Jessica Heidrich, Kristian Svensson et al. · Proceedings of the National Academy of Sciences Open access 13 Oct 1998 873
10 “All‐on‐Four” Immediate‐Function Concept with Brånemark System® Implants for Completely Edentulous Mandibles: A Retrospective Clinical Study Paulo S. Maló, Bo Rangert, Miguel de Araújo Nobre · Clinical Implant Dentistry and Related Research Mar 2003 777
11 Thioredoxin and Related Molecules–From Biology to Health and Disease Christopher Horst Lillig, Arne Holmgren · Antioxidants and Redox Signaling 20 Nov 2006 731
12 High efficiency polyoma DNA transfection of chloroquine treated cells Holger Luthman, Göran Magnusson · Nucleic Acids Research Open access 11 Mar 1983 714
13 The Role of the Thioredoxin and Glutaredoxin Pathways in Reducing Protein Disulfide Bonds in the Escherichia coliCytoplasm William A. Prinz, Fredrik Åslund, Arne Holmgren et al. · Journal of Biological Chemistry Open access Jun 1997 675
14 Glutaredoxins: Glutathione-Dependent Redox Enzymes with Functions Far Beyond a Simple Thioredoxin Backup System Aristi Potamitou Fernandes, Arne Holmgren · Antioxidants and Redox Signaling 8 Jan 2004 671
15 Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of theCBP/p300 coactivator by the hypoxia‐induciblefactor‐1α Pekka J. Kallio, Kensaku Okamoto, Sallyann O'Brien et al. · The EMBO Journal Open access 16 Nov 1998 669
16 Selenoproteins Jun Lu, Arne Holmgren · Journal of Biological Chemistry Open access 29 Aug 2008 619
17 Fluorogenic probes for disease-relevant enzymes Junji Zhang, Xianzhi Chai, Xiao‐Peng He et al. · Chemical Society Reviews Review 6 Dec 2018 617
18 The thioredoxin system in cancer Elias S.J. Arnér, Arne Holmgren · Seminars in Cancer Biology 29 Oct 2006 588
19 Mammalian deoxyribonucleoside kinases Elias S.J. Arnér, Staffan Eriksson · Pharmacology & Therapeutics 1995 584
20 Glutaredoxin systems Christopher Horst Lillig, Carsten Berndt, Arne Holmgren · Biochimica et Biophysica Acta (BBA) - General Subjects 19 Jun 2008 560
21 Bending overload and implant fracture: a retrospective clinical analysis. Bo Rangert, P H Krogh, Burton Langer et al. · PubMed 24 Aug 1995 553
22 Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence Liangwei Zhong, Elias S.J. Arnér, Arne Holmgren · Proceedings of the National Academy of Sciences Open access 9 May 2000 522
23 Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide Jun Lu, Eng‐Hui Chew, Arne Holmgren · Proceedings of the National Academy of Sciences Open access 18 Jul 2007 522
24 Thioredoxin Reductase Is Irreversibly Modified by Curcumin Jianguo Fang, Jun Lu, Arne Holmgren · Journal of Biological Chemistry Open access 7 May 2005 521
25 Antioxidant Function of Thioredoxin and Glutaredoxin Systems Arne Holmgren · Antioxidants and Redox Signaling Dec 2000 502
26 Lasers in dentistry Harvey A. Wigdor, Joseph T. Walsh, J.D.B. Featherstone et al. · Lasers in Surgery and Medicine 1995 489
27 Neocortical neurogenesis in humans is restricted to development Ratan D. Bhardwaj, Maurice A. Curtis, Kirsty L. Spalding et al. · Proceedings of the National Academy of Sciences Open access 10 Aug 2006 455
28 Inhibition of the Human Thioredoxin System Cristina M. L. Carvalho, Eng‐Hui Chew, Seyed Isaac Hashemy et al. · Journal of Biological Chemistry Open access 5 Mar 2008 454
29 All‐on‐4 Immediate‐Function Concept with Brånemark System® Implants for Completely Edentulous Maxillae: A 1‐Year Retrospective Clinical Study Paulo S. Maló, Bo Rangert, Miguel de Araújo Nobre · Clinical Implant Dentistry and Related Research Jun 2005 429
30 Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations Liangwei Zhong, Arne Holmgren · Journal of Biological Chemistry Open access Jun 2000 426
31 Redox Potentials of Glutaredoxins and Other Thiol-Disulfide Oxidoreductases of the Thioredoxin Superfamily Determined by Direct Protein-Protein Redox Equilibria Fredrik Åslund, Kurt D. Berndt, Arne Holmgren · Journal of Biological Chemistry Open access Dec 1997 416
