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Most cited papers from Open Data Institute

Open Data Institute

What are the most cited papers from Open Data Institute?

The most cited paper from Open Data Institute is "SARS-CoV-2 is associated with changes in brain structure in UK Biobank" (Gwenaëlle Douaud, Soojin Lee, Fidel Alfaro‐Almagro et al., 2022), with 1,594 citations. Next come "A genomic mutational constraint map using variation in 76,156 human genomes" (1,453) and "The evolution of SARS-CoV-2" (1,247).

Showing 50 of 59 papers. Every paper with more than 205 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 SARS-CoV-2 is associated with changes in brain structure in UK Biobank Gwenaëlle Douaud, Soojin Lee, Fidel Alfaro‐Almagro et al. · Nature Open access 7 Mar 2022 1,594
2 A genomic mutational constraint map using variation in 76,156 human genomes Siwei Chen et al. · Nature Open access238 authors 6 Dec 2023 1,453
3 The evolution of SARS-CoV-2 Peter V. Markov, Mahan Ghafari, Martin Beer et al. · Nature Reviews Microbiology ReviewOpen access 5 Apr 2023 1,247
4 1. The power of databases: The RRUFF project Barbara Lafuente, R. T. Downs, Heng‐Li Yang et al. Book chapter 11 Nov 2015 1,233
5 The evolutionary history of 2,658 cancers Moritz Gerstung et al. · Nature Open access1,441 authors 5 Feb 2020 1,149
6 The power of genetic diversity in genome-wide association studies of lipids Sarah E. Graham et al. · Nature Open access527 authors 9 Dec 2021 1,099
7 The trans-ancestral genomic architecture of glycemic traits Jihua Chen et al. · Nature Genetics Open access417 authors 31 May 2021 918
8 Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 Simon I Hay et al. · The Lancet Open access2,780 authors Oct 2025 762
9 COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England Marion M. Mafham, Enti Spata, Raph Goldacre et al. · The Lancet Open access 14 Jul 2020 753
10 SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway Brian J. Willett et al. · Nature Microbiology Open access692 authors 7 Jul 2022 739
11 Genomic Evolution of Breast Cancer Metastasis and Relapse Lucy R. Yates et al. · Cancer Cell Open access Aug 2017 712
12 Covasim: An agent-based model of COVID-19 dynamics and interventions Cliff C. Kerr et al. · PLoS Computational Biology Open access 26 Jul 2021 671
13 Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial Katherine R. W. Emary et al. · The Lancet Open access 30 Mar 2021 652
14 Classification and Personalized Prognosis in Myeloproliferative Neoplasms Jacob Grinfeld et al. · New England Journal of Medicine Open access 10 Oct 2018 641
15 Modeling COVID-19 scenarios for the United States IHME COVID-19 Forecasting Team et al. · Nature Medicine Open access 23 Oct 2020 608
16 Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes Stefan C. Dentro et al. · Cell Open access119 authors Apr 2021 577
17 Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK Koen Bernardus Pouwels, Emma Pritchard, Philippa Clare Matthews et al. · Nature Medicine Open access 14 Oct 2021 568
18 Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal Thomas J. Mitchell et al. · Cell Open access Apr 2018 566
19 Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 Mohsen Naghavi et al. · The Lancet Open access2,463 authors Oct 2025 500
20 Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition Bernardo Rodríguez–Martín et al. · Nature Genetics Open access1,448 authors 5 Feb 2020 490
21 Estimation of brain age delta from brain imaging Stephen M. Smith, Diego Vidaurre, Fidel Alfaro‐Almagro et al. · NeuroImage Open access 12 Jun 2019 484
22 Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis Mia Petljak et al. · Cell Open access Mar 2019 454
23 Pervasive chromosomal instability and karyotype order in tumour evolution Thomas B.K. Watkins et al. · Nature Open access 2 Sep 2020 415
24 Real-Time Polyp Detection, Localization and Segmentation in Colonoscopy Using Deep Learning Debesh Jha, Sharib Ali, Nikhil Kumar Tomar et al. · IEEE Access Open access 2021 408
25 Efficacy of contact tracing for the containment of the 2019 novel coronavirus (COVID-19) Matt J. Keeling, T. Déirdre Hollingsworth, Jonathan Michael Read · Journal of Epidemiology & Community Health Open access 23 Jun 2020 387
