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Most cited papers from Pharmac

What are the most cited papers from Pharmac?

The most cited paper from Pharmac is "CpG Motifs in Bacterial DNA and Their Immune Effects" (Arthur M. Krieg, 2002), with 2,585 citations. Next come "A pharmacokinetic analysis program (multi) for microcomputer." (2,459) and "Safety and antitumor activity of recombinant soluble Apo2 ligand" (2,234).

Showing 50 of 58 papers. Every paper with more than 278 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 CpG Motifs in Bacterial DNA and Their Immune Effects Arthur M. Krieg · Annual Review of Immunology Review Apr 2002 2,585
2 A pharmacokinetic analysis program (multi) for microcomputer. Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa et al. · Journal of Pharmacobio-Dynamics Open access 1981 2,459
3 Safety and antitumor activity of recombinant soluble Apo2 ligand Avi Ashkenazi, Roger Pai, Sharon Fong et al. · Journal of Clinical Investigation Open access 15 Jul 1999 2,234
4 Consolidated Health Economic Evaluation Reporting Standards (CHEERS)—Explanation and Elaboration: A Report of the ISPOR Health Economic Evaluation Publication Guidelines Good Reporting Practices Task Force Don Husereau, Michael Drummond, Stavros Petrou et al. · Value in Health Open access Mar 2013 2,069
5 Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement Don Husereau, Michael Drummond, Stavros Petrou et al. · BMJ Open access 25 Mar 2013 1,772
6 Recombinant Leptin for Weight Loss in Obese and Lean Adults Steven B. Heymsfield, Andrew S. Greenberg, Ken Fujioka et al. · JAMA 27 Oct 1999 1,430
7 Planar chips technology for miniaturization and integration of separation techniques into monitoring systems A. Manz, David J. Harrison, Elisabeth M. J. Verpoorte et al. · Journal of Chromatography A Feb 1992 1,038
8 The health economics of bladder cancer Marc F Botteman, Chris Leo Pashos, Alberto Cesare Luigi Redaelli et al. · PharmacoEconomics Dec 2003 889
9 Consensus guidelines for the detection of immunogenic cell death Oliver Kepp et al. · OncoImmunology Open access 2 Sep 2014 842
10 Human P-glycoprotein transports cyclosporin A and FK506. Takashi Saeki, Kazumitsu Ueda, Yusuke Tanigawara et al. · Journal of Biological Chemistry Open access Mar 1993 691
11 Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. Kazumitsu Ueda, Noboru Okamura, Midori Hirai et al. · Journal of Biological Chemistry Open access Dec 1992 677
12 Assessing the Gold Standard — Lessons from the History of RCTs Laura E. Bothwell, Jeremy A. Greene, Scott H. Podolsky et al. · New England Journal of Medicine Jun 2016 667
13 Interaction of Phytoestrogens with Estrogen Receptors .ALPHA. and .BETA.. Keiko Morito, Toshiharu Hirose, Junei Kinjo et al. · Biological and Pharmaceutical Bulletin Open access 2001 618
14 A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease Barry J. Snow, Fiona L. Rolfe, Michelle Marie Lockhart et al. · Movement Disorders 21 Jun 2010 618
15 Aristolochic acid and the etiology of endemic (Balkan) nephropathy Arthur P. Grollman, Shinya Shibutani, Masaaki Moriya et al. · Proceedings of the National Academy of Sciences Open access 9 Jul 2007 608
16 Immune Checkpoint Inhibitor Rechallenge After Immune-Related Adverse Events in Patients With Cancer Charles Dolladille, Stéphane Éderhy, Marion Sassier et al. · JAMA Oncology Open access 16 Apr 2020 601
17 A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke Pierre Amarenco et al. · New England Journal of Medicine Open access 18 Nov 2019 579
18 Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles Henry G. Morrison, Changquan Calvin Sun, Sesha Neervannan · International Journal of Pharmaceutics 28 May 2009 544
19 Characterization of Two Alternately Spliced Forms of Phospholipase D1 Scott M. Hammond, John M. Jenco, Shigeru Nakashima et al. · Journal of Biological Chemistry Open access Feb 1997 544
20 Validation of Acute Myocardial Infarction Cases in the National Health Insurance Research Database in Taiwan Ching Cheng, Cheng Han Lee, Po Sheng Chen et al. · Journal of Epidemiology Open access 2014 536
21 The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease Michelle Glass, Mike Dragunow, Richard L. M. Faull · Neuroscience May 2000 532
22 Accuracy of medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records Yuka Kiyota, Sebastian Schneeweiß, Robert J. Glynn et al. · American Heart Journal 23 Jun 2004 531
23 Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics Yohei Nishizato · Clinical Pharmacology & Therapeutics Jun 2003 513
24 Preclinical Pharmacokinetics of Ranibizumab (rhuFabV2) after a Single Intravitreal Administration Jacques Gaudreault, David Fei, Jeriza Rusit et al. · Investigative Ophthalmology & Visual Science 26 Jan 2005 504