32 Thiol redox control via thioredoxin and glutaredoxin systems C. Johansson, Arne Holmgren, Carsten Berndt et al. · Biochemical Society Transactions 27 Oct 2005 377
33 Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target Angela N Kuntz, Elisabeth Davioud–Charvet, Ahmed A. Sayed et al. · PLoS Medicine Open access 12 Jun 2007 372
34 S-Nitrosoglutathione Is Cleaved by the Thioredoxin System with Liberation of Glutathione and Redox Regulating Nitric Oxide Dragana Nikitovic, Arne Holmgren · Journal of Biological Chemistry Open access Aug 1996 369
35 The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase. Mikael Björnstedt, Jiyan Xue, Wuqing Huang et al. · Journal of Biological Chemistry Open access Nov 1994 360
36 Thiol redox control via thioredoxin and glutaredoxin systems Arne Holmgren, C. Johansson, Carsten Berndt et al. · Biochemical Society Transactions 26 Oct 2005 355
37 Selenocysteine in proteins—properties and biotechnological use Linda Johansson, Guro Gafvelin, Elias S.J. Arnér · Biochimica et Biophysica Acta (BBA) - General Subjects Open access 3 Jun 2005 354
38 Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme Tatyana Sandalova, Liangwei Zhong, Ylva Lindqvist et al. · Proceedings of the National Academy of Sciences Open access 31 Jul 2001 343
39 Thioredoxin, a Redox Enzyme Released in Infection and Inflammation, Is a Unique Chemoattractant for Neutrophils, Monocytes, and T Cells Riccardo Bertini, O. M. Zack Howard, Huifang Dong et al. · The Journal of Experimental Medicine Open access 7 Jun 1999 341
40 A Computed Tomographic Scan–Derived Customized Surgical Template and Fixed Prosthesis for Flapless Surgery and Immediate Loading of Implants in Fully Edentulous Maxillae: A Prospective Multicenter Study Daniël van Steenberghe, Roland Glauser, Ulf Blombäck et al. · Clinical Implant Dentistry and Related Research Jun 2005 337
41 Cloning and Expression of a Novel Human Glutaredoxin (Grx2) with Mitochondrial and Nuclear Isoforms Mathias Lundberg, C. Johansson, Joya Chandra et al. · Journal of Biological Chemistry Open access Jul 2001 336
42 Ending World Hunger. The Promise of Biotechnology and the Threat of Antiscience Zealotry Norman E. Borlaug · PLANT PHYSIOLOGY Open access Oct 2000 330
43 Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation David S. Liu, Cuong P. Duong, Sue Haupt et al. · Nature Communications Open access 28 Mar 2017 329
44 Inhibition of Mammalian Thioredoxin Reductase by Some Flavonoids: Implications for Myricetin and Quercetin Anticancer Activity Jun Lu, Laura V. Papp, Jianguo Fang et al. · Cancer Research 15 Apr 2006 325
45 Bone Tissue Responses to Surface‐Modified Zirconia Implants: A Histomorphometric and Removal Torque Study in the Rabbit Lars Sennerby, Amir Dasmah, Birgitta Larsson et al. · Clinical Implant Dentistry and Related Research Jun 2005 320
46 Human Mitochondrial Glutaredoxin Reduces S-Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase C. Johansson, Christopher Horst Lillig, Arne Holmgren · Journal of Biological Chemistry Open access Feb 2004 319
47 Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans Erik Schoenmakers et al. · Journal of Clinical Investigation Open access 17 Nov 2010 317
48 Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols Mikael Björnstedt, Mats Hámberg, Sushil Kumar et al. · Journal of Biological Chemistry Open access May 1995 314
49 Tilted Implants as an Alternative to Maxillary Sinus Grafting: A Clinical, Radiologic, and Periotest Study Carlos Aparicio, Pilar Perales, Bo Rangert · Clinical Implant Dentistry and Related Research 2001 313
50 Load factor control for implants in the posterior partially edentulous segment. B R Rangert, R M Sullivan, T M Jemt · PubMed 17 Jul 1997 303

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.