26 Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018 David W. Eyre, Nicholas D. Sanderson, Emily Lord et al. · Eurosurveillance Open access 5 Jul 2018 379
27 Statistical Challenges in “Big Data” Human Neuroimaging Stephen M. Smith, Thomas E. Nichols · Neuron Open access 2018 363
28 Whole-genome sequencing reveals host factors underlying critical COVID-19 Athanasios Kousathanas et al. · Nature Open access2,399 authors 7 Mar 2022 356
29 Bayesian inference of ancestral dates on bacterial phylogenetic trees Xavier Didelot, Nicholas J. Croucher, Stephen D. Bentley et al. · Nucleic Acids Research Open access 22 Aug 2018 354
30 Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality Emmanuel Stamatakis, Matthew N. Ahmadi, Jason M. R. Gill et al. · Nature Medicine Open access Dec 2022 353
31 Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom Jia Wei et al. · Nature Microbiology Open access 21 Jul 2021 349
32 Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults Mariaelisa Graff et al. · PLoS Genetics ReviewOpen access281 authors 27 Apr 2017 345
33 Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics Xiaodun Li et al. · Nature Communications Open access 24 Jul 2018 343
34 Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom Emma Pritchard, Philippa Clare Matthews, Nicole E Stoesser et al. · Nature Medicine Open access 9 Jun 2021 341
35 Impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England: a population-based study Eva J.A. Morris et al. · ˜The œLancet. Gastroenterology & hepatology Open access 14 Jan 2021 337
36 Noninvasive proteomic biomarkers for alcohol-related liver disease Lili Niu, Maja Sofie Thiele, Philipp Emanuel Geyer et al. · Nature Medicine Open access Jun 2022 336
37 Spatially resolved clonal copy number alterations in benign and malignant tissue Andrew M. Erickson et al. · Nature Open access 10 Aug 2022 335
38 New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk Yingchang Lu et al. · Nature Communications Open access259 authors Feb 2016 321
39 The Duration, Dynamics, and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Responses in Individual Healthcare Workers Sheila Lumley et al. · Clinical Infectious Diseases Open access242 authors 4 Jan 2021 311
40 Genomic landscape and chronological reconstruction of driver events in multiple myeloma Francesco Maura et al. · Nature Communications Open access 23 Aug 2019 279
41 Confound modelling in UK Biobank brain imaging Fidel Alfaro‐Almagro, Paul J. McCarthy, Soroosh Afyouni et al. · NeuroImage Open access 2 Jun 2020 274
42 Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines Jia Wei et al. · Nature Medicine Open access 14 Feb 2022 270
43 Solving the missing heritability problem Alexander I. Young · PLoS Genetics Open access 24 Jun 2019 269
44 Open science saves lives: lessons from the COVID-19 pandemic Lonni Besançon, Nathan Peiffer‐Smadja, Corentin Ségalas et al. · BMC Medical Research Methodology Open access 5 Jun 2021 267
45 A sensory appendage protein protects malaria vectors from pyrethroids Victoria Anne Ingham, Amalia Anthousi, Vassilis Douris et al. · Nature Open access 25 Dec 2019 265
46 Feasibility of Obtaining Measures of Lifestyle From a Smartphone App Michael V. McConnell, Anna Shcherbina, Aleksandra M. Pavlovic et al. · JAMA Cardiology Open access 14 Dec 2016 261
47 Efficient pedigree recording for fast population genetics simulation Jerome Kelleher, Kevin Thornton, Jaime Ashander et al. · PLoS Computational Biology Open access Nov 2018 258
48 Host genetics and infectious disease: new tools, insights and translational opportunities Andrew Kwok, Alexander J. Mentzer, Julian Charles Knight · Nature Reviews Genetics ReviewOpen access 4 Dec 2020 256
49 Ethics of instantaneous contact tracing using mobile phone apps in the control of the COVID-19 pandemic Michael James Parker, Christophe Fraser, Lucie Abeler‐Dörner et al. · Journal of Medical Ethics Open access 4 May 2020 255
50 Genomic and evolutionary classification of lung cancer in never smokers Tongwu Zhang et al. · Nature Genetics Open access Sep 2021 254

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.