25 Broadening Eligibility Criteria to Make Clinical Trials More Representative: American Society of Clinical Oncology and Friends of Cancer Research Joint Research Statement Edward S. Kim et al. · Journal of Clinical Oncology Open access 2 Oct 2017 497
26 p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. R M Hudziak, G D Lewis, M Winget et al. · Molecular and Cellular Biology Mar 1989 489
27 Interaction of Phytoestrogens with Estrogen Receptors .ALPHA. and .BETA.(II). Keiko Morito, Tohru Aomori, Toshiharu Hirose et al. · Biological and Pharmaceutical Bulletin Open access 2002 464
28 Antipsychotics and the Risk of Sudden Cardiac Death Wayne A. Ray, Sarah K Meredith, Purushottam B. Thapa et al. · Archives of General Psychiatry Dec 2001 431
29 Rituximab-Dependent Cytotoxicity by Natural Killer Cells Sébastien Dall’Ozzo, Sophie Tartas, Gilles Paintaud et al. · Cancer Research Jul 2004 427
30 Charge variants in IgG1 Leslie A. Khawli, Sirj Goswami, Ryan A. Hutchinson et al. · mAbs Open access Nov 2010 419
31 A New Model of Patient Tumor-Derived Breast Cancer Xenografts for Preclinical Assays Elisabetta Marangoni, Anne Vincent‐Salomon, Nathalie Auger et al. · Clinical Cancer Research Jul 2007 418
32 Acute and clinically relevant drug‐induced liver injury: a population based case‐control study Francisco José de Abajo, Dolores Montero, Mariano Madurga et al. · British Journal of Clinical Pharmacology Open access 4 Jun 2004 412
33 Antidepressant Use in Pregnancy and the Risk of Cardiac Defects Krista F. Huybrechts, Kristin K. Palmsten, Jerry Avorn et al. · New England Journal of Medicine Open access 18 Jun 2014 410
34 Treat or Eat: Food Insecurity, Cost-related Medication Underuse, and Unmet Needs Seth A. Berkowitz, Hilary Kessler Seligman, Niteesh K. Choudhry · The American Journal of Medicine Open access 17 Jan 2014 392
35 Prenatal undernutrition and cognitive function in late adulthood Susanne R. de Rooij, Hans Wouters, Julie E. Yonker et al. · Proceedings of the National Academy of Sciences Open access 13 Sep 2010 368
36 New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies Gabriella Martino, Michael Edler, Giuseppe La Regina et al. · Journal of Medicinal Chemistry 19 Jan 2006 365
37 Recent advances in the chemistry of organic thiocyanates Thomas Castanheiro, Jean Suffert, Morgan Donnard et al. · Chemical Society Reviews Review 11 Dec 2015 361
38 Aprotinin during Coronary-Artery Bypass Grafting and Risk of Death Sebastian Schneeweiß, John D. Seeger, Joan E. Landon et al. · New England Journal of Medicine 20 Feb 2008 358
39 Once-Daily Bronchodilators for Chronic Obstructive Pulmonary Disease: Indacaterol Versus Tiotropium James F. Donohue, Charles M. Fogarty, Jan O. Lötvall et al. · American Journal of Respiratory and Critical Care Medicine 12 May 2010 357
40 Developing and understanding biofluid vibrational spectroscopy: a critical review Matthew J. Baker, Shawn R. Hussain, Lila Lovergne et al. · Chemical Society Reviews ReviewOpen access 27 Nov 2015 352
41 Use of β-Blockers and Risk of Fractures Raymond G. Schlienger · JAMA Open access 14 Sep 2004 346
42 The Burden of Disease and the Changing Task of Medicine David Shumway Jones, Scott H. Podolsky, Jeremy A. Greene · New England Journal of Medicine Open access 21 Jun 2012 332
43 CPG 7909, an Immunostimulatory TLR9 Agonist Oligodeoxynucleotide, as Adjuvant to Engerix-B� HBV Vaccine in Healthy Adults: A Double-Blind Phase I/II Study Curtis Cooper, Heather L. Davis, Mary Lou Morris et al. · Journal of Clinical Immunology Nov 2004 330
44 In Vitro Antioxidant Studies on the Benzyl Tetra Isoquinoline Alkaloid Berberine Annie Shirwaikar, Arun Shirwaikar, K. Rajendran et al. · Biological and Pharmaceutical Bulletin Open access 2006 330
45 Clinical Pharmacokinetics of Linezolid, a Novel Oxazolidinone Antibacterial Dennis J. Stalker, Gail L. Jungbluth · Clinical Pharmacokinetics 2003 327
46 Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production Carmela Guido, Diana Whitaker‐Menezes, Claudia Capparelli et al. · Cell Cycle Open access 15 Aug 2012 320
47 The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation Narender R. Gavva, Anthony W. Bannon, Sekhar Surapaneni et al. · Journal of Neuroscience Open access 28 Mar 2007 314
48 Novel Hydrogels via Click Chemistry: Synthesis and Potential Biomedical Applications V. Crescenzi, Lisa Cornelio, Chiara Di Meo et al. · Biomacromolecules 25 May 2007 310
49 Sodium Intake, ACE Inhibition, and Progression to ESRD Stefan Vegter, Annalisa Perna, Maarten Jacobus Postma et al. · Journal of the American Society of Nephrology Open access 3 Dec 2011 305
50 Adverse drug reactions and off-label drug use in paediatric outpatients Benjamin Horen, Jean‐Louis Montastruc, Maryse Lapeyre‐Mestre · British Journal of Clinical Pharmacology Open access Dec 2002 296

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.